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Sang Mi Kim  (Kim SM) 3 Articles
Clinical Study
Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer
Sang Mi Kim, Eun Heui Kim, Bo Hyun Kim, Jong Ho Kim, Su Bin Park, Yoon Jeong Nam, Kang Hee Ahn, Min Young Oh, Won Jin Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim, In Ju Kim
Endocrinol Metab. 2015;30(4):494-501.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.494
  • 4,970 View
  • 52 Download
  • 36 Web of Science
  • 35 Crossref
AbstractAbstract PDFPubReader   
Background

Several inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte count ratio (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance of the NLR and PLR in papillary thyroid cancer (PTC). We evaluated the association of the preoperative NLR and PLR with clinicopathological characteristics in patients with PTC.

Methods

This study included 1,066 female patients who underwent total thyroidectomy for PTC. Patients were stratified into 4 quartiles by preoperative NLR and PLR. And the combination of preoperative NLR and PLR was calculated on the basis of data obtained value of tertile as follows: patients with both an elevated PLR and an elevated NLR were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively.

Results

The preoperative NLR and PLR were significantly lower in patients aged ≥45 years and in patients with Hashimoto's thyroiditis. The PLR was significantly higher in patients with tumor size >1 cm (P=0.021).When the patients were categorized into the aforementioned four groups, the group with the higher preoperative PLR was found to have a significantly increased incidence of lateral lymph node metastasis (LNM) (P=0.018). However, there are no significant association between the combination of preoperative NLR and PLR and prognostic factors in PTC patients.

Conclusion

These results suggest that a preoperative high PLR were significant associated with lateral LNM in female patients with PTC.

