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Min Jung Bae  (Bae MJ) 2 Articles
Bone Metabolism
Expression of Glucagon-Like Peptide 1 Receptor during Osteogenic Differentiation of Adipose-Derived Stem Cells
Yun Kyung Jeon, Min Jung Bae, Ju In Kim, Joo Hyoung Kim, Soo Jong Choi, Su Kyoung Kwon, Joon Hyop An, Sang Soo Kim, Bo Hyun Kim, Yong Ki Kim, In Joo Kim
Endocrinol Metab. 2014;29(4):567-573.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.567
  • 4,131 View
  • 34 Download
  • 29 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   
Background

Glucagon-like peptide 1 (GLP-1), an incretin hormone well known for its glucose-lowering effect, was recently reported to exert an anabolic effect on bone. Although the exact mechanism is not known, it likely involves the GLP-1 receptor (GLP-1R), which is expressed in some osteoblastic cell lines. Adipose-derived stem cells (ADSCs) have mesenchymal stem cell-specific characteristics, including osteoblastic differentiation potential. We evaluated the expression of GLP-1R during osteogenic differentiation of ADSCs.

Methods

ADSCs were isolated from subcutaneous adipose tissue obtained from three male donors during plastic surgery and were subjected to osteogenic induction. Mineralization was assessed by Alizarin Red staining on day 21. Expression of alkaline phosphatase (ALP), osteocalcin (OC), and GLP-1R was measured by real-time polymerase chain reaction in triplicate for each patient on days 0, 7, 14, and 21. Target mRNA expression levels were normalized to that of β-actin.

Results

ADSCs were fibroblast-like in morphology, adhered to plastic, and had multipotent differentiation potential, as assessed using specific antigen markers. The osteogenic markers ALP and OC were notably upregulated at 21 days. Osteogenic differentiation resulted in a time-dependent increase in the expression of GLP-1R (P=0.013).

Conclusion

We demonstrated upregulation of GLP-1R gene expression during osteogenic differentiation of ADSCs. This finding suggests that GLP-1 may induce osteogenic differentiation in bone tissue.

