Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Su Jung Baik  (Baik SJ) 1 Article
Clinical Study
Triglyceride Glucose Index Is Superior to the Homeostasis Model Assessment of Insulin Resistance for Predicting Nonalcoholic Fatty Liver Disease in Korean Adults
Sang Bae Lee, Min Kyung Kim, Shinae Kang, Kahui Park, Jung Hye Kim, Su Jung Baik, Ji Sun Nam, Chul Woo Ahn, Jong Suk Park
Endocrinol Metab. 2019;34(2):179-186.   Published online May 20, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.2.179
  • 5,486 View
  • 119 Download
  • 54 Citations
AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Background

Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance which is a well-known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and NAFLD. Thus, we investigated the relationship between the TyG index and NAFLD and the effectiveness of the TyG index compared with the homeostasis model assessment of insulin resistance (HOMA-IR) in identifying NAFLD in Korean adults.

Methods

Participants of 4,986 who underwent ultrasonography in a health promotion center were enrolled. The TyG index was calculated as ln [fasting triglycerides (mg/dL)×fasting glucose (mg/dL)/2], and HOMA-IR was estimated. NAFLD was diagnosed by ultrasonography.

Results

Significant differences were observed in metabolic parameters among the quartiles of the TyG index. The prevalence of NAFLD significantly increased with increment in the TyG index. After adjusting for multiple risk factors, a logistic regression analysis was performed. When the highest and lowest quartiles of the TyG index and HOMA-IR were compared, the odds ratios for the prevalence of NAFLD were 2.94 and 1.93 (95% confidence interval, 2.32 to 3.72 and 1.43 to 2.61; both P for trend <0.01), respectively. According to the receiver operating characteristic analysis, the TyG index was superior to HOMA-IR in predicting NAFLD.

Conclusion

The TyG index and prevalence of NAFLD were significantly related and the TyG index was superior to HOMA-IR in predicting NAFLD in Korean adults.

Citations

Citations to this article as recorded by  
  • The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis
    Qin Ling, Jiawei Chen, Xiao Liu, Yi Xu, Jianyong Ma, Peng Yu, Kai Zheng, Fuwei Liu, Jun Luo
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Triglyceride–Glucose Index as a Potential Indicator of Sarcopenic Obesity in Older People
    Bokun Kim, Gwonmin Kim, Yongkook Lee, Keisuke Taniguchi, Tomonori Isobe, Sechang Oh
    Nutrients.2023; 15(3): 555.     CrossRef
  • Association of insulin resistance with bone mineral density in a nationwide health check-up population in China
    Ming Zhuo, Ze Chen, Mao-Lin Zhong, Fang Lei, Juan-Juan Qin, Shuhua Liu, Ye-Mao Liu, Tao Sun, Xiao-Jing Zhang, Lihua Zhu, Jingjing Cai, Jun-Ming Ye, Erping Yang
    Bone.2023; 170: 116703.     CrossRef
  • Comparison of the Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict Nonalcoholic Fatty Liver Disease in Youths
    Kyungchul Song, Goeun Park, Hye Sun Lee, Myeongseob Lee, Hae In Lee, Han Saem Choi, Junghwan Suh, Ahreum Kwon, Ho-Seong Kim, Hyun Wook Chae
    The Journal of Pediatrics.2022; 242: 79.     CrossRef
  • The triglyceride-glucose index as a clinical useful marker for metabolic associated fatty liver disease (MAFLD): a population-based study among Iranian adults
    Ehsaneh Taheri, Mohammad Amin Pourhoseingholi, Alireza Moslem, Amir Hossein Hassani, Alireza Mousavi Jarrahi, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali, Behzad Hatami
    Journal of Diabetes & Metabolic Disorders.2022; 21(1): 97.     CrossRef
  • Comparison of triglyceride-glucose index and HOMA-IR for predicting prevalence and incidence of metabolic syndrome
    Da-Hye Son, Hye Sun Lee, Yong-Jae Lee, Jun-Hyuk Lee, Jee-Hye Han
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(3): 596.     CrossRef
  • Triglycerides/Glucose Index Is Associated with Sperm Parameters and Sperm DNA Fragmentation in Primary Infertile Men: A Cross-Sectional Study
    Federico Belladelli, Luca Boeri, Edoardo Pozzi, Giuseppe Fallara, Christian Corsini, Luigi Candela, Walter Cazzaniga, Daniele Cignoli, Luca Pagliardini, Alessia D’Arma, Paolo Capogrosso, Eugenio Ventimiglia, Francesco Montorsi, Andrea Salonia
    Metabolites.2022; 12(2): 143.     CrossRef
  • Association of triglyceride-glucose index and stroke recurrence among nondiabetic patients with acute ischemic stroke
    Xiaomeng Yang, Guangyao Wang, Jing Jing, Anxin Wang, Xiaoli Zhang, Qian Jia, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, Yongjun Wang, Yilong Wang
    BMC Neurology.2022;[Epub]     CrossRef
  • The triglycerides and glucose (TyG) index: A new marker associated with nonalcoholic steatohepatitis (NASH) in obese patients
    Benjamin Rivière, Audrey Jaussent, Valérie Macioce, Stéphanie Faure, Nicolas Builles, Patrick Lefebvre, Philippe Géraud, Marie-Christine Picot, Sandra Rebuffat, Eric Renard, Valérie Paradis, Marie-Dominique Servais, Nathalie de Preville, David Nocca, Anne
    Diabetes & Metabolism.2022; 48(4): 101345.     CrossRef
  • Association of triglyceride-glucose with cardiac hemodynamics in type 2 diabetes
    Chenxi Wang, Zhicong Zhao, Xia Deng, Zhensheng Cai, Tian Gu, Lian Li, Chang Guo, Dong Wang, Ling Yang, Li Zhao, Guoyue Yuan
    Diabetes and Vascular Disease Research.2022; 19(2): 147916412210833.     CrossRef
  • Comparison of the Modified TyG Indices and Other Parameters to Predict Non-Alcoholic Fatty Liver Disease in Youth
    Kyungchul Song, Hae Won Lee, Han Saem Choi, Goeun Park, Hye Sun Lee, Su Jin Kim, Myeongseob Lee, Junghwan Suh, Ahreum Kwon, Ho-Seong Kim, Hyun Wook Chae
    Biology.2022; 11(5): 685.     CrossRef
  • Triglyceride-Glucose Index for Early Prediction of Nonalcoholic Fatty Liver Disease: A Meta-Analysis of 121,975 Individuals
    Azizullah Beran, Hazem Ayesh, Mohammed Mhanna, Waseem Wahood, Sami Ghazaleh, Ziad Abuhelwa, Wasef Sayeh, Nameer Aladamat, Rami Musallam, Reem Matar, Saif-Eddin Malhas, Ragheb Assaly
    Journal of Clinical Medicine.2022; 11(9): 2666.     CrossRef
  • Triglyceride and Glucose Index as a Screening Tool for Nonalcoholic Liver Disease in Patients with Metabolic Syndrome
