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Min Joo Kim  (Kim MJ) 18 Articles
Thyroid
Active Surveillance for Low-Risk Thyroid Cancers: A Review of Current Practice Guidelines
Min Joo Kim, Jae Hoon Moon, Eun Kyung Lee, Young Shin Song, Kyong Yeun Jung, Ji Ye Lee, Ji-hoon Kim, Kyungsik Kim, Sue K. Park, Young Joo Park
Endocrinol Metab. 2024;39(1):47-60.   Published online February 15, 2024
DOI: https://doi.org/10.3803/EnM.2024.1937
  • 5,834 View
  • 433 Download
  • 2 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   ePub   
The indolent nature and favorable outcomes associated with papillary thyroid microcarcinoma have prompted numerous prospective studies on active surveillance (AS) and its adoption as an alternative to immediate surgery in managing low-risk thyroid cancer. This article reviews the current status of AS, as outlined in various international practice guidelines. AS is typically recommended for tumors that measure 1 cm or less in diameter and do not exhibit aggressive subtypes on cytology, extrathyroidal extension, lymph node metastasis, or distant metastasis. To determine the most appropriate candidates for AS, factors such as tumor size, location, multiplicity, and ultrasound findings are considered, along with patient characteristics like medical condition, age, and family history. Moreover, shared decision-making, which includes patient-reported outcomes such as quality of life and cost-effectiveness, is essential. During AS, patients undergo regular ultrasound examinations to monitor for signs of disease progression, including tumor growth, extrathyroidal extension, or lymph node metastasis. In conclusion, while AS is a feasible and reliable approach for managing lowrisk thyroid cancer, it requires careful patient selection, effective communication for shared decision-making, standardized follow-up protocols, and a clear definition of disease progression.

Citations

Citations to this article as recorded by  
  • 2023 Update of the Korean Thyroid Association Guidelines for the Management of Thyroid Nodules
    Eun Kyung Lee, Young Joo Park
    Clinical Thyroidology®.2024; 36(4): 153.     CrossRef
  • Association between exercise habits and incident type 2 diabetes mellitus in patients with thyroid cancer: nationwide population-based study
    Jiyun Park, Jin-Hyung Jung, Hyunju Park, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyungdo Han, Kyung-Soo Kim
    BMC Medicine.2024;[Epub]     CrossRef
  • Prediction of Recurrent Laryngeal Nerve Invasion in Thyroid Cancer by Ultrasound
    Jin Hyang Jung, Eunji Kim, Byung Ju Kang
    Journal of Surgical Ultrasound.2024; 11(1): 18.     CrossRef
  • Advances in clinical research on ultrasound-guided radiofrequency ablation for papillary thyroid microcarcinoma
    Hua Xu, Jin-yan Yang, Xing Zhao, Zhe Ma
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Systemic therapy for differentiated thyroid cancer with distant metastasis
    Eun Kyung Lee
    Journal of the Korean Medical Association.2024; 67(7): 484.     CrossRef
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Diabetes, obesity and metabolism
Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice
Jooyeop Lee, Min Joo Kim, Seoil Moon, Ji Yoon Lim, Kyong Soo Park, Hye Seung Jung
Endocrinol Metab. 2023;38(6):782-787.   Published online November 13, 2023
DOI: https://doi.org/10.3803/EnM.2023.1738
  • 1,402 View
  • 57 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Although pancreatic endoplasmic reticulum kinase (PERK) is indispensable to beta cells, low-dose PERK inhibitor improved glucose- stimulated insulin secretion (GSIS) and hyperglycemia in diabetic mice. Current study examined if partial deletion of Perk (Perk+/-) recapitulated the effects of PERK inhibitor, on the contrary to the complete deletion. Perk+/- mice and wild-type controls were fed with a high-fat diet (HFD) for 23 weeks. Glucose tolerance was evaluated along with serum insulin levels and islet morphology. Perk+/- mice on normal chow were comparable to wild-type mice in various metabolic features. HFD-induced obesity was not influenced by Perk reduction; however, HFD-induced glucose intolerance was significantly improved since 15-week HFD. HFD-induced compromises in GSIS were relieved by Perk reduction, accompanied by reductions in phosphorylated PERK and activating transcription factor 4 (ATF4) in the islets. Meanwhile, HFD-induced islet expansion was not significantly affected. In summary, partial deletion of Perk improved glucose tolerance and GSIS impaired by diet-induced obesity, without changes in body weights or islet mass.
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Thyroid
Clinical Outcomes of Repeated Radioactive Iodine Therapy for Graves’ Disease
Min Joo Kim, Sun Wook Cho, Ye An Kim, Hoon Sung Choi, Young Joo Park, Do Joon Park, Bo Youn Cho
Endocrinol Metab. 2022;37(3):524-532.   Published online June 16, 2022
DOI: https://doi.org/10.3803/EnM.2022.1418
  • 6,034 View
  • 251 Download
  • 4 Web of Science
  • 3 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Radioactive iodine (RAI) therapy is a successful therapeutic modality for Graves’ disease. However, RAI therapy can fail, and RAI therapy after antithyroid drugs (ATDs) has a lower remission rate. Therefore, many patients require repeated RAI therapy. This study investigated the clinical outcomes of repeated RAI therapy for Graves’ disease.
Methods
Patients who underwent RAI therapy as second-line therapy after failure of ATD treatment between 2001 and 2015 were reviewed. Remission was defined as hypothyroid or euthyroid status without ATD, and with or without levothyroxine at 12 months after RAI therapy.
Results
The 1-year remission rate after 2nd RAI therapy (66%, 152/230) is significantly higher than that after 1st RAI therapy (48%, 393/815) or long-term ATD treatment after 1st RAI therapy failure (42%). The clinical response to 2nd RAI therapy was more rapid. The median time intervals from the 2nd RAI therapy to ATD discontinuation (1.3 months) and to the start of levothyroxine replacement (2.5 months) were significantly shorter than those for the 1st RAI therapy. A smaller goiter size, a longer time interval between the 1st and 2nd RAI therapies, and a longer ATD discontinuation period predicted remission after the 2nd RAI therapy. Finally, in 78 patients who failed the 2nd RAI therapy, the mean ATD dosage significantly reduced 5.1 mg over 12 months.
Conclusion
Repeated RAI therapy can be a good therapeutic option, especially in patients with smaller goiters and those who are more responsive to the 1st RAI therapy.

Citations

Citations to this article as recorded by  
  • Prospective study to evaluate radioactive iodine of 20 mCi vs 10–15 mCi in Graves’ disease
    Wasit Kanokwongnuwat, Nawarat Penpong
    BMC Endocrine Disorders.2024;[Epub]     CrossRef
  • The Early Changes in Thyroid-Stimulating Immunoglobulin Bioassay over Anti-Thyroid Drug Treatment Could Predict Prognosis of Graves’ Disease
    Jin Yu, Han-Sang Baek, Chaiho Jeong, Kwanhoon Jo, Jeongmin Lee, Jeonghoon Ha, Min Hee Kim, Jungmin Lee, Dong-Jun Lim
    Endocrinology and Metabolism.2023; 38(3): 338.     CrossRef
  • Effect of liver dysfunction on outcome of radioactive iodine therapy for Graves’ disease
    Yuyang Ze, Fei Shao, Xuefeng Feng, Shanmei Shen, Yan Bi, Dalong Zhu, Xiaowen Zhang
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
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Thyroid
Comparison of Korean vs. American Thyroid Imaging Reporting and Data System in Malignancy Risk Assessment of Indeterminate Thyroid Nodules
Sunyoung Kang, Seul Ki Kwon, Hoon Sung Choi, Min Joo Kim, Young Joo Park, Do Joon Park, Sun Wook Cho
Endocrinol Metab. 2021;36(5):1111-1120.   Published online October 21, 2021
DOI: https://doi.org/10.3803/EnM.2021.1208
  • 4,863 View
  • 140 Download
  • 9 Web of Science
  • 9 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
The management of cytologically indeterminate thyroid nodules is challenging for clinicians. This study aimed to compare the diagnostic performance of the Korean Thyroid Imaging Reporting and Data Systems (K-TIRADS) with that of the American College of Radiology (ACR)-TIRADS for predicting the malignancy risk of indeterminate thyroid nodules.
Methods
Thyroid nodules diagnosed by fine-needle aspiration (FNA) followed by surgery or core needle biopsy at a single referral hospital were enrolled.
Results
Among 200 thyroid nodules, 78 (39.0%) nodules were classified as indeterminate by FNA (Bethesda category III, IV, and V), and 114 (57.0%) nodules were finally diagnosed as malignancy by surgery or core needle biopsy. The area under the curve (AUC) was higher for FNA than for either TIRADS system in all nodules, while all three methods showed similar AUCs for indeterminate nodules. However, for Bethesda category III nodules, applying K-TIRADS 5 significantly increased the risk of malignancy compared to a cytological examination alone (50.0% vs. 26.5%, P=0.028), whereas applying ACR-TIRADS did not lead to a change.
Conclusion
K-TIRADS and ACR-TIRADS showed similar diagnostic performance in assessing indeterminate thyroid nodules, and K-TIRADS had beneficial effects for malignancy prediction in Bethesda category III nodules.

Citations

Citations to this article as recorded by  
  • Is the nodule location a predictive risk factor for cancer in AUS/FLUS thyroid nodules? A retrospective cohort study
    Saad M. Alqahtani, Bassam A. Altalhi, Yousef S. Alalawi, Saif S. Al-Sobhi
    Asian Journal of Surgery.2024; 47(6): 2574.     CrossRef
  • Correlation between Ultrasound TI-RADS and Bethesda FNAC Scoring in Thyroid Lesions: A Retrospective Analysis
    Smriti Mathur, Amit Chail, Amit K. Das, Seerat Pal, Ranjit S. Lahel
    Medical Journal of Dr. D.Y. Patil Vidyapeeth.2024; 17(3): 533.     CrossRef
  • Diagnostic Performance of Various Ultrasound Risk Stratification Systems for Benign and Malignant Thyroid Nodules: A Meta-Analysis
    Ji-Sun Kim, Byung Guk Kim, Gulnaz Stybayeva, Se Hwan Hwang
    Cancers.2023; 15(2): 424.     CrossRef
  • The impact of thyroid imaging reporting and data system on the management of Bethesda III thyroid nodules
    Saad M. Alqahtani, Saif S. Al-Sobhi, Mohammed A. Alturiqy, Riyadh I. Alsalloum, Hindi N. Al-Hindi
    Journal of Taibah University Medical Sciences.2023; 18(3): 506.     CrossRef
  • Diagnostic Performance of Six Ultrasound Risk Stratification Systems for Thyroid Nodules: A Systematic Review and Network Meta-Analysis
    Do Hyun Kim, Sung Won Kim, Mohammed Abdullah Basurrah, Jueun Lee, Se Hwan Hwang
    American Journal of Roentgenology.2023; 220(6): 791.     CrossRef
  • Diagnostic efficiency among Eu-/C-/ACR-TIRADS and S-Detect for thyroid nodules: a systematic review and network meta-analysis
    Longtao Yang, Cong Li, Zhe Chen, Shaqi He, Zhiyuan Wang, Jun Liu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Comparison of diagnostic performance of two ultrasound risk stratification systems for thyroid nodules: a systematic review and meta-analysis
    Yun Jin Kang, Hee Sun Ahn, Gulnaz Stybayeva, Ju Eun Lee, Se Hwan Hwang
    La radiologia medica.2023; 128(11): 1407.     CrossRef
  • Diagnostic Performance of ACR and Kwak TI-RADS for Benign and Malignant Thyroid Nodules: An Update Systematic Review and Meta-Analysis
    Yun Jin Kang, Gulnaz Stybayeya, Ju Eun Lee, Se Hwan Hwang
    Cancers.2022; 14(23): 5961.     CrossRef
  • Comparison of Thyroid Imaging Reporting and Data Systems in Malignancy Risk Stratification of Indeterminate Thyroid Nodules
    Bo Hyun Kim
    Endocrinology and Metabolism.2021; 36(5): 974.     CrossRef
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Endocrine Research
DEHP Down-Regulates Tshr Gene Expression in Rat Thyroid Tissues and FRTL-5 Rat Thyrocytes: A Potential Mechanism of Thyroid Disruption
Min Joo Kim, Hwan Hee Kim, Young Shin Song, Ok-Hee Kim, Kyungho Choi, Sujin Kim, Byung-Chul Oh, Young Joo Park
Endocrinol Metab. 2021;36(2):447-454.   Published online March 31, 2021
DOI: https://doi.org/10.3803/EnM.2020.920
  • 6,054 View
  • 156 Download
  • 12 Web of Science
  • 14 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Di-2-ethylhexyl phthalate (DEHP) is known to disrupt thyroid hormonal status. However, the underlying molecular mechanism of this disruption is unclear. Therefore, we investigated the direct effects of DEHP on the thyroid gland.
Methods
DEHP (vehicle, 50 mg/kg, and 500 mg/kg) was administered to Sprague-Dawley rats for 2 weeks. The expression of the thyroid hormone synthesis pathway in rat thyroid tissues was analyzed through RNA sequencing analysis, quantitative reverse transcription-polymerase chain reaction (RT-PCR), and immunohistochemical (IHC) staining. DEHP was treated to FRTL-5 rat thyroid cells, and an RT-PCR analysis was performed. A reporter gene assay containing the promoter of thyroid stimulating hormone receptor (TSHR) in Nthy-ori 3-1 human thyroid cells was constructed, and luciferase activity was determined.
Results
After DEHP treatment, the free thyroxine (T4) and total T4 levels in rats significantly decreased. RNA sequencing analysis of rat thyroid tissues showed little difference between vehicle and DEHP groups. In the RT-PCR analysis, Tshr expression was significantly lower in both DEHP groups (50 and 500 mg/kg) compared to that in the vehicle group, and IHC staining showed that TSHR expression in the 50 mg/kg DEHP group significantly decreased. DEHP treatment to FRTL-5 cells significantly down-regulated Tshr expression. DEHP treatment also reduced luciferase activity in a reporter gene assay for TSHR.
Conclusion
Although overall genetic changes in the thyroid hormone synthesis pathway are not clear, DEHP exposure could significantly down-regulate Tshr expression in thyroid glands. Down-regulation of Tshr gene appears to be one of potential mechanisms of thyroid disruption by DEHP exposure.

Citations

Citations to this article as recorded by  
  • ARTS is essential for di-2-ethylhexyl phthalate (DEHP)-induced apoptosis of mouse Leydig cells
    Yue Li, Linlin Xu, Chaoju Hao, Si Yang, Jinglei Wang, Jiaxiang Chen
    Ecotoxicology and Environmental Safety.2024; 270: 115882.     CrossRef
  • Thyroid dysfunction caused by exposure to environmental endocrine disruptors and the underlying mechanism: A review
    Jie He, Jie Xu, Mucong Zheng, Kai Pan, Lilin Yang, Lina Ma, Chuyang Wang, Jie Yu
    Chemico-Biological Interactions.2024; 391: 110909.     CrossRef
  • Maternal Thyroid Hormones as Mediators between Phthalate Exposure and Neonatal Birth Weight: A Cross-Sectional Study from the Zunyi Birth Cohort
    Lin Tao, Dengqing Liao, Shimin Xiong, Lulu Dai, Yuan-zhong Zhou, Xubo Shen
    Environment & Health.2024;[Epub]     CrossRef
  • Thyroid under Attack: The Adverse Impact of Plasticizers, Pesticides, and PFASs on Thyroid Function
    Vinicius Gonçalves Rodrigues, Guilherme Henrique, Érica Kássia Sousa-Vidal, Rafaela Martins Miguel de Souza, Evelyn Franciny Cardoso Tavares, Nathana Mezzalira, Thacila de Oliveira Marques, Bruna Monteiro Alves, João Anthony Araújo Pinto, Luana Naomi Niwa
    Endocrines.2024; 5(3): 430.     CrossRef
  • Intrauterine exposure to di(2-ethylhexyl) phthalate (DEHP) disrupts the function of the hypothalamus-pituitary-thyroid axis of the F1 rats during adult life
    Érica Kássia Sousa-Vidal, Guilherme Henrique, Renata Elen Costa da Silva, Caroline Serrano-Nascimento
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Drinking water disinfection byproduct iodoacetic acid affects thyroid hormone synthesis in Nthy-ori 3–1 cells
    Jingyi Xiao, Yujie Sha, Yuwen Huang, Kunling Long, Huan Wu, Yan Mo, Qiyuan Yang, Shengkun Dong, Qiang Zeng, Xiao Wei
    Ecotoxicology and Environmental Safety.2023; 257: 114926.     CrossRef
  • Assessment of five typical environmental endocrine disruptors and thyroid cancer risk: a meta-analysis
    Yuyao Yang, Xiaoyue Bai, Juan Lu, Ronghao Zou, Rui Ding, Xiaohui Hua
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq
    Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications
    Xueting Zhang, Wen Qi, Qi Xu, Xu Li, Liting Zhou, Lin Ye
    Environmental Science and Pollution Research.2022; 29(2): 1634.     CrossRef
  • The possible thyroid disruptive effect of di-(2-ethyl hexyl) phthalate and the potential protective role of selenium and curcumin nanoparticles: a toxicological and histological study
    Naima Abd El-Halim Sherif, Asmaa El-Banna, Rehab Ahmed Abdel-Moneim, Zahraa Khalifa Sobh, Manal Ibrahim Fathy Balah
    Toxicology Research.2022; 11(1): 108.     CrossRef
  • Environmental disruption of reproductive rhythms
    Marie-Azélie Moralia, Clarisse Quignon, Marine Simonneaux, Valérie Simonneaux
    Frontiers in Neuroendocrinology.2022; 66: 100990.     CrossRef
  • Endocrine-disruptor endpoints in the ovary and thyroid of adult female rats exposed to realistic doses of di-(2-ethylhexyl) phthalate
    Amel Jebara, Asma Beltifa, Guissepa Di Bella, Lotfi Mabrouk, Hedi Ben Mansour
    Journal of Water and Health.2022; 20(8): 1256.     CrossRef
  • The influence of sunitinib and sorafenib, two tyrosine kinase inhibitors, on development and thyroid system in zebrafish larvae
    Gang Wei, Cao-xu Zhang, Yu Jing, Xia Chen, Huai-dong Song, Liu Yang
    Chemosphere.2022; 308: 136354.     CrossRef
  • Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: An in vitro mechanistic investigation
    Qi Xu, Liting Zhou, Hyonju Ri, Xu Li, Xueting Zhang, Wen Qi, Lin Ye
    Environmental Toxicology and Pharmacology.2022; 96: 104007.     CrossRef
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Clinical Study
Low Predictive Value of FRAX Adjusted by Trabecular Bone Score for Osteoporotic Fractures in Korean Women: A Community-Based Cohort Study
Hana Kim, Jung Hee Kim, Min Joo Kim, A Ram Hong, HyungJin Choi, EuJeong Ku, Ji Hyun Lee, Chan Soo Shin, Nam H. Cho
Endocrinol Metab. 2020;35(2):359-366.   Published online June 24, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.2.359
  • 6,888 View
  • 141 Download
  • 11 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   ePub   
Background
The value of the Fracture Risk Assessment Tool (FRAX) and the trabecular bone score (TBS) for assessing osteoporotic fracture risk has not been fully elucidated in Koreans. We conducted this study to clarify the predictive value of FRAX adjusted by TBS for osteoporotic fractures in Korean women.
Methods
After screening 7,192 eligible subjects from the Ansung cohort, 1,165 women aged 45 to 76 years with available bone mineral density (BMD) and TBS data were enrolled in this study. We assessed their clinical risk factors for osteoporotic fractures and evaluated the predictive value of FRAX with or without BMD and TBS.
Results
During the mean follow-up period of 7.5 years, 99 (8.5%) women suffered major osteoporotic fractures (MOFs) and 28 (2.4%) experienced hip fractures. FRAX without BMD, BMD-adjusted FRAX, and TBS-adjusted FRAX were significantly associated with the risk of MOFs (hazard ratio [HR] per percent increase, 1.08; 95% confidence interval [CI], 1.03 to 1.14; HR, 1.09; 95% CI, 1.03 to 1.15; and HR, 1.07; 95% CI, 1.02 to 1.13, respectively). However, BMD-adjusted FRAX and TBS-adjusted FRAX did not predict MOFs better than FRAX without BMD based on the Harrell’s C statistic. FRAX probabilities showed limited value for predicting hip fractures. The cut-off values of FRAX without BMD, FRAX with BMD, and FRAX with BMD adjusted by TBS for predicting MOFs were 7.2%, 5.0%, and 6.7%, respectively.
Conclusion
FRAX with BMD and TBS adjustment did not show better predictive value for osteoporotic fractures in this study than FRAX without adjustment. Moreover, the cut-off values of FRAX probabilities for treatment might be lower in Korean women than in other countries.

Citations

Citations to this article as recorded by  
  • Update on the utility of trabecular bone score (TBS) in clinical practice for the management of osteoporosis: a systematic review by the Egyptian Academy of Bone and Muscle Health
    Yasser El Miedany, Walaa Elwakil, Mohammed Hassan Abu-Zaid, Safaa Mahran
    Egyptian Rheumatology and Rehabilitation.2024;[Epub]     CrossRef
  • Enhancing Osteoporosis Management: A Thorough Examination of Surgical Techniques and Their Effects on Patient Outcomes
    Mihnea Popa, Adrian Cursaru, Bogdan Cretu, Sergiu Iordache, Georgian L Iacobescu, Razvan Spiridonica, Bogdan Serban, Catalin Cirstoiu
    Cureus.2024;[Epub]     CrossRef
  • Imaging bone turnover assessment through volumetric density-adjusted standardized uptake value using quantitative bone SPECT/CT in osteoporosis
    Dong Yun Lee, Jungsu S. Oh, Ji Wan Kim, Seung Hun Lee, Beom-Jun Kim, Jung-Min Koh, Jae Seung Kim, Jin-Sook Ryu
    EJNMMI Research.2024;[Epub]     CrossRef
  • Comparison of predictive value of FRAX, trabecular bone score, and bone mineral density for vertebral fractures in systemic sclerosis: A cross-sectional study
    Kyung-Ann Lee, Hyun-Joo Kim, Hyun-Sook Kim
    Medicine.2023; 102(2): e32580.     CrossRef
  • Screening for the primary prevention of fragility fractures among adults aged 40 years and older in primary care: systematic reviews of the effects and acceptability of screening and treatment, and the accuracy of risk prediction tools
    Michelle Gates, Jennifer Pillay, Megan Nuspl, Aireen Wingert, Ben Vandermeer, Lisa Hartling
    Systematic Reviews.2023;[Epub]     CrossRef
  • Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study
    Sung Hye Kong, Ae Jeong Jo, Chan Mi Park, Kyun Ik Park, Ji Eun Yun, Jung Hee Kim
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Disease
    Enisa Shevroja, Jean-Yves Reginster, Olivier Lamy, Nasser Al-Daghri, Manju Chandran, Anne-Laurence Demoux-Baiada, Lynn Kohlmeier, Marie-Paule Lecart, Daniel Messina, Bruno Muzzi Camargos, Juraj Payer, Sansin Tuzun, Nicola Veronese, Cyrus Cooper, Eugene V.
    Osteoporosis International.2023; 34(9): 1501.     CrossRef
  • Comparison of HU histogram analysis and BMD for proximal femoral fragility fracture assessment: a retrospective single-center case–control study
    Sun-Young Park, Hong Il Ha, Injae Lee, Hyun Kyung Lim
    European Radiology.2022; 32(3): 1448.     CrossRef
  • Association of Trabecular Bone Score-Adjusted Fracture Risk Assessment Tool with Coronary Artery Calcification in Women
    Tzyy-Ling Chuang, Yuh-Feng Wang, Malcolm Koo, Mei-Hua Chuang
    Diagnostics.2022; 12(1): 178.     CrossRef
  • Risk of osteoporotic fracture in women using the FRAX tool with and without bone mineral density score in patients followed at a tertiary outpatient clinic ‒ An observational study
    Maria Helena Sampaio Favarato, Maria Flora de Almeida, Arnaldo Lichtenstein, Milton de Arruda Martins, Mario Ferreira Junior
    Clinics.2022; 77: 100015.     CrossRef
  • Comparison of Trabecular Bone Score–Adjusted Fracture Risk Assessment (TBS-FRAX) and FRAX Tools for Identification of High Fracture Risk among Taiwanese Adults Aged 50 to 90 Years with or without Prediabetes and Diabetes
    Tzyy-Ling Chuang, Mei-Hua Chuang, Yuh-Feng Wang, Malcolm Koo
    Medicina.2022; 58(12): 1766.     CrossRef
  • Application of the Trabecular Bone Score in Clinical Practice
    Sung Hye Kong, Namki Hong, Jin-Woo Kim, Deog Yoon Kim, Jung Hee Kim
    Journal of Bone Metabolism.2021; 28(2): 101.     CrossRef
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Thyroid
Bisphenols and Thyroid Hormone
Min Joo Kim, Young Joo Park
Endocrinol Metab. 2019;34(4):340-348.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.340
  • 10,887 View
  • 255 Download
  • 68 Web of Science
  • 71 Crossref
AbstractAbstract PDFPubReader   ePub   

In recent decades, attention has been directed toward the effects of bisphenol A (BPA) on human health. BPA has estrogenic activity and is regarded as a representative endocrine disruptor. In addition, mounting evidence indicates that BPA can disrupt thyroid hormone and its action. This review examined human epidemiological studies to investigate the association between BPA exposure and thyroid hormone levels, and analyzed in vivo and in vitro experiments to identify the causal relationship and its mechanism of action. BPA is involved in thyroid hormone action not only as a thyroid hormone receptor antagonist, but also through several other mechanisms. Since the use of bisphenols other than BPA has recently increased, we also reviewed the effects of other bisphenols on thyroid hormone action.

