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Travis B. Conley  (Conley TB) 1 Article
Intermuscular Adipose Tissue Content and Intramyocellular Lipid Fatty Acid Saturation Are Associated with Glucose Homeostasis in Middle-Aged and Older Adults
Jung Eun Kim, Keagan Dunville, Junjie Li, Ji Xin Cheng, Travis B. Conley, Cortni S. Couture, Wayne W. Campbell
Endocrinol Metab. 2017;32(2):257-264.   Published online May 29, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.2.257
  • 3,693 View
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  • 11 Citations
AbstractAbstract PDFSupplementary MaterialPubReader   CrossRef-TDMCrossref - TDM
Background

Insulin resistance is associated with the higher content of intermuscular adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of data exist in humans. This study examined associations among IMAT content, IMCL saturation, and fasting glucose concentration in middle-aged and older adults with overweight or obesity.

Methods

Seventy-five subjects (26 males, 49 females) were recruited and thigh muscle and IMAT were assessed using magnetic resonance imaging. Vastus lateralis tissue was acquired from a subset of nine subjects and IMCL content and saturation were assessed using nonlinear dual complex microscopy.

Results

The characteristics of the 75 subjects were as follows: age 59±11 years, body mass index 30±5 kg/m2, fasting glucose concentration 5.2±0.5 mmol/L, fasting insulin concentration 12.2±7.3 µU/mL, fasting homeostatic model assessment of insulin resistance (HOMA-IR) 2.9±2.0 (mean±SD). IMAT to muscle tissue (MT) volume ratio was positively associated with the saturated fatty acid to unsaturated fatty acid ratio in IMCL. IMAT:MT was positively associated with fasting glucose concentration and HOMA-IR. IMCL saturation was positively associated with fasting glucose concentration while muscle cell area, IMCL area, and % IMCL in muscle cell were not associated with fasting glucose concentration.

Conclusion

These results indicate that higher intermuscular fat content and IMCL saturation may impact fasting glucose concentration in middle-aged and older adults with overweight or obesity. The centralization of adipose tissue in the appendicular region of the body may promote insulin resistance.

Citations

Citations to this article as recorded by  
  • Intermuscular adipose tissue in metabolic disease
    Bret H. Goodpaster, Bryan C. Bergman, Andrea M. Brennan, Lauren M. Sparks
    Nature Reviews Endocrinology.2023; 19(5): 285.     CrossRef
  • Muscle function and architecture in children with juvenile idiopathic arthritis
    Pierre Bourdier, Anthony Birat, Emmanuelle Rochette, Éric Doré, Daniel Courteix, Frédéric Dutheil, Bruno Pereira, Sébastien Ratel, Etienne Merlin, Pascale Duché
    Acta Paediatrica.2021; 110(1): 280.     CrossRef
  • NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle
    Gonzalo Jorquera, Javier Russell, Matías Monsalves-Álvarez, Gonzalo Cruz, Denisse Valladares-Ide, Carla Basualto-Alarcón, Genaro Barrientos, Manuel Estrada, Paola Llanos
    International Journal of Molecular Sciences.2021; 22(6): 3254.     CrossRef
  • Intermuscular Fat Content in Young Chinese Men With Newly Diagnosed Type 2 Diabetes: Based on MR mDIXON-Quant Quantitative Technique
    Fuyao Yu, Bing He, Li Chen, Fengzhe Wang, Haidong Zhu, Yanbin Dong, Shinong Pan
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • A Valid and Precise Semiautomated Method for Quantifying Intermuscular Fat Intramuscular Fat in Lower Leg Magnetic Resonance Images
    Andy K.O. Wong, Eva Szabo, Marta Erlandson, Marshall S. Sussman, Sravani Duggina, Anny Song, Shannon Reitsma, Hana Gillick, Jonathan D. Adachi, Angela M. Cheung
    Journal of Clinical Densitometry.2020; 23(4): 611.     CrossRef
  • Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease
    Alan Chait, Laura J. den Hartigh
    Frontiers in Cardiovascular Medicine.2020;[Epub]     CrossRef
  • Effects of weight loss during a very low carbohydrate diet on specific adipose tissue depots and insulin sensitivity in older adults with obesity: a randomized clinical trial
    Amy M Goss, Barbara Gower, Taraneh Soleymani, Mariah Stewart, May Pendergrass, Mark Lockhart, Olivia Krantz, Shima Dowla, Nikki Bush, Valene Garr Barry, Kevin R. Fontaine
    Nutrition & Metabolism.2020;[Epub]     CrossRef
  • Local In Vivo Measures of Muscle Lipid and Oxygen Consumption Change in Response to Combined Vitamin D Repletion and Aerobic Training in Older Adults
    D. Thomas, David Schnell, Maja Redzic, Mingjun Zhao, Hideat Abraha, Danielle Jones, Howard Brim, Guoqiang Yu
    Nutrients.2019; 11(4): 930.     CrossRef
  • Impact of different ectopic fat depots on cardiovascular and metabolic diseases
    Daniele Ferrara, Fabrizio Montecucco, Franco Dallegri, Federico Carbone
    Journal of Cellular Physiology.2019; 234(12): 21630.     CrossRef
  • Differential Relationship between Intermuscular Adipose Depots with Indices of Cardiometabolic Health
    Robert E. Bergia, Jung Eun Kim, Wayne W. Campbell
    International Journal of Endocrinology.2018; 2018: 1.     CrossRef
  • Association of sarcopenic obesity predicted by anthropometric measurements and 24-y all-cause mortality in elderly men: The Kuakini Honolulu Heart Program
    Kiyoshi Sanada, Randi Chen, Bradley Willcox, Tomoyuki Ohara, Aida Wen, Cody Takenaka, Kamal Masaki
    Nutrition.2018; 46: 97.     CrossRef

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