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Endocrinol Metab : Endocrinology and Metabolism


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Seong-Jang Kim  (Kim SJ) 1 Article
Bone Metabolism
Short-Term Caloric Restriction Does Not Reduce Bone Mineral Density in Rats with Early Type 2 Diabetes
Yun Kyung Jeon, Won Jin Kim, Myung Jun Shin, Hae-Young Chung, Sang Soo Kim, Bo Hyun Kim, Seong-Jang Kim, Yong Ki Kim, In Joo Kim
Endocrinol Metab. 2014;29(1):70-76.   Published online March 14, 2014
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AbstractAbstract PDFPubReader   

The effect of caloric restriction (CR) in the setting of diabetes on bone metabolism has not yet been fully studied. The aim of this study is to determine if short-term CR alters bone mass and metabolism in Otsuka Long-Evans Tokushima fatty (OLETF) rats, an animal model of type 2 diabetes.


Four groups (n=5) were created: OLETF rats with food ad libitum (AL), OLETF rats with CR, Long-Evans Tokusima Otsuka (LETO) rats with food AL, and LETO rats with CR. The CR condition was imposed on 24-week-old male rats using a 40% calorie reduction for 4 weeks. The effect of CR on femoral bone mineral density (BMD) was assessed by dual-energy X-ray absorptiometry. Serum markers were measured by immunoassay.


After 4 weeks of CR, body weight decreased in both strains. The BMD decreased in LETO rats and was maintained in OLETF rats. After adjustment for body weight, BMD remained lower in LETO rats (P=0.017) but not OLETF rats (P=0.410). Bone-specific alkaline phosphatase levels decreased in LETO rats (P=0.025) but not in OLEFT rats (P=0.347). Serum leptin levels were reduced after CR in both strains, but hyperleptinemia remained in OLETF rats (P=0.009). CR increased 25-hydroxyvitamin D levels in OLETF rats (P=0.009) but not in LETO rats (P=0.117). Additionally, interleukin-6 and tumor necrosis factor-α levels decreased only in OLETF rats (P=0.009).


Short-term CR and related weight loss were associated with decreases of femoral BMD in LETO rats while BMD was maintained in OLETF rats. Short-term CR may not alter bone mass and metabolism in type 2 diabetic rats.


Citations to this article as recorded by  
  • Changes in bone mass associated with obesity and weight loss in humans: Applicability of animal models
    Vivi F.H. Jensen, Anne-Marie Mølck, Majken Dalgaard, Fiona E. McGuigan, Kristina E. Akesson
    Bone.2021; 145: 115781.     CrossRef
  • Short‐term caloric restriction induced bone loss in both axial and appendicular bones by increasing adiponectin
    Junxiong Zhu, Can Liu, Jialin Jia, Chenggui Zhang, Wanqiong Yuan, Huijie Leng, Yingsheng Xu, Chunli Song
    Annals of the New York Academy of Sciences.2020; 1474(1): 47.     CrossRef
  • Dietary restrictions, bone density, and bone quality
    Tsang‐hai Huang, Gene P. Ables
    Annals of the New York Academy of Sciences.2016; 1363(1): 26.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
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