Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Sang Hyun Kim  (Kim SH) 1 Article
Thyroid
A Rare Manifestation of Hypothyroid Myopathy: Hoffmann's Syndrome
Kang Won Lee, Sun Hwa Kim, Kyoung Jin Kim, Sang Hyun Kim, Hee Young Kim, Byung-Jo Kim, Sin Gon Kim, Dong Seop Choi
Endocrinol Metab. 2015;30(4):626-630.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.626
  • 6,448 View
  • 90 Download
  • 9 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   

Hypothyroid myopathy is observed frequently and the resolution of the clinical manifestations of myopathy following thyroid hormone replacement is well known. However, a specific subtype of hypothyroid myopathy, Hoffmann's syndrome, characterized by increased muscular mass (pseudohypertrophy), proximal muscle weakness, muscle stiffness and cramps, is rarely reported. Herein, we describe a 34-year-old male who presented with proximal muscle weakness and non-pitting edema of the lower extremities. He initially visited the neurology department where he was suspected of having polymyositis. Additional laboratory evaluation revealed profound autoimmune hypothyroidism and elevated muscle enzymes including creatine kinase. The patient was started on levothyroxine treatment and, subsequently, clinical symptoms and biochemical parameters resolved with the treatment. The present case highlights that hypothyroidism should be considered in the differential diagnosis of musculoskeletal symptoms even in the absence of overt manifestations of hypothyroidism. To our knowledge, this is the first case reported in Korea.

Citations

Citations to this article as recorded by  
  • Hoffmann’s syndrome in the differential work-up of myopathic complaints: a case report
    Sabine Winter, Bianka Heiling, Niklas Eckardt, Christof Kloos, Hubertus Axer
    Journal of Medical Case Reports.2023;[Epub]     CrossRef
  • Hypothyroidism: A Peculiar Presentation
    Rita V Nogueira, Rui Lima, Carina Parente, Pedro Liberal, Lucia Santos
    Cureus.2023;[Epub]     CrossRef
  • Hoffman's syndrome as the presenting manifestation of non-primary hypothyroidism in a case of Prader-Willi Syndrome
    R. Ghosh, A. Ray, D. Roy, J. Benito-Leon
    Neurología.2022; 37(9): 824.     CrossRef
  • Hoffman's syndrome as the presenting manifestation of non-primary hypothyroidism in a case of Prader-Willi Syndrome
    R. Ghosh, A. Ray, D. Roy, J. Benito-Leon
    Neurología (English Edition).2022; 37(9): 824.     CrossRef
  • Hoffmann’s syndrome necessitating forearm fasciotomy: a case report
    Erling Aarsæther, Ragnar Joakimsen, Hanne Halvorsen, Trude Sildnes, Olav Sivertsen, Jan Due
    Journal of Medical Case Reports.2020;[Epub]     CrossRef
  • Hypothyroid myopathy: A peculiar clinical presentation of thyroid failure. Review of the literature
    Alessandro Sindoni, Carmelo Rodolico, Maria Angela Pappalardo, Simona Portaro, Salvatore Benvenga
    Reviews in Endocrine and Metabolic Disorders.2016; 17(4): 499.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism