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Jung Il Choi  (Choi JI) 3 Articles
Curcumin Enhances Docetaxel-Induced Apoptosis of 8505C Anaplastic Thyroid Carcinoma Cells
Jung Min Hong, Chan Sung Park, Il Seong Nam-Goong, Yon Seon Kim, Jong Cheol Lee, Myung Weol Han, Jung Il Choi, Young Il Kim, Eun Sook Kim
Endocrinol Metab. 2014;29(1):54-61.   Published online March 14, 2014
  • 4,042 View
  • 33 Download
  • 27 Web of Science
  • 27 Crossref
AbstractAbstract PDFPubReader   

Anaplastic thyroid cancer (ATC) is one of the most aggressive malignancies in humans, and its progression is poorly controlled by existing therapeutic methods. Curcumin has been shown to suppress inflammation and angiogenesis. In this study, we evaluated whether curcumin could augment docetaxel-induced apoptosis of ATC cells. We also analyzed changes in nuclear factor κB (NF-κB) and cyclooxygenase-2 (COX-2) expression levels to delineate possible mechanisms of their combined action.


ATC cells were cultured and treated with curcumin and docetaxel alone or in combination. The effects on cell viability were determined by MTS assay. Apoptosis was assessed by annexin V staining and confirmed by flow cytometric analysis. Caspase, COX-2, NF-κB levels were assayed by Western blotting.


Curcumin combined with docetaxel led to lower cell viability than treatment with docetaxel or curcumin alone. Annexin V staining followed by flow cytometric analysis demonstrated that curcumin treatment enhanced the docetaxel-induced apoptosis of ATC cells. Additionally, curcumin inhibited docetaxel-induced p65 activation and COX-2 expression.


We conclude that curcumin may enhance docetaxel's antitumor activity in ATC cells by interfering with NF-κB and COX-2. Our results suggest that curcumin may emerge as an attractive therapeutic candidate to enhance the antitumor activity of taxanes in ATC treatment.


Citations to this article as recorded by  
  • Research progress of plant-derived natural products in thyroid carcinoma
    Qiujing Du, Weidong Shen
    Frontiers in Chemistry.2024;[Epub]     CrossRef
  • Promising Approaches in Plant-Based Therapies for Thyroid Cancer: An Overview of In Vitro, In Vivo, and Clinical Trial Studies
    Ilona Kaczmarzyk, Martyna Nowak-Perlak, Marta Woźniak
    International Journal of Molecular Sciences.2024; 25(8): 4463.     CrossRef
  • Size-Controlled Preparation of Docetaxel- and Curcumin-Loaded Nanoemulsions for Potential Pulmonary Delivery
    Azren Aida Asmawi, Norazlinaliza Salim, Emilia Abdulmalek, Mohd Basyaruddin Abdul Rahman
    Pharmaceutics.2023; 15(2): 652.     CrossRef
  • In Vitro Evaluation of Anti-cancer Properties of Hongyoung on SNU-80 Anaplastic Thyroid Carcinoma Cell Line
    Gaeun Kim, Eun-Jung Kim
    Biomedical Science Letters.2023; 29(4): 321.     CrossRef
  • Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders
    Farzaneh Shakeri, Bahram Bibak, Mohammad Reza Safdari, Zakieh Keshavarzi, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
    Current Medicinal Chemistry.2022; 29(16): 2878.     CrossRef
  • Anticancer effects of natural phytochemicals in anaplastic thyroid cancer (Review)
    Yitian Li, Jing Zhang, Huihui Zhou, Zhen Du
    Oncology Reports.2022;[Epub]     CrossRef
  • Lactoferrin-dual drug nanoconjugate: Synergistic anti-tumor efficacy of docetaxel and the NF-κB inhibitor celastrol
    Mona A. Abdelmoneem, Mahmoud M. Abd Elwakil, Sherine N. Khattab, Maged W. Helmy, Adnan A. Bekhit, Mohammad A. Abdulkader, Amira Zaky, Mohamed Teleb, Kadria A. Elkhodairy, Fernando Albericio, Ahmed O. Elzoghby
    Materials Science and Engineering: C.2021; 118: 111422.     CrossRef
  • Phytochemicals in thyroid cancer: analysis of the preclinical studies
    Stefania Bulotta, Francesca Capriglione, Marilena Celano, Valeria Pecce, Diego Russo, Valentina Maggisano
    Endocrine.2021; 73(1): 8.     CrossRef
  • Danshen Extracts Prevents Obesity and Activates Mitochondrial Function in Brown Adipose Tissue
    Yoon Hee Cho, Cheol Ryong Ku, Young-Suk Choi, Hyeon Jeong Lee, Eun Jig Lee
    Endocrinology and Metabolism.2021; 36(1): 185.     CrossRef
  • Plant natural products with anti-thyroid cancer activity
    Javad Sharifi-Rad, Sadegh Rajabi, Miquel Martorell, Maria Dolores López, María Trinidad Toro, Susi Barollo, Decio Armanini, Patrick Valere Tsouh Fokou, Giuseppe Zagotto, Giovanni Ribaudo, Raffaele Pezzani
    Fitoterapia.2020; 146: 104640.     CrossRef
  • Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design
    Azren Aida Asmawi, Norazlinaliza Salim, Emilia Abdulmalek, Mohd Basyaruddin Abdul Rahman
    International Journal of Molecular Sciences.2020; 21(12): 4357.     CrossRef
  • Excipient selection and aerodynamic characterization of nebulized lipid-based nanoemulsion loaded with docetaxel for lung cancer treatment
    Azren Aida Asmawi, Norazlinaliza Salim, Cheng Loong Ngan, Haslina Ahmad, Emilia Abdulmalek, Mas Jaffri Masarudin, Mohd Basyaruddin Abdul Rahman
    Drug Delivery and Translational Research.2019; 9(2): 543.     CrossRef
  • Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells
    Faezeh Ghasemi, Mojtaba Shafiee, Zarrin Banikazemi, Mohammad Hossein Pourhanifeh, Hashem Khanbabaei, Amir Shamshirian, Shirin Amiri Moghadam, Reza ArefNezhad, Amirhossein Sahebkar, Amir Avan, Hamed Mirzaei
    Pathology - Research and Practice.2019; 215(10): 152556.     CrossRef
  • Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers
    Hye-Ji Shin, Kyung-A Hwang, Kyung-Chul Choi
    Nutrients.2019; 11(1): 125.     CrossRef
  • Radiosensitization effects of curcumin plus cisplatin on non‑small cell lung cancer A549 cells
    Yong Cai, Zhaoying Sheng, Shixiong Liang
    Oncology Letters.2019;[Epub]     CrossRef
  • Combined Effects of Baicalein and Docetaxel on Apoptosis in 8505c Anaplastic Thyroid Cancer Cells via Downregulation of the ERK and Akt/mTOR Pathways
    Chan Ho Park, Se Eun Han, Il Seong Nam-Goong, Young Il Kim, Eun Sook Kim
    Endocrinology and Metabolism.2018; 33(1): 121.     CrossRef
  • Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells
    Suzan Schwertheim, Frederik Wein, Klaus Lennartz, Karl Worm, Kurt Werner Schmid, Sien-Yi Sheu-Grabellus
    Journal of Cancer Research and Clinical Oncology.2017; 143(7): 1143.     CrossRef
  • Enhanced Radiosensitization Effect of Curcumin Delivered by PVP-PCL Nanoparticle in Lung Cancer
    Cuixia Wen, Yun Zhou, Chong Zhou, Yifan Zhang, Xiang Hu, Jun Li, Haitao Yin
    Journal of Nanomaterials.2017; 2017: 1.     CrossRef
  • Synergistic anticancer effect of curcumin and chemotherapy regimen FP in human gastric cancer MGC-803 cells
    Bin He, Wen Wei, Ji Liu, Yundan Xu, Gang Zhao
    Oncology Letters.2017; 14(3): 3387.     CrossRef
  • Pharmacokinetic effects of curcumin on docetaxel mediated by OATP1B1, OATP1B3 and CYP450s
    Xiaolin Sun, Junxiu Li, Chaorui Guo, Han Xing, Jie Xu, Yanli Wen, Zhixia Qiu, Qiuyang Zhang, Yi Zheng, Xijing Chen, Di Zhao
    Drug Metabolism and Pharmacokinetics.2016; 31(4): 269.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
  • Targeting the NF-κB Pathway as a Combination Therapy for Advanced Thyroid Cancer
    Nikita Pozdeyev, Adam Berlinberg, Qiong Zhou, Kelsey Wuensch, Hiroyuki Shibata, William M. Wood, Bryan R. Haugen, Jacques Emile Dumont
    PLOS ONE.2015; 10(8): e0134901.     CrossRef
  • Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: A review
    Kashif Mahmood, Khalid Mahmood Zia, Mohammad Zuber, Mahwish Salman, Muhammad Naveed Anjum
    International Journal of Biological Macromolecules.2015; 81: 877.     CrossRef
  • Ubiquitin modification in otolaryngology
    Masanobu Suzuki, Masashi Watanabe, Yuji Nakamaru, Dai Takagi, Satoshi Kano, Aya Homma, Shigetsugu Hatakeyama, Satoshi Fukuda
    Journal of Japan Society of Immunology & Allergology in Otolaryngology.2015; 33(3): 185.     CrossRef
  • Radiolabeled Polymeric Nanoconstructs Loaded with Docetaxel and Curcumin for Cancer Combinatorial Therapy and Nuclear Imaging
    Cinzia Stigliano, Jaehong Key, Maricela Ramirez, Santosh Aryal, Paolo Decuzzi
    Advanced Functional Materials.2015; 25(22): 3371.     CrossRef
  • The Multifaceted Role of Curcumin in Cancer Prevention and Treatment
    Muthu Shanmugam, Grishma Rane, Madhu Kanchi, Frank Arfuso, Arunachalam Chinnathambi, M. Zayed, Sulaiman Alharbi, Benny Tan, Alan Kumar, Gautam Sethi
    Molecules.2015; 20(2): 2728.     CrossRef
  • Curcumin inhibits the invasion of thyroid cancer cells via down-regulation of PI3K/Akt signaling pathway
    XiaoBo Xu, Jian Qin, WenYong Liu
    Gene.2014; 546(2): 226.     CrossRef
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Suppression of Pathogenic Autoreactive CD4+ T Cells by CD137-mediated Expansion of CD4+CD25+ Regulatory T Cells in Graves' Disease.
Eun Sook Kim, Hyo Won Jung, Jung Il Choi, Il Seung Nam-Goong, Soon Hyung Hong, Young Il Kim
J Korean Endocr Soc. 2007;22(5):332-338.   Published online October 1, 2007
  • 1,841 View
  • 22 Download
  • 1 Crossref
AbstractAbstract PDF
Graves' disease (GD) is an organ-specific autoimmune disease that is characterized by lymphocyte infiltration of the thyroid, which finally leads to follicular destruction. The CD4+CD25+ regulatory T cells are important for maintaining peripheral tolerance to self-antigens and impaired activity can cause autoimmune diseases. CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily and expressed on activated T cells, is a candidate molecule for a co-stimulatory role in autoimmune thyroid disease. In this study, we aimed to assay the frequency of CD4+CD25+ T cells in GD patients and to investigate the role of CD137-mediated costimulation in CD4+CD25+ T cells. METHODS: The frequencies of the CD4+CD25+ T cells in the peripheral blood (PB) of GD patients were determined by flow cytometric analysis. After the CD4+CD25+ T cells were isolated from PB mononuclear cells (PBMC) of the GD patients using immunomagnetic beads, the functional activity of the CD4+CD25+ T cells was characterized by use of a proliferation assay. mRNA expression of Foxp 3 in the CD4+CD25+ T cells of the GD patients was observed by real-time RT-PCR. RESULTS: In this study, we found that GD patients had a low proportion of CD4+CD25+ T cells (mean +/- SD; 1.47 +/- 0.31%) in PBMC as compared with normal subjects. CD137-mediated costimulation increased the expression of CD25 and Foxp 3 in CD4+ T cells in GD patients as compared with normal subjects. Moreover, the CD137-mediated costimulation also induced the proliferation of CD4+CD25+ T cells in GD patients, and the expanded CD4+CD25+ T cells could suppress other CD4+CD25- T cells in a co-culture. CONCLUSION: These results suggest that the peripheral expansion of CD4+CD25+ T cells by CD137-mediated co-stimulation can suppress effector T cells and may be a potent therapy for Graves' disease.


