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Jung Mi Chang  (Chang JM) 1 Article
Preoperative Localization and Intraoperative Parathyroid Hormone Assay in Korean Patients with Primary Hyperparathyroidism
Eirie Cho, Jung Mi Chang, Seok Young Yoon, Gil Tae Lee, Yun Hyi Ku, Hong Il Kim, Myung-Chul Lee, Guk Haeng Lee, Min Joo Kim
Endocrinol Metab. 2014;29(4):464-469.   Published online December 29, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.4.464
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  • 33 Download
  • 8 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   
Background

The intraoperative parathyroid hormone (IOPTH) assay is widely used in patients with primary hyperparathyroidism (PHPT). We investigated the usefulness of the IOPTH assay in Korean patients with PHPT.

Methods

We retrospectively reviewed the data of 33 patients with PHPT who underwent parathyroidectomy. Neck ultrasonography (US) and 99mTc-sestamibi scintigraphy (MIBI scan) were performed preoperatively and IOPTH assays were conducted.

Results

The sensitivity of neck US and MIBI scans were 91% and 94%, respectively. A 50% decrease in parathyroid hormone (PTH) levels 10 minutes after excision of the parathyroid gland was obtained in 91% (30/33) of patients and operative success was achieved in 97% (32/33) of patients. The IOPTH assay was 91% true-positive, 3% true-negative, 0% false-positive, and 6% false-negative. The overall accuracy of the IOPTH assay was 94%. In five cases with discordant neck US and MIBI scan results, a sufficient decrease in IOPTH levels helped the surgeon confirm the complete excision of the parathyroid gland with no additional neck exploration.

Conclusion

The IOPTH assay is an accurate tool for localizing hyperfunctioning parathyroid glands and is helpful for evaluating cases with discordant neck US and MIBI scan results.

Citations

Citations to this article as recorded by  
  • Single-Center Experience of Parathyroidectomy Using Intraoperative Parathyroid Hormone Monitoring
    Seong Hoon Kim, Si Yeon Lee, Eun Ah Min, Young Mi Hwang, Yun Suk Choi, Jin Wook Yi
    Medicina.2022; 58(10): 1464.     CrossRef
  • The natural history and hip geometric changes of primary hyperparathyroidism without parathyroid surgery
    Kyong Yeun Jung, A. Ram Hong, Dong Hwa Lee, Jung Hee Kim, Kyoung Min Kim, Chan Soo Shin, Seong Yeon Kim, Sang Wan Kim
    Journal of Bone and Mineral Metabolism.2017; 35(3): 278.     CrossRef
  • The utility of the radionuclide probe in parathyroidectomy for primary hyperparathyroidism
    MS Lim, M Jinih, CH Ngai, NM Foley, HP Redmond
    The Annals of The Royal College of Surgeons of England.2017; 99(5): 369.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
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