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Keisuke Enomoto 1 Article
Thyroid
Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer
Keisuke Enomoto, Muneki Hotomi
Endocrinol Metab. 2020;35(2):227-236.   Published online June 24, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.2.227
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AbstractAbstract PDFPubReader   ePub   
Thyroid cancer cells have a high amino acid demand for proliferation, invasion, and metastasis. Amino acids are taken up by thyroid cancer cells, both thyroid follicular cell and thyroid parafollicular cells (commonly called “C-cells”), via amino acid transporters. Amino acid transporters up-regulate in many cancers, and their expression level associate with clinical aggressiveness and prognosis. This is the review to discuss the therapeutic potential of amino acid transporters and as molecular targets in thyroid cancer.

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