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Endocrinol Metab : Endocrinology and Metabolism


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Sun Pyo Hong  (Hong SP) 1 Article
Clinical Study
Associations of Metabolic Syndrome with Total Testosterone and Homocysteine Levels in Male Korean Workers
Sook Hee Sung, Nam Hee Kim, Sun Pyo Hong, Jong-Keun Lee, Seung Jin Choi
Endocrinol Metab. 2019;34(2):158-168.   Published online June 24, 2019
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  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   ePub   

Low testosterone is associated with metabolic syndrome (MetS), and homocysteine (Hcy) is elevated in individuals with MetS. We investigated the relationships of total testosterone (TT) and serum Hcy levels with MetS in male Korean workers.


We conducted a cross-sectional study including 8,606 male workers, aged 20 to 58 years, who underwent a physical examination in 2015. MetS was diagnosed based on the criteria of the 2009 harmonized definition, while the Korean standard for waist circumference (WC) was used. Participants' biochemical parameters, including TT and serum Hcy, were measured, and participants were divided into quartiles. Multiple logistic regression models were used to estimate the association of MetS and its individual components depending on TT and serum Hcy quartiles.


The prevalence of MetS in the study population was 16%. TT was lower in participants with MetS than in those without MetS (P<0.001). By contrast, Hcy level was similar between groups (P=0.694). In multiple logistic regression analysis, the odds ratio for the lowest TT quartile was 1.29 (95% confidence interval, 1.06 to 1.57) after adjusting for potential confounders. Participants with lower TT were more likely to have high WC, hypertriglyceridemia, and low high density lipoprotein levels. Serum Hcy levels were not significantly associated with MetS. Of the five components of MetS, only WC was significantly associated with serum Hcy.


In male Korean workers, TT may be an independent predictor of MetS, and serum Hcy levels could be a marker of abdominal obesity. However, future prospective studies are needed.


Citations to this article as recorded by  
  • A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
    Shenghao Wu, Yanhong Wu, Lizi Fang, Junzhao Zhao, Yaoyao Cai, Weiting Xia
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
    Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Córdova, Juan C. Cabrera-Guzmán, Percy Herrera-Añazco, Vicente A. Benites-Zapata
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
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