Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism


Author index

Page Path
Seung-Soon Im  (Im SS) 2 Articles
Diabetes, obesity and metabolism
Phloretin Ameliorates Succinate-Induced Liver Fibrosis by Regulating Hepatic Stellate Cells
Cong Thuc Le, Giang Nguyen, So Young Park, Hanh Nguyen Dong, Yun Kyung Cho, Jae-Ho Lee, Seung-Soon Im, Dae-Hee Choi, Eun-Hee Cho
Endocrinol Metab. 2023;38(4):395-405.   Published online August 3, 2023
  • 1,383 View
  • 103 Download
AbstractAbstract PDFPubReader   ePub   
Hepatic stellate cells (HSCs) are the major cells which play a pivotal role in liver fibrosis. During injury, extracellular stimulators can induce HSCs transdifferentiated into active form. Phloretin showed its ability to protect the liver from injury, so in this research we would like to investigate the effect of phloretin on succinate-induced HSCs activation in vitro and liver fibrosis in vivo study.
In in vitro, succinate was used to induce HSCs activation, and then the effect of phloretin on activated HSCs was examined. In in vivo, succinate was used to generated liver fibrosis in mouse and phloretin co-treated to check its protection on the liver.
Phloretin can reduce the increase of fibrogenic markers and inhibits the proliferation, migration, and contraction caused by succinate in in vitro experiments. Moreover, an upregulation of proteins associated with aerobic glycolysis occurred during the activation of HSCs, which was attenuated by phloretin treatment. In in vivo experiments, intraperitoneal injection of phloretin decreased expression of fibrotic and glycolytic markers in the livers of mice with sodium succinate diet-induced liver fibrosis. These results suggest that aerobic glycolysis plays critical role in activation of HSCs and succinate can induce liver fibrosis in mice, whereas phloretin has therapeutic potential for treating hepatic fibrosis.
Intraperitoneal injection of phloretin attenuated succinate-induced hepatic fibrosis and alleviates the succinate-induced HSCs activation.
Close layer
Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation
Minsang Shin, Hye Suk Kang, Jae-Hyung Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im
Endocrinol Metab. 2017;32(1):11-17.   Published online January 19, 2017
  • 4,909 View
  • 66 Download
  • 22 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   

Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.