    Anca Maria Amzolini, Mircea-Cătălin Forțofoiu, Anca Barău Alhija, Ionela Mihaela Vladu, Diana Clenciu, Adina Mitrea, Maria Forțofoiu, Daniela Matei, Magdalena Diaconu, Marinela Sinziana Tudor, Elena Simona Micu
    Journal of Clinical Medicine.2022; 11(11): 3043.     CrossRef
  • Triglyceride glucose index is superior biomarker for predicting type 2 diabetes mellitus in children and adolescents
    Jong Seo Yoon, Hye Jin Lee, Hwal Rim Jeong, Young Suk Shim, Min Jae Kang, Il Tae Hwang
    Endocrine Journal.2022; 69(5): 559.     CrossRef
  • Triglyceride and glucose index is a simple and easy‐to‐calculate marker associated with nonalcoholic fatty liver disease
    Kyung‐Soo Kim, Sangmo Hong, Hong‐Yup Ahn, Cheol‐Young Park
    Obesity.2022; 30(6): 1279.     CrossRef
  • Evaluating Triglyceride and Glucose Index as a Simple and Easy-to-Calculate Marker for All-Cause and Cardiovascular Mortality
    Kyung-Soo Kim, Sangmo Hong, You-Cheol Hwang, Hong-Yup Ahn, Cheol-Young Park
    Journal of General Internal Medicine.2022; 37(16): 4153.     CrossRef
  • The Role of Insulin Resistance in Fueling NAFLD Pathogenesis: From Molecular Mechanisms to Clinical Implications
    Rossella Palma, Annamaria Pronio, Mario Romeo, Flavia Scognamiglio, Lorenzo Ventriglia, Vittorio Maria Ormando, Antonietta Lamazza, Stefano Pontone, Alessandro Federico, Marcello Dallio
    Journal of Clinical Medicine.2022; 11(13): 3649.     CrossRef
  • Comparison of the diagnostic value between triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol ratio in metabolic-associated fatty liver disease patients: a retrospective cross-sectional study
    Zhi Liu, He He, Yuzhao Dai, Lidan Yang, Shenling Liao, Zhenmei An, Shuangqing Li
    Lipids in Health and Disease.2022;[Epub]     CrossRef
  • Insulin Resistance Markers to Detect Nonalcoholic Fatty Liver Disease in a Male Hispanic Population
    Maritza Pérez-Mayorga, Jose P. Lopez-Lopez, Maria A. Chacon-Manosalva, Maria G Castillo, Johanna Otero, Daniel Martinez-Bello, Diego Gomez-Arbelaez, Daniel D. Cohen, Patricio Lopez-Jaramillo, Federico Ravaioli
    Canadian Journal of Gastroenterology and Hepatology.2022; 2022: 1.     CrossRef
  • Risk factors and prediction model for nonalcoholic fatty liver disease in northwest China
    Danting Li, Meiyu Zhang, Shengli Wu, Huiwen Tan, Nong Li
    Scientific Reports.2022;[Epub]     CrossRef
  • The triglyceride glucose index is associated with the cerebral small vessel disease in a memory clinic population
    Jiayu Zhang, Ming Hu, Yanqiu Jia, Shicong Zhao, Peiyuan Lv, Mingyue Fan, Yuanyuan Shi, Wei Jin
    Journal of Clinical Neuroscience.2022; 104: 126.     CrossRef
  • Integrating experimental model, LC-MS/MS chemical analysis, and systems biology approach to investigate the possible antidiabetic effect and mechanisms of Matricaria aurea (Golden Chamomile) in type 2 diabetes mellitus
    Yassin Ismail, Dina M. Fahmy, Maivel H. Ghattas, Mai M. Ahmed, Walaa Zehry, Samy M. Saleh, Dina M. Abo-elmatty
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Laboratory data clustering in defining population cohorts: Case study on metabolic indicators
    Ivan Pavicevic, Goran Miljus, Olgica Nedic
    Journal of the Serbian Chemical Society.2022; 87(9): 1025.     CrossRef
  • Association of triglyceride glucose-body mass index with non-small cell lung cancer risk: A case-control study on Chinese adults
    Feifei Wang, Ting He, Guoliang Wang, Tuo Han, Zhongqiang Yao
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Association Between Triglyceride-Glucose Index and Risk of Metabolic Dysfunction-Associated Fatty Liver Disease: A Cohort Study
    Ru Zhang, Qing Guan, Mengting Zhang, Yajie Ding, Zongzhe Tang, Hongliang Wang, Wei Zhang, Yue Chen, Rong Jiang, Yan Cui, Jie Wang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 3167.     CrossRef
  • Association between the triglyceride-glucose (TyG) index and increased blood pressure in normotensive subjects: a population-based study
    Dong-Hwa Lee, Jong Eun Park, So Young Kim, Hyun Jeong Jeon, Jong-Hyock Park
