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Shawna C. Fox  (Fox SC) 1 Article
Adrenal gland
Molecular Mechanisms of Primary Aldosteronism
Sergei G. Tevosian, Shawna C. Fox, Hans K. Ghayee
Endocrinol Metab. 2019;34(4):355-366.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.355
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  • 6 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   ePub   

Primary aldosteronism (PA) results from excess production of mineralocorticoid hormone aldosterone by the adrenal cortex. It is normally caused either by unilateral aldosterone-producing adenoma (APA) or by bilateral aldosterone excess as a result of bilateral adrenal hyperplasia. PA is the most common cause of secondary hypertension and associated morbidity and mortality. While most cases of PA are sporadic, an important insight into this debilitating disease has been derived through investigating the familial forms of the disease that affect only a minor fraction of PA patients. The advent of gene expression profiling has shed light on the genes and intracellular signaling pathways that may play a role in the pathogenesis of these tumors. The genetic basis for several forms of familial PA has been uncovered in recent years although the list is likely to expand. Recently, the work from several laboratories provided evidence for the involvement of mammalian target of rapamycin pathway and inflammatory cytokines in APAs; however, their mechanism of action in tumor development and pathophysiology remains to be understood.

Citations

Citations to this article as recorded by  
  • Mineralocorticoid Receptor and Aldosterone: Interaction Between NR3C2 Genetic Variants, Sex, and Age in a Mixed Cohort
    Mahyar Heydarpour, Wasita W Parksook, Luminita H Pojoga, Gordon H Williams, Jonathan S Williams
    The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • Proteomic analysis of urinary extracellular vesicles highlights specific signatures for patients with primary aldosteronism
    Lorenzo Bertolone, Annalisa Castagna, Marcello Manfredi, Domenica De Santis, Francesca Ambrosani, Elisa Antinori, Paolo Mulatero, Elisa Danese, Emilio Marengo, Elettra Barberis, Mariangela Veneri, Nicola Martinelli, Simonetta Friso, Francesca Pizzolo, Oli
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Focus on adrenal and related causes of hypertension in childhood and adolescence: Rare or rarely recognized?
    Flávia A. Costa-Barbosa, Rafael B. Giorgi, Claudio E. Kater
    Archives of Endocrinology and Metabolism.2022;[Epub]     CrossRef
  • Diseases caused by mutations in the Na+/K+ pump α1 gene ATP1A1
    Elisa D. Biondo, Kerri Spontarelli, Giovanna Ababioh, Lois Méndez, Pablo Artigas
    American Journal of Physiology-Cell Physiology.2021; 321(2): C394.     CrossRef
  • Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor
    Jin Young Lee, Da Ae Kim, Eunah Choi, Yun Sun Lee, So Jeong Park, Beom-Jun Kim
    Endocrinology and Metabolism.2021; 36(4): 865.     CrossRef
  • Progress on Genetic Basis of Primary Aldosteronism
    Izabela Karwacka, Łukasz Obołończyk, Sonia Kaniuka-Jakubowska, Michał Bohdan, Krzysztof Sworczak
    Biomedicines.2021; 9(11): 1708.     CrossRef
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