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Seung-Yun Han  (Han SY) 1 Article
Endocrine Research
Omega-3 Polyunsaturated Fatty Acids May Attenuate Streptozotocin-Induced Pancreatic β-Cell Death via Autophagy Activation in Fat1 Transgenic Mice
Won-Min Hwang, Dong-Ho Bak, Dong Ho Kim, Ju Young Hong, Seung-Yun Han, Keun-Young Park, Kyu Lim, Dong-Mee Lim, Jae Gu Kang
Endocrinol Metab. 2015;30(4):569-575.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.569
  • 4,908 View
  • 45 Download
  • 19 Web of Science
  • 21 Crossref
AbstractAbstract PDFPubReader   
Background

Inflammatory factors and β-cell dysfunction due to high-fat diets aggravate chronic diseases and their complications. However, omega-3 dietary fats have anti-inflammatory effects, and the involvement of autophagy in the etiology of diabetes has been reported. Therefore, we examined the protective effects of autophagy on diabetes using fat-1 transgenic mice with omega-3 self-synthesis capability.

Methods

Streptozotocin (STZ) administration induced β-cell dysfunction in mice; blood glucose levels and water consumption were subsequently measured. Using hematoxylin and eosin (H&E) and Masson's trichrome staining, we quantitatively assessed STZ-induced changes in the number, mass, and fibrosis of pancreatic islets in fat-1 and control mice. We identified the microtubule-associated protein 1A/1B light chain 3-immunoreactive puncta in β-cells and quantified p62 levels in the pancreas of fat-1 and control mice.

Results

STZ-induced diabetic phenotypes, including hyperglycemia and polydipsia, were attenuated in fat-1 mice. Histological determination using H&E and Masson's trichrome staining revealed the protective effects of the fat-1 expression on cell death and the scarring of pancreatic islets after STZ injection. In the β-cells of control mice, autophagy was abruptly activated after STZ treatment. Basal autophagy levels were elevated in fat-1 mice β-cells, and this persisted after STZ treatment. Together with autophagosome detection, these results revealed that n-3 polyunsaturated fatty acid (PUFA) enrichment might partly prevent the STZ-related pancreatic islet damage by upregulating the basal activity of autophagy and improving autophagic flux disturbance.

Conclusion

Fat-1 transgenic mice with a n-3 PUFA self-synthesis capability exert protective effects against STZ-induced β-cell death by activating autophagy in β-cells.

Citations

Citations to this article as recorded by  
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  • High n-3 fatty acids counteract hyperglycemia-induced insulin resistance in fat-1 miceviapre-adipocyte NLRP3 inflammasome inhibition
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  • Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
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  • Effects of the linoleic acid/docosahexaenoic acid ratio and concentration inducing autophagy in Raw264.7 cells against Staphylococcus aureus
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    Journal of Clinical Biochemistry and Nutrition.2020; 67(2): 146.     CrossRef
  • Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress
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  • Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome
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    Nutrients.2019; 11(9): 2137.     CrossRef
  • Survivin regulated by autophagy mediates hyperglycemia-induced vascular endothelial cell dysfunction
    Yu-Xue Xu, Caoxin Huang, Minyi Liu, Ningning Chen, Wenting Chen, Chen Yang, Yan Zhao, Xuejun Li, Junguo Duan, Suhuan Liu, Shuyu Yang
    Experimental Cell Research.2018; 364(2): 152.     CrossRef
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  • Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 transgenic mice ameliorates streptozocin-induced diabetic nephropathy
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