Citations

Citations to this article as recorded by  
  • Glucagon-like peptide-1 receptor promotes osteoblast differentiation of dental pulp stem cells and bone formation in a zebrafish scale regeneration model
    Shafei Zhai, Changkui Liu, Selvaraj Vimalraj, Raghunandhakumar Subramanian, Shahabe Saquib abullais, Suraj Arora, Sekaran Saravanan
    Peptides.2023; 163: 170974.     CrossRef
  • The associations of gut microbiota, endocrine system and bone metabolism
    Ye Tu, Xinyi Kuang, Ling Zhang, Xin Xu
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Effect of Liraglutide on Osteoporosis in a Rat Model of Type 2 Diabetes Mellitus: A Histological, Immunohistochemical, and Biochemical Study
    Maha Abdelhamid Fathy, Amal Anbaig, Raja Aljafil, Sherein F El-Sayed, Hanim Magdy Abdelnour, Mona Mostafa Ahmed, Eman M A Abdelghany, Sulaiman Mohammed Alnasser, Shaimaa Mohamed Abdelfattah Hassan, Amany Mohamed Shalaby
    Microscopy and Microanalysis.2023; 29(6): 2053.     CrossRef
  • Metabolic responses and benefits of glucagon‐like peptide‐1 (GLP‐1) receptor ligands
    Neil Tanday, Peter R. Flatt, Nigel Irwin
    British Journal of Pharmacology.2022; 179(4): 526.     CrossRef
  • Exendin‐4 enhances osteogenic differentiation of adipose tissue mesenchymal stem cells through the receptor activator of nuclear factor‐kappa B and osteoprotegerin signaling pathway
    Sarah A. Habib, Mohamed M. Kamal, Shohda A. El‐Maraghy, Mahmoud A. Senousy
    Journal of Cellular Biochemistry.2022; 123(5): 906.     CrossRef
  • Risk of fracture caused by anti-diabetic drugs in individuals with type 2 diabetes: A network meta-analysis
    Wen-Hsuan Tsai, Siang-Ke Kong, Chu-Lin Lin, Kai-Hsuan Cheng, Yi-Ting Cheng, Ming-Nan Chien, Chun-Chuan Lee, Ming-Chieh Tsai
    Diabetes Research and Clinical Practice.2022; 192: 110082.     CrossRef
  • Comprehensive Analysis of Novel Genes and Pathways Associated with Osteogenic Differentiation of Adipose Stem Cells
    Qiuni Gao, Xiaorong Ma, Zuoliang Qi, Jianxin Shi
    Disease Markers.2022; 2022: 1.     CrossRef
  • Novel Insights into the Roles and Mechanisms of GLP-1 Receptor Agonists against Aging-Related Diseases
    Wei Peng, Rui Zhou, Ze-Fang Sun, Jia-Wei Long, Yong-Qiang Gong
    Aging and disease.2022; 13(2): 468.     CrossRef
  • Correlation of Osteoporosis in Patients With Newly Diagnosed Type 2 Diabetes: A Retrospective Study in Chinese Population
    Yuhua Wen, Huijuan Li, Xiaoya Zhang, Peipei Liu, Jing Ma, Liya Zhang, Keqin Zhang, Lige Song
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Effects of Incretin-Related Diabetes Drugs on Bone Formation and Bone Resorption
    Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi
    International Journal of Molecular Sciences.2021; 22(12): 6578.     CrossRef
  • Liraglutide regulates bone destruction and exhibits anti-inflammatory effects in periodontitis in vitro and in vivo
    Yunxia Zhang, Xuemin Yuan, Yuyan Wu, Minyu Pei, Man Yang, Xuanye Wu, Yunqing Pang, Jing Wang
    Journal of Dentistry.2020; 94: 103310.     CrossRef
  • Exendin-4 regulates Wnt and NF-κB signaling in lipopolysaccharide-induced human periodontal ligament stem cells to promote osteogenic differentiation
    Honghong Liu, Jiawen Zheng, Taijing Zheng, Ping Wang
    International Immunopharmacology.2019; 75: 105801.     CrossRef
  • Effects of malvidin, cyanidin and delphinidin on human adipose mesenchymal stem cell differentiation into adipocytes, chondrocytes and osteocytes
    Liga Saulite, Kaspars Jekabsons, Maris Klavins, Ruta Muceniece, Una Riekstina
    Phytomedicine.2019; 53: 86.     CrossRef
  • Exendin-4 relieves the inhibitory effects of high glucose on the proliferation and osteoblastic differentiation of periodontal ligament stem cells
    Zijun Guo, Rui Chen, Fujun Zhang, Ming Ding, Ping Wang
    Archives of Oral Biology.2018; 91: 9.     CrossRef
  • Effects of gastric inhibitory polypeptide, glucagon‐like peptide‐1 and glucagon‐like peptide‐1 receptor agonists on Bone Cell Metabolism
    Morten S. S. Hansen, Michaela Tencerova, Jacob Frølich, Moustapha Kassem, Morten Frost
    Basic & Clinical Pharmacology & Toxicology.2018; 122(1): 25.     CrossRef
  • Liraglutide, a glucagon-like peptide-1 receptor agonist, facilitates osteogenic proliferation and differentiation in MC3T3-E1 cells through phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), extracellular signal-related kinase (ERK)1/2, and cAMP/pro
    Xuelun Wu, Shilun Li, Peng Xue, Yukun Li
    Experimental Cell Research.2017; 360(2): 281.     CrossRef
  • The Impact of Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms
    Chenhe Zhao, Jing Liang, Yinqiu Yang, Mingxiang Yu, Xinhua Qu
    Frontiers in Endocrinology.2017;[Epub]     CrossRef
  • Pathophysiology of Bone Fragility in Patients with Diabetes
    Andrea Palermo, Luca D’Onofrio, Raffaella Buzzetti, Silvia Manfrini, Nicola Napoli
    Calcified Tissue International.2017; 100(2): 122.     CrossRef
  • Activation of GLP-1 Receptor Promotes Bone Marrow Stromal Cell Osteogenic Differentiation through β-Catenin
    Jingru Meng, Xue Ma, Ning Wang, Min Jia, Long Bi, Yunying Wang, Mingkai Li, Huinan Zhang, Xiaoyan Xue, Zheng Hou, Ying Zhou, Zhibin Yu, Gonghao He, Xiaoxing Luo
    Stem Cell Reports.2016; 6(4): 579.     CrossRef
  • Mechanisms for the cardiovascular effects of glucagon-like peptide-1
    H. Poudyal
    Acta Physiologica.2016; 216(3): 277.     CrossRef
  • Perspectives in GLP-1 Research: New Targets, New Receptors
    Giulia Cantini, Edoardo Mannucci, Michaela Luconi
    Trends in Endocrinology & Metabolism.2016; 27(6): 427.     CrossRef
  • Chronic administration of Glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice
    M. Pereira, J. Jeyabalan, C.S. Jørgensen, M. Hopkinson, A. Al-Jazzar, J.P. Roux, P. Chavassieux, I.R. Orriss, M.E. Cleasby, C. Chenu
    Bone.2015; 81: 459.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • Impact of Anti-hyperglycemic Medications on Bone Health
    Naim M. Maalouf
    Clinical Reviews in Bone and Mineral Metabolism.2015; 13(1): 43.     CrossRef
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Obesity and Metabolism
Adiposity in the Relationship between Serum Vitamin D Level and Insulin Resistance in Middle-Aged and Elderly Korean Adults: The Korea National Health and Nutrition Examination Survey 2008
Ji Hyun Kang, Sang Soo Kim, Seung Su Moon, Won Jin Kim, Min Jung Bae, Bo Gwang Choi, Yun Kyung Jeon, Bo Hyun Kim, Yong Ki Kim, In Joo Kim
Endocrinol Metab. 2013;28(2):96-102.   Published online June 18, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.2.96
  • 2,956 View
  • 29 Download
  • 15 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   
Background