Citations

Citations to this article as recorded by  
  • The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies
    Maria Dalamaga, Dimitrios Kounatidis, Dimitrios Tsilingiris, Natalia G. Vallianou, Irene Karampela, Sotiria Psallida, Athanasios G. Papavassiliou
    International Journal of Molecular Sciences.2024; 25(1): 675.     CrossRef
  • Environmental toxicology of bisphenol A: Mechanistic insights and clinical implications on the neuroendocrine system
    Tongbing Qi, Dongqing Jing, Kexin Zhang, Junfeng Shi, Hongyan Qiu, Chengxia Kan, Fang Han, Chunyan Wu, Xiaodong Sun
    Behavioural Brain Research.2024; 460: 114840.     CrossRef
  • Antioxidant compounds from the Arthrospira platensis protect against Bisphenol A-induced nephrotoxicity in rats
    Khadidja Chouala, Kahina Boudjema, Yahia Khelef, Sadok Nani, Kheireddine Ouali, Mahieddine Boumendjel, Amel Boumendjel, Mahfoud Messarah
    Toxicology and Environmental Health Sciences.2024; 16(1): 75.     CrossRef
  • Associations of urinary non-persistent endocrine disrupting chemical biomarkers with early-to-mid pregnancy plasma sex-steroid and thyroid hormones
    Brad A. Ryva, Diana C. Pacyga, Kaitlyn Y. Anderson, Antonia M. Calafat, Jason Whalen, Max T. Aung, Joseph C. Gardiner, Joseph M. Braun, Susan L. Schantz, Rita S. Strakovsky
    Environment International.2024; 183: 108433.     CrossRef
  • Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid
    Teng Gao, Sijia Luo, Hongguang Li, Zijie Su, Qinghui Wen
    Heliyon.2024; 10(5): e27080.     CrossRef
  • Endocrine-Disrupting Chemical Exposure Induces Adverse Effects on the Population Dynamics of the Indo-Pacific Humpback Dolphin
    Dingyu Luo, Yongwei Guo, Zhiwei Liu, Lang Guo, Hongri Wang, Xikai Tang, Zhuo Xu, Yuping Wu, Xian Sun
    Environmental Science & Technology.2024; 58(21): 9102.     CrossRef
  • The effect of bisphenols on sex and thyroid hormone concentrations in cord blood among newborns
    Francis Manyori Bigambo, Zhaofang Chen, Wentao Yang, Qian Huang, Xu Wang
    Food and Chemical Toxicology.2024; 189: 114750.     CrossRef
  • Thyroid-disrupting effects of bisphenol S in male Wistar albino rats: Histopathological lesions, follicle cell proliferation and apoptosis, and biochemical changes
    Müşerref Bostancı, Burak Kaptaner, Abdulahad Doğan
    Toxicology and Industrial Health.2024; 40(11): 559.     CrossRef
  • Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin
    Yang Shen, Toine F. H. Bovee, Douwe Molenaar, Yoran Weide, Antsje Nolles, Carmen Braucic Mitrovic, Stefan P. J. van Leeuwen, Jochem Louisse, Timo Hamers
    Archives of Toxicology.2024; 98(11): 3797.     CrossRef
  • Do endocrine disrupting compounds impact earthworms? A comprehensive evidence review
    Tiago Azevedo, Mariana Gonçalves, Rita Silva-Reis, Beatriz Medeiros-Fonseca, Marta Roboredo, João R. Sousa, Paula A. Oliveira, Maria de Lurdes Pinto, Francisco Peixoto, Isabel Gaivão, Manuela Matos, Ana M. Coimbra
    Reviews in Environmental Science and Bio/Technology.2024; 23(3): 633.     CrossRef
  • Potential hazards of bisphenol A on the male reproductive system: Induction of programmed cell death in testicular cells
    Kadry M. Sadek, Norhan E. Khalifa, Eman E. Alshial, Sameh A. Abdelnour, Amany A‐R. Mohamed, Ahmed E. Noreldin
    Journal of Biochemical and Molecular Toxicology.2024;[Epub]     CrossRef
  • Electronic Waste Problem in Developing Nations: Mismanagement, Health Implications, and Circular Economy Opportunities
    Annisa Utami Rauf
    JURNAL KESEHATAN LINGKUNGAN .2024; 16(1): 18.     CrossRef
  • Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
    Exposure and Health.2023; 15(1): 53.     CrossRef
  • Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients
    Vincenzo Marotta, Lucia Grumetto, Ilaria Neri, Giacomo Russo, Anna Tortora, Giulia Izzo, Ilaria Panariello, Domenico Rocco, Luciano Pezzullo, Mario Vitale
    Environmental Pollution.2023; 316: 120478.     CrossRef
  • A case-control study of urinary concentrations of bisphenol A, bisphenol F, and bisphenol S and the risk of papillary thyroid cancer
    Lei Zhang, Jiahuai Zhang, Sai Fan, Yuxin Zhong, Jingguang Li, Yunfeng Zhao, Song Ni, Jiaying Liu, Yongning Wu
    Chemosphere.2023; 312: 137162.     CrossRef
  • Endocrine disruptors and endometriosis
    Sudipta Dutta, Sakhila K. Banu, Joe A. Arosh
    Reproductive Toxicology.2023; 115: 56.     CrossRef
  • Bisphenol A alternatives continuously contribute to the endocrine disruption in cetaceans
    Yongwei Guo, Wei Shi, Zhiwei Liu, Xian Sun, Jiaxue Wu, Yuping Wu
    Environment International.2023; 171: 107679.     CrossRef
  • Environmental endocrine disruptors and amphibian immunity: A bridge between the thyroid hormone axis and T cell development
    Connor C. McGuire, Jacques R. Robert
    Developmental & Comparative Immunology.2023; 140: 104617.     CrossRef
  • Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice
    Pieter Vancamp, Lucile Butruille, Anni Herranen, Anita Boelen, Jean-Baptiste Fini, Barbara A. Demeneix, Sylvie Remaud
    Environment International.2023; 172: 107770.     CrossRef
  • A Fast Method for Determination of Seven Bisphenols in Human Breast Milk Samples with the Use of HPLC-FLD
    Szymon Szubartowski, Tomasz Tuzimski
    Molecules.2023; 28(3): 1432.     CrossRef
  • Risk Assessment of Bisphenol A in the Korean General Population
    Myungsil Hwang, Seon-Joo Park, Hae-Jeung Lee
    Applied Sciences.2023; 13(6): 3587.     CrossRef
  • Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
    Ylenia Della Rocca, Enrico Matteo Traini, Francesca Diomede, Luigia Fonticoli, Oriana Trubiani, Alessia Paganelli, Jacopo Pizzicannella, Guya Diletta Marconi
    Pharmaceutics.2023; 15(3): 908.     CrossRef
  • The associations between concentrations of gestational bisphenol analogues and thyroid related hormones in cord blood: A prospective cohort study
    Jianya Xi, Xiujuan Su, Ziliang Wang, Honglei Ji, Yao Chen, Xiaofang Liu, Maohua Miao, Hong Liang, Wei Yuan
    Ecotoxicology and Environmental Safety.2023; 256: 114838.     CrossRef
  • Zebrafish (Danio rerio) TRβ- and TTR-based electrochemical biosensors: Construction and application for the evaluation of thyroid-disrupting activity of bisphenols
    Yuejiao Li, Zhenzhong Zhang, Jun Wang, Yeqi Shan, Hua Tian, Pengfei Cui, Shaoguo Ru
    Environmental Pollution.2023; 330: 121745.     CrossRef
  • Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review
    Rolf Grossklaus, Klaus-Peter Liesenkötter, Klaus Doubek, Henry Völzke, Roland Gaertner
    Nutrients.2023; 15(10): 2249.     CrossRef
  • Bisphenol A Analogues Inhibit Human and Rat 11β-Hydroxysteroid Dehydrogenase 1 Depending on Its Lipophilicity
    Hong Wang, Jianmin Sang, Zhongyao Ji, Yang Yu, Shaowei Wang, Yang Zhu, Huitao Li, Yiyan Wang, Qiqi Zhu, Renshan Ge
    Molecules.2023; 28(13): 4894.     CrossRef
  • Bisphenol A-Induced Endocrine Dysfunction and its Associated Metabolic Disorders
    Meenu Maniradhan, Latchoumycandane Calivarathan
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2023; 23(4): 515.     CrossRef
  • Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review
    Leila Peivasteh-roudsari, Raziyeh Barzegar-bafrouei, Kurush Aghbolagh Sharifi, Shamimeh Azimisalim, Marziyeh Karami, Solmaz Abedinzadeh, Shabnam Asadinezhad, Behrouz Tajdar-oranj, Vahideh Mahdavi, Adel Mirza Alizadeh, Parisa Sadighara, Margherita Ferrante
    Heliyon.2023; 9(7): e18140.     CrossRef
  • Bisphenol analogues induce thyroid dysfunction via the disruption of the thyroid hormone synthesis pathway
    Chao Hu, Yeqing Xu, Mingmin Wang, Shixuan Cui, Hangjun Zhang, Liping Lu
    Science of The Total Environment.2023; 900: 165711.     CrossRef
  • Distinct inhibitory strength of bisphenol A analogues on human and rat 11β-hydroxysteroid dehydrogenase 1: 3D quantitative structure-activity relationship and in silico molecular docking analysis
    Han Lu, Shaowei Wang, Jingyi Zheng, Yang Zhu, Yiyan Wang, Huitao Li, Ren-shan Ge
    Ecotoxicology and Environmental Safety.2023; 267: 115638.     CrossRef
  • Systematic Review on Safety of Bisphenol A: from Invention to the Present
    Hananeh KORDBACHEH, Bensu KARAHALİL
    Eurasian Journal of Toxicology.2023; 5(2): 37.     CrossRef
  • Bisphenol S dysregulates thyroid hormone homeostasis; Testicular survival, redox and metabolic status: Ameliorative actions of melatonin
    Aishwarya Sahu, Rakesh Verma
    Environmental Toxicology and Pharmacology.2023; 104: 104300.     CrossRef
  • Structural binding perspectives of common plasticizers and a flame retardant, BDE‐153, against thyroxine‐binding globulin: potential for endocrine disruption
    Ishfaq Ahmad Sheikh, Mohd Amin Beg
    Journal of Applied Toxicology.2022; 42(5): 841.     CrossRef
  • New insights on the effects of endocrine-disrupting chemicals on children
    Barbara Predieri, Crésio A.D. Alves, Lorenzo Iughetti
    Jornal de Pediatria.2022; 98: S73.     CrossRef
  • Toxic Metal Concentrations in Drinking Water and Possible Effect on Sex Hormones among Men in Sabongida-Ora, Edo State, Nigeria
    Osaro Ogie Enehizena, Mathias A. Emokpae
    Medicines.2022; 9(1): 4.     CrossRef
  • Bisphenols impact hormone levels in animals: A meta-analysis
    Alexander M. Rubin, Frank Seebacher
    Science of The Total Environment.2022; 828: 154533.     CrossRef
  • The effects of prenatal and lactational bisphenol A and/or di(2-ethylhexyl) phthalate exposure on female reproductive system
    Gizem Ozkemahli, Aylin Balci Ozyurt, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
    Toxicology Mechanisms and Methods.2022; 32(8): 597.     CrossRef
  • Associations of Phthalate Metabolites and Bisphenol A Levels with Obesity in Children: The Korean National Environmental Health Survey (KoNEHS) 2015 to 2017
    Moon Young Seo, Shinje Moon, Shin-Hye Kim, Mi Jung Park
    Endocrinology and Metabolism.2022; 37(2): 249.     CrossRef
  • Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China
    Huishen Huang, Jun Liang, Peng Tang, Chuanxiang Yu, Haoran Fan, Qian Liao, Jinghua Long, Dongxiang Pan, Xiaoyun Zeng, Shun Liu, Dongping Huang, Xiaoqiang Qiu
    Environmental Science and Pollution Research.2022; 29(58): 87170.     CrossRef
  • Bisphenols A, F, S and AF trigger apoptosis and/or endoplasmic reticulum stress in human endometrial stromal cells
    Ricardo Ferreira, Cristina Amaral, Georgina Correia-da-Silva, Marta Almada, Margarida Borges, Sara Cristina Cunha, José Oliveira Fernandes, Natércia Teixeira
    Toxicology.2022; 478: 153282.     CrossRef
  • Association between phenols and thyroid hormones: The role of iodothyronine deiodinase genes
    Blanca Sarzo, Reem Abumallouh, Natalia Marín, Sabrina Llop, Andrea Beneito, Inmaculada Lopez-Flores, Nerea Ferrero, Amrit Kaur Sakhi, Ferran Ballester, Maria-Jose Lopez-Espinosa
    Environmental Pollution.2022; 311: 119926.     CrossRef
  • Bisphenol A as a Factor in the Mosaic of Autoimmunity
    Zora Lazurova, Ivica Lazurova, Yehuda Shoenfeld
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2022; 22(7): 728.     CrossRef
  • Zebrafish as an emerging tool for drug discovery and development for thyroid diseases
    Poonam Yadav, Lopmudra P. Sarode, Ravinder Reddy Gaddam, Puneet Kumar, Jasvinder Singh Bhatti, Amit Khurana, Umashanker Navik
    Fish & Shellfish Immunology.2022; 130: 53.     CrossRef
  • Review of in silico studies dedicated to the nuclear receptor family: Therapeutic prospects and toxicological concerns
    Asma Sellami, Manon Réau, Matthieu Montes, Nathalie Lagarde
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Use of high-resolution metabolomics to assess the biological perturbations associated with maternal exposure to Bisphenol A and Bisphenol F among pregnant African American women
    Rachel Tchen, Youran Tan, Dana Boyd Barr, P. Barry Ryan, ViLinh Tran, Zhenjiang Li, Yi-Juan Hu, Alicia K. Smith, Dean P. Jones, Anne L. Dunlop, Donghai Liang
    Environment International.2022; 169: 107530.     CrossRef
  • Effects of bisphenol A on pancreas and thyroid gland of young and adult female Sprague Dawlеy rats
    D. Yahia, H. Hamdy, D. A. Salem, S. Afifi
    BULGARIAN JOURNAL OF VETERINARY MEDICINE.2022; 25(3): 426.     CrossRef
  • Bisphenol A analogues induce a feed-forward estrogenic response in zebrafish
    Silvia Karim, Ruixin Hao, Caroline Pinto, Jan-Åke Gustafsson, Marina Grimaldi, Patrick Balaguer, Maria Bondesson
    Toxicology and Applied Pharmacology.2022; 455: 116263.     CrossRef
  • Mediterranean Diet and Thyroid: An Interesting Alliance
    Giuseppe Bellastella, Lorenzo Scappaticcio, Francesco Caiazzo, Maria Tomasuolo, Raffaela Carotenuto, Mariangela Caputo, Stefania Arena, Paola Caruso, Maria Ida Maiorino, Katherine Esposito
    Nutrients.2022; 14(19): 4130.     CrossRef
  • Endocrine Disrupting Chemicals’ Effects in Children: What We Know and What We Need to Learn?
    Barbara Predieri, Lorenzo Iughetti, Sergio Bernasconi, Maria Elisabeth Street
    International Journal of Molecular Sciences.2022; 23(19): 11899.     CrossRef
  • Single and repeated bisphenol A treatment induces ROS, Aβ and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death
    Andrea Flores, Paula Moyano, Emma Sola, José Manuel García, Jimena García, María José Anadon, María Teresa Frejo, Maria Victoria Naval, Maria de la Cabeza Fernadez, Javier del Pino
    Food and Chemical Toxicology.2022; 170: 113500.     CrossRef
  • Application of High-Performance Liquid Chromatography Combined with Fluorescence Detector and Dispersive Liquid–Liquid Microextraction to Quantification of Selected Bisphenols in Human Amniotic Fluid Samples
    Szymon Szubartowski, Tomasz Tuzimski
    International Journal of Environmental Research and Public Health.2022; 20(1): 297.     CrossRef
  • The Association between Phenols and Thyroid Hormones: The Role of Iodothyronine Deiodinase Genes
    Blanca Sarzo, Reem Abumallouh, Natalia Marin, Sabrina Llop, Andrea Beneito, Inmaculada Lopez-Flores, Nerea Ferrero, Amrit Kaur Sakhi, ferran ballester, Maria-Jose Lopez-Espinosa
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Bisphenols emerging in Norwegian and Czech aquatic environments show transthyretin binding potency and other less-studied endocrine-disrupting activities
    Pavel Šauer, Helena Švecová, Kateřina Grabicová, Farah Gönül Aydın, Tomáš Mackuľak, Vít Kodeš, Line Diana Blytt, Liv Bruås Henninge, Roman Grabic, Hana Kocour Kroupová
    Science of The Total Environment.2021; 751: 141801.     CrossRef
  • Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview
    Mathilda Alsen, Catherine Sinclair, Peter Cooke, Kimia Ziadkhanpour, Eric Genden, Maaike van Gerwen
    Toxics.2021; 9(1): 14.     CrossRef
  • Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review
    Kok-Lun Pang, Johanna Nathania Lumintang, Kok-Yong Chin
    Nutrients.2021; 13(2): 529.     CrossRef
  • Human biomonitoring of bisphenol A along pregnancy: An exposure reconstruction of the EXHES-Spain cohort
    María Ángeles Martínez, Neus González, Anna Martí, Montse Marquès, Joaquim Rovira, Vikas Kumar, Martí Nadal
    Environmental Research.2021; 196: 110941.     CrossRef
  • Dietary Intake of Endocrine Disrupting Substances Presents in Environment and Their Impact on Thyroid Function
    Aneta Sokal, Sara Jarmakiewicz-Czaja, Jacek Tabarkiewicz, Rafał Filip
    Nutrients.2021; 13(3): 867.     CrossRef
  • BPA and BPA alternatives BPS, BPAF, and TMBPF, induce cytotoxicity and apoptosis in rat and human stem cells
    Kristen G. Harnett, Ashley Chin, Sonya M. Schuh
    Ecotoxicology and Environmental Safety.2021; 216: 112210.     CrossRef
  • Bisphenols and the Development of Type 2 Diabetes: The Role of the Skeletal Muscle and Adipose Tissue
    Fozia Ahmed, Maria Pereira, Céline Aguer
    Environments.2021; 8(4): 35.     CrossRef
  • Involvement of Thyroid Hormones in Brain Development and Cancer
    Gabriella Schiera, Carlo Maria Di Liegro, Italia Di Liegro
    Cancers.2021; 13(11): 2693.     CrossRef
  • Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels
    Mirjana Babić Leko, Ivana Gunjača, Nikolina Pleić, Tatijana Zemunik
    International Journal of Molecular Sciences.2021; 22(12): 6521.     CrossRef
  • Thyroid health in big city realities
    Liudmila L. Kamynina
    City Healthcare.2021; 2(2): 84.     CrossRef
  • Adverse effects of bisphenol B exposure on the thyroid and nervous system in early life stages of zebrafish
    Qian Yang, Zhenzhu Zhu, Qin Liu, Lihong Chen
    Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology.2021; 250: 109167.     CrossRef
  • Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development
    Kristen G. Harnett, Lucy G. Moore, Ashley Chin, Isabel C. Cohen, Rylee R. Lautrup, Sonya M. Schuh
    Current Research in Toxicology.2021; 2: 399.     CrossRef
  • A Review on the Occurrence, Exposure, and Health Impacts of Bisphenol A
    Prince Sharma, Khushboo Sharma, Geetika Sharma, Pooja Chadha
    Toxicology International.2021; : 337.     CrossRef
  • Thyroxine-binding globulin, peripheral deiodinase activity, and thyroid autoantibody status in association of phthalates and phenolic compounds with thyroid hormones in adult population
    Sohyeon Choi, Min Joo Kim, Young Joo Park, Sunmi Kim, Kyungho Choi, Gi Jeong Cheon, Yoon Hee Cho, Hye Li Jeon, Jiyoung Yoo, Jeongim Park
    Environment International.2020; 140: 105783.     CrossRef
  • Clinical expression of endocrine disruptors in children
    Lorenzo Iughetti, Laura Lucaccioni, Maria E. Street, Sergio Bernasconi
    Current Opinion in Pediatrics.2020; 32(4): 554.     CrossRef
  • Combined effects of di (2-ethylhexyl) phthalate and bisphenol A on thyroid hormone homeostasis in adolescent female rats
    Xuan Zhang, Yuejiao Zhao, Cheng Cheng, Liuli Li, Mingyang Xiao, Guopei Zhang, Xiaobo Lu
    Environmental Science and Pollution Research.2020; 27(32): 40882.     CrossRef
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    Birth Defects Research.2020; 112(17): 1341.     CrossRef
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    Reproductive Toxicology.2020; 98: 117.     CrossRef
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    ACS Sustainable Chemistry & Engineering.2020; 8(51): 18824.     CrossRef
Close layer
Clinical Study
Postoperative Thyroid-Stimulating Hormone Levels Did Not Affect Recurrence after Thyroid Lobectomy in Patients with Papillary Thyroid Cancer
Myung-Chul Lee, Min Joo Kim, Hoon Sung Choi, Sun Wook Cho, Guk Haeng Lee, Young Joo Park, Do Joon Park
Endocrinol Metab. 2019;34(2):150-157.   Published online May 10, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.2.150
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Thyroid-stimulating hormone (TSH) suppression is recommended for patients who undergo thyroidectomy for differentiated thyroid cancer (DTC). However, the impact of TSH suppression on clinical outcomes in low-risk DTC remains uncertain. Therefore, we investigated the effects of postoperative TSH levels on recurrence in patients with low-risk DTC after thyroid lobectomy.

Methods

Patients (n=1,528) who underwent thyroid lobectomy for papillary thyroid carcinoma between 2000 and 2012 were included in this study. According to the mean and dominant TSH values during the entire follow-up period or 5 years, patients were divided into four groups (<0.5, 0.5 to 1.9, 2.0 to 4.4, and ≥4.5 mIU/L). Recurrence-free survival was compared among the groups.

Results

During the 5.6 years of follow-up, 21 patients (1.4%) experienced recurrence. Mean TSH levels were within the recommended low-normal range (0.5 to 1.9 mIU/L) during the total follow-up period or 5 years in 38.1% or 36.0% of patients. The mean and dominant TSH values did not affect recurrence-free survival. Adjustment for other risk factors did not alter the results.

Conclusion

Serum TSH levels did not affect short-term recurrence in patients with low-risk DTC after thyroid lobectomy. TSH suppression should be conducted more selectively.

Citations

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  • Dynamic risk assessment in patients with differentiated thyroid cancer
    Erika Abelleira, Fernando Jerkovich
    Reviews in Endocrine and Metabolic Disorders.2024; 25(1): 79.     CrossRef
  • Stimulating thyroglobulin to TSH ratio predict long-term efficacy of 131I therapy in patients with differentiated thyroid cancer after total thyroidectomy: a retrospective study
    Xue Yin, Chao Lu, Danyang Sun, Yanhui Ji, Yan Wang, Hongyuan Zheng, Ziyu Ma, Qiang Jia, Jian Tan, Wei Zheng
    Endocrine.2024; 84(3): 1064.     CrossRef
  • Effect of thyroid-stimulating hormone suppression on quality of life in thyroid lobectomy patients: interim analysis of a multicenter, randomized controlled trial in low- to intermediate-risk thyroid cancer patients (MASTER study)
    Ja Kyung Lee, Eu Jeong Ku, Su-jin Kim, Woochul Kim, Jae Won Cho, Kyong Yeun Jung, Hyeong Won Yu, Yea Eun Kang, Mijin Kim, Hee Kyung Kim, Junsun Ryu, June Young Choi
    Annals of Surgical Treatment and Research.2024; 106(1): 19.     CrossRef
  • Impact of a mobile health intervention based on multi-theory model of health behavior change on self-management in patients with differentiated thyroid cancer: protocol for a randomized controlled trial
    Yang Jiang, Xiangju Sun, Maomin Jiang, Hewei Min, Jing Wang, Xinghua Fu, Jiale Qi, Zhenjie Yu, Xiaomei Zhu, Yibo Wu
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • Risk of Subsequent Primary Cancers in Thyroid Cancer Survivors according to the Dose of Levothyroxine: A Nationwide Cohort Study
    Min-Su Kim, Jang Won Lee, Min Kyung Hyun, Young Shin Song
    Endocrinology and Metabolism.2024; 39(2): 288.     CrossRef
  • Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part II. Follow-up Surveillance after Initial Treatment 2024
    Mijin Kim, Ji-In Bang, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Young Joo Park, Youngduk Seo, Young Shin Song, So Won Oh, Sang-Woo Lee, Eun Kyung Lee, Ji Ye Lee, Dong-Jun Lim, Ari Chong, Yun Jae Chung, Chae Moon Hong, Min Kyoung Lee, Bo Hyun Kim
    International Journal of Thyroidology.2024; 17(1): 115.     CrossRef
  • An age-and sex-matched postoperative therapy should be required in thyroid papillary carcinoma
    Caigu Yan, Jinjin Sun, Xianghui He, Lanning Jia
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Prognostic Implications of Maintaining the Target Thyroid-Stimulating Hormone Status Based on the 2015 American Thyroid Association Guidelines in Patients with Low-Risk Papillary Thyroid Carcinoma after Lobectomy: A 5-Year Landmark Analysis
    Ye Won Jeon, Young Jin Suh, Seung Taek Lim
    Cancers.2024; 16(19): 3253.     CrossRef
  • Outcomes and Trends of Treatments in High‐Risk Differentiated Thyroid Cancer
    Arash Abiri, Khodayar Goshtasbi, Sina J. Torabi, Edward C. Kuan, William B. Armstrong, Tjoson Tjoa, Yarah M. Haidar
    Otolaryngology–Head and Neck Surgery.2023; 168(4): 745.     CrossRef
  • Outcomes of Patients with an Intermediate‐Risk Group According to the Japanese Risk Classification of Papillary Thyroid Carcinoma
    Kiyomi Horiuchi, Mikiko Fujimoto, Kamio Hidenori, Yusaku Yoshida, Eiichiro Noguchi, Yoko Omi, Takahiro Okamoto
    World Journal of Surgery.2023; 47(10): 2464.     CrossRef
  • Effects of Isthmus Preservation on Postoperative Hypothyroidism after Lobectomy
    Yeong San Jeon, Wan Wook Kim
    International Journal of Thyroidology.2023; 16(1): 120.     CrossRef
  • Physical activity and reduced risk of fracture in thyroid cancer patients after thyroidectomy — a nationwide cohort study
    Jinyoung Kim, Kyungdo Han, Jin-Hyung Jung, Jeonghoon Ha, Chaiho Jeong, Jun-Young Heu, Se-Won Lee, Jeongmin Lee, Yejee Lim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Ki-Hyun Baek
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Association between thyroid stimulating hormone levels and papillary thyroid cancer risk: A meta-analysis
    Bin Xu, Shu-Yan Gu, Ning-Ming Zhou, Jun-Jie Jiang
    Open Life Sciences.2023;[Epub]     CrossRef
  • The Relationship between Thyrotropin Serum Concentrations and Thyroid Carcinoma
    Xueqi Zhang, Lijun Tian, Di Teng, Weiping Teng
    Cancers.2023; 15(20): 5017.     CrossRef
  • Differentiated thyroid cancer: a focus on post-operative thyroid hormone replacement and thyrotropin suppression therapy
    Benjamin J. Gigliotti, Sina Jasim
    Endocrine.2023; 83(2): 251.     CrossRef
  • Optimal Serum Thyrotropin Level for Patients with Papillary Thyroid Carcinoma After Lobectomy
    Siyuan Xu, Ying Huang, Hui Huang, Xiaohang Zhang, Jiaxin Qian, Xiaolei Wang, Zhengang Xu, Shaoyan Liu, Jie Liu
    Thyroid.2022; 32(2): 138.     CrossRef
  • Optimal Thyrotropin Following Lobectomy for Papillary Thyroid Cancer: Does It Exist?
    Lindsay Bischoff, Megan R. Haymart
    Thyroid.2022; 32(2): 117.     CrossRef
  • Evaluation of ITGA3 as a Biomarker of Progression and Recurrence in Papillary Thyroid Carcinoma
    Guoliang Zhang, Bing Li, Yuanmei Lin
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • The Question of an Optimal TSH Goal After Lobectomy for Papillary Thyroid Cancer
    Bernadette Biondi
    Clinical Thyroidology.2022; 34(2): 67.     CrossRef
  • Is Maintaining Thyroid-Stimulating Hormone Effective in Patients Undergoing Thyroid Lobectomy for Low-Risk Differentiated Thyroid Cancer? A Systematic Review and Meta-Analysis
    Ho-Ryun Won, Eonju Jeon, Jae Won Chang, Yea Eun Kang, Kunho Song, Sun Wook Kim, Dong Mee Lim, Tae Kwun Ha, Ki-Wook Chung, Hyo-Jeong Kim, Young Joo Park, Bon Seok Koo
    Cancers.2022; 14(6): 1470.     CrossRef
  • Research Review of Thermal Ablation in the Treatment of Papillary Thyroid Carcinoma
    Di Ou, Chen Chen, Tian Jiang, Dong Xu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • CACA guidelines for holistic integrative management of thyroid cancer
    Minghua Ge, Ming Gao, Ruochuan Cheng, Xiaohong Chen, Haixia Guan, Yansong Lin, Shaoyan Liu, Yu Wang, Chuanming Zheng, Xiangqian Zheng
    Holistic Integrative Oncology.2022;[Epub]     CrossRef
  • Value of thyroglobulin post hemithyroidectomy for cancer: a literature review
    Saam S. Tourani, Bill Fleming, Justin Gundara
    ANZ Journal of Surgery.2021; 91(4): 724.     CrossRef
  • Pros and cons of hemi‐thyroidectomy for low‐risk differentiated thyroid cancer
    Alexander J. Papachristos, Anthony Glover, Mark S. Sywak, Stan B. Sidhu
    ANZ Journal of Surgery.2021; 91(9): 1704.     CrossRef
  • Management and follow-up of differentiated thyroid cancer not submitted to radioiodine treatment: a systematic review
    Carla GAMBALE, Rossella ELISEI, Antonio MATRONE
    Minerva Endocrinologica.2021;[Epub]     CrossRef
  • The Recovery of Thyroid Function in Low-Risk Papillary Thyroid Cancer After Lobectomy: A 3-Year Follow-Up Study
    Yi Dou, Yingji Chen, Daixing Hu, Xinliang Su
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Controversy: For or against thyroid lobectomy in > 1 cm differentiated thyroid cancer?
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    Annales d'Endocrinologie.2021; 82(2): 78.     CrossRef
  • Thyroid cancer, recent advances in diagnosis and therapy
    Fadi Nabhan, Priya H. Dedhia, Matthew D. Ringel
    International Journal of Cancer.2021; 149(5): 984.     CrossRef
  • A Multicenter, Randomized, Controlled Trial for Assessing the Usefulness of Suppressing Thyroid Stimulating Hormone Target Levels after Thyroid Lobectomy in Low to Intermediate Risk Thyroid Cancer Patients (MASTER): A Study Protocol
    Eun Kyung Lee, Yea Eun Kang, Young Joo Park, Bon Seok Koo, Ki-Wook Chung, Eu Jeong Ku, Ho-Ryun Won, Won Sang Yoo, Eonju Jeon, Se Hyun Paek, Yong Sang Lee, Dong Mee Lim, Yong Joon Suh, Ha Kyoung Park, Hyo-Jeong Kim, Bo Hyun Kim, Mijin Kim, Sun Wook Kim, Ka
    Endocrinology and Metabolism.2021; 36(3): 574.     CrossRef
  • Long-term follow-up results of PTMC treated by ultrasound-guided radiofrequency ablation: a retrospective study
    Yalin Zhu, Ying Che, Shuhang Gao, Shuangsong Ren, Mengying Tong, Lina Wang, Fang Yang
    International Journal of Hyperthermia.2021; 38(1): 1225.     CrossRef
  • Thyroid Hormone Supplementation Therapy for Differentiated Thyroid Cancer After Lobectomy: 5 Years of Follow-Up
    Soo Young Kim, Hee Jun Kim, Seok-Mo Kim, Hojin Chang, Yong Sang Lee, Hang-Seok Chang, Cheong Soo Park
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Thyroid Lobectomy for Low to Intermediate Risk Differentiated Thyroid Cancer
    Dana M. Hartl, Joanne Guerlain, Ingrid Breuskin, Julien Hadoux, Eric Baudin, Abir Al Ghuzlan, Marie Terroir-Cassou-Mounat, Livia Lamartina, Sophie Leboulleux
    Cancers.2020; 12(11): 3282.     CrossRef
  • Annual Neck Ultrasonography Surveillance between 3 to 12 Years after Thyroid Lobectomy for Papillary Thyroid Microcarcinoma
    Jin Gu Kang, Jung Eun Choi, Soo Jung Lee, Su Hwan Kang
    International Journal of Thyroidology.2020; 13(2): 142.     CrossRef
  • Thyroid hormone therapy in differentiated thyroid cancer
    Giorgio Grani, Valeria Ramundo, Antonella Verrienti, Marialuisa Sponziello, Cosimo Durante
    Endocrine.2019; 66(1): 43.     CrossRef
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Miscellaneous
Corrigendum: Author's Name Correction. Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro)
Jae Hoon Moon, Ji-hoon Kim, Eun Kyung Lee, Kyu Eun Lee, Sung Hye Kong, Yeo Koon Kim, Woo-Jin Jeong, Chang Yoon Lee, Roh-Eul Yoo, Yul Hwangbo, Young Shin Song, Min Joo Kim, Sun Wook Cho, Su-jin Kim, Eun-Jae Chung, June Young Choi, Chang Hwan Ryu, You Jin Lee, Jeong Hun Hah, Yuh-Seog Jung, Junsun Ryu, Yunji Hwang, Sue K. Park, Ho Kyung Sung, Ka Hee Yi, Do Joon Park, Young Joo Park
Endocrinol Metab. 2018;33(3):427.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.427
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PDFPubReader   ePub   

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  • Invasiveness and Metastatic Aggressiveness in Small Differentiated Thyroid Cancers: Demography of Small Papillary Thyroid Carcinomas in the Swedish Population
    Haytham Bayadsi, Martin Bergman, Malin Sund, Joakim Hennings
    World Journal of Surgery.2020; 44(2): 461.     CrossRef
  • Clinical and pathologic predictors of lymph node metastasis in papillary thyroid microcarcinomas
    Ling Zhao, Xiaoya Sun, Yukun Luo, Fulin Wang, Zhaohui Lyu
    Annals of Diagnostic Pathology.2020; 49: 151647.     CrossRef
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Thyroid
Star-Shaped Intense Uptake of 131I on Whole Body Scans Can Reflect Good Therapeutic Effects of Low-Dose Radioactive Iodine Treatment of 1.1 GBq
Sung Hye Kong, Jung Ah Lim, Young Shin Song, Shinje Moon, Ye An Kim, Min Joo Kim, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
Endocrinol Metab. 2018;33(2):228-235.   Published online May 4, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.2.228
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AbstractAbstract PDFPubReader   ePub   
Background

After initial radioactive iodine (RAI) treatment in differentiated thyroid cancer patients, we sometimes observe a star-shaped region of intense uptake of 131I on whole body scans (WBSs), called a ‘star artifact.’ We evaluated the clinical implications of star artifacts on the success rate of remnant ablation and long-term prognosis.

Methods

Total 636 patients who received 131I dose of 1.1 GBq for the initial RAI therapy and who did not show distant metastasis at the time of diagnosis were retrospectively evaluated. A negative second WBS was used for evaluating the ablation efficacy of the RAI therapy. Among them, 235 patients (36.9%) showed a star artifact on their first WBS.

Results

In patients with first stimulated thyroglobulin (sTg) levels ≤2 ng/mL, patients with star artifacts had a higher rate of negative second WBS compared with those without star artifacts (77.8% vs. 63.9%, P=0.044), and showed significantly higher recurrence-free survival (P=0.043) during the median 8.0 years (range, 1.0 to 10.0) of follow-up. The 5- and 10-year recurrence rates (5YRR, 10YRR) were also significantly lower in patients with star artifacts compared with those without (0% vs. 4.9%, respectively, P=0.006 for 5YRR; 0% vs. 6.4%, respectively, P=0.005 for 10YRR). However, ablation success rate or recurrence-free survival was not different among patients whose first sTg levels >2 ng/mL regardless of star artifacts.

Conclusion

Therefore, star artifacts at initial RAI therapy imply a good ablation efficacy or a favorable long-term prognosis in patients with sTg levels ≤2 ng/mL.

Citations

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  • Prognostic value of star-shaped intense uptake of 131I in thyroid cancer patients
    Liu Xiao, Wen Jie Zhang, Yue Qi Wang, Lin Li
    Revista Española de Medicina Nuclear e Imagen Molecular (English Edition).2021; 40(1): 30.     CrossRef
  • Valores pronósticos de la captación en estrella de 131I en pacientes con cáncer diferenciado de tiroides
    L. Xiao, W.J. Zhang, Y.Q. Wang, L. Li
    Revista Española de Medicina Nuclear e Imagen Molecular.2021; 40(1): 30.     CrossRef
  • Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
    Yusuke Iizuka, Tomohiro Katagiri, Minoru Inoue, Kiyonao Nakamura, Takashi Mizowaki
    Scientific Reports.2021;[Epub]     CrossRef
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Thyroid
Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro)
Jae Hoon Moon, Ji-hoon Kim, Eun Kyung Lee, Kyu Eun Lee, Sung Hye Kong, Yeo Koon Kim, Woo-jin Jung, Chang Yoon Lee, Roh-Eul Yoo, Yul Hwangbo, Young Shin Song, Min Joo Kim, Sun Wook Cho, Su-jin Kim, Eun Jae Jung, June Young Choi, Chang Hwan Ryu, You Jin Lee, Jeong Hun Hah, Yuh-Seog Jung, Junsun Ryu, Yunji Hwang, Sue K. Park, Ho Kyung Sung, Ka Hee Yi, Do Joon Park, Young Joo Park
Endocrinol Metab. 2018;33(2):278-286.   Published online June 21, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.2.278
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AbstractAbstract PDFPubReader   ePub   
Background

The ongoing Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro) aims to observe the natural course of papillary thyroid microcarcinoma (PTMC), develop a protocol for active surveillance (AS), and compare the long-term prognosis, quality of life, and medical costs between the AS and immediate surgery groups.

Methods

This multicenter prospective cohort study of PTMC started in June 2016. The inclusion criteria were suspicious of malignancy or malignancy based on fine needle aspiration or core needle biopsy, age of ≥18 years, and a maximum diameter of ≤1 cm. If there was no major organ involvement, no lymph node/distant metastasis, and no variants with poor prognosis, the patients were explained of the pros and cons of immediate surgery and AS before selecting AS or immediate surgery. Follow-up visits (physical examination, ultrasonography, thyroid function, and questionnaires) are scheduled every 6 months during the first 2 years, and then every 1 year thereafter. Progression was defined as a maximum diameter increase of ≥3, ≥2 mm in two dimensions, suspected organ involvement, or lymph node/distant metastasis.

Results

Among 439 enrolled patients, 290 patients (66.1%) chose AS and 149 patients (33.9%) chose immediate surgery. The median follow-up was 6.7 months (range, 0.2 to 11.9). The immediate surgery group had a larger maximum tumor diameter, compared to the AS group (7.1±1.9 mm vs. 6.6±2.0 mm, respectively; P=0.014).

Conclusion

The results will be useful for developing an appropriate PTMC treatment policy based on its natural course and risk factors for progression.

Citations

Citations to this article as recorded by  
  • MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer
    Madelon J. H. Metman, Pascal K. C. Jonker, Luc H. J. Sondorp, Bettien M. van Hemel, Mark S. Sywak, Anthony J. Gill, Liesbeth Jansen, Paul J. van Diest, Tessa M. van Ginhoven, Clemens W. G. M. Löwik, Anh H. Nguyen, Dominic J. Robinson, Gooitzen M. van Dam,
    European Journal of Nuclear Medicine and Molecular Imaging.2024; 51(8): 2384.     CrossRef
  • 2023 Update of the Korean Thyroid Association Guidelines for the Management of Thyroid Nodules
    Eun Kyung Lee, Young Joo Park
    Clinical Thyroidology®.2024; 36(4): 153.     CrossRef
  • Ultrasound Imaging in Active Surveillance of Small, Low-Risk Papillary Thyroid Cancer
    Sangeet Ghai, David P Goldstein, Anna M Sawka
    Korean Journal of Radiology.2024; 25(8): 749.     CrossRef
  • Psychological adjustment to initial treatment for low‐risk thyroid cancer: Preliminary study
    Gabriella T. Seo, Mark L. Urken, Lauren E. Wein, Michael P. Saturno, Danielle Kapustin, Monica H. Xing, Lauren E. Yue, Eric M. Dowling, Tracey A. Revenson, Katherine J. Roberts, Robert Michael Tuttle
    Head & Neck.2023; 45(2): 439.     CrossRef
  • Response to Letter to the Editor on Surgical Outcomes in Patients With Low-Risk Papillary Thyroid Microcarcinoma From MAeSTro Study: Immediate Operation Versus Delayed Operation Following Active Surveillance: A Multicenter Prospective Cohort Study
    Hyeonuk Hwang, June Young Choi, Jae Hoon Moon, Eun Kyung Lee, Young Joo Park, Su-jin Kim, Yuh-Seog Jung
    Annals of Surgery Open.2023; 4(3): e311.     CrossRef
  • Lower Thyroid Cancer Mortality in Patients Detected by Screening: A Meta-Analysis
    Shinje Moon, Young Shin Song, Kyong Yeun Jung, Eun Kyung Lee, Young Joo Park
    Endocrinology and Metabolism.2023; 38(1): 93.     CrossRef
  • To Screen or Not to Screen?
    Do Joon Park
    Endocrinology and Metabolism.2023; 38(1): 69.     CrossRef
  • Surgical Outcomes in Patients With Low-risk Papillary Thyroid Microcarcinoma From MAeSTro Study
    Hyeonuk Hwang, June Young Choi, Hyeong Won Yu, Jae Hoon Moon, Ji-hoon Kim, Eun Kyung Lee, Yeo Koon Kim, Chang Yoon Lee, Sun Wook Cho, Eun-Jae Chung, Chang Hwan Ryu, Junsun Ryu, Ka Hee Yi, Do Joon Park, Kyu Eun Lee, Young Joo Park, Su-jin Kim, Yuh-Seog Jun
    Annals of Surgery.2023; 278(5): e1087.     CrossRef
  • US Predictors of Papillary Thyroid Microcarcinoma Progression at Active Surveillance
    Ji Ye Lee, Ji-hoon Kim, Yeo Koon Kim, Chang Yoon Lee, Eun Kyung Lee, Jae Hoon Moon, Hoon Sung Choi, Hwangbo Yul, Sun Wook Cho, Su-jin Kim, Kyu Eun Lee, Do Joon Park, Young Joo Park
    Radiology.2023;[Epub]     CrossRef
  • Active Surveillance of Thyroid Microcarcinomas: a Critical View
    Claudio R. Cernea, Leandro Luongo Matos, Cecília Eugênio, Giovanna Mattos Ferreira, Yasmin Sa Cerqueira, Ana Kober N. Leite, Felipe A. B. Vanderlei, Dorival de Carlucci, Renato N. Gotoda, Flávio C. Hojaij, Vergilius J. F. Araújo-Filho
    Current Oncology Reports.2022; 24(1): 69.     CrossRef
  • Active Surveillance Versus Thyroid Surgery for Differentiated Thyroid Cancer: A Systematic Review
    Roger Chou, Tracy Dana, Megan Haymart, Angela M. Leung, Ralph P. Tufano, Julie Ann Sosa, Matthew D. Ringel
    Thyroid.2022; 32(4): 351.     CrossRef
  • A Review of Active Surveillance of Papillary Thyroid Microcarcinoma
    Cho Rok Lee
    Journal of Endocrine Surgery.2022; 22(1): 1.     CrossRef
  • Active Surveillance Versus Immediate Surgery for Low-Risk Papillary Thyroid Microcarcinoma Patients in South Korea: A Cost-Minimization Analysis from the MAeSTro Study
    Kyungsik Kim, June Young Choi, Su-jin Kim, Eun Kyung Lee, Young Ki Lee, Jun Sun Ryu, Kyu Eun Lee, Jae Hoon Moon, Young Joo Park, Sun Wook Cho, Sue K. Park
    Thyroid.2022; 32(6): 648.     CrossRef
  • A cross-sectional survey of patient treatment choice in a multicenter prospective cohort study on active surveillance of papillary thyroid microcarcinoma (MAeSTro)
    Yul Hwangbo, June Young Choi, Eun Kyung Lee, Chang Hwan Ryu, Sun Wook Cho, Eun Jae Chung, Jeong Hun Hah, Woo-Jin Jeong, Sue K. Park, Yuh-Seog Jung, Ji-hoon Kim, Min Joo Kim, Su-jin Kim, Yeo Koon Kim, Chang Yoon Lee, Ji Ye Lee, You Jin Lee, Hyeong Won Yu,
    Thyroid.2022;[Epub]     CrossRef
  • Progression of Low-Risk Papillary Thyroid Microcarcinoma During Active Surveillance: Interim Analysis of a Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma in Korea
    Eun Kyung Lee, Jae Hoon Moon, Yul Hwangbo, Chang Hwan Ryu, Sun Wook Cho, June Young Choi, Eun-Jae Chung, Woo-Jin Jeong, Yuh-Seog Jung, Junsun Ryu, Su-jin Kim, Min Joo Kim, Yeo Koon Kim, Chang Yoon Lee, Ji Ye Lee, Hyeong Won Yu, Jeong Hun Hah, Kyu Eun Lee,
    Thyroid.2022; 32(11): 1328.     CrossRef
  • Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma
    Iwao Sugitani, Yasuhiro Ito, Dai Takeuchi, Hirotaka Nakayama, Chie Masaki, Hisakazu Shindo, Masanori Teshima, Kazuhiko Horiguchi, Yusaku Yoshida, Toshiharu Kanai, Mitsuyoshi Hirokawa, Kiyomi Y. Hames, Isao Tabei, Akira Miyauchi
    Thyroid.2021; 31(2): 183.     CrossRef
  • Effect of Initial Treatment Choice on 2-year Quality of Life in Patients with Low-risk Papillary Thyroid Microcarcinoma
    Jae Hoon Moon, Chang Hwan Ryu, Sun Wook Cho, June Young Choi, Eun-Jae Chung, Jeong Hun Hah, Yul Hwangbo, Woo-Jin Jeong, Yuh-Seog Jung, Ji-hoon Kim, Min Joo Kim, Su-jin Kim, Yeo Koon Kim, Chang Yoon Lee, Eun Kyung Lee, Ji Ye Lee, Kyu Eun Lee, You Jin Lee,
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(3): 724.     CrossRef
  • Adoption of Active Surveillance for Very Low-Risk Differentiated Thyroid Cancer in the United States: A National Survey
    Susan C Pitt, Nan Yang, Megan C Saucke, Nicholas Marka, Bret Hanlon, Kristin L Long, Alexandria D McDow, J P Brito, Benjamin R Roman
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(4): 1728.     CrossRef
  • Protocol for a Korean Multicenter Prospective Cohort Study of Active Surveillance or Surgery (KoMPASS) in Papillary Thyroid Microcarcinoma
    Min Ji Jeon, Yea Eun Kang, Jae Hoon Moon, Dong Jun Lim, Chang Yoon Lee, Yong Sang Lee, Sun Wook Kim, Min-Hee Kim, Bo Hyun Kim, Ho-Cheol Kang, Minho Shong, Sun Wook Cho, Won Bae Kim
    Endocrinology and Metabolism.2021; 36(2): 359.     CrossRef
  • Multifocality and Progression of Papillary Thyroid Microcarcinoma During Active Surveillance
    Ryuta Nagaoka, Aya Ebina, Kazuhisa Toda, Tomoo Jikuzono, Marie Saitou, Masaomi Sen, Hiroko Kazusaka, Mami Matsui, Keiko Yamada, Hiroki Mitani, Iwao Sugitani
    World Journal of Surgery.2021; 45(9): 2769.     CrossRef
  • Active Surveillance as an Effective Management Option for Low-Risk Papillary Thyroid Microcarcinoma
    Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Endocrinology and Metabolism.2021; 36(4): 717.     CrossRef
  • The Concept of Economic Evaluation and Its Application in Thyroid Cancer Research
    Kyungsik Kim, Mijin Kim, Woojin Lim, Bo Hyun Kim, Sue K. Park
    Endocrinology and Metabolism.2021; 36(4): 725.     CrossRef
  • Genomic and Transcriptomic Characteristics According to Size of Papillary Thyroid Microcarcinoma
    Young Shin Song, Byung-Hee Kang, Seungbok Lee, Seong-Keun Yoo, Young Sik Choi, Jungsun Park, Dong Yoon Park, Kyu Eun Lee, Jeong-Sun Seo, Young Joo Park
    Cancers.2020; 12(5): 1345.     CrossRef
  • Experience with Active Surveillance of Thyroid Low-Risk Carcinoma in a Developing Country
    Alvaro Sanabria
    Thyroid.2020; 30(7): 985.     CrossRef
  • Association of Patient Age With Progression of Low-risk Papillary Thyroid Carcinoma Under Active Surveillance
    Alexandra Koshkina, Rouhi Fazelzad, Iwao Sugitani, Akira Miyauchi, Lehana Thabane, David P. Goldstein, Sangeet Ghai, Anna M. Sawka
    JAMA Otolaryngology–Head & Neck Surgery.2020; 146(6): 552.     CrossRef
  • Active surveillance in low risk papillary thyroid carcinoma
    Fabian Pitoia, Anabella Smulever
    World Journal of Clinical Oncology.2020; 11(6): 320.     CrossRef
  • Early Diagnosis of Low-Risk Papillary Thyroid Cancer Results Rather in Overtreatment Than a Better Survival
    Jolanta Krajewska, Aleksandra Kukulska, Malgorzata Oczko-Wojciechowska, Agnieszka Kotecka-Blicharz, Katarzyna Drosik-Rutowicz, Malgorzata Haras-Gil, Barbara Jarzab, Daria Handkiewicz-Junak
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • The dilemma of papillary thyroid microcarcinoma management. To operate or not to operate, that is the question
    Juan C Galofré
    Endocrinología, Diabetes y Nutrición.2019; 66(8): 469.     CrossRef
  • Computed Tomography for Detecting Cervical Lymph Node Metastasis in Patients Who Have Papillary Thyroid Microcarcinoma with Tumor Characteristics Appropriate for Active Surveillance
    Dong-Hwa Lee, Yeo Koon Kim, Hyeong Won Yu, June Young Choi, So Yeon Park, Jae Hoon Moon
    Thyroid.2019; 29(11): 1653.     CrossRef
  • The dilemma of papillary thyroid microcarcinoma management. To operate or not to operate, that is the question
    Juan C Galofré
    Endocrinología, Diabetes y Nutrición (English ed.).2019; 66(8): 469.     CrossRef
  • Longitudinal Assessment of Quality of Life According to Treatment Options in Low-Risk Papillary Thyroid Microcarcinoma Patients: Active Surveillance or Immediate Surgery (Interim Analysis of MAeSTro)
    Sung Hye Kong, Junsun Ryu, Min Joo Kim, Sun Wook Cho, Young Shin Song, Ka Hee Yi, Do Joon Park, Yul Hwangbo, You Jin Lee, Kyu Eun Lee, Su-jin Kim, Woo-Jin Jeong, Eun-Jae Chung, Jeong Hun Hah, June Young Choi, Chang Hwan Ryu, Yuh-Seog Jung, Jae Hoon Moon,
    Thyroid.2019; 29(8): 1089.     CrossRef
  • Ultrasound-guided percutaneous laser ablation for papillary thyroid microcarcinoma: a retrospective analysis of 37 patients
    Lili Ji, Qin Wu, Jun Gu, Xuedong Deng, Wei Zhou, Xing Fan, Feng Zhou
    Cancer Imaging.2019;[Epub]     CrossRef
  • Evolving management considerations in active surveillance for micropapillary thyroid carcinoma
    Allen S. Ho, Irene Chen, Michelle Melany, Wendy L. Sacks
    Current Opinion in Endocrinology, Diabetes & Obesity.2018; 25(5): 353.     CrossRef
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Obesity and Metabolism
Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells
Min Joo Kim, Ok Kyong Choi, Kyung Sil Chae, Min Kyeong Kim, Jung Hee Kim, Masaaki Komatsu, Keiji Tanaka, Hakmo Lee, Sung Soo Chung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hye Seung Jung
Endocrinol Metab. 2015;30(1):65-70.   Published online March 27, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.1.65
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AbstractAbstract PDFPubReader   
Background

Damaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells. Here, we investigated mitochondrial function and the expression of mitochondrial complexes in autophagy-related 7 (Atg7)-deficient β-cells.

Methods

To evaluate the effect of autophagy deficiency on mitochondrial function in pancreatic β-cells, we isolated islets from Atg7F/F:RIP-Cre+ mice and wild-type littermates. Oxygen consumption rate and intracellular adenosine 5'-triphosphate (ATP) content were measured. The expression of mitochondrial complex genes in Atg7-deficient islets and in β-TC6 cells transfected with siAtg7 was measured by quantitative real-time polymerase chain reaction.

Results

Baseline oxygen consumption rate of Atg7-deficient islets was significantly lower than that of control islets (P<0.05). Intracellular ATP content of Atg7-deficient islets during glucose stimulation was also significantly lower than that of control islets (P<0.05). By Oxygraph-2k analysis, mitochondrial respiration in Atg7-deficient islets was significantly decreased overall, although state 3 respiration and responses to antimycin A were unaffected. The mRNA levels of mitochondrial complexes I, II, III, and V in Atg7-deficient islets were significantly lower than in control islets (P<0.05). Down-regulation of Atg7 in β-TC6 cells also reduced the expression of complexes I and II, with marginal significance (P<0.1).

Conclusion

Impairment of autophagy in pancreatic β-cells suppressed the expression of some mitochondrial respiratory complexes, and may contribute to mitochondrial dysfunction. Among the complexes, I and II seem to be most vulnerable to autophagy deficiency.

Citations

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  • Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet
    Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller,
    iScience.2021; 24(10): 103099.     CrossRef
  • Natural compound oblongifolin C inhibits autophagic flux, and induces apoptosis and mitochondrial dysfunction in human cholangiocarcinoma QBC939 cells
    Aiqing Zhang, Wei He, Huimin Shi, Xiaodan Huang, Guozhong Ji
    Molecular Medicine Reports.2016; 14(4): 3179.     CrossRef
  • Autophagy deficiency in β cells blunts incretin-induced suppression of glucagon release from α cells
    Min Joo Kim, Ok Kyong Choi, Kyung Sil Chae, Hakmo Lee, Sung Soo Chung, Dong-Sik Ham, Ji-Won Kim, Kun-Ho Yoon, Kyong Soo Park, Hye Seung Jung
    Islets.2015; 7(5): e1129096.     CrossRef
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Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary Hyperparathyroidism
Eirie Cho, Jung Mi Chang, Seok Young Yoon, Gil Tae Lee, Yun Hyi Ku, Hong Il Kim, Myung-Chul Lee, Guk Haeng Lee, Min Joo Kim
Endocrinol Metab. 2014;29(4):464-469.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.464
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AbstractAbstract PDFPubReader   
Background

The intraoperative parathyroid hormone (IOPTH) assay is widely used in patients with primary hyperparathyroidism (PHPT). We investigated the usefulness of the IOPTH assay in Korean patients with PHPT.

Methods

We retrospectively reviewed the data of 33 patients with PHPT who underwent parathyroidectomy. Neck ultrasonography (US) and 99mTc-sestamibi scintigraphy (MIBI scan) were performed preoperatively and IOPTH assays were conducted.

Results

The sensitivity of neck US and MIBI scans were 91% and 94%, respectively. A 50% decrease in parathyroid hormone (PTH) levels 10 minutes after excision of the parathyroid gland was obtained in 91% (30/33) of patients and operative success was achieved in 97% (32/33) of patients. The IOPTH assay was 91% true-positive, 3% true-negative, 0% false-positive, and 6% false-negative. The overall accuracy of the IOPTH assay was 94%. In five cases with discordant neck US and MIBI scan results, a sufficient decrease in IOPTH levels helped the surgeon confirm the complete excision of the parathyroid gland with no additional neck exploration.

Conclusion

The IOPTH assay is an accurate tool for localizing hyperfunctioning parathyroid glands and is helpful for evaluating cases with discordant neck US and MIBI scan results.

Citations

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  • Single-Center Experience of Parathyroidectomy Using Intraoperative Parathyroid Hormone Monitoring
    Seong Hoon Kim, Si Yeon Lee, Eun Ah Min, Young Mi Hwang, Yun Suk Choi, Jin Wook Yi
    Medicina.2022; 58(10): 1464.     CrossRef
  • The natural history and hip geometric changes of primary hyperparathyroidism without parathyroid surgery
    Kyong Yeun Jung, A. Ram Hong, Dong Hwa Lee, Jung Hee Kim, Kyoung Min Kim, Chan Soo Shin, Seong Yeon Kim, Sang Wan Kim
    Journal of Bone and Mineral Metabolism.2017; 35(3): 278.     CrossRef
  • The utility of the radionuclide probe in parathyroidectomy for primary hyperparathyroidism
    MS Lim, M Jinih, CH Ngai, NM Foley, HP Redmond
    The Annals of The Royal College of Surgeons of England.2017; 99(5): 369.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
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Thyroid
Medullary Thyroid Carcinoma with Ectopic Adrenocorticotropic Hormone Syndrome
Hong Seok Choi, Min Joo Kim, Chae Ho Moon, Jong Ho Yoon, Ha Ra Ku, Geon Wook Kang, Im Il Na, Seung-Sook Lee, Byung-Chul Lee, Young Joo Park, Hong Il Kim, Yun Hyi Ku
Endocrinol Metab. 2014;29(1):96-100.   Published online March 14, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.1.96
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AbstractAbstract PDFPubReader   

Ectopic adrenocorticotropic hormone (ACTH) syndrome is caused most frequently by a bronchial carcinoid tumor or by small cell lung cancer. Medullary thyroid carcinoma (MTC) is a rare etiology of ectopic ACTH syndrome. We describe a case of Cushing syndrome due to ectopic ACTH production from MTC in a 48-year-old male. He was diagnosed with MTC 14 years ago and underwent total thyroidectomy, cervical lymph node dissection and a series of metastasectomies. MTC was confirmed by the pathological examination of the thyroid and metastatic mediastinal lymph node tissues. Two years after his last surgery, he developed Cushingoid features, such as moon face and central obesity, accompanied by uncontrolled hypertension and new-onset diabetes. The laboratory results were compatible with ectopic ACTH syndrome. A bilateral adrenalectomy improved the clinical and laboratory findings that were associated with Cushing syndrome. This is the first confirmed case of ectopic ACTH syndrome caused by MTC in Korea.

