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So Hun Kim  (Kim SH) 11 Articles
Calcium & bone metabolism
Familial Correlation and Heritability of Hand Grip Strength in Korean Adults (Korea National Health and Nutrition Examination Survey 2014 to 2019)
Seong Hee Ahn, Eun Byeol Park, Seongha Seo, Yongin Cho, Da Hea Seo, So Hun Kim, Young Ju Suh, Seongbin Hong
Endocrinol Metab. 2023;38(6):709-719.   Published online November 7, 2023
DOI: https://doi.org/10.3803/EnM.2023.1740
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  • 41 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
The onset and progression of sarcopenia are highly variable among individuals owing to genetic and environmental factors. However, there are a limited number of studies measuring the heritability of muscle strength in large numbers of parent-adult offspring pairs. We aimed to investigate the familial correlation and heritability of hand grip strength (HGS) among Korean adults.
Methods
This family-based cohort study on data from the Korea National Health and Nutrition Examination Survey (2014 to 2019) included 5,004 Koreans aged ≥19 years from 1,527 families. HGS was measured using a digital grip strength dynamometer. Familial correlations of HGS were calculated in different pairs of relatives. Variance component methods were used to estimate heritability.
Results
The heritability estimate of HGS among Korean adults was 0.154 (standard error, 0.066). Correlation coefficient estimates for HGS between parent-offspring, sibling, and spouse pairs were significant at 0.07, 0.10, and 0.23 (P<0.001, P=0.041, and P<0.001, respectively). The total variance in the HGS phenotype was explained by additive genetic (15.4%), shared environmental (11.0%), and unique environmental (73.6%) influences. The odds of weak HGS significantly increased in the offspring of parents with weak HGS (odds ratio [OR], 1.69–3.10; P=0.027–0.038), especially in daughters (OR, 2.04–4.64; P=0.029–0.034).
Conclusion
HGS exhibits a familial correlation and significant heritable tendency in Korean adults. Therefore, Asian adults, especially women, who have parents with weak HGS, need to pay special attention to their muscle health with the help of healthy environmental stimuli.
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Clinical Study
Big Data Articles (National Health Insurance Service Database)
Effect of Teneligliptin versus Sulfonylurea on Major Adverse Cardiovascular Outcomes in People with Type 2 Diabetes Mellitus: A Real-World Study in Korea
Da Hea Seo, Kyoung Hwa Ha, So Hun Kim, Dae Jung Kim
Endocrinol Metab. 2021;36(1):70-80.   Published online February 24, 2021
DOI: https://doi.org/10.3803/EnM.2020.777
  • 4,604 View
  • 184 Download
  • 4 Web of Science
  • 4 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Results regarding the cardiovascular (CV) effects of dipeptidyl peptidase-4 (DPP-4) inhibitors are inconsistent. This study aimed to assess the effects of teneligliptin, a DPP-4 inhibitor, on the risk of major CV outcomes in type 2 diabetes mellitus (T2DM) patients compared to sulfonylurea.
Methods
From January 1, 2015 to December 31, 2017, we conducted a retrospective cohort study using the Korean National Health Insurance Service database. A total of 6,682 T2DM patients who were newly prescribed DPP-4 inhibitors or sulfonylurea were selected and matched in a 1:1 ratio by propensity score. The hazard ratios (HRs) for all-cause mortality, hospitalization for heart failure (HHF), all-cause mortality or HHF, myocardial infarction (MI), stroke, and hypoglycemia were assessed.
Results
During 641 days of follow-up, the use of teneligliptin was not associated with an increased risk of all-cause mortality (HR, 1.00; 95% confidence interval [CI], 0.85 to 1.19), HHF (HR, 0.99; 95% CI, 0.86 to 1.14), all-cause mortality or HHF (HR, 1.02; 95% CI, 0.90 to 1.14), MI (HR, 0.90; 95% CI, 0.68 to 1.20), and stroke (HR, 1.00; 95% CI, 0.86 to 1.17) compared to the use of sulfonylurea. However, it was associated with a significantly lower risk of hypoglycemia (HR, 0.68; 95% CI, 0.49 to 0.94) compared to sulfonylurea therapy.
Conclusion
Among T2DM patients, teneligliptin therapy was not associated with an increased risk of CV events including HHF, but was associated with a lower risk of hypoglycemia compared to sulfonylurea therapy.

