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Endocrinol Metab : Endocrinology and Metabolism


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Lynda F Bonewald  (Bonewald LF) 1 Article
The Osteocyte Network as a Source and Reservoir of Signaling Factors.
Lynda F Bonewald
Endocrinol Metab. 2010;25(3):161-165.   Published online September 1, 2010
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AbstractAbstract PDF
Within the past few years, information regarding osteocyte function as been emerging and expanding significantly. No longer is the osteocyte considered a passive cell acting simply as a 'placeholder' within mineralized bone. Osteocytes are derived from osteoblast progenitors and in the adult skeleton compose 90-95% of all bone cells. Therefore, the function of these cells in the adult and aging skeleton has become the focus of recent investigation. These cells are proving to be multifunctional, ranging from mechanotransduction, to regulation of mineral homeostasis, to control of bone remodeling. The osteocyte as a source and reservoir of signaling factors important in health and maintenance of the adult skeleton is addressed in this review.


Citations to this article as recorded by  
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    George Pellegrino, Max Roman, J. Christopher Fritton
    Journal of Biomechanics.2017; 60: 116.     CrossRef
  • A facile in vitro model to study rapid mineralization in bone tissues
    Anthony J Deegan, Halil M Aydin, Bin Hu, Sandeep Konduru, Jan Herman Kuiper, Ying Yang
    BioMedical Engineering OnLine.2014;[Epub]     CrossRef
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