- Thyroid
- Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder
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Hyeong-Moo Shin, Jiwon Oh, Rebecca J. Schmidt, Elizabeth N. Pearce
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Endocrinol Metab. 2022;37(6):819-829. Published online November 23, 2022
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DOI: https://doi.org/10.3803/EnM.2022.1598
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- Autism spectrum disorder (ASD), with its high economic and societal costs, is a growing public health concern whose prevalence has risen steadily over the last two decades. Although actual increased incidence versus improved diagnosis remains controversial, the increased prevalence of ASD suggests non-inherited factors as likely contributors. There is increasing epidemiologic evidence that abnormal maternal thyroid function during pregnancy is associated with increased risk of child ASD and other neurodevelopmental disorders. Prenatal exposure to endocrine-disrupting chemicals such as per- and polyfluoroalkyl substances (PFAS) is known to disrupt thyroid function and can affect early brain development; thus, thyroid dysfunction is hypothesized to mediate this relationship. The concept of a potential pathway from prenatal PFAS exposure through thyroid dysfunction to ASD etiology is not new; however, the extant literature on this topic is scant. The aim of this review is to evaluate and summarize reports with regard to potential mechanisms in this pathway.
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Citations
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Hormone Molecular Biology and Clinical Investigation.2025;[Epub] CrossRef - Maternal per- and polyfluoroalkyl substance concentrations and placental DNA methylation of thyroid hormone-related genes
Zhenzhen Xie, Longmei Jin, Qihan Wu, Honglei Ji, Maohua Miao, Xiuxia Song, Haijun Zhu, Huijia Su, Wei Yuan, Hong Liang
Journal of Hazardous Materials.2025; 489: 137545. CrossRef - Endocrine Disruptors and Thyroid Health
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Endocrine Practice.2024; 30(2): 172. CrossRef - Maternal Thyroid Dysfunction During Pregnancy as an Etiologic Factor in Autism Spectrum Disorder: Challenges and Opportunities for Research
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Journal of Clinical Medicine.2024; 13(18): 5549. CrossRef - Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts
Lucas Gaillard, Robert Barouki, Etienne Blanc, Xavier Coumoul, Karine Andréau
Trends in Endocrinology & Metabolism.2024;[Epub] CrossRef - Per- and polyfluoroalkyl substances (PFAS) in Indian environment: Prevalence, impacts and solutions
G.V. Koulini, Vignesh Vinayagam, Indumathi M. Nambi, R. Ravi Krishna
Journal of Water Process Engineering.2024; 66: 105988. CrossRef - Association between PFAS exposure and thyroid health: A systematic review and meta-analysis for adolescents, pregnant women, adults and toxicological evidence
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Science of The Total Environment.2024; 953: 175958. CrossRef - Neurotoxicity of per- and polyfluoroalkyl substances: Evidence and future directions
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Science of The Total Environment.2024; 955: 176941. CrossRef - Associations Between Heavy Metal Exposure from Milk and Steroid Hormones in Mothers
Zheng Wang, Caixia Liang, Li Li Shi, Cheng-Sheng Zhu, Shenghang Wang, Shoji F. Nakayama, Teruhiko Kido, Xian Liang Sun, Jiancong Shan
Biological Trace Element Research.2024;[Epub] CrossRef - Effects of Endocrine-Disrupting Chemicals on Human Health
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Laboratory Medicine Online.2023; 13(3): 129. CrossRef
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