The role of adiposity in the relationship between serum vitamin D levels and insulin resistance has not yet been fully studied. This aim of this study is to clarify the role of adiposity in the relationship between serum vitamin D level and insulin resistance among middle-aged and elderly Korean adults.

Methods

We used data from 2,710 individuals aged ≥50 years based on national data from a representative sample of the fourth Korea National Health and Nutrition Examination Survey IV-2 in 2008.

Results

After adjustment for potential confounders, body mass index (BMI) was significantly associated with 25(OH) vitamin D (P=0.008). However, waist circumference was not significantly associated with 25(OH) vitamin D. In the stratified analyses, 25(OH) vitamin D was found to be negatively associated with fasting insulin and homeostasis model assessment estimate of insulin resistance (HOMA-IR) in participants with BMIs ≥25 kg/m2 (P=0.003 for both insulin and HOMR-IR) but was not found to be associated in those with BMIs <23 kg/m2. However, we observed a significant inverse in the association of 25(OH) vitamin D with fasting insulin and HOMA-IR in both the normal (P=0.001 and P<0.001 and the abdominally obese group (P=0.010 and P=0.009) in the stratified analyses according to abdominal obesity.

Conclusion

Our results support that the idea that endogenously-produced vitamin D might be stored in subcutaneous fat deposits. In addition, the association of vitamin D with insulin resistance in middle-aged and elderly Korean adults was stronger when it was stratified by BMI than when abdominal obesity status.