Citations

Citations to this article as recorded by  
  • Evaluation of the correlation of neutrophil/lymphocyte ratio with prognostic classification systems in papillary thyroid carcinoma patients
    Eren Ozan Yildiz, Kutay Işcen, Feyza Kaya, Onur Alptekin Güney, Suat Can Ulukent
    Medicine.2024; 103(5): e37210.     CrossRef
  • The Association of Pretreatment Systemic Immune Inflammatory Response Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR) with Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma
    Yihua Gu, Ming Yu, Jiaqin Deng, Yeqian Lai
    International Journal of General Medicine.2024; Volume 17: 2887.     CrossRef
  • Preoperative serum inflammation-based scores in medullary thyroid cancer
    Ana Abrantes Figueiredo, Susana Esteves, Margarida Maria Moura, Pedro Marques, Joana Simões-Pereira, Valeriano Leite
    Endocrinología, Diabetes y Nutrición.2023; 70(1): 48.     CrossRef
  • Preoperative serum inflammation-based scores in medullary thyroid cancer
    Ana Abrantes Figueiredo, Susana Esteves, Margarida Maria Moura, Pedro Marques, Joana Simões-Pereira, Valeriano Leite
    Endocrinología, Diabetes y Nutrición (English ed.).2023; 70(1): 48.     CrossRef
  • Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis
    Elena Russo, Mathilda Guizzardi, Luca Canali, Francesca Gaino, Andrea Costantino, Gherardo Mazziotti, Andrea Lania, Silvia Uccella, Luca Di Tommaso, Fabio Ferreli, Luca Malvezzi, Giuseppe Spriano, Giuseppe Mercante
    Reviews in Endocrine and Metabolic Disorders.2023; 24(6): 1205.     CrossRef
  • Association of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Clinicopathological Features and Short-Term Outcome in Well-Differentiated Thyroid Cancer
    Sumeet Suresh Malapure, Sibi Oommen, Shivanand Bhushan, Sucharitha Suresh, K. Devaraja
    Indian Journal of Nuclear Medicine.2023; 38(4): 313.     CrossRef
  • The predictive value of hematologic parameters in the risk of thyroid malignancy in cases with atypia/follicular lesion of undetermined significance
    Hayri Bostan, Muhammed Erkam Sencar, Murat Calapkulu, Sema Hepsen, Pinar Akhanli, Hakan Duger, Bekir Ucan, Muhammed Kizilgul, Ilknur Ozturk Unsal, Mustafa Ozbek, Erman Cakal
    European Archives of Oto-Rhino-Laryngology.2022; 279(8): 4077.     CrossRef
  • Prognostic Impact of Inflammatory Markers PLR, LMR, PDW, MPV in Medullary Thyroid Carcinoma
    Canxiao Li, Han Zhang, Shijie Li, Daqi Zhang, Jingting Li, Gianlorenzo Dionigi, Nan Liang, Hui Sun
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The role of neutrophil to lymphocyte and platelet to lymphocyte ratios in diagnosing thyroid nodule
    HaiderSalim Mihson, AyadKhani Maikhan, AliRodan Shuwelif
    Mustansiriya Medical Journal.2022; 21(2): 155.     CrossRef
  • Comparison of Mean Platelet Volume, Platelet Distribution Width, Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Lymphocyte/Monocyte Ratio in Patients with Differentiated Thyroid Cancer According to TSH Levels
    Seher ÇETİNKAYA ALTUNTAŞ, Ömercan TOPALOĞLU
    Batı Karadeniz Tıp Dergisi.2022; 6(3): 302.     CrossRef
  • Delta Neutrophil Index and Neutrophil‐to‐Lymphocyte Ratio in the Differentiation of Thyroid Malignancy and Nodular Goiter
    Mehmet Buğra Bozan, Fatih Mehmet Yazar, İlhami Taner Kale, Mehmet Fatih Yüzbaşıoğlu, Ömer Faruk Boran, Ayşe Azak Bozan
    World Journal of Surgery.2021; 45(2): 507.     CrossRef
  • Factors Affecting Central Node Metastasis and Metastatic Lymph Node Ratio in Papillary Thyroid Cancer
    Jungirl Seok, Chang Hwan Ryu, Seog Yun Park, Chang Yoon Lee, Young Ki Lee, Yul Hwangbo, Eun Kyung Lee, You Jin Lee, Tae Sung Kim, Seok‐ki Kim, Yuh‐Seog Jung, Junsun Ryu
    Otolaryngology–Head and Neck Surgery.2021; 165(4): 519.     CrossRef
  • Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter
    Hakan BÖLÜKBAŞI, Serhan YILMAZ
    Ege Tıp Dergisi.2021; 60(1): 63.     CrossRef
  • Development and Validation of a Nomogram for Preoperative Prediction of Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma and Type 2 Diabetes Mellitus
    Chao He, Yiqiao Lu, Binqi Wang, Jie He, Haiguang Liu, Xiaohua Zhang
    Cancer Management and Research.2021; Volume 13: 2499.     CrossRef
  • The diagnostic predictive value of neutrophil-to-lymphocyte ratio in thyroid cancer adjusted for tumor size
    Taek Yoon Cheong, Sang Duk Hong, Keun-Woo Jung, Yoon Kyoung So, Paula Soares
    PLOS ONE.2021; 16(5): e0251446.     CrossRef
  • Usefulness of pre-thyroidectomy neutrophil–lymphocyte, platelet–lymphocyte, and monocyte–lymphocyte ratios for discriminating lymph node and distant metastases in differentiated thyroid cancer
    Cínthia Minatel Riguetto, Icléia Siqueira Barreto, Frederico Fernandes Ribeiro Maia, Lígia Vera Montali da Assumpção, Denise Engelbrecht Zantut-Wittmann
    Clinics.2021; 76: e3022.     CrossRef
  • Serum Inflammation-based Scores in Endocrine Tumors
    Pedro Marques, Friso de Vries, Olaf M Dekkers, Márta Korbonits, Nienke R Biermasz, Alberto M Pereira
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(10): e3796.     CrossRef
  • Diferansiye Tiroid Kanserli Hastalarda Preoperatif Nötrofil / Lenfosit Oranının Boyun Ultrasonografisi ve Patolojik Bulgularla İlişkisi
    Mehmet Esat DUYMUŞ
    Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi.2021; 54(2): 243.     CrossRef
  • Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
    Sorina Martin, Theodor Mustata, Oana Enache, Oana Ion, Andreea Chifulescu, Anca Sirbu, Carmen Barbu, Adrian Miron, Cosmin Giulea, Florin Andrei, Simona Fica
    Diagnostics.2021; 11(11): 1959.     CrossRef
  • The prognostic and diagnostic use of hematological parameters in subacute thyroiditis patients
    Murat Calapkulu, Muhammed Erkam Sencar, Davut Sakiz, Hakan Duger, Ilknur Ozturk Unsal, Mustafa Ozbek, Erman Cakal
    Endocrine.2020; 68(1): 138.     CrossRef
  • Association of the Preoperative Inflammation-Based Scores with TNM Stage and Recurrence in Patients with Papillary Thyroid Carcinoma: A Retrospective, Multicenter Analysis


