- Endocrine Research
- The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes
-
Cheol Ryong Ku, Yoon Hee Cho, Zhen-Yu Hong, Ha Lee, Sue Ji Lee, Seung-soo Hong, Eun Jig Lee
-
Endocrinol Metab. 2016;31(2):328-335. Published online April 8, 2016
-
DOI: https://doi.org/10.3803/EnM.2016.31.2.328
-
-
4,632
View
-
53
Download
-
27
Web of Science
-
27
Crossref
-
Abstract
PDFPubReader
- Background
Resveratrol (RSV) is a polyphenolic phytoalexin that has many effects on metabolic diseases such as diabetes and obesity. Given the importance of brown adipose tissue (BAT) for energy expenditure, we investigated the effects of RSV on brown adipocytes. MethodsFor the in vitro study, interscapular BAT was isolated from 7-week-old male Sprague Dawley rats. For the in vivo study, 7-week-old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were divided into four groups and treated for 27 weeks with: standard diet (SD); SD+RSV (10 mg/kg body weight, daily); high fat diet (HFD); HFD+RSV. RSV was provided via oral gavage once daily during the in vivo experiments. ResultsRSV treatment of primary cultured brown preadipocytes promoted mitochondrial activity, along with over-expression of estrogen receptor α (ER-α). In OLETF rats, both HFD and RSV treatment increased the weight of BAT and the differentiation of BAT. However, only RSV increased the mitochondrial activity and ER-α expression of BAT in the HFD-fed group. Finally, RSV improved the insulin sensitivity of OLETF rats by increasing the mitochondrial activity of BAT, despite having no effects on white adipocytes and muscles in either diet group. ConclusionRSV could improve insulin resistance, which might be associated with mitochondrial activity of brown adipocyte. Further studies evaluating the activity of RSV for both the differentiation and mitochondrial activity of BAT could be helpful in investigating the effects of RSV on metabolic parameters.
-
Citations
Citations to this article as recorded by
- Natural Bioactive Compounds from Foods Inhibited Pigmentation Especially Potential Application of Fucoxanthin to Chloasma: a Mini-Review
Yida Wang, Hang Qi Food Reviews International.2024; 40(1): 20. CrossRef - Resveratrol combats chronic diseases through enhancing mitochondrial quality
Weichu Tao, Hu Zhang, Xia Jiang, Ning Chen Food Science and Human Wellness.2024; 13(2): 597. CrossRef - Polyphenol Compound 18a Modulates UCP1-Dependent Thermogenesis to Counteract Obesity
Xueping Wen, Yufei Song, Mei Zhang, Yiping Kang, Dandan Chen, Hui Ma, Fajun Nan, Yanan Duan, Jingya Li Biomolecules.2024; 14(6): 618. CrossRef - Detraining after short‐term exercise induces hyperphagia and obesity with fatty liver and brown adipose tissue whitening in young male OLETF rats
Takaya Oshima, Kaho Takaishi, Misuzu Nishihira, Son Tien Nguyen, Susumu Urakawa, Haruya Ohno, Naoto Fujita Physiological Reports.2024;[Epub] CrossRef - The Potential to Fight Obesity with Adipogenesis Modulating Compounds
Jiaqi Zhao, Ailin Zhou, Wei Qi International Journal of Molecular Sciences.2022; 23(4): 2299. CrossRef - Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
Liwen Wang, Jie Hu, Haiyan Zhou The World Journal of Men's Health.2021; 39(4): 606. CrossRef - Precision Nutrition to Activate Thermogenesis as a Complementary Approach to Target Obesity and Associated-Metabolic-Disorders
Marina Reguero, Marta Gómez de Cedrón, Sonia Wagner, Guillermo Reglero, José Carlos Quintela, Ana Ramírez de Molina Cancers.2021; 13(4): 866. CrossRef - Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence
Proshanta Roy, Daniele Tomassoni, Enea Traini, Ilenia Martinelli, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati Antioxidants.2021; 10(6): 858. CrossRef - Activation of Brown Adipose Tissue and Promotion of White Adipose Tissue Browning by Plant-based Dietary Components in Rodents: A Systematic Review
Francisco J Osuna-Prieto, Borja Martinez-Tellez, Antonio Segura-Carretero, Jonatan R Ruiz Advances in Nutrition.2021; 12(6): 2147. CrossRef - Role of Dietary Polyphenols in Adipose Tissue Browning: A Narrative Review