Citations

Citations to this article as recorded by  
  • A Novel Biosensor and Algorithm to Predict Vitamin D Status by Measuring Skin Impedance
    Jin-Chul Heo, Doyoon Kim, Hyunsoo An, Chang-Sik Son, Sangwoo Cho, Jong-Ha Lee
    Sensors.2021; 21(23): 8118.     CrossRef
  • Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
    Min-Hee Kim, Jeongmin Lee, Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Bong Yun Cha
    Scientific Reports.2018;[Epub]     CrossRef
  • Association of serum 25-hydroxyvitamin D and diabetes-related factors in Korean adults without diabetes: The Fifth Korea National Health and Nutrition Examination Survey 2010–2012
    Hyunah Kim, Hyunyong Lee, Hyeon Woo Yim, Hun-Sung Kim
    Primary Care Diabetes.2018; 12(1): 59.     CrossRef
  • Does the Risk of Metabolic Syndrome Increase in Thyroid Cancer Survivors?
    Min-Hee Kim, Jin-young Huh, Dong-jun Lim, Moo-Il Kang
    Thyroid.2017; 27(7): 936.     CrossRef
  • Different effect of alcohol consumption on hypertension according to metabolic health status
    H K Yang, K Han, Y-M Park, H-S Kwon, K-H Yoon, S-H Lee
    Journal of Human Hypertension.2016; 30(10): 591.     CrossRef
  • Serum 25-Hydroxyvitamin D Concentration Is Independently Inversely Associated with Insulin Resistance in the Healthy, Non-Obese Korean Population
    So Young Ock, Kyoung Hwa Ha, Bu Kyung Kim, Hyeon Chang Kim, Jee-Seon Shim, Myung Ha Lee, Young Me Yoon, Dae Jung Kim
    Diabetes & Metabolism Journal.2016; 40(5): 367.     CrossRef
  • The Relationship Between the Level of Serum 25-Hydroxyvitamin D and Renal Function in Patients Without Chronic Kidney Disease: A Cross-Sectional Study
    Young Jin Tak, Jeong Gyu Lee, Sang Heon Song, Yun Jin Kim, Sangyeoup Lee, Dong Wook Jung, Yu Hyeon Yi, Young Hye Cho, Eun Jung Choi, Hye Rim Hwang
    Journal of Renal Nutrition.2015; 25(2): 88.     CrossRef
  • Relationship between serum 25-hydroxyvitamin D concentration and risks of metabolic syndrome in children and adolescents from Korean National Health and Nutrition Examination survey 2008-2010
    Dong Yup Lee, Ah Reum Kwon, Jung Min Ahn, Ye Jin Kim, Hyun Wook Chae, Duk Hee Kim, Ho-Seong Kim
    Annals of Pediatric Endocrinology & Metabolism.2015; 20(1): 46.     CrossRef
  • Lower serum zinc levels are associated with unhealthy metabolic status in normal-weight adults: The 2010 Korea National Health and Nutrition Examination Survey
    H.K. Yang, S.H. Lee, K. Han, B. Kang, S.Y. Lee, K.H. Yoon, H.S. Kwon, Y.M. Park
    Diabetes & Metabolism.2015; 41(4): 282.     CrossRef
  • The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance Is Largely Attributable to Central Adiposity in Overweight and Obese Adults
    Christian S Wright, Eileen M Weinheimer-Haus, James C Fleet, Munro Peacock, Wayne W Campbell
    The Journal of Nutrition.2015; 145(12): 2683.     CrossRef
  • Vitamin D Status and Its Relation with Abdominal Adiposity and Cardiovascular Risk Factors of Korean Adults in Certain Areas
    Sae-Ron Shin, A Lum Han, Seong-Hoon Park
    The Korean Journal of Obesity.2015; 24(1): 30.     CrossRef
  • Identifying subgroups of obesity using the product of triglycerides and glucose: the Korea National Health and Nutrition Examination Survey, 2008–2010
    Seung‐Hwan Lee, Kyungdo Han, Hae Kyung Yang, Mee Kyoung Kim, Kun‐Ho Yoon, Hyuk‐Sang Kwon, Yong‐Moon Park
    Clinical Endocrinology.2015; 82(2): 213.     CrossRef
  • A novel criterion for identifying metabolically obese but normal weight individuals using the product of triglycerides and glucose
    S-H Lee, K Han, H K Yang, H-S Kim, J-H Cho, H-S Kwon, Y-M Park, B-Y Cha, K-H Yoon
    Nutrition & Diabetes.2015; 5(4): e149.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Unprotected daily sun exposure is differently associated with central adiposity and beta-cell dysfunction by gender: The Korean national health and nutrition examination survey (KNHANES) V
    Jung Hun Ohn, In Ho Kwon, Juri Park, Ohk Hyun Ryu, Seong Jin Lee, Doo-Man Kim, Sung-Hee Ihm, Moon-Gi Choi, Hyung Joon Yoo, Eun-Gyoung Hong
    Environmental Research.2014; 133: 253.     CrossRef
  • Low Vitamin D Serum Levels May Be a Modifiable Risk Factor for Obesity and Cognitive Impairment in Middle-Age Egyptian Women
    Yusr I. Kazem, Maha I. A. Moaty, Salwa M. El-Shebini, Salwa T. Tapozada, Laila M. Hanna
    Open Access Macedonian Journal of Medical Sciences.2014; 2(2): 283.     CrossRef
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Endocrinol Metab : Endocrinology and Metabolism