Citations to this article as recorded by  
  • Predictive potential of various plasma inflammation-, angiogenesis-, and extracellular matrix remodeling-associated mediators for intra-amniotic inflammation and/or microbial invasion of the amniotic cavity in preterm labor
    Eunwook Joo, Subeen Hong, Kyo Hoon Park, Hyeon Ji Kim, Min Jung Lee, Sue Shin
    Archives of Gynecology and Obstetrics.2024;[Epub]     CrossRef
  • The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications
    Małgorzata Woronkowicz, Harry Roberts, Piotr Skopiński
    Biology.2024; 13(3): 144.     CrossRef
  • Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
    Chiahsuan Chin, Ranjithkumar Ravichandran, Kristina Sanborn, Timothy Fleming, Stephen B. Wheatcroft, Mark T. Kearney, Sofya Tokman, Rajat Walia, Michael A. Smith, David J. Flint, Thalachallour Mohanakumar, Ross M. Bremner, Angara Sureshbabu
    Cell Reports Medicine.2023; 4(3): 100945.     CrossRef
  • Circulating IGF-1 and IGFBP-2 may be biomarkers for risk stratification in patients with acute coronary syndrome: A prospective cohort study
    Wei Wang, Ying Sun, De-Gang Mo, Tai Li, Heng-Chen Yao
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(9): 1740.     CrossRef
  • Receptor Tyrosine Kinase: Still an Interesting Target to Inhibit the Proliferation of Vascular Smooth Muscle Cells
    Yilin Xiong, Yan Wang, Tao Yang, Yunmei Luo, Shangfu Xu, Lisheng Li
    American Journal of Cardiovascular Drugs.2023; 23(5): 497.     CrossRef
  • Octopus death and dying
    Z Yan Wang
    Integrative And Comparative Biology.2023; 63(6): 1209.     CrossRef
  • Efficient generation of functional pancreatic β cells from dental-derived stem cells via laminin-induced differentiation
    Riham M. Aly, Hadeer A. Aglan, Ghada Nour Eldeen, Nadia S. Mahmoud, Eman H. Aboul-Ezz, Hanaa H. Ahmed
    Journal of Genetic Engineering and Biotechnology.2022; 20(1): 85.     CrossRef
  • Insulin-like growth factor signalling and its significance as a biomarker in fish and shellfish research
    S. Chandhini, Bushra Trumboo, Seena Jose, Tincy Varghese, M. Rajesh, V. J. Rejish Kumar
    Fish Physiology and Biochemistry.2021; 47(4): 1011.     CrossRef
  • Nanomaterials for Chronic Kidney Disease Detection
    Solmaz Maleki Dizaj, Aziz Eftekhari, Shakar Mammadova, Elham Ahmadian, Mohammadreza Ardalan, Soodabeh Davaran, Aygun Nasibova, Rovshan Khalilov, Mahbuba Valiyeva, Sevil Mehraliyeva, Ebrahim Mostafavi
    Applied Sciences.2021; 11(20): 9656.     CrossRef
  • Producción de las proteínas de unión al factor de crecimiento insulinoide durante el desarrollo de la fibrosis hepática por hepatitis C crónica
    D. Rosique-Oramas, M. Martínez-Castillo, A. Raya, Z. Medina-Ávila, F. Aragón, J. Limón-Castillo, A. Hernández-Barragán, A. Santoyo, E. Montalvo-Javé, J.L. Pérez-Hernández, F. Higuera-de la Tijera, A. Torre, D. Kershenobich, G. Gutiérrez-Reyes
    Revista de Gastroenterología de México.2020; 85(4): 390.     CrossRef
  • Interacción cardiorrenal y evolución de la insuficiencia cardiaca. ¿Tiene un papel la proteína de unión del factor de crecimiento de tipo insulina 2?
    Susana Ravassa, Javier Beaumont, Germán Cediel, Josep Lupón, Begoña López, Ramón Querejeta, Javier Díez, Antoni Bayés-Genís, Arantxa González
    Revista Española de Cardiología.2020; 73(10): 835.     CrossRef
  • Molecular identification of grass carp igfbp2 and the effect of glucose, insulin, and glucagon on igfbp2 mRNA expression
    Guokun Yang, Wenli Zhao, Chaobin Qin, Liping Yang, Xiaolin Meng, Ronghua Lu, Xiao Yan, Xianglin Cao, Yanmin Zhang, Guoxing Nie
    Fish Physiology and Biochemistry.2020; 46(4): 1469.     CrossRef
  • Production of insulin-like growth factor-binding proteins during the development of hepatic fibrosis due to chronic hepatitis C
    D. Rosique-Oramas, M. Martínez-Castillo, A. Raya, Z. Medina-Ávila, F. Aragón, J. Limón-Castillo, A. Hernández-Barragán, A. Santoyo, E. Montalvo-Javé, J.L. Pérez-Hernández, F. Higuera-de la Tijera, A. Torre, D. Kershenobich, G. Gutiérrez-Reyes
    Revista de Gastroenterología de México (English Edition).2020; 85(4): 390.     CrossRef
  • Cardiorenal interaction and heart failure outcomes. A role for insulin-like growth factor binding protein 2?
    Susana Ravassa, Javier Beaumont, Germán Cediel, Josep Lupón, Begoña López, Ramón Querejeta, Javier Díez, Antoni Bayés-Genís, Arantxa González
    Revista Española de Cardiología (English Edition).2020;[Epub]     CrossRef
  • Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes
    Emanuele Bosi, Lorella Marselli, Carmela De Luca, Mara Suleiman, Marta Tesi, Mark Ibberson, Decio L Eizirik, Miriam Cnop, Piero Marchetti
    NAR Genomics and Bioinformatics.2020;[Epub]     CrossRef
  • Transcriptional Analysis of FOXO1, C/EBP- and PPAR-2 Genes and Their association with Obesity-Related Insulin Resistance
    Boughanem, Cabrera-Mulero, Millán-Gómez, Garrido-Sánchez, Cardona, Tinahones, Moreno-Santos, Macías-González
    Genes.2019; 10(9): 706.     CrossRef
  • Immune biomarkers in maternal plasma to identify histologic chorioamnionitis in women with preterm labor
    Jeong Woo Park, Kyo Hoon Park, Song Yi Kook, Young Mi Jung, Yu Mi Kim
    Archives of Gynecology and Obstetrics.2019; 299(3): 725.     CrossRef
  • Insulin like growth factor binding protein 2 (IGFBP-2) for risk prediction in patients with severe aortic stenosis undergoing Transcatheter Aortic Valve Implantation (TAVI)
    Johanna Maria Muessig, Michael Lichtenauer, Bernhard Wernly, Malte Kelm, Marcus Franz, Laura Bäz, Paul Christian Schulze, Victoria Racher, Georg Zimmermann, Hans-Reiner Figulla, Vera Paar, Uta C. Hoppe, Philippe Rouet, Alexander Lauten, Christian Jung
    International Journal of Cardiology.2019; 277: 54.     CrossRef
  • Molecular cloning and expression pattern of IGFBP-2a in black porgy (Acanthopagrus schlegelii) and evolutionary analysis of IGFBP-2s in the species of Perciformes
    Xinyi Zhang, Zhiyong Zhang, Zhenpeng Yu, Jiayi Li, Shuyin Chen, Ruijian Sun, Chaofeng Jia, Fei Zhu, Qian Meng, Shixia Xu
    Fish Physiology and Biochemistry.2019; 45(5): 1731.     CrossRef
  • Current Insights into the Role of the Growth Hormone-Insulin-Like Growth Factor System in Short Children Born Small for Gestational Age
    Judith S. Renes, Jaap van Doorn, Anita C.S. Hokken-Koelega
    Hormone Research in Paediatrics.2019; 92(1): 15.     CrossRef
  • Insulin-Like Growth Factor (IGF) System in Liver Diseases
    Agnieszka Adamek, Aldona Kasprzak
    International Journal of Molecular Sciences.2018; 19(5): 1308.     CrossRef
  • IGFBP2 is a potential biomarker in acute kidney injury (AKI) and resveratrol-loaded nanoparticles prevent AKI
    Hai-Lun Li, Zhuan Yan, Zun-Ping Ke, Xiao-Feng Tian, Li-Li Zhong, Yong-Tao Lin, Yong Xu, Dong-Hui Zheng
    Oncotarget.2018; 9(93): 36551.     CrossRef
  • Multiple optic gland signaling pathways implicated in octopus maternal behaviors and death
    Z. Yan Wang, Clifton W. Ragsdale
    Journal of Experimental Biology.2018;[Epub]     CrossRef
  • Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes
    Daniel Garcia de la Serrana, Daniel J. Macqueen
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism