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Endocrinol Metab : Endocrinology and Metabolism


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So-ichiro Fukada 1 Article
Diabetes, Obesity and Metabolism
Exercise/Resistance Training and Muscle Stem Cells
So-ichiro Fukada, Ayasa Nakamura
Endocrinol Metab. 2021;36(4):737-744.   Published online August 10, 2021
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AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Skeletal muscle has attracted attention as endocrine organ, because exercise-dependent cytokines called myokines/exerkines are released from skeletal muscle and are involved in systemic functions. While, local mechanical loading to skeletal muscle by exercise or resistance training alters myofiber type and size and myonuclear number. Skeletal muscle-resident stem cells, known as muscle satellite cells (MuSCs), are responsible for the increased number of myonuclei. Under steady conditions, MuSCs are maintained in a mitotically quiescent state but exit from that state and start to proliferate in response to high physical activity. Alterations in MuSC behavior occur when myofibers are damaged, but the lethal damage to myofibers does not seem to evoke mechanical loading-dependent MuSC activation and proliferation. Given that MuSCs proliferate without damage, it is unclear how the different behaviors of MuSCs are controlled by different physical activities. Recent studies demonstrated that myonuclear number reflects the size of myofibers; hence, it is crucial to know the properties of MuSCs and the mechanism of myonuclear accretion by MuSCs. In addition, the elucidation of mechanical load-dependent changes in muscle resident cells, including MuSCs, will be necessary for the discovery of new myokines/exerkines and understating skeletal muscle diseases.


Citations to this article as recorded by  
  • Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors
    Hamed Alizadeh Pahlavani
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Molecular mechanisms of exercise contributing to tissue regeneration
    Jibao Chen, Ren Zhou, Ye Feng, Lin Cheng
    Signal Transduction and Targeted Therapy.2022;[Epub]     CrossRef

Endocrinol Metab : Endocrinology and Metabolism