Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Teresita Bellido  (Bellido T) 1 Article
Why to Keep Osteocytes Alive and How?.
Teresita Bellido
J Korean Endocr Soc. 2009;24(4):223-226.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.223
  • 1,640 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
It has been long proposed that the osteocyte network continually compares present mechanical strains to usual levels of strain, and triggers signals to osteoclasts or osteoblasts resulting in bone loss or gain, as needed. Whereas physiological levels of mechanical stimulation maintain bone mass, too low or too high levels of strain induce bone resorption. One mechanism by which osteocytes may trigger bone resorption is by undergoing apoptosis. Either low or high levels of mechanical loading lead to increased prevalence of osteocyte apoptosis, which temporally precedes and is spatially associated with osteoclast recruitment and the subsequent increase in bone resorption[1,2]. A cause and effect relationship between osteocyte death and bone resorption has been demonstrated using a transgenic mouse model of inducible osteocyte ablation in which osteocyte apoptosis was sufficient to trigger osteoclast recruitment[3]. In addition, the normal osteoclastogenic response to unloading was missing in bones from osteocyte-depleted mice, confirming that osteocytes are indispensable for the skeletal adaptation to weightlessness. Because osteocyte apoptosis is inhibited not only by mechanical stimulation but also by estrogens and bisphosphonates, these findings raise the intriguing possibility that preservation of osteocyte viability contributes to the anti-remodeling properties of these agents.

Citations

Citations to this article as recorded by  
  • Navicular syndrome in sport horses as a result of the disorder of biological bone tissue turnover rhythm: a review
    Marcin Komosa, Halina Purzyc, Monika Wojnar, Hieronim Frąckowiak, Franciszek Kobryńczuk
    Biological Rhythm Research.2013; 44(3): 339.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism
TOP