Citations

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  • Association between age at diagnosis of type 2 diabetes and cardiovascular morbidity and mortality risks: A nationwide population-based study
    Da Hea Seo, Mina Kim, Young Ju Suh, Yongin Cho, Seong Hee Ahn, Seongbin Hong, So Hun Kim
    Diabetes Research and Clinical Practice.2024; 208: 111098.     CrossRef
  • Systematic review and meta-analysis of teneligliptin for treatment of type 2 diabetes
    R. Pelluri, S. Kongara, V. R. Nagasubramanian, S. Mahadevan, J. Chimakurthy
    Journal of Endocrinological Investigation.2023; 46(5): 855.     CrossRef
  • Finding the most cost-effective option from commonly used Dipeptidyl peptidase-4 inhibitors in India: a systematic study
    Harmanjit Singh, Ekta Arora, Seerat Narula, Mandeep Singla, Armaan Otaal, Jatin Sharma
    Expert Review of Endocrinology & Metabolism.2023; 18(4): 347.     CrossRef
  • Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes
    Yewon Na, Soo Wan Kim, Ie Byung Park, Soo Jung Choi, Seungyoon Nam, Jaehun Jung, Dae Ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(11): 3022.     CrossRef
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Obesity and Metabolism
Metformin-Associated Lactic Acidosis: Predisposing Factors and Outcome
Min Ju Kim, Ju Young Han, Jun Young Shin, Shin Il Kim, Jeong Min Lee, Seongbin Hong, So Hun Kim, Moon Suk Nam, Yong Seong Kim
Endocrinol Metab. 2015;30(1):78-83.   Published online March 27, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.1.78
  • 4,415 View
  • 75 Download
  • 28 Web of Science
  • 26 Crossref
AbstractAbstract PDFPubReader   
Background

Metformin is considered the first choice oral treatment for type 2 diabetes patients in the absence of contraindications. Rarely, life-threatening complications associated with metformin treatment are seen in some patients with underlying diseases. The aim of this study was to further investigate the clinical profiles and risk factors for metformin-associated lactic acidosis (MALA) and the treatment modalities according to survival.

Methods

To identify MALA, we performed a retrospective study in seven diabetic patients who were taking metformin and had been diagnosed with lactic acidosis at Inha University Hospital between 1995 and 2012. For each patient, we recorded the age, sex, daily metformin dosage, laboratory test results, admission diagnosis, and risk factors. Also, concurrent conditions, treatment modalities, and outcomes were evaluated.

Results

Six patients had risk factors for lactic acidosis before admission. All patients had renal impairment on admission as a precipitating risk factor. Five patients survived and two patients died despite early renal replacement therapy. Older patients tended to have a poorer prognosis.

Conclusion

Renal function must be monitored in elderly type 2 diabetes mellitus patients with underlying diseases and conditions causing renal impairment who begin metformin treatment. Accurate recognition of MALA and initiation of renal replacement are essential for treatment.

