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Endocrinol Metab : Endocrinology and Metabolism


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Jung Woo Han  (Han JW) 1 Article
Clinical Study
Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
Ji Sun Nam, Jung Woo Han, Sang Bae Lee, Ji Hong You, Min Jin Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn
Endocrinol Metab. 2018;33(3):364-371.   Published online September 18, 2018
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  • 6 Crossref
AbstractAbstract PDFPubReader   ePub   

Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.


Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.


Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.


Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.


Citations to this article as recorded by  
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  • Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus
    Yuwei Dong, Gongping Huang, Xin Wang, Zhaoming Chu, Jingzhi Miao, Houwen Zhou, Mingqing Xu
    PLOS ONE.2020; 15(10): e0241078.     CrossRef
  • Association of three SNPs in adiponectin gene with lipid traits of Tianzhu Black Muscovy (Cairina moschata)
    Yuan-Yu Qin, Yi-Yu Zhang, Hua-Lun Luo, Lei Wu
    Molecular Biology Reports.2019; 46(1): 325.     CrossRef
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