- Clinical Study
- Prognostic Factors in Patients Hospitalized with Diabetic Ketoacidosis
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Avinash Agarwal, Ambuj Yadav, Manish Gutch, Shuchi Consul, Sukriti Kumar, Ved Prakash, Anil Kumar Gupta, Annesh Bhattacharjee
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Endocrinol Metab. 2016;31(3):424-432. Published online September 1, 2016
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DOI: https://doi.org/10.3803/EnM.2016.31.3.424
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Abstract
PDF PubReader Crossref - TDM
- Background
Diabetic ketoacidosis (DKA) is characterized by a biochemical triad of hyperglycemia, acidosis, and ketonemia. This condition is life-threatening despite improvements in diabetic care. The purpose of this study was to evaluate the clinical and biochemical prognostic markers of DKA. We assessed correlations in prognostic markers with DKA-associated morbidity and mortality. MethodsTwo hundred and seventy patients that were hospitalized with DKA over a period of 2 years were evaluated clinically and by laboratory tests. Serial assays of serum electrolytes, glucose, and blood pH were performed, and clinical outcome was noted as either discharged to home or death. ResultsThe analysis indicated that significant predictors included sex, history of type 1 diabetes mellitus or type 2 diabetes mellitus, systolic blood pressure, diastolic blood pressure, total leukocyte count, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, blood urea nitrogen, serum creatinine, serum magnesium, serum phosphate, serum osmolality, serum glutamic oxaloacetic transaminases, serum glutamic pyruvic transaminases, serum albumin, which were further regressed and subjected to multivariate logistic regression (MLR) analysis. The MLR analysis indicated that males were 7.93 times more likely to have favorable outcome compared with female patients (odds ratio, 7.93; 95% confidence interval, 3.99 to 13.51), while decreases in mean APACHE II score (14.83) and serum phosphate (4.38) at presentation may lead to 2.86- and 2.71-fold better outcomes, respectively, compared with higher levels (APACHE II score, 25.00; serum phosphate, 6.04). ConclusionSex, baseline biochemical parameters such as APACHE II score, and phosphate level were important predictors of the DKA-associated mortality.
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Citations
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Michal Michaelis, Tzippy Shochat, Ilan Shimon, Amit Akirov Diabetes/Metabolism Research and Reviews.2021;[Epub] CrossRef - Incidence, characteristics and long-term outcomes of patients with diabetic ketoacidosis: a prospective prognosis cohort study in an emergency department
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Aida Elkituni, Halla Elshwekh, Nesrein M. Bendala, Wafeya S. Atwear, Fawzia A. Aldaba, Abdulmunam M. Fellah Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(3): 771. CrossRef - Frequency of Diabetic Ketoacidosis and Its Determinants Among Pediatric Diabetes Mellitus Patients in Northwest Ethiopia
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Ketan K. Dhatariya, Nicole S. Glaser, Ethel Codner, Guillermo E. Umpierrez Nature Reviews Disease Primers.2020;[Epub] CrossRef - Risk and Relevance of Insulin Pump Therapy in the Aetiology of Ketoacidosis in People with Type 1 Diabetes
Lena Christina Giessmann, Peter Herbert Kann Experimental and Clinical Endocrinology & Diabetes.2020; 128(11): 745. CrossRef - Clinical and biochemical profile, precipitants and prognostic factors of diabetic ketoacidosis: A retrospective study from a tertiary care center of north India
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Mette Louise Blouner Gram Kjærulff, Birgitte Schmidt Astrup Journal of Forensic and Legal Medicine.2019; 63: 34. CrossRef - Defining and characterising diabetic ketoacidosis in adults
Ketan K. Dhatariya Diabetes Research and Clinical Practice.2019; 155: 107797. CrossRef - Effects of diabetic ketoacidosis in the respiratory system
Alice Gallo de Moraes, Salim Surani World Journal of Diabetes.2019; 10(1): 16. CrossRef - Increasing Hospitalizations for DKA: A Need for Prevention Programs
Priyathama Vellanki, Guillermo E. Umpierrez Diabetes Care.2018; 41(9): 1839. CrossRef - Guidelines and controversies in the management of diabetic ketoacidosis – A mini-review
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Saperstein Y, Park J, McFarlane SI International Journal of Clinical Endocrinology and Metabolism.2018; : 008. CrossRef - Incidence and prevalence of diabetic ketoacidosis (DKA) among adults with type 1 diabetes mellitus (T1D): a systematic literature review
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