    Wenjie Chen, Tao Wei, Zhihui Li, Rixiang Gong, Jianyong Lei, Jingqiang Zhu, Tao Huang
    Cancer Management and Research.2020; Volume 12: 1809.     CrossRef
  • Inflammatory biomarkers and dynamics of neutrophil-to-lymphocyte ratio in anaplastic thyroid carcinoma
    Haruhiko Yamazaki, Kiminori Sugino, Kenichi Matsuzu, Chie Masaki, Junko Akaishi, Kiyomi Hames, Chisato Tomoda, Akifumi Suzuki, Takashi Uruno, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Munetaka Masuda, Koichi Ito
    Endocrine.2020; 70(1): 115.     CrossRef
  • Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment
    Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Jian Zhang
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Hipertiroidi Hastalarında Tedavi Öncesi ve Sonrası Trombosit/Lenfosit ve Nötrofil/Lenfosit Oranlarının Değerlendirilmesi
    Çiğdem CİNDOĞLU, Mehmet GÜLER, Mehmet Ali EREN, Tevfik SABUNCU
    Harran Üniversitesi Tıp Fakültesi Dergisi.2020; 17(1): 104.     CrossRef
  • Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma
    Faruk Kutluturk, Serdar S. Gul, Safak Sahin, Turker Tasliyurt
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2019; 19(6): 859.     CrossRef
  • The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition
    Gilda Varricchi, Stefania Loffredo, Giancarlo Marone, Luca Modestino, Poupak Fallahi, Silvia Martina Ferrari, Amato de Paulis, Alessandro Antonelli, Maria Rosaria Galdiero
    International Journal of Molecular Sciences.2019; 20(16): 3934.     CrossRef
  • Different prognostic values of individual hematologic parameters in papillary thyroid cancer due to age-related changes in immunity
    Kwan Ho Lee, Eun Young Seok, Eun Young Kim, Ji Sup Yun, Yong Lai Park, Chan Heun Park
    Annals of Surgical Treatment and Research.2019; 96(2): 70.     CrossRef
  • Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres
    Dimitrios K. Manatakis, Sophia Tseleni-Balafouta, Lazaros Tzelves, Dimitrios Balalis, Adelais Tzortzopoulou, Dimitrios P. Korkolis, George H. Sakorafas, Emmanouil Gontikakis, Georgios Plataniotis
    Journal of Thyroid Research.2018; 2018: 1.     CrossRef
  • Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study
    Arif Emre, Sami Akbulut, Mehmet Sertkaya, Muharrem Bitiren, Ilhami Taner Kale, Ertan Bulbuloglu, Cemil Colak
    World Journal of Clinical Cases.2018; 6(3): 20.     CrossRef
  • Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions
    Nikolaos Machairas, Ioannis D. Kostakis, Anastasia Prodromidou, Paraskevas Stamopoulos, Themistoklis Feretis, Zoe Garoufalia, Christos Damaskos, Gerasimos Tsourouflis, Gregory Kouraklis
    Endocrine Research.2017; 42(4): 311.     CrossRef
  • Evaluation of Hemocytometer Parameters as Potential Biomarkers in Benign Multinodular Goiter and Papillary Thyroid Carcinoma
    Erdal Uysal, Seyit Mehmet Ceylan, Efe Sezgin, Hasan Bakir, Ahmet Orhan Gurer, Basar Aksoy, Mehmet Bastemir
    Iranian Red Crescent Medical Journal.2017;[Epub]     CrossRef
  • Clinical Value of Blood Neutrophil to Lymphocyte Ratio in Patients with Papillary Thyroid Carcinoma with Neck Lymph Node Metastasis
    Hwa Bin Kim, Hyoung Shin Lee, Sung Won Kim, Seok Won Jeon, Ji Ah Song, Kang Dae Lee
    International Journal of Thyroidology.2017; 10(2): 89.     CrossRef
  • Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
    Dimitrios K. Manatakis, Sofia Tseleni-Balafouta, Dimitrios Balalis, Vasiliki N. Soulou, Dimitrios P. Korkolis, George H. Sakorafas, Georgios Plataniotis, Emmanouil Gontikakis
    International Journal of Endocrinology.2017; 2017: 1.     CrossRef
  • Association of the preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with lymph node metastasis and recurrence in patients with medullary thyroid carcinoma
    Ke Jiang, Jianyong Lei, Wenjie Chen, Yanping Gong, Han Luo, Zhihui Li, Rixiang Gong, Jingqiang Zhu
    Medicine.2016; 95(40): e5079.     CrossRef
  • Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
    Ji-Feng Liu, Luo Ba, Hong Lv, Dan Lv, Jin-Tao Du, Xiao-Mei Jing, Ning-Jing Yang, Shao-Xin Wang, Chao Li, Xiao-Xia Li
    Scientific Reports.2016;[Epub]     CrossRef
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A Case of Ectopic Thyroid Tissue Diagnosed by Fine Needle Aspiration in the Lateral Neck.
Kyung Nam Lee, Sang Mi Kim, Jin Hee Choi, Kwang Duck Ryu, Bo Won Kim, Min Ji Shin, Bo Hyun Kim, In Ju Kim
Endocrinol Metab. 2012;27(3):217-221.   Published online September 19, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.3.217
  • 2,311 View
  • 22 Download
  • 2 Crossref
AbstractAbstract PDF
Ectopic thyroid glands generally occur in the midline as a result of abnormal median migration and their presence in lateral to the midline is rare. Embryologically, the thyroid gland is derived from two anlages: a large median endodermal anlage and two lateral anlages. The median anlage produces most of the thyroid parenchyma, whereas the lateral anlage is derived from the fourth pharyngeal pouch and contributes 1-30% of the thyroid weight. In rare cases, failure of the lateral anlage to fuse with the median anlage can result in lateral ectopic thyroid gland. For many years, lateral, aberrant thyroid tissue in adults was a term used almost exclusively for metastatic thyroid carcinoma. However, aberrant, benign ectopic thyroid tissue rarely occurs. We present a 47-year-old man who had incidentally detected mass on the right lateral neck. He was clinically in a euthyroid status and the thyroid function test results were normal as well. Neck ultrasonography revealed a mild diffuse goiter and a 1.22 x 0.65 cm sized ovoid mass like lesion was located in the right level IV of the neck. The result of fine needle aspiration cytology was adenomatous goiter without lymphoid tissue or any malignancy. We rarely report aberrant, benign ectopic thyroid presence as a lateral neck mass.

