- Thyroid
- Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
-
Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo
-
Endocrinol Metab. 2022;37(5):703-718. Published online October 4, 2022
-
DOI: https://doi.org/10.3803/EnM.2022.1553
-
-
27,290
View
-
2,853
Download
-
94
Web of Science
-
112
Crossref
-
Abstract
PDFPubReader ePub
- The fifth edition of the World Health Organization (WHO) histologic classification of thyroid neoplasms released in 2022 includes newly recognized tumor types, subtypes, and a grading system. Follicular cell-derived neoplasms are categorized into three families (classes): benign tumors, low-risk neoplasms, and malignant neoplasms. The terms “follicular nodular disease” and “differentiated high-grade thyroid carcinoma” are introduced to account for multifocal hyperplastic/neoplastic lesions and differentiated thyroid carcinomas with high-grade features, respectively. The term “Hürthle cells” is replaced with “oncocytic cells.” Invasive encapsulated follicular and cribriform morular variants of papillary thyroid carcinoma (PTC) are now redefined as distinct tumor types, given their different genetic alterations and clinicopathologic characteristics from other PTC subtypes. The term “variant” to describe a subclass of tumor has been replaced with the term “subtype.” Instead, the term “variant” is reserved to describe genetic alterations. A histologic grading system based on the mitotic count, necrosis, and/or the Ki67 index is used to identify high-grade follicular-cell derived carcinomas and medullary thyroid carcinomas. The 2022 WHO classification introduces the following new categories: “salivary gland-type carcinomas of the thyroid” and “thyroid tumors of uncertain histogenesis.” This review summarizes the major changes in the 2022 WHO classification and their clinical relevance.
-
Citations
Citations to this article as recorded by
- Exploring the application of FNA-Tg for the diagnosis of cervical lymph node metastasis in PTC
Tingting Liu, Lin Deng, Hongming Lin, Ruohan Su, Zhiqing Lin, Hu Zhao, Sheng Huang European Journal of Surgical Oncology.2025; 51(2): 109489. CrossRef - Tumeurs de la thyroïde : nouveautés de la classification OMS 2022
Serge Guyétant, Myriam Decaussin Petrucci, Emmanuelle Leteurtre Annales de Pathologie.2024; 44(1): 5. CrossRef - Diagnostic Performance of [18F]TFB PET/CT Compared with Therapeutic Activity [131I]Iodine SPECT/CT and [18F]FDG PET/CT in Recurrent Differentiated Thyroid Carcinoma
David Ventura, Matthias Dittmann, Florian Büther, Michael Schäfers, Kambiz Rahbar, Daniel Hescheler, Michael Claesener, Philipp Schindler, Burkhard Riemann, Robert Seifert, Wolfgang Roll Journal of Nuclear Medicine.2024; 65(2): 192. CrossRef - Canine follicular cell and medullary thyroid carcinomas: Immunohistochemical characterization
Jana Jankovic, Eve Tièche, Martina Dettwiler, Kerstin Hahn, Stephanie Scheemaeker, Martin Kessler, Sylvie Daminet, Sven Rottenberg, Miguel Campos Veterinary Pathology.2024; 61(4): 524. CrossRef - Clinicopathological features of differentiated thyroid carcinoma as predictors of the effects of radioactive iodine therapy
Wen Liu, Beibei Jiang, Jingli Xue, Ruijing Liu, Yuqing Wei, Peifeng Li Annals of Diagnostic Pathology.2024; 69: 152243. CrossRef - Management of aggressive variants of papillary thyroid cancer
Ying Ki Lee, Aleix Rovira, Paul V. Carroll, Ricard Simo Current Opinion in Otolaryngology & Head & Neck Surgery.2024; 32(2): 125. CrossRef - Artificial Intelligence Detected the Relationship Between Nuclear Morphological Features and Molecular Abnormalities of Papillary Thyroid Carcinoma
Toui Nishikawa, Ibu Matsuzaki, Ayata Takahashi, Iwamoto Ryuta, Fidele Yambayamba Musangile, Kanako Sagan, Mizuki Nishikawa, Yurina Mikasa, Yuichi Takahashi, Fumiyoshi Kojima, Shin-ichi Murata Endocrine Pathology.2024; 35(1): 40. CrossRef - Review of the 2023 World Congress on Thyroid Cancer (WCTC 2023, London): is there light at the end of the tunnel for patients with neglected cancer?
S.M. Cherenko INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2024; 19(8): 609. CrossRef - Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma
Lindsay A. Bischoff, Ian Ganly, Laura Fugazzola, Erin Buczek, William C. Faquin, Bryan R. Haugen, Bryan McIver, Caitlin P. McMullen, Kate Newbold, Daniel J. Rocke, Marika D. Russell, Mabel Ryder, Peter M. Sadow, Eric Sherman, Maisie Shindo, David C. Shonk JAMA Otolaryngology–Head & Neck Surgery.2024; 150(3): 265. CrossRef - Malignancy in a Solitary Thyroid Nodule: A Retrospective Histopathological Evaluation
Hassan Alzahrani International Journal of General Medicine.2024; Volume 17: 135. CrossRef - Pathologie thyroïdienne. Actualités et problèmes pratiques. Introduction
Serge Guyétant Annales de Pathologie.2024; 44(2): 90. CrossRef - Diagnostic implication of thyroid spherules for cytological diagnosis of thyroid nodules
Heeseung Sohn, Kennichi Kakudo, Chan Kwon Jung Cytopathology.2024; 35(3): 383. CrossRef - Aggressive Primary Thyroid Mucoepidermoid Carcinoma with Extensive Pulmonary Involvement
Marius Mitrache, Dana Terzea, Anca Sirbu, Simona Fica Biomedicines.2024; 12(2): 285. CrossRef - Unravelling the role of long non-coding RNAs in modulating the Hedgehog pathway in cancer
Shailendra Singh Chandel, Anurag Mishra, Gaurav Dubey, Ravindra Pal Singh, Mithilesh Singh, Mohit Agarwal, Himmat Singh Chawra, Neelima Kukreti Pathology - Research and Practice.2024; 254: 155156. CrossRef - Hürthle cell (Oncocytic) carcinoma – Is hemithyroidectomy enough?