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Fructose consumption correlates with triglyceride-glucose index and glycemic status in healthy adults
    Eda Keskin, Havvanur Yoldas Ilktac
    Clinical Nutrition ESPEN.2022; 52: 184.     CrossRef
  • Independent and combined effects of triglyceride-glucose index on prehypertension risk: a cross-sectional survey in China
    Hong Xie, Jian Song, Liangliang Sun, Xinxin Xie, Yehuan Sun
    Journal of Human Hypertension.2021; 35(3): 207.     CrossRef
  • Association of Triglyceride-Glucose Index with Bone Mineral Density in Non-diabetic Koreans: KNHANES 2008–2011
    Jee Hee Yoon, A Ram Hong, Wonsuk Choi, Ji Yong Park, Hee Kyung Kim, Ho-Cheol Kang
    Calcified Tissue International.2021; 108(2): 176.     CrossRef
  • Triglyceride‐Glucose Index (TyG) is associated with erectile dysfunction: A cross‐sectional study
    Mehmet Yilmaz, Mustafa Karaaslan, Senol Tonyali, Mecit Celik, Tuncay Toprak, Oner Odabas
    Andrology.2021; 9(1): 238.     CrossRef
  • Triglyceride Glucose Index and Related Parameters (Triglyceride Glucose-Body Mass Index and Triglyceride Glucose-Waist Circumference) Identify Nonalcoholic Fatty Liver and Liver Fibrosis in Individuals with Overweight/Obesity
    Mohammad E. Khamseh, Mojtaba Malek, Rowshanak Abbasi, Hoda Taheri, Maryam Lahouti, Fariba Alaei-Shahmiri
    Metabolic Syndrome and Related Disorders.2021; 19(3): 167.     CrossRef
  • Triglyceride and glucose index and the risk of gestational diabetes mellitus: A nationwide population-based cohort study
    Jung A Kim, Jinsil Kim, Eun Roh, So-hyeon Hong, You-Bin Lee, Sei Hyun Baik, Kyung Mook Choi, Eunjin Noh, Soon Young Hwang, Geum Joon Cho, Hye Jin Yoo
    Diabetes Research and Clinical Practice.2021; 171: 108533.     CrossRef
  • Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
    Jung A. Kim, Soon Young Hwang, Ji Hee Yu, Eun Roh, So-hyeon Hong, You-Bin Lee, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Nan Hee Kim, Sin Gon Kim, Sei Hyun Baik, Kyung Mook Choi
    Scientific Reports.2021;[Epub]     CrossRef
  • The triglycerides and glucose index is strongly associated with hepatic steatosis in children with overweight or obesity
    Luis E. Simental-Mendía, César Javier Ortega-Pacheco, Elvira García-Guerrero, María Alejandra Sicsik-Aragón, Fernando Guerrero-Romero, Gerardo Martínez-Aguilar
    European Journal of Pediatrics.2021; 180(6): 1755.     CrossRef
  • Triglyceride-glucose index and the risk of stroke and its subtypes in the general population: an 11-year follow-up
    Anxin Wang, Guangyao Wang, Qian Liu, Yingting Zuo, Shuohua Chen, Boni Tao, Xue Tian, Penglian Wang, Xia Meng, Shouling Wu, Yongjun Wang, Yilong Wang
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Association Between Triglyceride Glucose Index and Non-Small Cell Lung Cancer Risk in Chinese Population
    Xin Yan, Yujuan Gao, Jingzhi Tong, Mi Tian, Jinghong Dai, Yi Zhuang
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Triglyceride Glucose Index Is Associated With Arterial Stiffness and 10-Year Cardiovascular Disease Risk in a Chinese Population
    Wen Guo, Wenfang Zhu, Juan Wu, Xiaona Li, Jing Lu, Pei Qin, Cheng Zhu, Nianzhen Xu, Qun Zhang
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • An Analysis of the Potential Relationship of Triglyceride Glucose and Body Mass Index With Stroke Prognosis
    Zongyi Hou, Yuesong Pan, Yindong Yang, Xiaofan Yang, Xianglong Xiang, Yilong Wang, Zixiao Li, Xingquan Zhao, Hao Li, Xia Meng, Yongjun Wang
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review
    Raquel Cano, José Pérez, Lissé Dávila, Ángel Ortega, Yosselin Gómez, Nereida Valero-Cedeño, Heliana Parra, Alexander Manzano, Teresa Véliz Castro, María Albornoz, Gabriel Cano, Joselyn Rojas-Quintero, Maricarmen Chacín, Valmore Bermúdez
    International Journal of Molecular Sciences.2021; 22(9): 4807.     CrossRef
  • Triglyceride glucose (TyG) index and the progression of liver fibrosis: A cross-sectional study
    Helda Tutunchi, Fatemeh Naeini, Majid Mobasseri, Alireza Ostadrahimi