Citations

Citations to this article as recorded by  
  • Metformin Treatment Reduces the Incidence of Rheumatoid Arthritis: A Two-Sample Mendelian Randomized Study
    Jialin Liang, Yuanqing Cai, Jianan Zhang, Zhaopu Jing, Leifeng Lv, Guangyang Zhang, Rupeng Zhang, Ruiyu Liu, Kai Nan, Xiaoqian Dang
    Journal of Clinical Medicine.2023; 12(7): 2461.     CrossRef
  • PLGA-based microspheres loaded with metformin hydrochloride: Modified double emulsion method preparation, optimization, characterization, and in vitro evaluation
    Priyanka Chauhan, Himanshu Paliwal, Chetan Singh Chauhan, Ankit Paliwal
    Annales Pharmaceutiques Françaises.2023; 81(6): 997.     CrossRef
  • Metformin-associated lactic acidosis: underlying multiple myeloma
    Clara GOMES, Ana FERREIRA, Neuza SOARES, Vanessa CHAVES, Luís LEMOS, Sofia TAVARES, Marta COUTO
    Gazzetta Medica Italiana Archivio per le Scienze Mediche.2022;[Epub]     CrossRef
  • Metformin-associated lactic acidosis and factors associated with 30-day mortality
    Kanin Thammavaranucupt, Boonchan Phonyangnok, Watanyu Parapiboon, Laddaporn Wongluechai, Watthikorn Pichitporn, Jirut Sumrittivanicha, Somnuek Sungkanuparph, Arkom Nongnuch, Kulapong Jayanama, Donovan Anthony McGrowder
    PLOS ONE.2022; 17(8): e0273678.     CrossRef
  • Metformin Associated Lactic Acidosis in Clinical Practice – A Case Series
    Philipp Schädle, Otto Tschritter, Monika Kellerer
    Experimental and Clinical Endocrinology & Diabetes.2021; 129(11): 842.     CrossRef
  • Effect of continuous use of metformin on kidney function in diabetes patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
    Qi Yu, Jia-Jia Zhu, Wen-Xian Liu
    BMC Cardiovascular Disorders.2020;[Epub]     CrossRef
  • Metformin: current clinical applications in nondiabetic patients with cancer
    Kailin Chen, Yajun Li, Zhen Guo, Yong Zeng, Wei Zhang, Hui Wang
    Aging.2020; 12(4): 3993.     CrossRef
  • Specifics of diabetes in old age
    Markéta Kubíčková
    Interní medicína pro praxi.2019; 21(4): 223.     CrossRef
  • The Association between Metformin Therapy and Lactic Acidosis
    Isabelle H. S. Kuan, Ruth L. Savage, Stephen B. Duffull, Robert J. Walker, Daniel F. B. Wright
    Drug Safety.2019; 42(12): 1449.     CrossRef
  • Metformin overdose: A serious iatrogenic complication—Western France Poison Control Centre Data Analysis
    Alexandre Stevens, Jean‐François Hamel, Ali Toure, Samy Hadjadj, David Boels
    Basic & Clinical Pharmacology & Toxicology.2019; 125(5): 466.     CrossRef
  • Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery
    Laura N. Deden, Edo O. Aarts, Stephanie C. W. Aelfers, Marcel M. G. J. van Borren, Ignace M. C. Janssen, Frits J. Berends, Hans de Boer
    Obesity Surgery.2018; 28(4): 1080.     CrossRef
  • Metformin-related lactic acidosis: Case report
    Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba C
    Colombian Journal of Anesthesiology.2017; 45(4): 353.     CrossRef
  • Metformin-related lactic acidosis: Case report☆
    Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba C
    Colombian Journal of Anesthesiology.2017; 45(4): 353.     CrossRef
  • Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes
    Eun Young Lee, Sena Hwang, Yong-ho Lee, Seo Hee Lee, Young Mi Lee, Hua Pyong Kang, Eugene Han, Woonhyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
    Yonsei Medical Journal.2017; 58(2): 312.     CrossRef
  • Hypoglycemia and severe lactic acidosis in a dog following metformin exposure
    Nicole Barrella, Beth Eisenberg, Stephanie Nicole Simpson
    Clinical Case Reports.2017; 5(12): 2097.     CrossRef
  • Acidosis láctica por metformina: reporte de caso
    Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba C
    Revista Colombiana de Anestesiología.2017; 45(4): 353.     CrossRef
  • Towards natural mimetics of metformin and rapamycin
    Alexander Aliper, Leslie Jellen, Franco Cortese, Artem Artemov, Darla Karpinsky-Semper, Alexey Moskalev, Andrew G. Swick, Alex Zhavoronkov
    Aging.2017; 9(11): 2245.     CrossRef
  • Metformin-Associated Lactic Acidosis
    Martin R. Hevesy
    Advanced Emergency Nursing Journal.2017; 39(1): 26.     CrossRef