Taylor O. Julsrud, Trenton R. Foster, Robert A. Vierkant, Melanie L. Lyden, Travis J. McKenzie, Mabel Ryder, Benzon M. Dy Surgical Oncology Insight.2024; 1(1): 100010. CrossRef - Échographie des carcinomes thyroïdiens différenciés de souche folliculaire
P.Y. Marcy, M. Tassart, J.G. Marchand, J. Sanglier, A. Bizeau, E. Ghanassia Journal d'imagerie diagnostique et interventionnelle.2024; 7(2): 54. CrossRef - Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study
Chankyung Kim, Shipra Agarwal, Andrey Bychkov, Jen-Fan Hang, Agnes Stephanie Harahap, Mitsuyoshi Hirokawa, Kennichi Kakudo, Somboon Keelawat, Chih-Yi Liu, Zhiyan Liu, Truong Phan-Xuan Nguyen, Chanchal Rana, Huy Gia Vuong, Yun Zhu, Chan Kwon Jung Virchows Archiv.2024; 484(4): 645. CrossRef - Cas no5. High-grade Tall cell papillary carcinoma
Myriam Decaussin-Petrucci Annales de Pathologie.2024; 44(2): 114. CrossRef - Primary Squamous Cell Carcinoma of the Thyroid Has a Molecular Genetic Profile Distinct From That of Anaplastic Thyroid Carcinoma
Meihua Ye, Zhenying Guo, Jingjing Xu, Yanling Jin, Xianglei He, Minghua Ge American Journal of Surgical Pathology.2024; 48(8): 1024. CrossRef - Current and future of immunotherapy for thyroid cancer based on bibliometrics and clinical trials
Ke Wang, Ying Zhang, Yang Xing, Hong Wang, Minghua He, Rui Guo Discover Oncology.2024;[Epub] CrossRef - Cas no6. Anaplastic thyroid carcinoma, epidermoid subtype
Myriam Decaussin-Petrucci Annales de Pathologie.2024; 44(2): 120. CrossRef - Papillary Thyroid Carcinoma With Lymphoepithelial Features and Lacking Association With Epstein-Barr Virus (EBV): A Rare Case
Ahmed Bendari, Saroja Devi Geetha, Reham Al-Refai, Xuelin Zhong, Sunder Sham, Manju Harshan Cureus.2024;[Epub] CrossRef - Clinical and morphological features and unsolved issues in diagnosis of aggressive forms of papillary thyroid carcinoma
Denis V. Korotovsky, Sergey V. Sergiiko, Sergey A. Lukyanov Perm Medical Journal.2024; 41(1): 90. CrossRef - Finding possible diagnostic markers for differentiating benign and malignant thyroid tumors on example investigate of rheological properties1
I. Javakhishvili, T. Sanikidze, K. Mardaleishvili, N. Momtselidze, T. Urdulashvili, M. Mantskava, L. Prantl, F. Jung Clinical Hemorheology and Microcirculation.2024; 87(4): 515. CrossRef - Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma
Lia Rodrigues, Arnaud Da Cruz Paula, Paula Soares, João Vinagre Cells.2024; 13(7): 561. CrossRef - Management of Poorly Differentiated Thyroid Cancer and Differentiated High-Grade Thyroid Carcinoma
Iram S. Alam, Kepal N. Patel Surgical Clinics of North America.2024; 104(4): 751. CrossRef - What’s new in thyroid pathology 2024: updates from the new WHO classification and bethesda system
Andrey Bychkov, Chan Kwon Jung Journal of Pathology and Translational Medicine.2024; 58(2): 98. CrossRef - Ultrasound–Histopathological Presentation of Thyroid and Ovary Lesions in Adolescent Patients with DICER1 Syndrome: Case Reports and Literature Overview
Dominika Januś, Monika Kujdowicz, Konrad Kaleta, Kamil Możdżeń, Jan Radliński, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Marcin Maślanka, Wojciech Górecki, Jerzy B. Starzyk Children.2024; 11(4): 403. CrossRef - Surgical treatment of solid variant of papillary thyroid carcinoma: Fifteen-year experience of a tertiary center
Katarina Tausanović, Marina Stojanović, Milan Jovanović, Boban Stepanović, Jovan Ilić, Sara Ivaniš, Vladan Živaljević Medicinska istrazivanja.2024; 57(1): 121. CrossRef - Critical appraisal of the WHO 2022 classification of thyroid cancer
Mithraa Devi Sekar, Debasis Gochhait, Sadishkumar Kamalanathan Thyroid Research and Practice.2024;[Epub] CrossRef - Patterns in the Reporting of Aggressive Histologic Subtypes in Papillary Thyroid Cancer
Yeon J. Lee, Caitlin E. Egan, Jacques A. Greenberg, Teagan Marshall, Abhinay Tumati, Brendan M. Finnerty, Toni Beninato, Rasa Zarnegar, Thomas J. Fahey, Minerva A. Romero Arenas Journal of Surgical Research.2024; 298: 325. CrossRef - An individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma
Zhihong Wang, He Wang, Yan Zhou, Lu Li, Mengge Lyu, Chunlong Wu, Tianen He, Lingling Tan, Yi Zhu, Tiannan Guo, Hongkun Wu, Hao Zhang, Yaoting Sun Nature Communications.2024;[Epub] CrossRef - Clinical and Paraclinical Considerations Regarding ki67’s Role in the Management of Differentiated Thyroid Carcinoma—A Literature Review
Claudiu Peștean, Alexandru Pavel, Doina Piciu Medicina.2024; 60(5): 769. CrossRef - Can the analysis of chromatin texture and nuclear fractal dimensions serve as effective means to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features from other malignancies with follicular pattern in the thyroid?: a s
Geet Bhuyan, Anjumoni Rabha Ultrastructural Pathology.2024; 48(4): 310. CrossRef - A Comprehensive Review and Insights into the New Entity of Differentiated High-Grade Thyroid Carcinoma
Agnes Stephanie Harahap, Regina Stefani Roren, Shofiyya Imtiyaz Current Oncology.2024; 31(6): 3311. CrossRef - Predictive Factors of Radioactive Iodine Therapy Refractoriness in Patients with Differentiated Thyroid Carcinoma
Majdouline Bel Lakhdar, Ayat Mouaden, Mourad Zekri, Dounia Alami, Hamza Zarouf, Imad Ghfir, Hasnae Guerrouj World Journal of Nuclear Medicine.2024; 23(03): 185. CrossRef - Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 4. Pathological Diagnosis and Staging after Thyroidectomy 2024
Su-Jin Shin, Hee Young Na, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Young Joo Park, Young Shin Song, Eun Kyung Lee, Dong-Jun Lim, Yun Jae Chung, Chan Kwon Jung International Journal of Thyroidology.2024; 17(1): 61. CrossRef - Management of Parapharyngeal Metastatic Medullary Thyroid Carcinoma Via a Combined Trans-Cervical and Trans-Oral Robotic Approach
Clémentine Hyvrard, Florent Couineau, Tiffany Rigal, Serena Louerat, Stéphane Hans, Robin Baudouin Annals of Otology, Rhinology & Laryngology.2024; 133(9): 823. CrossRef - Eggshell Calcifications at Thyroid Ultrasound: A Sample-focused Analysis of Cytological Findings and Post-thyroidectomy Pathological Correlates
Florentina Ioniţă Radu, Ana M. Gheorghe , Oana C. Sima , Mara Carsote , Claudiu Nistor Romanian Journal of Military Medicine.2024; 127(6): 428. CrossRef - Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space
Patricio Cabané, Claudio Correa, Ignacio Bode, Rodrigo Aguilar, Alvaro A. Elorza International Journal of Molecular Sciences.2024; 25(12): 6719. CrossRef - Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks
Wenjing Chen, Young Shin Song, Han Sai Lee, Chien-Wei Lin, Junguee Lee, Yea Eun Kang, Seon-Kyu Kim, Seon-Young Kim, Young Joo Park, Jong-In Park Oncogene.2024; 43(31): 2431. CrossRef - Utilizing Immunoglobulin G4 Immunohistochemistry for Risk Stratification in Patients with Papillary Thyroid Carcinoma Associated with Hashimoto Thyroiditis
Faridul Haq, Gyeongsin Park, Sora Jeon, Mitsuyoshi Hirokawa, Chan Kwon Jung Endocrinology and Metabolism.2024; 39(3): 468. CrossRef - The Role of SPECT/CT and PET/CT Hybrid Imaging in the Management of Ectopic Thyroid Carcinoma—A Systematic Review
Claudiu Peștean, Alexandru Pavel, Doina Piciu Diagnostics.2024; 14(13): 1369. CrossRef - Long-term survival outcomes of systemic therapy in patients with isolated and mixed medullary thyroid cancer
Manal S. Fawzy, Aziza Ali Alenezi, Baraah T. Abu AlSel, Eman A. Toraih Heliyon.2024; 10(13): e33654. CrossRef - Radioactive iodine therapy for thyroid cancer coexisting with Hashimoto’s thyroiditis: a systematic review and meta-analysis
Xiang-Yi Chen, Yang Tan, Dawei Wang, Zhi-Xiao Wei British Journal of Radiology.2024; 97(1160): 1423. CrossRef - Advances in clinical research on ultrasound-guided radiofrequency ablation for papillary thyroid microcarcinoma
Hua Xu, Jin-yan Yang, Xing Zhao, Zhe Ma Frontiers in Oncology.2024;[Epub] CrossRef - Proteomics profile in encapsulated follicular patterned thyroid neoplasms
Truong Phan-Xuan Nguyen, Sittiruk Roytrakul, Supranee Buranapraditkun, Shanop Shuangshoti, Nakarin Kitkumthorn, Somboon Keelawat Scientific Reports.2024;[Epub] CrossRef - Understanding the factors of wearable devices among the patients with thyroid cancer: A modified UTAUT2 model
LingLi Song, BinXian Li, HaiBo Wu, CuiCui Wu, XueQi Zhang, Zhiyuan Yu PLOS ONE.2024; 19(7): e0305944. CrossRef - Warthin like papillary thyroid carcinoma: A rare case report
Anjali Goyal, Riya Shah, Monali Halpati, Kinjal Damor, Prahari Nayankumar Updhyaya IP Journal of Diagnostic Pathology and Oncology.2024; 9(2): 134. CrossRef - Simultaneous occurrence of papillary thyroid carcinoma, medullary thyroid carcinoma, and lymphoma: A case report
Zengfang Hao, Hanjing Cui, Yuehong Li, Wenxin Wu, Yuan Wang, Haijun Dan, Lei Lou, Hengshu Wang, Pengxin Zhao Medicine.2024; 103(33): e39363. CrossRef - Emerging Strategies in Thyroid Cancer Immunotherapy: A Comprehensive Systematic Review and Meta-Analysis of Clinical Outcomes
Daniel Alejandro Estrella Cornejo, Meylin Yalitza Carriel Alvarado, Norma Susana Chávez Villagómez, Alberto Dario Díaz Parra, María Fernanda Navas Espinosa Salud, Ciencia y Tecnología.2024; 4: 1241. CrossRef - Advances in the Diagnosis and Treatment of Follicular Thyroid Carcinoma: A Comprehensive Review
Vasundara Gopalan, Swati G Deshpande, Anup A Zade, Darshana Tote, Rahul Rajendran, Shubham Durge, Abhilasha Bhargava Cureus.2024;[Epub] CrossRef - WHO 2022 updates on follicular cell and c-cell derived thyroid neoplasm
Parth Goswami, Tarang Patel, Rushang Dave, Gyanendra Singh, Anurag Singh, Tushar Kalonia Journal of Medicine and Life.2024; 17(1): 15. CrossRef - Oncocytic Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Case Report
Kaveripakam Ajay Joseph, Sana Ahuja, Sufian Zaheer Indian Journal of Surgical Oncology.2024;[Epub] CrossRef - Enhancing diagnostic precision in thyroid nodule assessment: evaluating the efficacy of a novel cell preservation technique in fine-needle aspiration cytology
Diana-Raluca Streinu, Octavian Constantin Neagoe, Andreea Borlea, Ion Icma, Mihnea Derban, Dana Stoian Frontiers in Endocrinology.2024;[Epub] CrossRef - Prognosis of Poorly Differentiated Thyroid Carcinoma: A Systematic Review and Meta-Analysis
Ji Young Kim, Jae Kyung Myung, Soyun Kim, Kyung Tae, Yun Young Choi, Soo Jin Lee Endocrinology and Metabolism.2024; 39(4): 590. CrossRef - Comparing therapeutic outcomes: radioactive iodine therapy versus non-radioactive iodine therapy in differentiated thyroid cancer
Robert Aurelian Tiucă, Oana Mirela Tiucă, Raluca Monica Pop, Ionela Maria Paşcanu Frontiers in Endocrinology.2024;[Epub] CrossRef - Solitär fibröser Tumor in einem follikulären Adenom der Schilddrüse
Sarah Theurer, Simon Schimmack, Hideo A. Baba Die Pathologie.2024; 45(6): 404. CrossRef - Dihydroartemisinin Inhibits Epithelial–Mesenchymal Transition Progression in Medullary Thyroid Carcinoma Through the Hippo Signaling Pathway Regulated by Interleukin-6
Ruicong Li, Xinyu Zhang, Yanan Ge, Zhen Zhao, Liangliang Feng, Xiaoming Li Cancer Biotherapy and Radiopharmaceuticals.2024;[Epub] CrossRef - Educational exchange in thyroid core needle biopsy diagnosis: enhancing pathological interpretation through guideline integration and peer learning
Agnes Stephanie Harahap, Chan Kwon Jung Journal of Pathology and Translational Medicine.2024; 58(5): 205. CrossRef - Neoadjuvant Treatment in Locally Advanced Thyroid Carcinoma
Víctor Navas Moreno, Fernando Sebastián Valles, Marcos Lahera Vargas, Berta Hernández Marín, Elena Carrillo López, Mónica Marazuela, José Luis Muñoz de Nova Journal of Clinical Medicine.2024; 13(19): 5769. CrossRef - SEOM-GETNE-TTCC Clinical guideline thyroid cancer (2023)
Teresa Alonso-Gordoa, Paula Jimenez-Fonseca, Javier Martinez-Trufero, Miguel Navarro, Ignacio Porras, Jordi Rubió-Casadevall, Marta Arregui Valles, Neus Basté, Jorge Hernando, Lara Iglesias Docampo Clinical and Translational Oncology.2024; 26(11): 2902. CrossRef - CYTOLOGICAL DIAGNOSTICS OF THYROID DISEASES: BASIC PRINCIPLES AND FEATURES OF APPLICATION IN MODERN CONDITIONS
V. I. Vovk Ukrainian Journal of Laboratory Medicine.2024;[Epub] CrossRef - PET/CT imaging of differentiated and medullary thyroid carcinoma using the novel SSTR-targeting peptide [18F]SiTATE – first clinical experiences
Sophie C. Kunte, Vera Wenter, Johannes Toms, Simon Lindner, Marcus Unterrainer, Friederike Eilsberger, Klaus Jurkschat, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Maximilian W. Tiling, Gabriel T. Sheikh, Dirk Mehrens, Matthias Brendel, Johannes Rüb European Journal of Nuclear Medicine and Molecular Imaging.2024;[Epub] CrossRef - Coexisting Medullary and Papillary Thyroid Carcinomas: A Case of Dual Neoplasia With a High Risk of Misdiagnosis
Santiago Sierra Castillo, Maria A Henao Rincón, David Aristizabal Colorado, David Alexander Vernaza Trujillo, Alin Abreu Lomba Cureus.2024;[Epub] CrossRef - Complexities in diagnosis and treatment of medullary thyroid cancer. Clinical observation
E. V. Frolova, N. N. Naumova, E. V. Salautin, E. A. Volodina Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH).2024; 14(4): 99. CrossRef - Unifocal Conventional Papillary Thyroid Carcinoma with Coexisting Caseating Granulomatous Inflammation in India
Umasankary Calaisselvane, Banushree Chandrasekhar Srinivasamurthy, Mima Maychet B. Sangma, M. Shyamala Gowri Indian Journal of Otolaryngology and Head & Neck Surgery.2024;[Epub] CrossRef - Nomogram predicts cervical lymph node metastasis of pathological subtypes of papillary thyroid carcinoma
Ziyu Luo, Wenhan Li, Binliang Huo, Jianhui Li Langenbeck's Archives of Surgery.2024;[Epub] CrossRef - High-grade encapsulated follicular cell thyroid carcinomas
A.Yu. Abrosimov, A.A. Kuryshev Russian Journal of Archive of Pathology.2024; 86(5): 60. CrossRef - Nouveautés en pathologie thyroïdienne : classification OMS 2022, système Bethesda 2023, biologie moléculaire et testing moléculaire
Mohamed Amine Bani, Sophie Moog, Voichita Suciu, Livia Lamartina, Abir Al Ghuzlan Bulletin du Cancer.2024; 111(10): 10S5. CrossRef - Histopathological Analysis of Thyroid Nodules with Taller-Than-Wide Shape in Adults
Xi-Yue Yang, Li-Fang Huang, Yue-Jian Han, Xiao-Xin Cen, Zong-Xin Tao International Journal of General Medicine.2024; Volume 17: 5123. CrossRef - The role of elastography in determining the risk of malignant thyroid nodules in children
Aleksandra Kiszka-Wiłkojć, Anna Taczanowska-Niemczuk, Dominika Januś, Marcin Maślanka, Joanna Godlewska, Monika Kujdowicz, Michał Wiłkojć, Wojciech Górecki Frontiers in Endocrinology.2024;[Epub] CrossRef - Cytologic hallmarks and differential diagnosis of papillary thyroid carcinoma subtypes
Agnes Stephanie Harahap, Chan Kwon Jung Journal of Pathology and Translational Medicine.2024; 58(6): 265. CrossRef - Aggressive primary salivary gland-type carcinoma of the thyroid: a case report
J. Chen, J. Zhang, K. Sun, T. Liu International Journal of Oral and Maxillofacial Surgery.2024;[Epub] CrossRef - Impact of Intraoperative Nanocarbon Staining and parathyroid autotransplantation on parathyroid injury and recovery in adult thyroidectomy: a retrospective cohort study
Chen Chen, Xiaole Wang, Gang Liu, Yi Huang BMC Surgery.2024;[Epub] CrossRef - Папиллярный рак щитовидной железы с фиброматозоподобной стромой
Д. А. Матвеева , Д. Н. Дербугов , А. Ю. Абросимов , В. Н. Гриневич Oncopathology.2024;[Epub] CrossRef - Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma
Chan Kwon Jung, Shipra Agarwal, Jen-Fan Hang, Dong-Jun Lim, Andrey Bychkov, Ozgur Mete Endocrine Pathology.2023; 34(1): 1. CrossRef - The 5th edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma
Fulvio Basolo, Elisabetta Macerola, Anello Marcello Poma, Liborio Torregrossa Endocrine.2023; 80(3): 470. CrossRef - Preoperative Risk Stratification of Follicular-patterned Thyroid Lesions on Core Needle Biopsy by Histologic Subtyping and RAS Variant-specific Immunohistochemistry
Meejeong Kim, Sora Jeon, Chan Kwon Jung Endocrine Pathology.2023; 34(2): 247. CrossRef - Ultrasound evolution of parenchymal changes in the thyroid gland with autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma – a follow-up study
Dominika Januś, Monika Kujdowicz, Małgorzata Wójcik, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Wojciech Górecki, Jerzy B. Starzyk Frontiers in Endocrinology.2023;[Epub] CrossRef - Papillary thyroid carcinoma with aggressive fused follicular and solid growth pattern: A unique histological subtype with high‐grade malignancy?
Shin‐ichi Murata, Ibu Matsuzaki, Mitsuo Kishimoto, Naomi Katsuki, Toshinori Onishi, Mitsuyoshi Hirokawa, Fumiyoshi Kojima Pathology International.2023; 73(5): 207. CrossRef - Multi-Omics and Management of Follicular Carcinoma of the Thyroid
Thifhelimbilu Emmanuel Luvhengo, Ifongo Bombil, Arian Mokhtari, Maeyane Stephens Moeng, Demetra Demetriou, Claire Sanders, Zodwa Dlamini Biomedicines.2023; 11(4): 1217. CrossRef - Molecular Genetics of Diffuse Sclerosing Papillary Thyroid Cancer
Meshael Alswailem, Balgees Alghamdi, Anwar Alotaibi, Abeer Aljomiah, Hindi Al-Hindi, Avaniyapuram Kannan Murugan, Mohamed Abouelhoda, Yufei Shi, Ali S Alzahrani The Journal of Clinical Endocrinology & Metabolism.2023; 108(9): e704. CrossRef - Multifunctional Phase-Transition Nanoparticles for Effective Targeted Sonodynamic-Gene Therapy Against Thyroid Papillary Carcinoma
Shihui Guan, Dengke Teng, Hui Wang, Qimeihui Wang, Xi Zhen, Guoqing Sui, Yang Wang, Lingyu Zhu, Yuanqiang Lin, Dan Jiao, Feng Guo International Journal of Nanomedicine.2023; Volume 18: 2275. CrossRef - Utilizing Dynamic Risk Stratification in Patients With Tall Cell Variant Papillary Thyroid Cancer
David Zimmer, Gilman Plitt, Brandon Prendes, Jamie Ku, Natalie Silver, Eric Lamarre, Emrullah Yilmaz, Jessica Geiger, Christian Nasr, Lea El Hage, Mario Skugor, Shauna Cambpell, Shlomo Koyfman, Jacob Miller, Neil Woody, Katherine Heiden, Nikhil Joshi, Tar The Laryngoscope.2023; 133(9): 2430. CrossRef - Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022
Dominika Januś, Małgorzata Wójcik, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Monika Kujdowicz, Małgorzata Czogała, Wojciech Górecki, Jerzy B. Starzyk Frontiers in Endocrinology.2023;[Epub] CrossRef - Medullary Thyroid Carcinoma: A Single Institute Experience
Sonal Trivedi, T. Salahuddin, Mohamed Taher Mithi, Priyank Rathod, Arpit Bandi, Shashank J. Pandya, Mohit Sharma, Shailesh Patel, Vikas Warikoo, Ketul Puj, Abhijeet Salunkhe, Keval Patel, Shivam Pandya Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(4): 2884. CrossRef - FNAC (Fine needle aspiration cytology) and histopathological correlation and reclassification of thyroid neoplasm in accordance with WHO classification 2022
Fareeda Joshi, Shreya Hegde Indian Journal of Pathology and Oncology.2023; 10(2): 132. CrossRef - Papillary thyroid carcinoma associated with non‑functioning parathyroid carcinoma with Warthin's tumor of the parotid gland: A case report and brief literature review
Ari Abdullah, Aras Qaradakhy, Yadgar Saeed, Abdulwahid Salih, Seema Karim, Osama Ali, Shko Hassan, Shalaw Nasraldeen, Shvan Mohammed, Fahmi Kakamad Medicine International.2023;[Epub] CrossRef - Warthin-like papillary thyroid carcinoma: a case report and comprehensive review of the literature
Abdel Mouhaymen Missaoui, Fatma Hamza, Wafa Belabed, Manel Mellouli, Mohamed Maaloul, Slim Charfi, Issam Jardak, Tahya Sellami-Boudawara, Nabila Rekik, Mohamed Abid Frontiers in Endocrinology.2023;[Epub] CrossRef - Reevaluating diagnostic categories and associated malignancy risks in thyroid core needle biopsy
