Endocrinology and Metabolism

Peng Chin Kek (Kek PC)

1 Article

Clinical Study
Factors Associated with Resolution of Hypertension after Adrenalectomy in Patients with Primary Aldosteronism: Wann Jia Loh, Dawn Shao Ting Lim, Lih Ming Loh, Peng Chin Kek; Endocrinol Metab. 2018;33(3):355-363. Published online August 14, 2018; DOI: https://doi.org/10.3803/EnM.2018.33.3.355

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Background

The aim of this study was to investigate the factors associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism. A secondary aim was to describe our use of the contralateral ratio in adrenal venous sampling (AVS) in the setting of suboptimal successful cannulation rates.

Methods

A retrospective review of patients who underwent AVS followed by unilateral adrenalectomy for primary aldosteronism was performed.

Results

Complete resolution of hypertension and hypokalemia was seen in 17 of 40 patients (42.5%), while a clinical improvement in hypertension was seen in 38 of 40 (95%). Shorter duration of hypertension, mean aldosteronoma resolution score (ARS), and a high ARS of 3 to 5 were associated with resolution of hypertension after adrenalectomy (P=0.02, P=0.02, and P=0.004, respectively). Of the individual components of ARS, only a duration of hypertension of ≤6 years was associated with resolution of hypertension after adrenalectomy (P=0.03).

Conclusion

A shorter duration of hypertension was significantly associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism.

Citations

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