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Kyoung Hwa Ha  (Ha KH) 6 Articles
Diabetes, obesity and metabolism
Changes in the Epidemiological Landscape of Diabetes in South Korea: Trends in Prevalence, Incidence, and Healthcare Expenditures
Kyoung Hwa Ha, Dae Jung Kim
Endocrinol Metab. 2024;39(5):669-677.   Published online September 25, 2024
DOI: https://doi.org/10.3803/EnM.2024.2073
  • 1,658 View
  • 126 Download
  • 1 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Diabetes is a serious public health concern that significantly contributes to the global burden of disease. In Korea, the prevalence of diabetes is 12.5% among individuals aged 19 and older, and 14.8% among individuals aged 30 and older as of 2022. The total number of people with diabetes among those aged 19 and older is estimated to be 5.4 million. The incidence of diabetes decreased from 8.1 per 1,000 persons in 2006 to 6.3 per 1,000 persons in 2014, before rising again to 7.5 per 1,000 persons in 2019. Meanwhile, the incidence of type 1 diabetes increased significantly, from 1.1 per 100,000 persons in 1995 to 4.8 per 100,000 persons in 2016, with the prevalence reaching 41.0 per 100,000 persons in 2017. Additionally, the prevalence of gestational diabetes saw a substantial rise from 4.1% in 2007 to 22.3% in 2023. These changes have resulted in increases in the total medical costs for diabetes, covering both outpatient and inpatient services. Therefore, effective diabetes prevention strategies are urgently needed.

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  • Trends in prescribing sodium‐glucose cotransporter 2 inhibitors for individuals with type 2 diabetes with and without cardiovascular‐renal disease in South Korea, 2015–2021
    Kyoung Hwa Ha, Soyoung Shin, EunJi Na, Dae Jung Kim
    Journal of Diabetes Investigation.2024;[Epub]     CrossRef
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Diabetes, obesity and metabolism
Financial Benefits of Renal Dose-Adjusted Dipeptidyl Peptidase-4 Inhibitors for Patients with Type 2 Diabetes and Chronic Kidney Disease
Hun Jee Choe, Yeh-Hee Ko, Sun Joon Moon, Chang Ho Ahn, Kyoung Hwa Ha, Hyeongsuk Lee, Jae Hyun Bae, Hyung Joon Joo, Hyejin Lee, Jang Wook Son, Dae Jung Kim, Sin Gon Kim, Kwangsoo Kim, Young Min Cho
Endocrinol Metab. 2024;39(4):622-631.   Published online August 1, 2024
DOI: https://doi.org/10.3803/EnM.2024.1965
  • 1,132 View
  • 47 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Dipeptidyl peptidase-4 (DPP4) inhibitors are frequently prescribed for patients with type 2 diabetes; however, their cost can pose a significant barrier for those with impaired kidney function. This study aimed to estimate the economic benefits of substituting non-renal dose-adjusted (NRDA) DPP4 inhibitors with renal dose-adjusted (RDA) DPP4 inhibitors in patients with both impaired kidney function and type 2 diabetes.
Methods
This retrospective cohort study was conducted from January 1, 2012 to December 31, 2018, using data obtained from common data models of five medical centers in Korea. Model 1 applied the prescription pattern of participants with preserved kidney function to those with impaired kidney function. In contrast, model 2 replaced all NRDA DPP4 inhibitors with RDA DPP4 inhibitors, adjusting the doses of RDA DPP4 inhibitors based on individual kidney function. The primary outcome was the cost difference between the two models.
Results
In total, 67,964,996 prescription records were analyzed. NRDA DPP4 inhibitors were more frequently prescribed to patients with impaired kidney function than in those with preserved kidney function (25.7%, 51.3%, 64.3%, and 71.6% in patients with estimated glomerular filtration rates [eGFRs] of ≥60, <60, <45, and <30 mL/min/1.73 m2, respectively). When model 1 was applied, the cost savings per year were 7.6% for eGFR <60 mL/min/1.73 m2 and 30.4% for eGFR <30 mL/min/1.73 m2. According to model 2, 15.4% to 51.2% per year could be saved depending on kidney impairment severity.
Conclusion
Adjusting the doses of RDA DPP4 inhibitors based on individual kidney function could alleviate the economic burden associated with medical expenses.
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Clinical Study
Big Data Articles (National Health Insurance Service Database)
Effect of Teneligliptin versus Sulfonylurea on Major Adverse Cardiovascular Outcomes in People with Type 2 Diabetes Mellitus: A Real-World Study in Korea
Da Hea Seo, Kyoung Hwa Ha, So Hun Kim, Dae Jung Kim
Endocrinol Metab. 2021;36(1):70-80.   Published online February 24, 2021
DOI: https://doi.org/10.3803/EnM.2020.777
  • 6,207 View
  • 213 Download
  • 7 Web of Science
  • 6 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Results regarding the cardiovascular (CV) effects of dipeptidyl peptidase-4 (DPP-4) inhibitors are inconsistent. This study aimed to assess the effects of teneligliptin, a DPP-4 inhibitor, on the risk of major CV outcomes in type 2 diabetes mellitus (T2DM) patients compared to sulfonylurea.
Methods
From January 1, 2015 to December 31, 2017, we conducted a retrospective cohort study using the Korean National Health Insurance Service database. A total of 6,682 T2DM patients who were newly prescribed DPP-4 inhibitors or sulfonylurea were selected and matched in a 1:1 ratio by propensity score. The hazard ratios (HRs) for all-cause mortality, hospitalization for heart failure (HHF), all-cause mortality or HHF, myocardial infarction (MI), stroke, and hypoglycemia were assessed.
Results
During 641 days of follow-up, the use of teneligliptin was not associated with an increased risk of all-cause mortality (HR, 1.00; 95% confidence interval [CI], 0.85 to 1.19), HHF (HR, 0.99; 95% CI, 0.86 to 1.14), all-cause mortality or HHF (HR, 1.02; 95% CI, 0.90 to 1.14), MI (HR, 0.90; 95% CI, 0.68 to 1.20), and stroke (HR, 1.00; 95% CI, 0.86 to 1.17) compared to the use of sulfonylurea. However, it was associated with a significantly lower risk of hypoglycemia (HR, 0.68; 95% CI, 0.49 to 0.94) compared to sulfonylurea therapy.
Conclusion
Among T2DM patients, teneligliptin therapy was not associated with an increased risk of CV events including HHF, but was associated with a lower risk of hypoglycemia compared to sulfonylurea therapy.

Citations

Citations to this article as recorded by  
  • Association between age at diagnosis of type 2 diabetes and cardiovascular morbidity and mortality risks: A nationwide population-based study
    Da Hea Seo, Mina Kim, Young Ju Suh, Yongin Cho, Seong Hee Ahn, Seongbin Hong, So Hun Kim
    Diabetes Research and Clinical Practice.2024; 208: 111098.     CrossRef
  • Association between Age at Diagnosis of Type 2 Diabetes and Subsequent Risk of Dementia and Its Major Subtypes
    Da Hea Seo, Mina Kim, Yongin Cho, Seong Hee Ahn, Seongbin Hong, So Hun Kim
    Journal of Clinical Medicine.2024; 13(15): 4386.     CrossRef
  • Assessment of cardiovascular risk with sulfonylurea use in type 2 diabetes mellitus: A retrospective cohort study
    Jari Delbaere, Ewoud Deboever, Bert Vaes, Frank Nobels, Pavlos Mamouris, Geert Goderis
    Primary Care Diabetes.2024; 18(6): 599.     CrossRef
  • Systematic review and meta-analysis of teneligliptin for treatment of type 2 diabetes
    R. Pelluri, S. Kongara, V. R. Nagasubramanian, S. Mahadevan, J. Chimakurthy
    Journal of Endocrinological Investigation.2023; 46(5): 855.     CrossRef
  • Finding the most cost-effective option from commonly used Dipeptidyl peptidase-4 inhibitors in India: a systematic study
    Harmanjit Singh, Ekta Arora, Seerat Narula, Mandeep Singla, Armaan Otaal, Jatin Sharma
    Expert Review of Endocrinology & Metabolism.2023; 18(4): 347.     CrossRef
  • Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes
    Yewon Na, Soo Wan Kim, Ie Byung Park, Soo Jung Choi, Seungyoon Nam, Jaehun Jung, Dae Ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(11): 3022.     CrossRef
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Corrigendum: Correction of Acknowledgments: Epidemiology of Childhood Obesity in Korea
Kyoung Hwa Ha, Dae Jung Kim
Endocrinol Metab. 2017;32(1):144.   Published online March 20, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.144
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  • 27 Download
  • 2 Web of Science
  • 2 Crossref
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  • Comparison of growth response and adverse reaction according to growth hormone dosing strategy for children with short stature: LG Growth Study
    Kyungchul Song, Mo Kyung Jung, Jun Suk Oh, Su Jin Kim, Han Saem Choi, Myeongseob Lee, Junghwan Suh, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim
    Growth Hormone & IGF Research.2023; 69-70: 101531.     CrossRef
  • Systematic estimation of BMI
    Meng-Jie Shan, Yang-Fan Zou, Peng Guo, Jia-Xu Weng, Qing-Qing Wang, Ya-Lun Dai, Hui-Bin Liu, Yuan-Meng Zhang, Guan-Yin Jiang, Qi Xie, Ling-Bing Meng
    Medicine.2019; 98(21): e15810.     CrossRef
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Obesity and Metabolism
Epidemiology of Childhood Obesity in Korea
Kyoung Hwa Ha, Dae Jung Kim
Endocrinol Metab. 2016;31(4):510-518.   Published online November 3, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.4.510
  • 7,201 View
  • 76 Download
  • 43 Web of Science
  • 40 Crossref
AbstractAbstract PDFPubReader   

Over the past several decades, the prevalence of obesity has increased dramatically worldwide and is increasing not only in developed countries, but also in developing countries. This increase may lead to an increase in the incidence of chronic diseases throughout the lifespan. In Korean children and adolescents, the prevalence of obesity increased from 6.8% in 1998 to 10.0% in 2013. Obesity is a state that more commonly influences children and adolescents of lower socioeconomic status (SES) than those with a higher SES. However, the prevalence of metabolic syndrome in a nationally representative sample of Korean adolescents decreased from 1998 to 2012. According to the Diabetes Fact Sheet of the Korean Diabetes Association, the prevalence of type 2 diabetes among children aged 18 years or younger was 153.5 per 100,000 in 2006 and 205.0 per 100,000 in 2013. Obesity is a complex disease influenced by many interacting factors, such as adipocytokines, lipopolysaccharide-binding protein, adenovirus 36 infection, birth weight, lifestyle, and endocrine-disrupting chemicals. Obesity in youth can adversely impact practically every organ system and lead to serious consequences, such as metabolic, gastrointestinal, pulmonary, cardiovascular, and psychosocial complications. Therefore, coordinated efforts by governments, organizations, communities, and individuals are needed to prevent and treat childhood obesity. In particular, a long-term policy to improve the social environment will also be necessary.

Citations

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Obesity and Metabolism
Trends in the Diabetes Epidemic in Korea
Kyoung Hwa Ha, Dae Jung Kim
Endocrinol Metab. 2015;30(2):142-146.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.142
  • 5,975 View
  • 49 Download
  • 67 Web of Science
  • 79 Crossref
AbstractAbstract PDFPubReader   

Diabetes mellitus is a leading cause of mortality and increased disability-adjusted life years worldwide. In Korea, the prevalence of diabetes increased from 8.6% to 11.0% in 2001 to 2013 and the prevalence of adult obesity, which is the most important risk factor of diabetes, increased from 29.2% to 31.8% during the same period. There has been a dramatic increase in the number of obese Koreans with diabetes in recent decades and the prevalence of diabetes in people aged 40 years and older also increased in 2001 to 2013. Nevertheless, the mean age at the first diagnosis of diabetes was very similar for men in 2005 and 2013, while the mean age for women decreased slightly. There is an inverse linear relationship between body mass index and age at the diagnosis of diabetes among those who are newly diagnosed. Accordingly, the prevalence of diabetes is increasingly shifting to younger individuals and those who are obese. Therefore, public efforts should focus on healthy lifestyle changes, primary prevention measures, screening for the early detection of diabetes, and long-term management.

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    Nutrients.2020; 12(2): 352.     CrossRef
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    International Journal of Diabetes in Developing Countries.2020; 40(2): 178.     CrossRef
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    Experimental and Therapeutic Medicine.2020;[Epub]     CrossRef
  • Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
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    PLOS ONE.2019; 14(3): e0213285.     CrossRef
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    Diabetes & Metabolism Journal.2019; 43(4): 487.     CrossRef
  • Analysis of diabetes quality assessment findings and future directions for the appropriate management of diabetes in Korea
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    The Korean Journal of Internal Medicine.2019; 34(1): 125.     CrossRef
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    Diabetes & Metabolism Journal.2019; 43(6): 804.     CrossRef
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  • Changes in real-life practice for hepatocellular carcinoma patients in the Republic of Korea over a 12-year period: A nationwide random sample study
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  • Association between continuity of care and type 2 diabetes development among patients with thyroid disorder
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    Medicine.2019; 98(52): e18537.     CrossRef
  • Association of C-Reactive Protein with Risk of Developing Type 2 Diabetes Mellitus, and Role of Obesity and Hypertension: A Large Population-Based Korean Cohort Study
    Suganya Kanmani, Minji Kwon, Moon-Kyung Shin, Mi Kyung Kim
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    Jieul Lee, Jihye Kim
    Nutrition Research and Practice.2018; 12(5): 396.     CrossRef
  • Diabetes, Frequency of Exercise, and Mortality Over 12 Years: Analysis of the National Health Insurance Service-Health Screening (NHIS-HEALS) Database
    Woo Young Shin, Taehee Lee, Da-Hye Jeon, Hyeon Chang Kim
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    Bo Hyun Kim, Joong-Won Park
    Clinical and Molecular Hepatology.2018; 24(1): 1.     CrossRef
  • Letter: Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index (Diabetes Metab J 2018;42:137-46)
    Ah Reum Khang
    Diabetes & Metabolism Journal.2018; 42(3): 249.     CrossRef
  • Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial
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    Journal of Ginseng Research.2018; 42(1): 90.     CrossRef
  • Response: Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index (Diabetes Metab J2018;42:137-46)
    Kyoung Hwa Ha, Dae Jung Kim, Sungrae Kim
    Diabetes & Metabolism Journal.2018; 42(3): 251.     CrossRef
  • Prediction of Type 2 Diabetes Remission after Bariatric or Metabolic Surgery
    Ji Yeon Park
    Journal of Obesity & Metabolic Syndrome.2018; 27(4): 213.     CrossRef
  • Waist‐to‐calf circumstance ratio is an independent predictor of hepatic steatosis and fibrosis in patients with type 2 diabetes
    Eun Yeong Choe, Yong‐ho Lee, Young Ju Choi, Byung Wook Huh, Byung‐Wan Lee, Soo‐Kyung Kim, Eun Seok Kang, Bong‐Soo Cha, Eun Jig Lee, Kap Bum Huh, Zobair M Younossi
    Journal of Gastroenterology and Hepatology.2018; 33(5): 1082.     CrossRef
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    Suyoung Kim, Eun-Hee Nah, Seon Cho
    Journal of Health Informatics and Statistics.2018; 43(3): 237.     CrossRef
  • Risk of new-onset diabetes among patients treated with statins according to hypertension and gender: Results from a nationwide health-screening cohort
    Sang-Eun Lee, Ji Min Sung, In-Jeong Cho, Hyeon Chang Kim, Hyuk-Jae Chang, Lamberto Manzoli
    PLOS ONE.2018; 13(4): e0195459.     CrossRef
  • Outcomes of living donor kidney transplantation in diabetic patients: age and sex matched comparison with non-diabetic patients
    Chung Hee Baek, Hyosang Kim, Seung Don Baek, Mun Jang, Wonhak Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
    The Korean Journal of Internal Medicine.2018; 33(2): 356.     CrossRef
  • An Analysis of The Morbidity and Mortality of Diabetes Mellitus in a Forensic Context
    Chong Zhou, Roger W. Byard
    Journal of Forensic Sciences.2018; 63(4): 1149.     CrossRef
  • Favorable glycemic response after pancreatoduodenectomy in both patients with pancreatic cancer and patients with non-pancreatic cancer
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  • Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study
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    Diabetes & Metabolism Journal.2018; 42(5): 402.     CrossRef
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    Jae-woo Lee, Hee-Taik Kang, Hyoung-Ji Lim, Byoungjin Park
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  • Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index
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    Diabetes & Metabolism Journal.2018; 42(2): 137.     CrossRef
  • Nonalcoholic fatty liver disease-associated hepatocellular carcinoma in a hepatitis B virus-endemic area
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    European Journal of Gastroenterology & Hepatology.2018; 30(9): 1090.     CrossRef
  • Prediction of Diabetes Remission after Bariatric or Metabolic Surgery
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  • Incidence and predictors of type 2 diabetes among Koreans: A 12-year follow up of the Korean Genome and Epidemiology Study
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  • Glycated Hemoglobin and All-Cause Mortality in Korean Type 2 Diabetes
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    The Journal of Korean Diabetes.2017; 18(4): 275.     CrossRef
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    Journal of Obesity & Metabolic Syndrome.2017; 26(2): 102.     CrossRef
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  • Factors that could explain the increasing prevalence of type 2 diabetes among adults in a Canadian province: a critical review and analysis
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