- The Osteocyte Network as a Source and Reservoir of Signaling Factors.
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Lynda F Bonewald
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Endocrinol Metab. 2010;25(3):161-165. Published online September 1, 2010
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DOI: https://doi.org/10.3803/EnM.2010.25.3.161
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- Within the past few years, information regarding osteocyte function as been emerging and expanding significantly. No longer is the osteocyte considered a passive cell acting simply as a 'placeholder' within mineralized bone. Osteocytes are derived from osteoblast progenitors and in the adult skeleton compose 90-95% of all bone cells. Therefore, the function of these cells in the adult and aging skeleton has become the focus of recent investigation. These cells are proving to be multifunctional, ranging from mechanotransduction, to regulation of mineral homeostasis, to control of bone remodeling. The osteocyte as a source and reservoir of signaling factors important in health and maintenance of the adult skeleton is addressed in this review.
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Citations
Citations to this article as recorded by  - Contributions of Resin Cast Etching to Visualising the Osteocyte Lacuno-Canalicular Network Architecture in Bone Biology and Tissue Engineering
Mari Sato, Furqan A. Shah
Calcified Tissue International.2023;[Epub] CrossRef - Effects of the basic multicellular unit and lamellar thickness on osteonal fatigue life
George Pellegrino, Max Roman, J. Christopher Fritton
Journal of Biomechanics.2017; 60: 116. CrossRef - A facile in vitro model to study rapid mineralization in bone tissues
Anthony J Deegan, Halil M Aydin, Bin Hu, Sandeep Konduru, Jan Herman Kuiper, Ying Yang
BioMedical Engineering OnLine.2014;[Epub] CrossRef
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