Chan Kwon Jung Journal of Pathology and Translational Medicine.2023; 57(4): 208. CrossRef - Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
Ioana Balinisteanu, Monica-Cristina Panzaru, Lavinia Caba, Maria-Christina Ungureanu, Andreea Florea, Ana Maria Grigore, Eusebiu Vlad Gorduza Biomedicines.2023; 11(8): 2143. CrossRef - Deep learning prediction model for central lymph node metastasis in papillary thyroid microcarcinoma based on cytology
Wenhao Ren, Yanli Zhu, Qian Wang, Yuntao Song, Zhihui Fan, Yanhua Bai, Dongmei Lin Cancer Science.2023; 114(10): 4114. CrossRef - Cytology and Histology of Thyroid Nodules: Exploring Novel Insights in the Molecular Era for Enhanced Patient Management
Beatrix Cochand-Priollet, Zahra Maleki Current Oncology.2023; 30(8): 7753. CrossRef - Agrin is a novel oncogenic protein in thyroid cancer
Anna Adamiok‑Ostrowska, Małgorzata Grzanka, Barbara Czarnocka Oncology Letters.2023;[Epub] CrossRef - Analysis of Pathological Features of Thyroid Carcinoma in the Western Yunnan
身吾 王 Advances in Clinical Medicine.2023; 13(10): 15820. CrossRef - Insight of novel biomarkers for papillary thyroid carcinoma through multiomics
Wei Liu, Junkan Zhu, Zhen Wu, Yongxiang Yin, Qiao Wu, Yiming Wu, Jiaojiao Zheng, Cong Wang, Hongyan Chen, Talal Jamil Qazi, Jun Wu, Yuqing Zhang, Houbao Liu, Jingmin Yang, Daru Lu, Xumin Zhang, Zhilong Ai Frontiers in Oncology.2023;[Epub] CrossRef - Identification of NIFTP-Specific mRNA Markers for Reliable Molecular Diagnosis of Thyroid Tumors
So-Yeon Lee, Jong-Lyul Park, Kwangsoon Kim, Ja Seong Bae, Jae-Yoon Kim, Seon-Young Kim, Chan Kwon Jung Endocrine Pathology.2023; 34(3): 311. CrossRef - Somatostatin Receptor Type 2 and Thyroid-Stimulating Hormone Receptor Expression in Oncocytic Thyroid Neoplasms: Implications for Prognosis and Treatment
Andrea Gillis, Rui Zheng-Pywell, Chandler McLeod, Dezhi Wang, John M. Ness, Rachael Guenter, Jason Whitt, Tomas A. Prolla, Herbert Chen, Manuel Lora Gonzalez, Bart Rose, Ricardo V. Lloyd, Renata Jaskula-Sztul, Diana Lin Modern Pathology.2023; 36(12): 100332. CrossRef - Comparison of Treatment and Prognosis Between Follicular Variant
Papillary Thyroid Carcinoma and Classical Papillary Thyroid
Carcinoma
Bing Zhang, Wenming Wu, Jinjing Liu, Zhou Liang, Liang Zong Hormone and Metabolic Research.2023; 55(12): 855. CrossRef - Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
Isabella Merante Boschin, Loris Bertazza, Carla Scaroni, Caterina Mian, Maria Rosa Pelizzo Frontiers in Medicine.2023;[Epub] CrossRef - Utility of the Growth Differentiation Factor-15 in the Differential Diagnosis of Follicular-Patterned Lesions of the Thyroid on Cytopathologic and Histopathologic Samples
Prasanna V Perumal, Neelaiah Siddaraju, Sunil K Saxena, Soundravally Rajendiran, Ramachandra V Bhat Cureus.2023;[Epub] CrossRef - Investigation of pre‐operative demographic, biochemical, sonographic and cytopathological findings in low‐risk thyroid neoplasms
Muzaffer Serdar Deniz, Didem Özdemir, Narin Nasıroğlu İmga, Hüsniye Başer, Fatma Neslihan Çuhacı Seyrek, Ayşegül Aksoy Altınboğa, Oya Topaloğlu, Reyhan Ersoy, Bekir Çakır Clinical Endocrinology.2023; 99(5): 502. CrossRef - Applications of machine and deep learning to thyroid cytology and histopathology: a review
Greg Slabaugh, Luis Beltran, Hasan Rizvi, Panos Deloukas, Eirini Marouli Frontiers in Oncology.2023;[Epub] CrossRef - The Asian Thyroid Working Group, from 2017 to 2023
Kennichi Kakudo, Chan Kwon Jung, Zhiyan Liu, Mitsuyoshi Hirokawa, Andrey Bychkov, Huy Gia Vuong, Somboon Keelawat, Radhika Srinivasan, Jen-Fan Hang, Chiung-Ru Lai Journal of Pathology and Translational Medicine.2023; 57(6): 289. CrossRef - Anaplastic thyroid cancer: Pathogenesis, prognostic factors and genetic landscape (Review)
Abdul-Mohsen Alhejaily, Omar Alhuzim, Yazeed Alwelaie Molecular and Clinical Oncology.2023;[Epub] CrossRef - Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review
Poupak Fallahi, Armando Patrizio, Giulio Stoppini, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Eugenia Balestri, Valeria Mazzi, Chiara Botrini, Gilda Varricchi, Salvatore Ulisse, Marco Ghionzoli, Alessandro Antonelli, Silvia Martina Ferrari Current Oncology.2023; 30(12): 10237. CrossRef - Construction and validation of a nomogram for predicting cervical lymph node metastasis in diffuse sclerosing variant of papillary thyroid carcinoma
Xunyi Lin, Jiaxing Huo, Huan Zhang, Hang Su, Fenghua Zhang Langenbeck's Archives of Surgery.2023;[Epub] CrossRef - A 16-Year Single-Center Series of Trachea Resections for Locally Advanced Thyroid Carcinoma
Julia I. Staubitz-Vernazza, Sina Schwind, Oana Lozan, Thomas J. Musholt Cancers.2023; 16(1): 163. CrossRef - Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer
Yuji Nagayama, Koichiro Hamada Metabolites.2022; 12(12): 1214. CrossRef - Developments to improve outcomes in thyroid surgery
Thomas J. Musholt Innovative Surgical Sciences.2022; 7(3-4): 77. CrossRef - The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure
Tetiana Bogdanova, Serhii Chernyshov, Liudmyla Zurnadzhy, Tatiana I. Rogounovitch, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Sergii Masiuk, Shunichi Yamashita, Vladimir A. Saenko Frontiers in Endocrinology.2022;[Epub] CrossRef
- Clinical Study
- Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms
-
Chan Kwon Jung, Andrey Bychkov, Dong Eun Song, Jang-Hee Kim, Yun Zhu, Zhiyan Liu, Somboon Keelawat, Chiung-Ru Lai, Mitsuyoshi Hirokawa, Kaori Kameyama, Kennichi Kakudo
-
Endocrinol Metab. 2021;36(1):123-133. Published online February 24, 2021
-
DOI: https://doi.org/10.3803/EnM.2020.860
-
-
6,311
View
-
168
Download
-
12
Web of Science
-
13
Crossref
-
Abstract
PDFPubReader ePub
- Background
Assessing nuclear features is diagnostically challenging in the aspect of thyroid pathology. The aim of this study was to determine whether pathologists could distinguish BRAF-like and RAS-like nuclear features morphologically and identify morphological features to differentiate thyroid tumors with RAS-like mutations from encapsulated papillary thyroid carcinoma (PTC) with predominant follicular growth and BRAFV600E mutation.
Methods Representative whole slide images of 16 encapsulated thyroid tumors with predominant follicular growth were reviewed by 12 thyroid pathologists using a web browser-based image viewer. Total nuclear score was calculated from semi-quantitatively scored eight nuclear features. The molecular profile of RAS and BRAF genes was determined by Sanger sequencing.
Results Total nuclear score ranging 0 to 24 could differentiate BRAF-like tumors from RAS-like tumors with a cut-off value of score 14. The interobserver agreement was the highest for the assessment of nuclear pseudoinclusions (NPIs) but the lowest for nuclear elongation and sickle-shaped nuclei. NPIs were found in tumors with BRAFV600E mutation, but not in tumors with RAS-like mutations. Total nuclear scores were significantly higher for tumors with BRAFV600E than for those with RAS-like mutations (P<0.001).
Conclusion Our results suggest that NPIs and high nuclear scores have diagnostic utility as rule-in markers for differentiating PTC with BRAFV600E mutation from benign or borderline follicular tumors with RAS-like mutations. Relaxation of rigid criteria for nuclear features resulted in an overdiagnosis of PTC. Immunostaining or molecular testing for BRAFV600E mutation is a useful adjunct for cases with high nuclear scores to identify true PTC.
-
Citations
Citations to this article as recorded by
- Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study
Chankyung Kim, Shipra Agarwal, Andrey Bychkov, Jen-Fan Hang, Agnes Stephanie Harahap, Mitsuyoshi Hirokawa, Kennichi Kakudo, Somboon Keelawat, Chih-Yi Liu, Zhiyan Liu, Truong Phan-Xuan Nguyen, Chanchal Rana, Huy Gia Vuong, Yun Zhu, Chan Kwon Jung Virchows Archiv.2024; 484(4): 645. CrossRef - Clinicopathologic Features and Cytologic Correlation of ALK-Rearranged Papillary Thyroid Carcinoma: A Series of Eight Cases
Kun-Ping Shih, Yu-Cheng Lee, Jia-Jiun Tsai, Shu-Hui Lin, Chih-Yi Liu, Wan-Shan Li, Chien-Feng Li, Jen-Fan Hang Endocrine Pathology.2024; 35(2): 134. CrossRef - Small Multi-Gene DNA Panel Can Aid in Reducing the Surgical Resection Rate and Predicting the Malignancy Risk of Thyroid Nodules
Moon Young Oh, Hye-Mi Choi, Jinsun Jang, Heejun Son, Seung Shin Park, Minchul Song, Yoo Hyung Kim, Sun Wook Cho, Young Jun Chai, Woosung Chung, Young Joo Park Endocrinology and Metabolism.2024; 39(5): 777. CrossRef - Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study
Agnes Stephanie Harahap, Mutiah Mutmainnah, Maria Francisca Ham, Dina Khoirunnisa, Abdillah Hasbi Assadyk, Husni Cangara, Aswiyanti Asri, Diah Prabawati Retnani, Fairuz Quzwain, Hasrayati Agustina, Hermawan Istiadi, Indri Windarti, Krisna Murti, Muhammad Journal of Pathology and Translational Medicine.2024; 58(6): 299. CrossRef - The Presence of Typical “BRAFV600E-Like” Atypia in Papillary Thyroid Carcinoma is Highly Specific for the Presence of the BRAFV600E Mutation
John Turchini, Loretta Sioson, Adele Clarkson, Amy Sheen, Leigh Delbridge, Anthony Glover, Mark Sywak, Stan Sidhu, Anthony J. Gill Endocrine Pathology.2023; 34(1): 112. CrossRef - Could Oxidative Stress Play a Role in the Development and Clinical Management of Differentiated Thyroid Cancer?
Maria Kościuszko, Angelika Buczyńska, Adam Jacek Krętowski, Anna Popławska-Kita Cancers.2023; 15(12): 3182. CrossRef - Pitfalls in thyroid pathology and the medicolegal aspects of error
David N Poller Diagnostic Histopathology.2023; 29(11): 495. CrossRef - Developing Models to Predict BRAFV600E and RAS Mutational Status in Papillary Thyroid Carcinoma Using Clinicopathological Features and pERK1/2 Immunohistochemistry Expression
Agnes Stephanie Harahap, Imam Subekti, Sonar Soni Panigoro, Asmarinah, Lisnawati, Retno Asti Werdhani, Hasrayati Agustina, Dina Khoirunnisa, Mutiah Mutmainnah, Fajar Lamhot Gultom, Abdillah Hasbi Assadyk, Maria Francisca Ham Biomedicines.2023; 11(10): 2803. CrossRef - The Asian Thyroid Working Group, from 2017 to 2023
Kennichi Kakudo, Chan Kwon Jung, Zhiyan Liu, Mitsuyoshi Hirokawa, Andrey Bychkov, Huy Gia Vuong, Somboon Keelawat, Radhika Srinivasan, Jen-Fan Hang, Chiung-Ru Lai Journal of Pathology and Translational Medicine.2023; 57(6): 289. CrossRef - Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile
Ivana Kholová, Elina Haaga, Jaroslav Ludvik, David Kalfert, Marie Ludvikova Diagnostics.2022; 12(2): 250. CrossRef - Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo Endocrinology and Metabolism.2022; 37(5): 703. CrossRef - Different Threshold of Malignancy for RAS-like Thyroid Tumors Causes Significant Differences in Thyroid Nodule Practice
Kennichi Kakudo Cancers.2022; 14(3): 812. CrossRef - The Incidence of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Meta-Analysis Assessing Worldwide Impact of the Reclassification
Chanchal Rana, Huy Gia Vuong, Thu Quynh Nguyen, Hoang Cong Nguyen, Chan Kwon Jung, Kennichi Kakudo, Andrey Bychkov Thyroid.2021;[Epub] CrossRef
- Thyroid
- Updates in the Pathologic Classification of Thyroid Neoplasms: A Review of the World Health Organization Classification
-
Yanhua Bai, Kennichi Kakudo, Chan Kwon Jung
-
Endocrinol Metab. 2020;35(4):696-715. Published online December 2, 2020
-
DOI: https://doi.org/10.3803/EnM.2020.807
-
-
18,692
View
-
1,369
Download
-
45
Web of Science
-
48
Crossref
-
Abstract
PDFPubReader ePub
- Advances in medical sciences and evidence-based medicine have led to momentous changes in classification and management of thyroid neoplasms. Much progress has been made toward avoiding overdiagnosis and overtreatment of thyroid cancers. The new 2017 World Health Organization (WHO) classification of thyroid neoplasms updated the diagnostic criteria and molecular and genetic characteristics reflecting the biology and behavior of the tumors, and newly introduced the category of borderline malignancy or uncertain malignant potential. Some neoplasms were subclassified, renamed, or redefined as a specific entity. This review introduces changes in the fourth edition WHO classification of thyroid tumors and updates the contemporary diagnosis and classification of thyroid tumors. We also discuss several challenges with the proposal of new diagnostic entities, since they have unique histopathologic and molecular features and clinical relevance.
-
Citations
Citations to this article as recorded by
- Canine thyroid carcinomas: A review with emphasis on comparing the compact subtype of follicular thyroid carcinomas and medullary thyroid carcinomas
Jillian M. Athey, Miranda D. Vieson, Keith Bailey, Dan Rudmann, Wes A. Baumgartner, Kim A. Selting Veterinary Pathology.2024; 61(1): 7. CrossRef - Accuracy and diagnostic performance of the Bethesda system for reporting thyroid cytopathology in a tertiary endocrine surgical referral center in Belgium
Sam Kinet, Hendrik Cornette, Klaas Van Den Heede, Nele Brusselaers, Sam Van Slycke World Journal of Surgery.2024; 48(2): 386. CrossRef - Retrospective study of BRAFV600E mutation and CT features of papillary thyroid carcinoma
Xiaoquan Hong, Juxiang Li, Shaoyin Duan, Youkuang You PeerJ.2024; 12: e16810. CrossRef - “Examining the link between tooth agenesis and papillary thyroid cancer: is there a risk factor?” Observational study
Željana Matošić, Luka Šimunović, Tomislav Jukić, Roko Granić, Senka Meštrović Progress in Orthodontics.2024;[Epub] CrossRef - Research Progress of Tg and TgAb in Lymph Node Metastasis of Papillary Thyroid Carcinoma
月 高 Advances in Clinical Medicine.2024; 14(03): 499. CrossRef - A patient with a rare co‐occurrence of papillary and follicular thyroid carcinomas
Vijayvardhan Kamalumpundi, Erin Meyers, Maisoon Torfah, Marcelo Lima de Gusmão Correia Clinical Case Reports.2024;[Epub] CrossRef - Coexistence of intrathyroid thymic carcinoma and papillary thyroid carcinoma: a case report and literature review
Maryam Vajihinejad, Ali Ataei, Mohammad Pashmchi, Ali Aledavoud, Vahid Zand, Mohammad Ali Broomand, Mohammad Mohammadi, Niloofar Zare Reshkuiyeh Frontiers in Oncology.2024;[Epub] CrossRef - Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers; Part I. Initial Management of Differentiated Thyroid Cancers - Chapter 4. Pathological Diagnosis and Staging after Thyroidectomy 2024
Su-Jin Shin, Hee Young Na, Ho-Cheol Kang, Sun Wook Kim, Dong Gyu Na, Young Joo Park, Young Shin Song, Eun Kyung Lee, Dong-Jun Lim, Yun Jae Chung, Chan Kwon Jung International Journal of Thyroidology.2024; 17(1): 61. CrossRef - Clinical–Pathological Features of Thyroid Neoplasms in Young Patients Diagnosed in a Single Center
Aura Jurescu, Dan Brebu, Alexandra Corina Faur, Octavia Vita, Robert Barna, Adrian Vaduva, Oana Popa, Anca Muresan, Mihaela Iacob, Marioara Cornianu, Remus Cornea Life.2024; 14(6): 696. CrossRef - Clinical, Pathological, and Immunohistochemical Predictors of Cause-Specific Mortality in Papillary Thyroid Cancer: Multivariate Analysis
M. A. Bakarev, A. A. Ivanov, E. L. Lushnikova Bulletin of Experimental Biology and Medicine.2024; 177(3): 353. CrossRef - Molecular Markers in Follicular and Oncocytic Thyroid Carcinomas: Clinical Application of Molecular Genetic Testing
Alicia Belaiche, Grégoire B. Morand, Sena Turkdogan, Esther ShinHyun Kang, Véronique-Isabelle Forest, Marc P. Pusztaszeri, Michael P. Hier, Alex M. Mlynarek, Keith Richardson, Nader Sadeghi, Marco A. Mascarella, Sabrina D. Da Silva, Richard J. Payne Current Oncology.2024; 31(10): 5919. CrossRef - Rare Columnar Cell Variant of Papillary Thyroid Carcinoma with Cervical
Spine Metastasis: A Case Report
Jihye Yu, Goeun Yang, Ha Yeun Oh, Yoon Jong Ryu Current Medical Imaging Reviews.2024;[Epub] CrossRef - Genetic analysis and clinicopathologic features of locally advanced papillary thyroid cancers: a prospective observational study
Zheng Ding, Xuanbin Tao, Xianzhao Deng, Bomin Guo, Jie Kang, Bo Wu, Zhili Yang, Chunyan Chen, Ping Liu, Yingchao Zhang, Youben Fan, Zhiyan Liu Journal of Cancer Research and Clinical Oncology.2023; 149(9): 6303. CrossRef - Intrathyroid thymic carcinoma: clinicopathological features and whole exome sequencing analysis
Jiayu Li, Run Xiang, Yunzhu Li, Qiong Liao, Yang Liu Virchows Archiv.2023; 482(5): 813. CrossRef - Lenvatinib as a Promising Treatment Option for Unresectable Hürthle Cell Carcinoma: A Case Report
Parth S Shirode, Anil D'cruz, Sataksi Chatterjee, Swayambhu Bhandarkar Cureus.2023;[Epub] CrossRef - Histological Variants of Papillary Thyroid Cancer in Relation to Clinical and Morphological Parameters and Prognosis
A. A. Ivanov, M. A. Bakarev, E. L. Lushnikova Bulletin of Experimental Biology and Medicine.2023; 174(5): 647. CrossRef - Molecular profile of follicular tumors of the thyroid gland
D. D. Dolidze, A. V. Shabunin, S. D. Сovantsev, Z. A. Bagateliya, Yu. N. Kobzev, D. L. Rotin, K. A. Mulaeva, M. V. Kovaleva Head and Neck Tumors (HNT).2023; 13(1): 102. CrossRef - The predictive models based on multimodality ultrasonography for the differential diagnosis of thyroid nodules smaller than 10 mm
Gang Li, Sai Ma, Fan Zhang, Chao Jia, Long Liu, Feng Gao, Qiusheng Shi, Rong Wu, Lianfang Du, Fan Li The British Journal of Radiology.2023;[Epub] CrossRef - The Warthin-like variant of papillary thyroid carcinomas: a clinicopathologic analysis report of two cases
Xing Zhao, Yijia Zhang, Pengyu Hao, Mingzhen Zhao, Xingbin Shen Oncologie.2023; 25(5): 581. CrossRef - Giant Anaplastic Thyroid Carcinoma of Sarcomatoid Type with Obstructive Symptoms: A Case Report
Gustavo D Saenz-Poma, Shirley N Cisneros-Chumacero, Juan D Millan-Landeo, Nayra Quispe-Yauri, Alba S Zevallos World Journal of Endocrine Surgery.2023; 15(1): 18. CrossRef - Differentiating Benign from Malignant Thyroid Tumors by Kinase Activity Profiling and Dabrafenib BRAF V600E Targeting
Riet Hilhorst, Adrienne van den Berg, Piet Boender, Tom van Wezel, Tim Kievits, Rik de Wijn, Rob Ruijtenbeek, Willem E. Corver, Hans Morreau Cancers.2023; 15(18): 4477. CrossRef - Agrin is a novel oncogenic protein in thyroid cancer
Anna Adamiok‑Ostrowska, Małgorzata Grzanka, Barbara Czarnocka Oncology Letters.2023;[Epub] CrossRef - Investigation of pre‐operative demographic, biochemical, sonographic and cytopathological findings in low‐risk thyroid neoplasms
Muzaffer Serdar Deniz, Didem Özdemir, Narin Nasıroğlu İmga, Hüsniye Başer, Fatma Neslihan Çuhacı Seyrek, Ayşegül Aksoy Altınboğa, Oya Topaloğlu, Reyhan Ersoy, Bekir Çakır Clinical Endocrinology.2023; 99(5): 502. CrossRef - The Asian Thyroid Working Group, from 2017 to 2023
