- Diabetes, Obesity and Metabolism
- Impact of Post-Transplant Diabetes Mellitus on Survival and Cardiovascular Events in Kidney Transplant Recipients
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Ja Young Jeon, Shin Han-Bit, Bum Hee Park, Nami Lee, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee, Seung Jin Han
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Endocrinol Metab. 2023;38(1):139-145. Published online February 6, 2023
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DOI: https://doi.org/10.3803/EnM.2022.1594
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 Abstract
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- Background
Post-transplant diabetes mellitus (PTDM) is a risk factor for poor outcomes after kidney transplantation (KT). However, the outcomes of KT have improved recently. Therefore, we investigated whether PTDM is still a risk factor for mortality, major atherosclerotic cardiovascular events (MACEs), and graft failure in KT recipients.
Methods
We studied a retrospective cohort of KT recipients (between 1994 and 2017) at a single tertiary center, and compared the rates of death, MACEs, overall graft failure, and death-censored graft failure after KT between patients with and without PTDM using Kaplan-Meier analysis and a Cox proportional hazard model.
Results
Of 571 KT recipients, 153 (26.8%) were diagnosed with PTDM. The mean follow-up duration was 9.6 years. In the Kaplan- Meier analysis, the PTDM group did not have a significantly increased risk of death or four-point MACE compared with the non-diabetes mellitus group (log-rank test, P=0.957 and P=0.079, respectively). Multivariate Cox proportional hazard models showed that PTDM did not have a negative impact on death or four-point MACE (P=0.137 and P=0.181, respectively). In addition, PTDM was not significantly associated with overall or death-censored graft failure. However, patients with a long duration of PTDM had a higher incidence of four-point MACE.
Conclusion
Patient survival and MACEs were comparable between groups with and without PTDM. However, PTDM patients with long duration diabetes were at higher risk of cardiovascular disease.
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Citations
Citations to this article as recorded by  - Computed tomography-based intermuscular adipose tissue analysis and its role in predicting post-kidney transplantation diabetes mellitus
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Asian Journal of Surgery.2025; 48(1): 221. CrossRef - Prognostic impact of post-transplant diabetes mellitus in kidney allograft recipients: a meta-analysis
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Endocrine.2024; 85(2): 695. CrossRef - Prevalence of new-onset diabetes mellitus after kidney transplantation: a systematic review and meta-analysis
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Journal of Clinical & Translational Endocrinology.2024; 36: 100343. CrossRef
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