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Kyoung-Nyoun Kim  (Kim KN) 1 Article
Obesity and Metabolism
Sex Factors in the Metabolic Syndrome as a Predictor of Cardiovascular Disease
Sunghwan Suh, Jongha Baek, Ji Cheol Bae, Kyoung-Nyoun Kim, Mi Kyoung Park, Duk Kyu Kim, Nam H. Cho, Moon-Kyu Lee
Endocrinol Metab. 2014;29(4):522-529.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.522
  • 4,389 View
  • 37 Download
  • 16 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

Metabolic syndrome (MetS) is a condition characterized by a cluster of metabolic disorders and is associated with increased risk of cardiovascular disease (CVD). This study analyzed data from the Korean Health and Genome Study to examine the impact of MetS on CVD.

Methods

A total of 8,898 subjects (4,241 males and 4,657 females), 40 to 69 years of age, were enrolled and evaluated for the development of new onset CVD from 2001 to 2012 (median 8.1 years of follow-up).

Results

The prevalence of MetS at baseline was 22.0% (932/4,241) and 29.7% (1,383/4,657) in males and females, respectively. MetS was associated with increased risk of coronary heart disease (CHD; hazard ratio [HR], 1.818; 95% confidence interval [CI], 1.312 to 2.520 in males; HR, 1.789; 95% CI, 1.332 to 2.404 in females) and CVD (HR, 1.689; 95% CI, 1.295 to 2.204 in males; HR, 1.686; 95% CI, 1.007 to 2.192 in females). Specifically, MetS was associated with risk of future stroke in females only (HR, 1.486; 95% CI, 1.007 to 2.192). Among MetS components, abdominal obesity and hypertension were independent predictors of both CHD and CVD. In addition, a higher number of MetS components correlated with higher CVD risk.

Conclusion

MetS is a significant risk factor for the development of CVD although its impact varies between sexes.

Citations

Citations to this article as recorded by  
  • Cardiovascular age of workers with different employment categories
    Byung-Kook Lee, Jaeouk Ahn, Nam-Soo Kim, Jungsun Park, Yangho Kim
    Archives of Environmental & Occupational Health.2022; 77(3): 243.     CrossRef
  • Effects of Anthocyanin-rich Berries on the Risk of Metabolic Syndrome: A Systematic Review and Meta-analysis
    Mikkel Roulund Wilken, Max Norman Tandrup Lambert, Christine Bodelund Christensen, Per Bendix Jeppesen
    Review of Diabetic Studies.2022; 18(1): 42.     CrossRef
  • Rate and risk factors of metabolic components and component combinations according to hypertension status in Tibetans in a cross-sectional study
    Jihong Hu, Brian Thompson, Shuxia Wang, Minhao Guo, Chunjuan Yan, Fengfeng Ding, Peng Guo, Li Chen, Zhuoma Cao, Jianzong Wang
    Medicine.2022; 101(43): e31320.     CrossRef
  • Gender differences in changes in metabolic syndrome status and its components and risk of cardiovascular disease: a longitudinal cohort study
    Azra Ramezankhani, Fereidoun Azizi, Farzad Hadaegh
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • The Association of Metabolic Syndrome with the development of cardiovascular disease among Kazakhs in remote rural areas of Xinjiang, China: a cohort study
    Wenwen Yang, Shuxia Guo, Haixia Wang, Yu Li, Xianghui Zhang, Yunhua Hu, Heng Guo, Kui Wang, Yizhong Yan, Jingyu Zhang, Jiaolong Ma, Lei Mao, Lati Mu, Jiaming Liu, Yanpeng Song, Changjing Li, Zhuo Ma, Rulin Ma, Jia He
    BMC Public Health.2021;[Epub]     CrossRef
  • Serum Arylsulfatase and Acid Phosphatase Activity in Patients with Metabolic Syndrome as a Result of Oxidative Damage to Lysosomes
    Dorota M. Olszewska-Słonina
    Protein & Peptide Letters.2021; 28(11): 1246.     CrossRef
  • Validation of Risk Prediction Models for Atherosclerotic Cardiovascular Disease in a Prospective Korean Community-Based Cohort
    Jae Hyun Bae, Min Kyong Moon, Sohee Oh, Bo Kyung Koo, Nam Han Cho, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2020; 44(3): 458.     CrossRef
  • The Prevalence of Obesity and Metabolic Syndrome in the Korean Military Compared with the General Population
    Jung Hwan Lee, Da Hea Seo, Min Jung Nam, Geon Hui Lee, Dong Hee Yang, Min Joo Lee, Ung-Rim Choi, Seongbin Hong
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Relationship between serum bilirubin levels and cardiovascular disease
    Sunghwan Suh, Young Rak Cho, Mi Kyoung Park, Duk Kyu Kim, Nam H. Cho, Moon-Kyu Lee, Christian Herder
    PLOS ONE.2018; 13(2): e0193041.     CrossRef
  • Comparison Between Metabolic Syndrome and the Framingham Risk Score as Predictors of Cardiovascular Diseases Among Kazakhs in Xinjiang
    Wenwen Yang, Rulin Ma, Xianghui Zhang, Heng Guo, Jia He, Lei Mao, Lati Mu, Yunhua Hu, Yizhong Yan, Jiaming Liu, Jiaolong Ma, Shugang Li, Yusong Ding, Mei Zhang, Jingyu Zhang, Shuxia Guo
    Scientific Reports.2018;[Epub]     CrossRef
  • Impact of interactions among metabolic syndrome components on the development of cardiovascular disease among Kazakhs in Xinjiang
    Wenwen Yang, Xiang Gao, Xianghui Zhang, Yunhua Hu, Heng Guo, Kui Wang, Yizhong Yan, Jia He, Jingyu Zhang, Jiaolong Ma, Lei Mao, Lati Mu, Jiaming Liu, Shugang Li, Yusong Ding, Mei Zhang, Rulin Ma, Shuxia Guo, Mahesh Narayan
    PLOS ONE.2018; 13(10): e0205703.     CrossRef
  • Prediction of cardiovascular disease in Korean population: based on health risk appraisal of national health screening program
    Jae Moon Yun, Tae Gon Yoo, Seung-Won Oh, Be Long Cho, Eunyoung Kim, Insob Hwang
    Journal of the Korean Medical Association.2017; 60(9): 746.     CrossRef
  • Metabolic Syndrome Is a Strong Risk Factor for Minor Ischemic Stroke and Subsequent Vascular Events
    Guang-Sheng Wang, Dao-Ming Tong, Xiao-Dong Chen, Tong-Hui Yang, Ye-Ting Zhou, Xiao-Bo Ma, Gianpaolo Reboldi
    PLOS ONE.2016; 11(8): e0156243.     CrossRef
  • Metabolic syndrome related to cardiovascular events in a 10-year prospective study
    Laura Kazlauskienė, Jūratė Butnorienė, Antanas Norkus
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome
    Seung Han, Kyoung Ha, Ja Jeon, Hae Kim, Kwan Lee, Dae Kim
    International Journal of Environmental Research and Public Health.2015; 12(9): 11396.     CrossRef
  • Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression
    Wei-Jen Ting, Wei-Wen Kuo, Dennis Hsieh, Yu-Lan Yeh, Cecilia-Hsuan Day, Ya-Hui Chen, Ray-Jade Chen, Viswanadha Padma, Yi-Hsing Chen, Chih-Yang Huang
    International Journal of Molecular Sciences.2015; 16(10): 25881.     CrossRef
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