- Adrenal gland
- Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism
-
Sabrina Diano
-
Endocrinol Metab. 2013;28(1):3-5. Published online March 25, 2013
-
DOI: https://doi.org/10.3803/EnM.2013.28.1.3
-
-
4,825
View
-
45
Download
-
21
Crossref
-
Abstract
PDF PubReader
To understand the etiology of metabolic disorders, including obesity and type II diabetes, it is essential to gain better insight into how stored and available energy sources are monitored by the central nervous system. In particular, a comprehension of the fine cellular interplay and intracellular mechanisms that enable appropriate hypothalamic and consequent endocrine and behavioral responses to both circulating hormonal and nutrient signals remains elusive. Recent data, including those from our laboratories, raised the notion that reactive oxygen species (ROS) generation is not merely a by-product of substrate oxidation, but it plays a crucial role in modulating cellular responses involved in the regulation of energy metabolism. These review summarizes the published recent data on the effect of ROS levels in the regulation of neuronal function, including that of hypothalamic melanocortin neurons, pro-opiomelanocortin and neuropeptide Y-/agouti related peptide-neurons, in the modulation of food intake.
-
Citations
Citations to this article as recorded by 
- Regulation of hypothalamic reactive oxygen species and feeding behavior by phosphorylation of the beta 2 thyroid hormone receptor isoform
Svetlana Minakhina, Sun Young Kim, Fredric E. Wondisford Scientific Reports.2024;[Epub] CrossRef - Overexpression of PpmTERF18 enhances the antioxidant capacity of peach fruit to alleviate oxidative damage
Xiaoshan Guo, Guangqin Jing, Shuhua Zhu, Jianrong Feng, Dandan Huang Scientia Horticulturae.2023; 318: 112123. CrossRef - Insights into the promising prospect of pharmacological approaches targeting mitochondrial dysfunction in major human diseases: At a glance
Md.Mominur Rahman, Md.Taslim Sarker, Sabbir Ahmed, Md.Nur Uddin, Md.Shariful Islam, Md.Rezaul Islam, Shanto Das, Nobendu Mukherjee, Hassan A. Hemeg, Abdur Rauf, Bimal Kumar Ghimire, Muthu Thiruvengadam Process Biochemistry.2023; 132: 41. CrossRef - Structure-based analysis and rational design of human peroxiredoxin-1's C-terminus-derived peptides to target sulfiredoxin-1 in pancreatic cancer
Xiaoqiong Wu, Rongyuan Qiu, Wei Yi, Juan Chen, Zhou Zhang, Ji Zhang, Zhiyuan Zhu Biophysical Chemistry.2022; 288: 106857. CrossRef - Drp1 is required for AgRP neuronal activity and feeding
Sungho Jin, Nal Ae Yoon, Zhong-Wu Liu, Jae Eun Song, Tamas L Horvath, Jung Dae Kim, Sabrina Diano eLife.2021;[Epub] CrossRef - Mechanism of deoxynivalenol mediated gastrointestinal toxicity: Insights from mitochondrial dysfunction
Shuai Wang, Kuntan Wu, Dongfang Xue, Cong Zhang, Shahid Ali Rajput, Desheng Qi Food and Chemical Toxicology.2021; 153: 112214. CrossRef - Redox Signaling from and to Peroxisomes: Progress, Challenges, and Prospects
Marc Fransen, Celien Lismont Antioxidants & Redox Signaling.2019; 30(1): 95. CrossRef - The melanocortin pathway and control of appetite-progress and therapeutic implications
Giulia Baldini, Kevin D Phelan Journal of Endocrinology.2019; 241(1): R1. CrossRef - Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration
Mengshi Zhang, Youwei Chen, Hanqian Xu, Li Yang, Feng Yuan, Lei Li, Ying Xu, Ying Chen, Chao Zhang, Gufa Lin Developmental Cell.2018; 46(4): 397. CrossRef - Hypothalamic Mitochondrial Dysfunction as a Target in Obesity and Metabolic Disease
Juan Cunarro, Sabela Casado, Javier Lugilde, Sulay Tovar Frontiers in Endocrinology.2018;[Epub] CrossRef - Role of oxidative stress and antioxidants in daily nutrition and human health
Geir Bjørklund, Salvatore Chirumbolo Nutrition.2017; 33: 311. CrossRef - DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons
Anna Santoro, Michela Campolo, Chen Liu, Hiromi Sesaki, Rosaria Meli, Zhong-Wu Liu, Jung Dae Kim, Sabrina Diano Cell Metabolism.2017; 25(3): 647. CrossRef - Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats
Virginia Mela, Oskarina Hernandez, Caroline Hunsche, Francisca Diaz, Julie A. Chowen, Mónica De la Fuente Molecular and Cellular Endocrinology.2017; 454: 125. CrossRef - Effects of chlorogenic acid on intracellular calcium regulation in lysophosphatidylcholine-treated endothelial cells
Hye-Jin Jung, Seung-Soon Im, Dae-Kyu Song, Jae-Hoon Bae BMB Reports.2017; 50(6): 323. CrossRef - Trimetazidine attenuates pressure overload-induced early cardiac energy dysfunction via regulation of neuropeptide Y system in a rat model of abdominal aortic constriction
Ailan Chen, Wanglin Li, Xinyu Chen, Yuechun Shen, Wenjun Dai, Qi Dong, Xinchun Li, Caiwen Ou, Minsheng Chen BMC Cardiovascular Disorders.2016;[Epub] CrossRef - Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
Seung-Jae Kim, Ji-Young Cha, Hye Suk Kang, Jae-Ho Lee, Ji Yoon Lee, Jae-Hyung Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im BMB Reports.2016; 49(5): 276. CrossRef - The sulfiredoxin–peroxiredoxin (Srx–Prx) axis in cell signal transduction and cancer development
Murli Mishra, Hong Jiang, Lisha Wu, Hedy A. Chawsheen, Qiou Wei Cancer Letters.2015; 366(2): 150. CrossRef - Effects of methanolic extracts of edible plants on RAGE in high-glucose-induced human endothelial cells
Mizue Okada, Yoshinori Okada Bio-Medical Materials and Engineering.2015; 25(3): 257. CrossRef - Reactive oxygen species are physiological mediators of the noradrenergic signaling pathway in the mouse supraoptic nucleus
Ronald St-Louis, Caroline Parmentier, Valérie Grange-Messent, Sakina Mhaouty-Kodja, Hélène Hardin-Pouzet Free Radical Biology and Medicine.2014; 71: 231. CrossRef - Reactive oxygen species play a role in muscle wasting during thyrotoxicosis
Sara Santos Bernardes, Flávia Alessandra Guarnier, Poliana Camila Marinello, André Armani, Andréa Name Colado Simão, Rubens Cecchini, Alessandra Lourenço Cecchini Cell and Tissue Research.2014; 357(3): 803. CrossRef - Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee Endocrinology and Metabolism.2014; 29(3): 251. CrossRef
|