Citations

Citations to this article as recorded by  
  • Ectopic Thyroid Mimicking Lymph Node Metastasis of Thyroid Cancer
    Min Young Cho, Dong Young Kim
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(6): 417.     CrossRef
  • A Case of Lateral Ectopic Thyroid Mimicking the Metastatic Lymphadenopathy
    Seung Ho Kim, Jung Heob Sohn, Jung Yeon Kim
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2019; 62(10): 588.     CrossRef
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A Case of Bilateral Struma Ovarii Combined with Subclinical Hyperthyroidism.
Sang Mi Kim, Bo Kwang Choi, Ji Hyun Kang, Mi Ra Kim, Yun Kyung Jeon, Sang Soo Kim, Bo Hyun Kim, In Ju Kim
Endocrinol Metab. 2012;27(1):72-76.   Published online March 1, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.1.72
  • 1,922 View
  • 24 Download
  • 2 Crossref
AbstractAbstract PDF
Struma ovarii is a rare monodermal variant of ovarian teratoma accounting for only 2% of all mature teratomas. To be classified as a struma ovarii, teratoma must be composed predominantly of mature thyroid tissue (> 50%). This tumor is generally benign, although malignant transformation has been reported. Struma ovarii occur mostly as unilateral cases, so bilateral cases are quite rare (less than 6% of cases). Struma ovarii occur largely without symptoms or are accompanied by non-specific symptoms, such as abdominal pain, a palpable abdominal mass, and abdominal distension. The preoperative diagnosis is generally difficult. The incidence of hyperthyroidism has been reported to be 5-10% of patients with struma ovarii. Thus, cases of functional bilateral struma ovarii are very rare. We report a case of bilateral struma ovarii with subclinical thyrotoxicosis and a diffuse goiter, mimicking a malignant ovarian tumor, and include a brief review of related literature.

Citations

Citations to this article as recorded by  
  • Benign Teratoma of the Thyroid Gland
    Chan Young Oak, Hee Kyung Kim, Tae Mi Yoon, Sang Chul Lim, Hyun Bum Park, Hyung Chul Park, Min Gui Han, Ho-Cheol Kang
    Endocrinology and Metabolism.2013; 28(2): 144.     CrossRef
  • Metastatic follicular struma ovarii complicating pregnancy: a case report and review of the literature
    Woohyung Lee, Nam-Joon Yi, Hyeyoung Kim, Youngrok Choi, Minsu Park, Geun Hong, June Young Choi, Hyun Hoon Chung, Kwang-Woong Lee, Do-Joon Park, Hye Sook Min, June-key Chung, Kyung-Suk Suh
    Korean Journal of Hepato-Biliary-Pancreatic Surgery.2012; 16(3): 123.     CrossRef
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