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Miki Inoue 1 Article
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Coordination of Multiple Cellular Processes by NR5A1/Nr5a1
Ken-ichirou Morohashi, Miki Inoue, Takashi Baba
Endocrinol Metab. 2020;35(4):756-764.   Published online December 23, 2020
DOI: https://doi.org/10.3803/EnM.2020.402
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  • 11 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   ePub   
The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In relation to these striking phenotypes, NR5A1/Nr5a1 has the potential to reprogram cells to steroidogenic cells, endow pluripotency, and regulate cell proliferation. However, due to limited knowledge regarding NR5A1 target genes, the mechanism by which NR5A1/Nr5a1 regulates these fundamental processes has remained unknown. Recently, newlyestablished technologies have enabled the identification of NR5A1 target genes related to multiple metabolic processes, as well as the aforementioned biological processes. Considering that active cellular processes are expected to be accompanied by active metabolism, NR5A1 may act as a key factor for processes such as cell differentiation, proliferation, and survival by coordinating these processes with cellular metabolism. A complete and definite picture of the cellular processes coordinated by NR5A1/Nr5a1 could be depicted by accumulating evidence of the potential target genes through whole genome studies.

Citations

Citations to this article as recorded by  
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    Cell Reports.2024; 43(2): 113715.     CrossRef
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    Luis Ramos
    Genes & Diseases.2024; 11(4): 101160.     CrossRef
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    Denis Houzelstein, Caroline Eozenou, Carlos F. Lagos, Maëva Elzaiat, Joelle Bignon-Topalovic, Inma Gonzalez, Vincent Laville, Laurène Schlick, Somboon Wankanit, Prochi Madon, Jyotsna Kirtane, Arundhati Athalye, Federica Buonocore, Stéphanie Bigou, Gerard
    Nature Communications.2024;[Epub]     CrossRef
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    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Role of NR5A1 Gene Mutations in Disorders of Sex Development: Molecular and Clinical Features
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    Current Issues in Molecular Biology.2024; 46(5): 4519.     CrossRef
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    Theo Cardozo Brascher, Leonardo de Bortoli, Guilherme Toledo-Silva, Flávia Lucena Zacchi, Guilherme Razzera
    Chemosphere.2024; 361: 142443.     CrossRef
  • Conditional disruption of Nr5a1 directed by Sox9-Cre impairs adrenal development
    Ayako Tagami, Yayoi Ikeda, Kyoko Ishizuka, Mamiko Maekawa
    Scientific Reports.2024;[Epub]     CrossRef
  • Worldwide cohort study of 46, XY differences/disorders of sex development genetic diagnoses: geographic and ethnic differences in variants
    Chen Jiali, Peng Huifang, Jiang Yuqing, Zeng Xiantao, Jiang Hongwei
    Frontiers in Genetics.2024;[Epub]     CrossRef
  • Nuclear Receptor Gene Variants Underlying Disorders/Differences of Sex Development through Abnormal Testicular Development
    Atsushi Hattori, Maki Fukami
    Biomolecules.2023; 13(4): 691.     CrossRef
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    Life Sciences.2023; 325: 121744.     CrossRef
  • Induced pluripotent stem cell line generated from a patient with differences in sex development (DSD) and multiple genetic variants including a large deletion in NR5A1
    Aisha L. Siebert, Grace B. Schwartz, Hana Kubo, Monica M. Laronda
    Stem Cell Research.2023; 71: 103154.     CrossRef
  • Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis
    Sirine Souali-Crespo, Diana Condrea, Nadège Vernet, Betty Féret, Muriel Klopfenstein, Erwan Grandgirard, Violaine Alunni, Marie Cerciat, Matthieu Jung, Chloé Mayere, Serge Nef, Manuel Mark, Frédéric Chalmel, Norbert B. Ghyselinck
    Development.2023;[Epub]     CrossRef
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