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  • Medullary thyroid carcinoma with ACHT-dependent Cushing's syndrome: Therapeutic possibilities
    Dušan Ilić, Sanja Ognjanović, Bojana Popović, Valentina Elezović-Kovačević, Milica Opalić-Palibrk, Lena Radić, Katarina Krstić, Đuro Macut
    Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma.2024; 29(93): 46.     CrossRef
  • Medullary Thyroid Cancer with Ectopic Cushing's Syndrome: A Case Report and Systematic Review of Detailed Cases from the Literature
    Andrea Corsello, Vittoria Ramunno, Pietro Locantore, Giovanni Pacini, Esther Diana Rossi, Francesco Torino, Alfredo Pontecorvi, Carmela De Crea, Rosa Maria Paragliola, Marco Raffaelli, Salvatore Maria Corsello
    Thyroid.2022; 32(11): 1281.     CrossRef
  • Mucosal Neuroma Cues for Endocrine Emergency Treatment
    Gyu Gang Choi, Hwan Jin Lee, Hyo Jin Han, Young Beom Jeong, Heung Bum Lee, Ji Hyun Park
    Endocrinology and Metabolism.2021; 36(6): 1312.     CrossRef
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    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • Rapid response of hypercortisolism to vandetanib treatment in a patient with advanced medullary thyroid cancer and ectopic Cushing syndrome
    Fabián Pitoia, Fernanda Bueno, Angélica Schmidt, Sabrina Lucas, Graciela Cross
    Archives of Endocrinology and Metabolism.2015; 59(4): 343.     CrossRef
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Characterization of Incidentally Detected Adrenal Pheochromocytoma.
Ye An Kim, Yul Hwangbo, Min Joo Kim, Hyung Jin Choi, Je Hyun Seo, Yenna Lee, Soo Heun Kwak, Eu Jeong Ku, Tae Jung Oh, Eun Roh, Jae Hyun Bae, Jung Hee Kim, Kyoung Soo Park, Seong Yeon Kim
Endocrinol Metab. 2012;27(2):132-137.   Published online June 20, 2012
DOI: https://doi.org/10.3803/EnM.2012.27.2.132
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AbstractAbstract PDF
BACKGROUND
In approach to an adrenal incidentaloma, early exclusion of pheochromocytoma is clinically important, due to the risk of catecholamine crisis. The aims of this study are to investigate the characteristics of incidentally detected pheochromocytomas, compared with that of the other adrenal incidentalomas, and to compare these characteristics with those of symptomatic pheochromocytomas. METHODS: In this retrospective study, we reviewed the medical records of 198 patients with adrenal incidentaloma from 2001 to 2010. We analyzed the clinical, laboratory and radiological data of pheochromocytomas, in comparison with those of the other adrenal incidentalomas. We also compared the characteristics of these incidentally detected pheochromocytomas with the medical records of 28 pathologically proven pheochromocytomas, diagnosed based on typical symptoms. RESULTS: Among the 198 patients with adrenal incidentaloma, nineteen patients were diagnosed with pheochromocytoma. Pheochromocytomas showed larger size and higher Hounsfield unit at precontrast computed tomography (CT) than did non-pheochromocytomas. All pheochromocytomas were larger than 2.0 cm, and the Hounsfield units were 19 or higher in precontrast CT. When both criteria of size > 2.0 cm and Hounsfield unit > 19 were met, the sensitivity and specificity for the diagnosis of pheochromocytoma were 100% and 79.3%, respectively. Compared with patients with pheochromocytoma, diagnosed based on typical symptoms, patients with incidentally detected pheochromocytoma were older, presented less often with hypertension, and showed lower levels of 24-hour urine metanephrine. CONCLUSION: Adrenal incidentaloma with < 2.0 cm in size or < or = 19 Hounsfield units in precontrast CT imaging was less likely to be a pheochromocytoma. Patients with incidentally discovered pheochromocytoma showed lower catecholamine metabolites, compared with those patients with symptomatic pheochromocytoma.

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  • Guidelines for the Management of Adrenal Incidentaloma: the Korean Endocrine Society, Committee of Clinical Practice Guidelines
    Jung-Min Lee, Mee Kyoung Kim, Seung-Hyun Ko, Jung-Min Koh, Bo-Yeon Kim, Sang-Wan Kim, Soo-Kyung Kim, Hae-Jin Kim, Ohk-Hyun Ryu, Juri Park, Jung-Soo Lim, Seong Yeon Kim, Young Kee Shong, Soon Jib Yoo
    The Korean Journal of Medicine.2017; 92(1): 4.     CrossRef
  • Clinical Guidelines for the Management of Adrenal Incidentaloma
    Jung-Min Lee, Mee Kyoung Kim, Seung-Hyun Ko, Jung-Min Koh, Bo-Yeon Kim, Sang Wan Kim, Soo-Kyung Kim, Hae Jin Kim, Ohk-Hyun Ryu, Juri Park, Jung Soo Lim, Seong Yeon Kim, Young Kee Shong, Soon Jib Yoo
    Endocrinology and Metabolism.2017; 32(2): 200.     CrossRef
  • Characterization of Incidentally Detected Adrenal Pheochromocytoma
    Soon Jib Yoo, Woohyeon Kim
    Endocrinology and Metabolism.2012; 27(2): 116.     CrossRef
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A Case Report of Bilateral Adrenocortical Carcinoma Complicated by Adrenal Insufficiency.
Min Joo Kim, Jung Hee Kim, Tae Young Kim, Sang Wan Kim
Endocrinol Metab. 2011;26(3):243-247.   Published online September 1, 2011
DOI: https://doi.org/10.3803/EnM.2011.26.3.243
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AbstractAbstract PDF
Adrenocortical carcinoma is often functional and presents with signs and symptoms of adrenal steroid hormone excess. Adrenal insufficiency secondary to bilateral adrenocortical carcinoma is a particularly rare complication. We recently encountered a case of bilateral adrenocortical carcinoma complicated by adrenal insufficiency. A 52-year-old male was transferred to this hospital complaining of general weakness and weight loss. A bilateral adrenal mass was detected on abdomen CT. Plasma cortisol and aldosterone failed to rise during the rapid ACTH stimulation test. The CT-guided adrenal biopsy revealed findings consistent with adrenocortical carcinoma. Left hemiparesis was developed and brain metastasis was detected via brain MRI. Despite the application of gamma knife surgery and chemotherapy, the disease progressed and the patient died.

Citations

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  • Bilateral Adrenocortical Carcinoma Presenting as Acute Adrenal Insufficiency
    Anshita Aggarwal, Aprajita Verma, Aparajita Roy, Bindu Kulshreshtha
    European Endocrinology.2020; 16(2): 172.     CrossRef
  • A Case of Bilateral ACTH-independent Adrenal Adenomas with Cushing's Syndrome Treated by Ipsilateral Total and Contralateral Partial Laparoscopic Adrenalectomy
    Seung Ah Park, Dong min Jung, Soon young Kim, Nan Young Choi, Tae-jun Kim, Yong kyun Kim, Seong kyun Na, Chul Sik Kim, Seong Jin Lee, Sung-Hee Ihm, Jun Goo Kang
    The Korean Journal of Obesity.2013; 22(4): 254.     CrossRef
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Androgen Receptor Gene CAG Repeat Polymorphism and Effect of Testosterone Therapy in Hypogonadal Men in Korea.
Min Joo Kim, Jin Taek Kim, Sun Wook Cho, Sang Wan Kim, Chan Soo Shin, Kyong Soo Park, Seong Yeon Kim
Endocrinol Metab. 2011;26(3):225-231.   Published online September 1, 2011
DOI: https://doi.org/10.3803/EnM.2011.26.3.225
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AbstractAbstract PDF
BACKGROUND
As the number of CAG repeats in the androgen receptor (AR) gene increases, transcriptional activities decrease and the effects of testosterone decline. In this study, we evaluated the importance of the CAG repeat polymorphism in regard to the effect/safety of testosterone therapy in hypogonadal Korean men. METHODS: The number of CAG repeats was determined in 42 hypogonadal men who underwent testosterone therapy for more than 24 months between December 1999 and August 2007. Body mass index, lean body mass, body fat, bone mineral density, type I collagen N-telopeptide (NTx), osteocalcin, lipid profile, hematocrit and PSA levels prior to and after 24 months of testosterone therapy were identified in our medical record review. RESULTS: Twenty-four months of testosterone therapy increased lean body mass, hematocrit, and PSA levels and reduced body fat, NTx, and HDL cholesterol levels. The mean number of CAG repeats in the AR gene was 23 +/- 3 (range, 15-29) in hypogonadal Korean men. The number of CAG repeats was not found to be associated with changes in lean body mass, body fat, NTx, HDL cholesterol, hematocrit, or PSA levels during testosterone therapy. CONCLUSIONS: No association between the number of CAG repeats in the AR gene and the effect/safety of testosterone therapy was detected in hypogonadal Korean men.

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  • Androgen Receptor CAG Repeat Length as a Risk Factor of Late-Onset Hypogonadism in a Korean Male Population
    Jong Wook Kim, Young Dae Bae, Sun Tae Ahn, Jin Wook Kim, Je Jong Kim, Du Geon Moon
    Sexual Medicine.2018; 6(3): 203.     CrossRef
  • Positive Correlation between Androgen Receptor CAG Repeat Length and Metabolic Syndrome in a Korean Male Population
    Jong Wook Kim, Young Dae Bae, Sun Tae Ahn, Jin Wook Kim, Je Jong Kim, Du Geon Moon
    The World Journal of Men's Health.2018; 36(1): 73.     CrossRef
  • Genome-Based Approaches in Endocrinology and Metabolism: From Clinical and Research Aspects
    Sihoon Lee
    Endocrinology and Metabolism.2011; 26(3): 208.     CrossRef
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Pituitary Apoplexy in Korea - Characteristics, Treatment Options and Outcomes.
Jung Ah Lim, Jin Taek Kim, Min Joo Kim, Tae Hyuk Kim, Yenna Lee, Hwa Young Cho, Chan Soo Shin, Kyong Soo Park, Hak Chul Jang, Bo Youn Cho, Hong Kyu Lee, Seong Yeon Kim
J Korean Endocr Soc. 2009;24(4):247-253.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.247
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AbstractAbstract PDF
BACKGROUND
Reports on pituitary apoplexy in Korea are limited. There are two treatment options for pituitary apoplexy - surgical decompression and conservative management. In this study, we examined clinical presentation and outcomes following different therapies in Korean patients with pituitary apoplexy. METHODS: Clinical data and treatment outcomes from 52 patients with pituitary apoplexy who visited Seoul National University Hospital between January 1992 and June 2008 were reviewed retrospectively. Patients were divided into 2 groups according to management options (a surgery group vs. a conservative management group) and their outcomes were compared. For patients who underwent surgery due to neurological symptoms, outcomes were compared between early and late surgery groups. RESULTS: Headache (73.1%) was the most common presenting symptom, and more than half of the patients were reported to have visual symptoms. The most common type of pathology was a nonfunctioning pituitary adenoma (67.3%). Nine patients received conservative management and 43 underwent surgical decompression. Their recovery from neurological and endocrinological abnormalities were similar. Among patients who showed neurological symptoms, 9 underwent surgery within 1 week of symptom onset and 24 underwent surgery after 1 week. There was no significant difference between outcomes of early and late surgery groups except recovery from impaired visual deficit was greater in the late surgery group. CONCLUSION: Patients with pituitary apoplexy in Korea show similar clinical features as similar patients in other countries. In our study, there was no significant difference between clinical outcomes of the surgery group and the conservative treatment group.

Citations

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  • The Outcomes of Pituitary Apoplexy with Conservative Treatment: Experiences at a Single Institution
    Youngbeom Seo, Yong Hwy Kim, Yun-Sik Dho, Jung Hee Kim, Jin Wook Kim, Chul-Kee Park, Dong Gyu Kim
    World Neurosurgery.2018; 115: e703.     CrossRef
  • Characteristics and Treatment Options of Pituitary Apoplexy
    Dong-Sun Kim
    Journal of Korean Endocrine Society.2009; 24(4): 237.     CrossRef
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