    Clinical Nutrition ESPEN.2021; 44: 483.     CrossRef
  • Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome
    M. Mirr, D. Skrypnik, P. Bogdański, M. Owecki
    Journal of Endocrinological Investigation.2021; 44(12): 2831.     CrossRef
  • Association Between the Triglyceride–Glucose Index and Outcomes of Nonalcoholic Fatty Liver Disease: A Large-Scale Health Management Cohort Study
    Jing Liu, Liying Guan, Meng Zhao, Qihang Li, An Song, Ling Gao, Haiyan Lin, Jiajun Zhao
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 2829.     CrossRef
  • Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015
    Wonsuk Choi, Ji Yong Park, A. Ram Hong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang, Sun Young Lee
    PLOS ONE.2021; 16(7): e0254630.     CrossRef
  • Triglyceride glucose-waist to height ratio: a novel and effective marker for identifying hepatic steatosis in individuals with type 2 diabetes mellitus
    Mojtaba Malek, Mohammad E. Khamseh, Haleh Chehrehgosha, Sohrab Nobarani, Fariba Alaei-Shahmiri
    Endocrine.2021; 74(3): 538.     CrossRef
  • The association between triglyceride-glucose index, cardio-cerebrovascular diseases, and death in Korean adults: A retrospective study based on the NHIS-HEALS cohort
    Joungyoun Kim, Sang-Jun Shin, Hee-Taik Kang, Claudio Passino
    PLOS ONE.2021; 16(11): e0259212.     CrossRef
  • A population-based study of TyG index distribution and its relationship to cardiometabolic risk factors in children and adolescents
    Jong Seo Yoon, Young Suk Shim, Hae Sang Lee, Il Tae Hwang, Jin Soon Hwang
    Scientific Reports.2021;[Epub]     CrossRef
  • Comparison of several blood lipid-related indexes in the screening of non-alcoholic fatty liver disease in women: a cross-sectional study in the Pearl River Delta region of southern China
    Jingrui Wang, Zhenzhen Su, Yijin Feng, Ruihan Xi, Jiamin Liu, Peixi Wang
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • The value of the triglyceride-glucose index in the diagnosis of insulin resistance in early forms of non-alcoholic fatty liver disease
    A. A. Shipovskaya, N. A. Larina, I. V. Kurbatova, O. P. Dudanova
    Experimental and Clinical Gastroenterology.2021; (10): 43.     CrossRef
  • Triglyceride Glucose-Waist Circumference Is Superior to the Homeostasis Model Assessment of Insulin Resistance in Identifying Nonalcoholic Fatty Liver Disease in Healthy Subjects
    Hwi Seung Kim, Yun Kyung Cho, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
    Journal of Clinical Medicine.2021; 11(1): 41.     CrossRef
  • Homeostasis model assessment of insulin resistance and lobular inflammation in nondiabetic patients with nonalcoholic fatty liver disease: methodological considerations
    Denis Monneret, Dominique Bonnefont-Rousselot
    European Journal of Gastroenterology & Hepatology.2020; 32(4): 542.     CrossRef
  • Helicobacter pylori infection may increase the severity of nonalcoholic fatty liver disease via promoting liver function damage, glycometabolism, lipid metabolism, inflammatory reaction and metabolic syndrome
    Chen Chen, Caiyun Zhang, Xuelin Wang, Feijuan Zhang, Ze Zhang, Pengchai Ma, Shuzhi Feng
    European Journal of Gastroenterology & Hepatology.2020; 32(7): 857.     CrossRef
  • Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
    Kyung-Soo Kim, Byung-Wan Lee
    Clinical and Molecular Hepatology.2020; 26(4): 430.     CrossRef
  • The triglyceride-glucose index is associated with the severity of hepatic steatosis and the presence of liver fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults
    Wen Guo, Jing Lu, Pei Qin, Xiaona Li, Wenfang Zhu, Juan Wu, Nianzhen Xu, Qun Zhang
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Association between triglyceride glucose-body mass index and non-alcoholic fatty liver disease in the non-obese Chinese population with normal blood lipid levels: a secondary analysis based on a prospective cohort study
    Yaling Li, Rui Zheng, Jie Li, Shuyi Feng, Li Wang, Zhiming Huang
    Lipids in Health and Disease.2020;[Epub]     CrossRef

Endocrinol Metab : Endocrinology and Metabolism