Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism


Author index

Page Path
Tae-Kyung Kim  (Kim TK) 1 Article
Physiological Parameters in the Blood of a Murine Stress-Induced Depression Model before and after Repeated Passive Exercise
Tae-Kyung Kim, Jin-Young Park, Pyung-Lim Han
Endocrinol Metab. 2015;30(3):371-380.   Published online January 5, 2015
  • 3,542 View
  • 37 Download
  • 8 Citations
AbstractAbstract PDFPubReader   

Animal models are necessary to study the mechanism underlying the effects of exercise on depression but an effective procedure for exercise treatment and exercise effects on physiological parameters in a specific depression model need to be characterized.


Physiological parameters including lactate, partial pressue of O2 (pO2) and CO2 (pCO2) saturated O2 (sO2), pH, HCO3, total CO2 (TCO2), and base excess extracellular fluid (BEecf) levels in the blood were measured after treatment with passive exercise in normal mice and a stress-induced depression model.


Normal mice or mice that were subjected to daily 2-hour restraint for 14 days (2 hours×14 days of restraint) were placed on a running wheel that was rotating at a speed of 9 m/min for 1 hour per day for 1 to 21 days. After repeated exercise in mice that were previously subjected to 2 hours×14 days restraint, plasma lactate levels decreased, the levels of pO2, sO2, and pH tended to increase, and the levels of pCO2 decreased in the absence of significant changes in HCO3, TCO2, and BEecf. However, none of these changes were additive to the stress effects or were much more severe than those induced after repeated passive exercise in normal mice.


These results suggest that passive exercise for 1 hour daily for 14 to 21 consecutive days on a running wheel rotating at a speed of 9 m/min may be used as an exercise protocol without inducing severe additive effects on physiological burdens.


Citations to this article as recorded by  
  • VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors
    Soo Ji Baek, Jin Sung Park, Jinhyun Kim, Yukio Yamamoto, Keiko Tanaka-Yamamoto
    eLife.2022;[Epub]     CrossRef
  • Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study
    S.T. Jenz, C.D. Goodyear, P.R. TSgt Graves, S. Goldstein, M.R. Shia, E.E. Redei
    Neurobiology of Stress.2021; 14: 100323.     CrossRef
  • Aggravated mucosal and immune damage in a mouse model of ulcerative colitis with stress
    Yanxia Gong, Wei Niu, Yanping Tang, Qingyu Zhang, Simiao Liu, Xi Liu, Xiao Wang, Yang Xu
    Experimental and Therapeutic Medicine.2019;[Epub]     CrossRef
  • G9a-Mediated Regulation of OXT and AVP Expression in the Basolateral Amygdala Mediates Stress-Induced Lasting Behavioral Depression and Its Reversal by Exercise
    Tae-Kyung Kim, Jung-Eun Lee, Ji-Eun Kim, Jin-Young Park, Juli Choi, Hannah Kim, Eun-Hwa Lee, Pyung-Lim Han
    Molecular Neurobiology.2016; 53(5): 2843.     CrossRef
  • Can Exercise Make You Smarter, Happier, and Have More Neurons? A Hormetic Perspective
    Simona Gradari, Anna Pallé, Kerry R. McGreevy, Ángela Fontán-Lozano, José L. Trejo
    Frontiers in Neuroscience.2016;[Epub]     CrossRef
  • Chronic stress and moderate physical exercise prompt widespread common activation and limited differential activation in specific brain regions
    Tae-Kyung Kim, Pyung-Lim Han
    Neurochemistry International.2016; 99: 252.     CrossRef
  • Exercise and Depression
    Jang Won Son
    Endocrinology and Metabolism.2015; 30(3): 270.     CrossRef
  • Antidepressant effects of exercise are produced via suppression of hypocretin/orexin and melanin-concentrating hormone in the basolateral amygdala
    Tae-Kyung Kim, Ji-Eun Kim, Jin-Young Park, Jung-Eun Lee, Juli Choi, Hannah Kim, Eun-Hwa Lee, Seung-Woo Kim, Ja-Kyeong Lee, Hyun-Sik Kang, Pyung-Lim Han
    Neurobiology of Disease.2015; 79: 59.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism