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Myung-Jin Choi  (Choi MJ) 1 Article
Thyroid
Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
Pyoung Ahn, Hyun-Jun Min, Sang-Hyun Park, Byoung-Mu Lee, Myung-Jin Choi, Jong-Woo Yoon, Ja-Ryong Koo
Endocrinol Metab. 2013;28(4):331-334.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.331
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  • 9 Crossref
AbstractAbstract PDFPubReader   

Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.

Citations

Citations to this article as recorded by  
  • Case report: Rhabdomyolysis and kidney injury in a statin-treated hypothyroid patient–kill two birds with one stone
    Wen-Fang Chiang, Jenq-Shyong Chan, Po-Jen Hsiao, Shih-Hua Lin
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Secondary dyslipidemia: its treatments and association with atherosclerosis
    Hidekatsu Yanai, Hiroshi Yoshida
    Global Health & Medicine.2021; 3(1): 15.     CrossRef
  • Hypothyroidism-associated rhabdomyolysis: A new case report and review of the reported cases
    FahmiYousef Khan, TheebOsama Sulaiman, RazaAli Akbar
    Imam Journal of Applied Sciences.2021; 6(2): 31.     CrossRef
  • Phenotyping of Korean patients with better-than-expected efficacy of moderate-intensity statins using tensor factorization
    Jingyun Choi, Yejin Kim, Hun-Sung Kim, In Young Choi, Hwanjo Yu, Katriina Aalto-Setala
    PLOS ONE.2018; 13(6): e0197518.     CrossRef
  • Discovery of potential novel microsomal triglyceride transfer protein inhibitors via virtual screening of pharmacophore modelling and molecular docking
    Ludi Jiang, Yusu He, Ganggang Luo, Yongqiang Yang, Gongyu Li, Yanling Zhang
    Molecular Simulation.2016; 42(15): 1223.     CrossRef
  • Statin‐related aminotransferase elevation according to baseline aminotransferases level in real practice in Korea
    H.‐S. Kim, S. H. Lee, H. Kim, S.‐H. Lee, J. H. Cho, H. Lee, H. W. Yim, S.‐H. Kim, I.‐Y. Choi, K.‐H. Yoon, J. H. Kim
    Journal of Clinical Pharmacy and Therapeutics.2016; 41(3): 266.     CrossRef
  • Creatinine as predictor value of mortality and acute kidney injury in rhabdomyolysis
    R. Baeza‐Trinidad, A. Brea‐Hernando, S. Morera‐Rodriguez, Y. Brito‐Diaz, S. Sanchez‐Hernandez, L. El Bikri, E. Ramalle‐Gomara, J. L. Garcia‐Alvarez
    Internal Medicine Journal.2015; 45(11): 1173.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of dyslipidemia: mind the gaps!
    Vasilios G. Athyros, Niki Katsiki, Asterios Karagiannis, Dimitri P. Mikhailidis
    Current Medical Research and Opinion.2014; 30(9): 1701.     CrossRef
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