  • Metformin associated lactic acidosis (MALA): clinical profiling and management
    Alessandra Moioli, Barbara Maresca, Andrea Manzione, Antonello Maria Napoletano, Daniela Coclite, Nicola Pirozzi, Giorgio Punzo, Paolo Menè
    Journal of Nephrology.2016; 29(6): 783.     CrossRef
  • Risk assessment and management of post-transplant diabetes mellitus
    Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
    Metabolism.2016; 65(10): 1559.     CrossRef
  • Temporal trends in the use of antidiabetic medicines: a nationwide 9-year study in older people living in New Zealand
    Prasad S. Nishtala, Mohammed Saji Salahudeen
    Therapeutic Advances in Drug Safety.2016; 7(5): 184.     CrossRef
  • Metformin-associated lactic acidosis: Current perspectives on causes and risk
    Ralph DeFronzo, G. Alexander Fleming, Kim Chen, Thomas A. Bicsak
    Metabolism.2016; 65(2): 20.     CrossRef
  • Lactic acidosis and the relationship with metformin usage
    Weiyi Huang, Ronald L. Castelino, Gregory M. Peterson
    Medicine.2016; 95(46): e4998.     CrossRef
  • Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
    Hye Suk Kang, Ho-Chan Cho, Jae-Ho Lee, Goo Taeg Oh, Seung-Hoi Koo, Byung-Hyun Park, In-Kyu Lee, Hueng-Sik Choi, Dae-Kyu Song, Seung-Soon Im
    Scientific Reports.2016;[Epub]     CrossRef
  • Metformin-associated lactic acidosis: time to let it go?
    Chantal Mathieu
    Journal of Diabetes and its Complications.2015; 29(8): 974.     CrossRef
  • Metformin: risk-benefit profile with a focus on cancer
    Nicoletta Provinciali, Matteo Lazzeroni, Massimiliano Cazzaniga, Franco Gorlero, Barbara K Dunn, Andrea DeCensi
    Expert Opinion on Drug Safety.2015; 14(10): 1573.     CrossRef
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Retraction: Contributing Factors to Different Natural Courses of Posttansplantation Diabetes Mellitus in Renal Allograft Recipients.
Kyu Yeon Hur, Myoung Soo Kim, Jae Hyun Nam, Eun Seok Kang, Hyun Joo Lee, So Hun Kim, Bong Soo Cha, Chul Woo Ahn, Soon Il Kim, Yu Seun Kim, Hyun Chul Lee
J Korean Endocr Soc. 2007;22(6):479.   Published online December 1, 2007
DOI: https://doi.org/10.3803/jkes.2007.22.6.479
  • 1,464 View
  • 21 Download
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Contributing Factors to Different Natural Courses of Posttansplantation Diabetes Mellitus in Renal Allograft Recipients.
Kyu Yeon Hur, Myoung Soo Kim, Jae Hyun Nam, Eun Seok Kang, Hyun Joo Lee, So Hun Kim, Bong Soo Cha, Chul Woo Ahn, Soon Il Kim, Yu Seun Kim, Hyun Chul Lee
J Korean Endocr Soc. 2006;21(5):373-381.   Published online October 1, 2006
DOI: https://doi.org/10.3803/jkes.2006.21.5.373
  • 1,903 View
  • 21 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
New onset diabetes is a major complication after kidney transplantation. However, the natural course of posttransplantation diabetes mellitus (PTDM) remains unclear. The aim of this study was to demonstrate the detailed natural courses of PTDM according to the onset and persistency of hyperglycemia, and to investigate risk factors for development of different courses of PTDM in renal allograft recipients. METHODS: A total of 77 renal allograft recipients without previously known diabetes were enrolled and performed a serial 75 g oral glucose tolerance test at 0, 1, and 7 years after kidney transplantation. Patients were classified according to the onset and persistency of PTDM: early PTMD (E-PTDM), late PTDM (L-PTDM), persistent PTDM (P-PTDM), transient PTMD (T-PTDM), and non-PTDN (N-PTDM). RESULTS: The incidence of each group was as follows: E-PTDM, 39%; L-PTDM, 11.7%; P-PTDM, 23.4% T-PTDM, 15.6%; N-PTDM, 49.3%. Tacrolimus and female gender were associated with the development of E-PTDM. Among E-PTDM, age at transplantation was a high risk factor for the development of P-PTDM. Higher BMI at year1 was associated with the development of L-PTDM. CONCLUSION: Different risk factors were associated with various natural courses of PTDM. Since old age and female gender are not modifiable risk factors, it may be important to modify immunosuppressive therapy regimens for the prevention of E-PTDM and control of body weight for L-PTDM.

Citations

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  • Efficacy and Safety of Gemigliptin in Post-Transplant Patients With Type 2 Diabetes Mellitus
    Jaehyun Bae, Youjin Kim, Yongin Cho, Minyoung Lee, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Bong-Soo Cha, Dong Jin Joo, Kyu Ha Huh, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
    Transplantation Proceedings.2019; 51(10): 3444.     CrossRef
  • Post-transplantation Diabetes Mellitus
    Kun-Ho Yoon
    Journal of Korean Endocrine Society.2006; 21(5): 370.     CrossRef
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The Effect of Treatment Modalities on Survival Rates of Patients with Anaplastic Thyroid Carcinoma.
Jae Myoung Choi, Mi Jeong Kim, Seung Won Lee, Kyoung Eun Song, Yoon Sok Chung, Kwan Woo Lee, Dae Jung Kim, Sung Hee Choi, So Hun Kim, Min Ho Cho, Yumie Rhee, Chul Woo Ahn, Sung Kil Lim, Kyung Rae Kim
J Korean Endocr Soc. 2005;20(2):127-133.   Published online April 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.2.127
  • 1,686 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Anaplastic thyroid carcinoma represents 2% to 5% of all thyroid cancers and it is one of the most aggressive human cancers. Local extension at the time of diagnosis and distant metastases are almost always the rule. Its lethality is evidenced by a 5-year survival rate of 3.6% and a median survival time of 4 months. We retrospectively reviewed patients with this disease at 4 tertiary referral centers. METHODS: From 1990 to 2003, 19 cases(9 men and 10 women, mean age: 65.1+/-7.1 years) of anaplastic thyroid carcinoma were reviewed via the medical records. The overall survival rates according to the prognostic factors and the treatment modalities were analyzed. RESULTS: The presenting symptoms included rapidly enlarged neck masses in 16 patients, shortness of breath in 3 patients, hoarseness in 4 patients, dysphagia in 2 patients and chest wall pain in 1 patient. The mean diameter of tumor was 7.2cm. Local extension was seen in all of the cases that had undergone surgery. Distant metastases(lung 6, bone 2, abdominal carcinomatosis 2, brain 1 and mediastinum 1) were seen in 9 patients. Surgical treatment was performed in 10 patients. Radiotherapy was performed in 9 patients and chemotherapy was done in 5 patients; radiotherapy was performed alone in 2 patients, combination chemo-radiotherapy was performed in 3 patients, postoperative radiotherapy was performed in 2 patients and postoperative combination chemo-radiotherapy was performed in 2 patients. 4 patients were treated cons ervatively after the confirmative diagnosis. The overall median survival time was 123 days(range: 23~621 days); the median survival time was 129 days in the treatment group(n=15), and 27 days in the no treatment group (n=4), and significantly higher survival rates were observed for the treated patients(p=0.02). According to the treatment modalities, patients who underwent surgical treatment and postoperative radiotherapy and/or chemotherapy were observed to have significantly higher survival rates than patients in the radiotherapy and/or chemotherapy group(p=0.03), and also than those patients in the surgical treatment only group(p=0.04). CONCLUSION: We found that aggressive surgical treatment and postoperative radiotherapy and/or chemotherapy improved the survival rates of patients with anaplastic thyroid carcinoma even though local invasion and distant metastases was generally observed to occur

Citations

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  • Anaplastic Thyroid Carcinoma: Experience of a Single Institute
    Dongbin Ahn, Jin Ho Sohn
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2012; 55(1): 37.     CrossRef
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A Case of Multiple Endocrine Neoplasia Type 1 with Mutation in MENIN Gene.
Se Eun Park, Eun Seok Kang, Hyun Joo Lee, So Hun Kim, Mi Young Do, Shin Ae Kang, Seung Jin Han, Hyeong Jin Kim, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Il Jin Kim, Hyun Chul Lee
J Korean Endocr Soc. 2005;20(1):71-77.   Published online February 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.1.71
  • 1,947 View
  • 22 Download
  • 6 Crossref
AbstractAbstract PDF
Multiple endocrine neoplasia type 1(MEN 1) is an autosomal dominantly inherited syndrome, characterized by the combined occurrence of tumors of the parathyroid glands, endocrine pancreas, and anterior pituitary gland. The MENIN gene, which is a kind of tumor suppressor gene, is located at the chromosomal locus 11q13. It consists of one untranslated exon and nine exons encoding the menin protein. We report a case of a 22-yearss-old woman with MEN type 1, who was proven to have a mutation in the MENIN gene. The patient was admitted because of repeated hypoglycemia. The fasting plasma glucose level was 32mg/dL. Seventy two hours fasting test showed an the insulin/glucose ratio as 0.33. Endoscopic ultrasonography detected multiple masses on the pancreas. The arterial -stimulated venous sampling(ASVS) with calcium showed sudden step up of insulin at the head and tail portions of the pancreas. The sellar MRI showed a pituitary mass that produced prolactin. Instead of a pathologic diagnosis from operational specimen, the genetic analysis revealed a mutation in the MENIN 1 gene(exon 2, 200~201insAGCCC).

