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Pyoung Ahn  (Ahn P) 1 Article
Thyroid
Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
Pyoung Ahn, Hyun-Jun Min, Sang-Hyun Park, Byoung-Mu Lee, Myung-Jin Choi, Jong-Woo Yoon, Ja-Ryong Koo
Endocrinol Metab. 2013;28(4):331-334.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.331
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  • 11 Crossref
AbstractAbstract PDFPubReader   

Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.

Citations

Citations to this article as recorded by  
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    Molecular Simulation.2016; 42(15): 1223.     CrossRef
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    H.‐S. Kim, S. H. Lee, H. Kim, S.‐H. Lee, J. H. Cho, H. Lee, H. W. Yim, S.‐H. Kim, I.‐Y. Choi, K.‐H. Yoon, J. H. Kim
    Journal of Clinical Pharmacy and Therapeutics.2016; 41(3): 266.     CrossRef
  • Creatinine as predictor value of mortality and acute kidney injury in rhabdomyolysis
    R. Baeza‐Trinidad, A. Brea‐Hernando, S. Morera‐Rodriguez, Y. Brito‐Diaz, S. Sanchez‐Hernandez, L. El Bikri, E. Ramalle‐Gomara, J. L. Garcia‐Alvarez
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    Current Medical Research and Opinion.2014; 30(9): 1701.     CrossRef
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