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Sang Seop Chung  (Chung SS) 5 Articles
10 Years Prospective Study for the Surgical Total Removal of Pituitary Tumor; Preliminary Report - 2, 5 Years Follow Up.
Eun Jig Lee, Sung Kil Lim, Kap Bum Huh, Sun Ho Kim, Dong Ik Kim, Byung Hee Lee, Ju Heon Yoon, Su Yeon Choi, Joong Uhn Choi, Sang Seop Chung, Kyu Chang Lee
J Korean Endocr Soc. 1994;10(2):85-94.   Published online November 6, 2019
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AbstractAbstract PDF
The goal of the pituitary tumor surgery is restoration of the normal endocrine function and releaving the pressure effects of the tumor mass on the adjacent neural structures. The authors had proceeded with the 10 years prospective follow-up study for the endocrine function and recurrence of pituitary tumor in the patients who received the complete total resection of tumor mass by the means of total capsulectomy.The authors will discuss the preliminary result of 2.5 years follow-up of this study.
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In Situ Hybridization Analysis of Human Growth Hormone and Prolactin Secreting Pitultary Adenomas.
Jae Wha Jo, Eun Jig Lee, Moon Suk Nam, Kyung Rae Kim, Sung Kil Lim, Hyun Chul Lee, Kap Bum Huh, Tae Seung Kim, Sun Ho Kim, Joong Uhn Choi, Kyu Chang Lee, Hyun Joo Jung, Sang Seop Chung
J Korean Endocr Soc. 1994;9(2):82-92.   Published online November 6, 2019
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  • 29 Download
AbstractAbstract PDF
A non-isotopic in situ hybridization method with biotin-labelled oligonucleotide probes was used to examine growth hormone(GH) and prolactin(PRL) gene expression in 32 patients with pituitary adenomas; 13 were prolactinomas, 8 GH secreting adenomas, and 11 mixed GH and PRL secreting adenomas.Positive immunostaining for GH was found in all patients with GH secreting adenomas, and mixed GH and PRL secreting adenomas. Positive immunostaining for PRL was found in all patients with prolactinomas and 9(81.8%) of 11 mixed GH and PRL secreting adenomas, 5(62.5%) of 8 GH secreting adenomas. Immunohistochemistry revealed that 13 were lactotrope adenomas, 5 somatotrope adenomas, and 14 GH and PRL cell adenomas.In situ hybridization revealed that GH mRNA expression was found in all the patients with somatotrope adenomas and GH and PRL cell adenomas, and 6(46.1%) of 13 lactotrope adenomas. PRL mRNA expression was 100% in lactotrope and GH and PRL cell adenomas, and 4(80.0%) of 5 somatotrope adenomas.The patients with a clinical diagnosis of acromegaly had detectable PRL mRNA in their neoplasm and it is suggested that the PRL cells in the adenomas did not result from dedifferentiation, but from the neoplastic stimulus for some mixed tumors probably occurred in cells previously committed to produce PRL and GH. In lactotrope adenomas, the PRL cells of the patients without expression of GH mRNA may be arised from cells programmed to secrete PRL or precussor PRL cells rather than from mixed GH-PRL cells. The finding that some patients produced mRNA detectable by in situ hybridization, but no hormone detectable by immunohistochemistry within tumor was suggested of a silent adenoma.These observations indicated that in situ hybridization studies may improve the classification of pituitary adenomas and may provide a precise knowledge of the biology of these neoplasms.
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A clinical study of cushing's disease.
Chan Hee Lee, Eun Jig Lee, Kyung Rae Kim, Kyeong Mi Lee, Jae Sik Cho, Hyun Chul Lee, Dong Ik Kim, Doe Heum Yoon, Young Soo Kim, Sang Seop Chung, Kyu Chang Lee, Tae Seung Kim
J Korean Endocr Soc. 1993;8(3):273-280.   Published online January 1, 2001
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  • 16 Download
AbstractAbstract PDF
No abstract available.
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Estrogen receptors of human pituitary adenomas.
Eun Jig Lee, Kyung Rae Kim, Hyun Chul Lee, Yoon Sok Chung, Kwang Jin Ahn, Sung Kil Lim, Mi Rim Kim, Chang Mi Kim, Kyung Za Ryu, Do Heum Yoon, Sang Seop Chung, Kyu Chang Lee
J Korean Endocr Soc. 1992;7(3):208-215.   Published online January 1, 2001
  • 1,153 View
  • 16 Download
AbstractAbstract PDF
No abstract available.
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Pituitary oncocytoma.
Eun Jig Lee, Kyung Rai Kim, Hyun Chul Lee, Kwang Jin Ahn, Yoon Sok Chung, Sung Kil Lim, Kap Bum Huh, Woo Ick Yang, Woo Hee Chung, Tae Seung Kim, Do Heum Yoon, Sang Seop Chung
J Korean Endocr Soc. 1992;7(1):16-23.   Published online January 1, 2001
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  • 17 Download
AbstractAbstract PDF
No abstract available.
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