Citations

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  • Genetic and Epigenetic Analysis in Korean Patients with Multiple Endocrine Neoplasia Type 1
    Yoon Jung Chung, Sena Hwang, Jong Ju Jeong, Sun Yong Song, Se Hoon Kim, Yumie Rhee
    Endocrinology and Metabolism.2014; 29(3): 270.     CrossRef
  • A Case of Familial Multiple Endocrine Neoplasia Type 1 with a Novel Mutation in theMEN1Gene
    Min Jung Kim, Eun Hee Kim, Mi-Seon Shin, Joo Hui Kim, Hee Kyung Na, Seong Joon Park, Sang Ah Lee, Eun Hee Koh, Woo Je Lee, Ki Ho Song, Joong-Yeol Park, Ki-Up Lee, Gu-Hwan Kim, Han-Wook Yoo, Min-Seon Kim
    Endocrinology and Metabolism.2011; 26(2): 171.     CrossRef
  • Somatic Mutational Analysis of MEN1 and Phenotypic Correlation in Sporadic Parathyroid Tumors
    Young Su Chae, Hee Jin Kim, Sun Wook Kim, Myung-Chul Chang
    Journal of the Korean Surgical Society.2009; 76(1): 15.     CrossRef
  • Multiple Endocrine Neoplasia Type 1 with Multiple Leiomyomas Linked to a Novel Mutation in the MEN1 Gene
    Heekyoung Choi, Sehyun Kim, Jae-Hoon Moon, Yoon Hee Lee, Yumie Rhee, Eun Seok Kang, Chul Woo Ahn, Bong Soo Cha, Eun Jig Lee, Kyung Rae Kim, Hyun Chul Lee, Seon Yong Jeong, Hyun Ju Kim, Sung-Kil Lim
    Yonsei Medical Journal.2008; 49(4): 655.     CrossRef
  • A Case of Familial Multiple Endocrine Neoplasia Type 1 with MEN1 Gene Mutation
    Young Eun Jo, Yong-Jun Choi, Yun Kyung Kim, Sang Mi Ahn, Sun Hye Jung, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee, Ji-Hee Hong, Seon-Yong Jeong, Hyon J Kim, Yoon-Sok Chung
    Journal of Korean Endocrine Society.2007; 22(1): 68.     CrossRef
  • A Case of Familial Multiple Endocrine Neoplasia with MEN1 Gene Mutation
    Hye-Young Sung, Yeon-Joo Chun, Hyeug Lee, Bum Jun Kwon, Kun Woo Park, Jung Min Lee, Sung Dae Moon, Sang Ah Chang, Je-Ho Han
    Journal of Korean Endocrine Society.2006; 21(6): 560.     CrossRef
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Adiponectin Gene Polymorphism and Carotid Artery Intima-Media thickness in Type 2 Diabetes.
Eun Seok Kang, So Young Park, So Hun Kim, Hyun Joo Lee, Kyu Yeon Hur, Seung Jin Han, Se Eun Park, Hyeong Jin Kim, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
J Korean Endocr Soc. 2005;20(1):29-39.   Published online February 1, 2005
DOI: https://doi.org/10.3803/jkes.2005.20.1.29
  • 1,720 View
  • 18 Download
AbstractAbstract PDF
BACKGROUND
The aim of this study was to examine the association between the common polymorphisms of the adiponectin gene(ACDC) and the intima-media thickness(IMT) of the common carotid arteries in type 2 diabetic patients. METHODS: The B mode ultrasound examination of carotid artery was performed on 133 type 2 diabetic patients. The carotid IMT was calculated using the Intimascope computer program. The SNP45 and SNP276 of the ACDC were examined. RESULTS: There was no significant difference in the carotid IMT among the SNP45 genotypes(0.66+/-0.18mm for TT, 0.71+/-0.12mm for TG and 0.64+/-0.15mm for GG, P=NS). Subjects carrying the SNP276 GG genotype had a markedly lower serum adiponectin concentration than those carrying the TT genotype(3.35+/-2.00microgram/mL vs. 4.98+/-2.24microgram/mL, P=0.029) The carotid IMT was significantly higher in patients with the SNP276 GG genotype than those with the TT genotype (0.70+/-0.17mm vs. 0.59+/-0.13mm, P=0.032). Patients with the +45GG/+276GG genotype combination showed significantly higher mean carotid IMT than the other genotype combinations(0.78+/-0.09mm vs. 0.71+/-0.15mm, P=0.013) CONCLUSIONS: These results suggest that the adiponectin gene, SNP276 is associated with the carotid IMT in type 2 diabetic patients. Further studies are will be needed to confirm these genotypephenotype associations.
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A Case of Follicular Thyroid Carcinoma Developed in Pendred Syndrome.
So Hun Kim, Ji Young Jung, Sung Jae Shin, So Young Park, Si Hoon Lee, Yoo Mee Kim, Yu Mie Rhee, Soon Won Hong, Bong Soo Cha, Chul Woo Ahn, Kyung Rae Kim, Sung Kil Lim, Hyun Chul Lee
J Korean Endocr Soc. 2004;19(4):411-418.   Published online August 1, 2004
  • 1,023 View
  • 22 Download
AbstractAbstract PDF
Pendred syndrome is an autosomal recessive genetic disorder, which is characterized by sensorineural hearing loss, goiter and a positive perchlorate discharge test. It is caused by mutations of the PDS gene, and its clinical characteristics vary widely. The thyroid function in most cases is normal, or shows only mild hypothyroidism. In Pendred syndrome, there is an organification defect that leads to defective thyroid hormone synthesis, followed by chronic TSH stimulation. Herein is reported a case of a follicular thyroid carcinoma associated with Pendred syndrome. To our knowledge, this is the first case reported in Korea. The patient presented with a huge anterior neck mass, sensorineural hearing loss and a positive perchlorate discharge test. Fine needle aspiration cytology suggested malignancy of the thyroid, and a total thyroidectomy, with central compartment node dissection, was performed. The pathology from the thyroid mass showed a poorly differentiated follicular thyroid carcinoma
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A Case of Thyroid Papillary Cancer Associated with Familial Adenomatous Polyposis.
Sung Jae Shin, Hyun Joo Lee, So Hun Kim, Wan Sub Shim, Sihoon Lee, Yoo Mee Kim, Yumie Rhee, Tae Il Kim, Bong Soo Cha, Hyun Chul Lee, Sung Kil Lim
J Korean Endocr Soc. 2004;19(2):209-216.   Published online April 1, 2004
  • 1,012 View
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Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, typically characterized by multiple colorectal adenomas and increased incidence of colorectal carcinomas if left untreated. It is caused by germline mutations of the adenomatous polyposis coli (APC) gene, which has been mapped on chromosome 5q21, and is accompanied by various benign and malignant extracolonic manifestations. The prevalence of thyroid tumors developing in patients with FAP is about 1~2%, are associated with FAP and have certain characteristics; mean age of tumor diagnosis at less than 30 years of age, the pathology is the papillary histiotype in more than 90% of cases, including a so-called cribriform- morular pattern, and multifocality is a frequent feature. In a genetic analysis, thyroid cancer in FAP usually has a mutation in the 5-portion of exon 15 between 778 and 1309, on chromosome 5q21. Also, the ret/PTC (especially ret/PTC1 and ret/PTC3) and p53 genes are thought probably to be associated with thyroid cancer in FAP patients. A case of familial adenomatous polyposis, accompanied by thyroid papillary cancer, was experienced in a 29 year-old female. She had hundreds of adenomas throughout the entire colon and congenital hypertrophy of the retinal pigment epithelium (CHRPE). The pathological finding of thyroid cancer was revealed as a mixture of cribriform, trabecular and papillary patterns. In a genetic analysis, she and her brother had a germline mutation of the APC gene at codon 1309. In Korea, there has been no previous case of cribriform-morular pattern and familial genetic analysis in FAP associated with thyroid cancer. Therefore, this case is reported, with a review of the literature
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A Case of Hypercalcemia Associated with Hepatic Tuberculosis.
So Young Park, Eun Seok Kang, So Hun Kim, Mi Young Do, Kyu Yeon Hur, Bong Soo Cha, Sung Kil Lim, Hyun Chul Lee, Sang Hoon Ahn, Young Myoung Moon, Young Nyun Park
J Korean Endocr Soc. 2004;19(1):64-68.   Published online February 1, 2004
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In this report, a 70-year-old female patient was detected with laboratory findings of hypercalcemia. The most common causes of hypercalcemia are primary hyperparathyroidism and malignant disease. Her laboratory tests did not show any evidence for neither primary hyperparathyroidism nor malignant diseases. Thus, granulomatous disease was suspected as the cause of the hypercalcemia. Liver MRI (magnetic resonance image) was performed on the subject, which suggested the presence of hepatic tuberculosis and sarcoidosis. Because the chest x-ray did not show a definite tuberculous lesion, we performed a laparoscopic liver biopsy for a final diagnosis. Findings from the biopsy specimen showed typical tuberculosis. After treatment with tuberculosis medication, hypercalcemia of the subject was resolved. Hypercalcemia is a well recognized as a possible complication of active pulmonary tuberculosis. But one should consider hepatic tuberculosis without pulmonary tuberculosis as a cause of hypercalcemia.
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Endocrinol Metab : Endocrinology and Metabolism