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Min Jin Kim  (Kim MJ) 1 Article
Clinical Study
Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
Ji Sun Nam, Jung Woo Han, Sang Bae Lee, Ji Hong You, Min Jin Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn
Endocrinol Metab. 2018;33(3):364-371.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.364
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  • 5 Citations
AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM
Background

Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.

Methods

Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.

Results

Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.

Conclusion

Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.

Citations

Citations to this article as recorded by  
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    Xuyang Wang, Wangling Chen, Wei Lao, Yunxin Chen
    Hormone and Metabolic Research.2022; 54(02): 119.     CrossRef
  • Association of CAPN10 (SNP-19) genetic polymorphism and obesity with T2DM: a study on Bengali Hindu caste population
    Pranabesh Sarkar, Diptendu Chatterjee, Arup Ratan Bandyopadhyay
    International Journal of Diabetes in Developing Countries.2021; 41(1): 37.     CrossRef
  • Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study
    Ariunbold Chuluun-Erdene, Orgil Sengeragchaa, Tsend-Ayush Altangerel, Purevjal Sanjmyatav, Batnaran Dagdan, Solongo Battulga, Lundiamaa Enkhbat, Nyamjav Byambasuren, Munkhzol Malchinkhuu, Munkhtstetseg Janlav
    Medical Sciences.2020; 8(3): 38.     CrossRef
  • Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus
    Yuwei Dong, Gongping Huang, Xin Wang, Zhaoming Chu, Jingzhi Miao, Houwen Zhou, Mingqing Xu
    PLOS ONE.2020; 15(10): e0241078.     CrossRef
  • Association of three SNPs in adiponectin gene with lipid traits of Tianzhu Black Muscovy (Cairina moschata)
    Yuan-Yu Qin, Yi-Yu Zhang, Hua-Lun Luo, Lei Wu
    Molecular Biology Reports.2019; 46(1): 325.     CrossRef

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