Kennichi Kakudo, Chan Kwon Jung, Zhiyan Liu, Mitsuyoshi Hirokawa, Andrey Bychkov, Huy Gia Vuong, Somboon Keelawat, Radhika Srinivasan, Jen-Fan Hang, Chiung-Ru Lai Journal of Pathology and Translational Medicine.2023; 57(6): 289. CrossRef - Drug-induced inhibition of HMGA and EZH2 activity as a possible therapy for anaplastic thyroid carcinoma
Marco De Martino, Simona Pellecchia, Myriam Decaussin-Petrucci, Domenico Testa, Nathalia Meireles Da Costa, Pierlorenzo Pallante, Paolo Chieffi, Alfredo Fusco, Francesco Esposito Cell Cycle.2023; 22(23-24): 2552. CrossRef - RESULTS OF A MORPHOLOGICAL STUDY OF THE THYROID GLAND IN PATIENTS WITH AUTOIMMUNE THYROIDITIS
F. G. Sadikhov World of Medicine and Biology.2023; 19(86): 137. CrossRef - Anaplastik Tiroid Karsinomu Tanısında Morfolojik ve İmmünohistokimyasal Bulguların Yeri: 10 Yıllık Seri
Özlem SARAYDAROĞLU, Rabia DÖLEK, Özen ÖZ GÜL, Ercüment GÜRLÜLER Uludağ Üniversitesi Tıp Fakültesi Dergisi.2023; 49(3): 411. CrossRef - The Efficacy of ACR TI-RADS in the Management of Suspected Thyroid Nodules and Its Correlation With the Bethesda Scoring System
Emrah Karatay, Mirkhalig Javadov, Kinyas Kartal Journal of Diagnostic Medical Sonography.2022; 38(4): 309. CrossRef - Systematic evaluation of the anti-tumor effect of Phellinus linteus polysaccharide in thyroid carcinoma in vitro
Kun Yu, Zhuo Tan, Ying Xin Molecular Biology Reports.2022; 49(4): 2785. CrossRef - Clinical Significance of Circulating Tumor Cells (CTCs) and Survivin on Predicting Prognosis in Thyroid Cancer Patients
Xun Weng, YangYang, Yujiao Cai, Fu Wang Disease Markers.2022; 2022: 1. CrossRef - Identification of DPP4/CTNNB1/MET as a Theranostic Signature of Thyroid Cancer and Evaluation of the Therapeutic Potential of Sitagliptin
Sheng-Yao Cheng, Alexander T. H. Wu, Gaber El-Saber Batiha, Ching-Liang Ho, Jih-Chin Lee, Halimat Yusuf Lukman, Mohammed Alorabi, Abdullah N. AlRasheedi, Jia-Hong Chen Biology.2022; 11(2): 324. CrossRef - Retrospective evaluation of radioactive iodine ablation therapy in the Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) and Thyroid tumors with uncertain malignity potential
Mehmet Refik GÖKTUĞ, Özen ÖZ GÜL, Soner CANDER Turkish Journal of Internal Medicine.2022; 4: 88. CrossRef - Extracellular Vesicles as Signal Carriers in Malignant Thyroid Tumors?
Małgorzata Grzanka, Anna Stachurska-Skrodzka, Anna Adamiok-Ostrowska, Ewa Gajda, Barbara Czarnocka International Journal of Molecular Sciences.2022; 23(6): 3262. CrossRef - Thyroid Cancer Detection in a Routine Clinical Setting: Performance of ACR TI-RADS, FNAC, and Molecular Testing in Prospective Cohort Study
Tereza Grimmichova, Petra Pacesova, Martin Hill, Barbora Pekova, Marketa Vankova, Jitka Moravcova, Jana Vrbikova, Zdenek Novak, Karolina Mastnikova, Eliska Vaclavikova, Josef Vcelak, Bela Bendlova, Jana Drozenova, Vlasta Sykorova Biomedicines.2022; 10(5): 954. CrossRef - Advantages of Small Incision Surgery in Thyroid Tumors
Wen Feng, Yuan Feng, Qixian Diao, Jian Zhou, Zhaoqi Dong Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1. CrossRef - Radioactive Iodine Therapy Does not Improve Cancer-specific Survival in Hürthle Cell Carcinoma of the Thyroid
Xiaofei Wang, Xun Zheng, Jingqiang Zhu, Zhihui Li, Tao Wei The Journal of Clinical Endocrinology & Metabolism.2022; 107(11): 3144. CrossRef - Latency Trend Analysis as a Guide to Screening Malignancy Survivors for Second Primary Thyroid Cancer
Mohammad Hussein, Lauren Mueller, Peter P. Issa, Muhib Haidari, Lily Trinh, Eman Toraih, Emad Kandil Biomedicines.2022; 10(8): 1984. CrossRef - Ultrasonographic characteristics of Hürthle cell neoplasms: prediction of malignancy
Min Je Kim, Jung Hee Shin, Soo Yeon Hahn, Young Lyun Oh, Sun Wook Kim, Tae Hyuk Kim, Yaeji Lim, Sanghyuk Lee Ultrasonography.2022; 41(4): 689. CrossRef - Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo Endocrinology and Metabolism.2022; 37(5): 703. CrossRef - A Matched-Pair Analysis of Nuclear Morphologic Features Between Core Needle Biopsy and Surgical Specimen in Thyroid Tumors Using a Deep Learning Model
Faridul Haq, Andrey Bychkov, Chan Kwon Jung Endocrine Pathology.2022; 33(4): 472. CrossRef - Clinicopathological features and prognostic factors analysis of multiple synchronous distinct subtypes of primary thyroid carcinoma
Quanwei Dai, Xinghao Fu, Yalei Ding, Qi He, Xinguang Qiu Endocrine.2022; 79(3): 491. CrossRef - Prevalence of Thyroid Lesions in Thyroidectomy Specimens - A Histomorphological Study in Urban Industrial Area
Shirish Sahebrao Chandanwale, Diva Sutreja, Payal Patel, Anubhaw Verma, Sushma Kulkarni Journal of Head & Neck Physicians and Surgeons.2022; 10(1): 80. CrossRef - Best Achievements in Clinical Thyroidology in 2020
Eun Kyung Lee, Young Joo Park Endocrinology and Metabolism.2021; 36(1): 30. CrossRef - High Prevalence of DICER1 Mutations and Low Frequency of Gene Fusions in Pediatric Follicular-Patterned Tumors of the Thyroid
Ja-Seong Bae, Seung-Hyun Jung, Mitsuyoshi Hirokawa, Andrey Bychkov, Akira Miyauchi, Sohee Lee, Yeun-Jun Chung, Chan Kwon Jung Endocrine Pathology.2021; 32(3): 336. CrossRef - Deep Learning Fast Screening Approach on Cytological Whole Slides for Thyroid Cancer Diagnosis
Yi-Jia Lin, Tai-Kuang Chao, Muhammad-Adil Khalil, Yu-Ching Lee, Ding-Zhi Hong, Jia-Jhen Wu, Ching-Wei Wang Cancers.2021; 13(15): 3891. CrossRef - How to identify indolent thyroid tumors unlikely to recur and cause cancer death immediately after surgery—Risk stratification of papillary thyroid carcinoma in young patients—
Kennichi Kakudo, Zhiyan Liu, Yanhua Bai, Yaqiong Li, Naomi Kitayama, Shinya Satoh, Masahiro Nakashima, Chan Kwon Jung Endocrine Journal.2021; 68(8): 871. CrossRef - Papillary Thyroid Cancer Prognosis: An Evolving Field
Salvatore Ulisse, Enke Baldini, Augusto Lauro, Daniele Pironi, Domenico Tripodi, Eleonora Lori, Iulia Catalina Ferent, Maria Ida Amabile, Antonio Catania, Filippo Maria Di Matteo, Flavio Forte, Alberto Santoro, Piergaspare Palumbo, Vito D’Andrea, Salvator Cancers.2021; 13(21): 5567. CrossRef - Intrasalivary Thymic Carcinoma: A Case Report and Literature Review
Michał Kunc, Alexandra Kamieniecki, Grzegorz Walczak, Tomasz Nowicki, Bartosz Wasąg, Bogusław Mikaszewski, Dominik Stodulski, Wojciech Biernat Head and Neck Pathology.2021; 16(3): 857. CrossRef
|