Juan Salazar, Clímaco Cano, José L. Pérez, Ana Castro, María P. Díaz, Bermary Garrido, Rubén Carrasquero, Maricarmen Chacín, Manuel Velasco, Luis D´Marco, Joselyn Rojas-Quintero, Valmore Bermúdez Current Pharmaceutical Design.2020; 26(35): 4444. CrossRef - Brown and Brite: The Fat Soldiers in the Anti-obesity Fight
Shireesh Srivastava, Richard L. Veech Frontiers in Physiology.2019;[Epub] CrossRef - Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity
Oh Yoen Kim, Ji Yeon Chung, Juhyun Song Pharmacological Research.2019; 148: 104411. CrossRef - Ginsenoside Rb2 Alleviates Obesity by Activation of Brown Fat and Induction of Browning of White Fat
Yilian Hong, Yi Lin, Qiya Si, Lijuan Yang, Weisong Dong, Xuejiang Gu Frontiers in Endocrinology.2019;[Epub] CrossRef - Programming of the Beige Phenotype in White Adipose Tissue of Adult Mice by Mild Resveratrol and Nicotinamide Riboside Supplementations in Early Postnatal Life
Alba Serrano, Madhu Asnani-Kishnani, Ana María Rodríguez, Andreu Palou, Joan Ribot, María Luisa Bonet Molecular Nutrition & Food Research.2018;[Epub] CrossRef - Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis
Tanila Wood dos Santos, Quélita Cristina Pereira, Lucimara Teixeira, Alessandra Gambero, Josep A. Villena, Marcelo Lima Ribeiro International Journal of Molecular Sciences.2018; 19(9): 2757. CrossRef - Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue
Perla P. Argentato, Helena de Cássia César, Débora Estadella, Luciana P. Pisani British Journal of Nutrition.2018; 120(6): 619. CrossRef - Effects of Genistein on Differentiation and Viability of Human Visceral Adipocytes
Elena Grossini, Serena Farruggio, Giulia Raina, David Mary, Giacomo Deiro, Sergio Gentilli Nutrients.2018; 10(8): 978. CrossRef - A comprehensive review of the health perspectives of resveratrol
Abdur Rauf, Muhammad Imran, Hafiz Ansar Rasul Suleria, Bashir Ahmad, Dennis G. Peters, Mohammad S. Mubarak Food & Function.2017; 8(12): 4284. CrossRef - The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
Yea Eun Kang, Sorim Choung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku Endocrinology and Metabolism.2017; 32(3): 383. CrossRef - A nutritional perspective on UCP1-dependent thermogenesis
M. Luisa Bonet, Josep Mercader, Andreu Palou Biochimie.2017; 134: 99. CrossRef - The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity
Yueshui Zhao, Bo Chen, Jing Shen, Lin Wan, Yinxin Zhu, Tao Yi, Zhangang Xiao, Lin-sen Qing Oxidative Medicine and Cellular Longevity.2017;[Epub] CrossRef - Articles inEndocrinology and Metabolismin 2016
Won-Young Lee Endocrinology and Metabolism.2017; 32(1): 62. CrossRef - Antiobesity effects of resveratrol: which tissues are involved?
Alfredo Fernández‐Quintela, Iñaki Milton‐Laskibar, Marcela González, Maria P. Portillo Annals of the New York Academy of Sciences.2017; 1403(1): 118. CrossRef - Resveratrol attenuates triglyceride accumulation associated with upregulation of Sirt1 and lipoprotein lipase in 3T3-L1 adipocytes
Haruki Imamura, Daiji Nagayama, Noriko Ishihara, Syo Tanaka, Rena Watanabe, Yasuhiro Watanabe, Yuta Sato, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Kei Endo, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno Molecular Genetics and Metabolism Reports.2017; 12: 44. CrossRef - Resveratrol has dose-dependent effects on DNA fragmentation and mitochondrial activity of ovine secondary follicles cultured in vitro
T.J.S. Macedo, V.R.P. Barros, A.P.O. Monte, B.B. Gouveia, M.É.S. Bezerra, A.Y.P. Cavalcante, R.S. Barberino, V.G. Menezes, M.H.T. Matos Zygote.2017; 25(4): 434. CrossRef - Response: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes (Endocrinol Metab2016;31:328-35, Cheol Ryong Ku et al.)
Cheol Ryong Ku, Eun Jig Lee Endocrinology and Metabolism.2016; 31(3): 482. CrossRef - Letter: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes (Endocrinol Metab2016;31:328-35, Cheol Ryong Ku et al.)
Ji-Young Cha Endocrinology and Metabolism.2016; 31(3): 480. CrossRef
|