- A Case of Idiopathic Myelofibrosis Associated with Acromegaly Patient.
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Jun Young Song, Pyoung Rak Choi, Hong Jun You, Seong Hoon Shin, Yu Ri Kim, Young Sik Choi, Yo Han Park, Mi Hyang Kim, Bong Kwon Chun, Young Duk Joh
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J Korean Endocr Soc. 2006;21(4):328-332. Published online August 1, 2006
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DOI: https://doi.org/10.3803/jkes.2006.21.4.328
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Abstract
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- Acromegaly is a chronic condition resulting from the excessive secretion of growth hormone and insulin like growth factor 1, generally from pituitary adenoma. Although there have been several reports suggesting the possible association of hematologic malignancies with acromegaly, myelofibrosis with acromegaly is very rare. Here we report 54-year-old male patient with myelofibrosis accompanied with acromegaly. We treated this patient with low dose thalidomide (50 mg/day) and prednisone (30 mg/day). We reported this case with literature review.
- A Case of Pituitary Mucormycosis in Diabetic Patient with Acromegaly and Gastric Cancer.
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Pyoung Rak Choi, Hong Jun Yu, Seung Wu Yang, Gyu Jong Kim, Hark Rim, Yu Ri Kim, Young Sik Choi, Yo Han Park, Bong Kwon Chun
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J Korean Endocr Soc. 2006;21(3):245-250. Published online June 1, 2006
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DOI: https://doi.org/10.3803/jkes.2006.21.3.245
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Abstract
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- Rhino-orbito-cerebral mucormycosis (ROCM) is an uncommon, acute, and aggressive fungal infection occurring in several immunocompromised states including poorly controlled diabetes. ROCM causes a very high residual morbidity and mortality due to the angioinvasion property of the fungus. Acromegaly is a chronic condition resulting from the excessive secretion of growth hormone, generally from pituitary adenoma. Although it has been demonstrated that acromegalic patients have an increased risk of neoplasm, gastric cancer with acromegaly is very rare. We experienced a case of pituitary mucormycosis in the diabetic patient with acromegaly and gastric cancer. The patient was treated successfully with subtotal gastrectomy for early gastric cancer, transsphenoidal surgery for pituitary adenoma, and a systemic application of amphotericin B for the mucormycosis.
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