Citations to this article as recorded by  
  • Effects of Gastrodia elata Blume on Apoptotic Cell Death of Liver Cancer Cells by Expression of Bcl-2, Bax, and AMPKα
    Jae Hyun Park, Min Ho Kang, Ji Woo Hong, So Hee Kim, Yoon Seon Hwang, Jae Hoon Park, Jin Woo Kim
    Korean Journal of Medicinal Crop Science.2022; 30(5): 311.     CrossRef
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Expression of 4-1BB and 4-1BBL in Graves'Disease.
Eun Sook Kim, Hyo Won Jung, Il Sung Nam-Goong, Soon Joo Woo, Jung Il Choi, Young Il Kim
J Korean Endocr Soc. 2006;21(2):116-124.   Published online April 1, 2006
  • 1,888 View
  • 22 Download
  • 1 Crossref
AbstractAbstract PDF
4-1BB mediated costimulatory signal is a recently identified immunotherapeutic strategy for treating autoimmune diseases without depressing the immune response. In this study, we investigated the expression of 4-1BB and 4-1BBL on the peripheral blood mononuclear cells (PBMC) and we assessed whether the serum levels of soluble (s) 4-1BB and s4-1BBL in the patients with Graves' disease (GD) and compared them with normal subjects. METHODS: Expression of 4-1BB and 4-1BBL on PBMC of GD patients was determined by flow cytometry. The concentrations of s4-1BB and s4-1BBL were assessed in the sera of GD patients by performing ELISA. RESULTS: 4-1BB was constitutively expressed on naive CD4+ and CD8+ T cells of the GD patients and this was increased by stimulation. 4-1BBL was also expressed on the antigen-presenting cells such as CD19+ B cells, monocytes and dendritic cells in GD patients. The serum levels of s4-1BB and s4-1BBL were significantly higher in GD patients than those in controls, and these levels were significantly correlated with the serum levels of thyroid-binding inhibitory immunoglobulin and free T4. CONCLUSION: These results indicate that effector T cells of GD patients can be activated through the 4-1BB-mediated costimulatory signal. Elevated s4-1BB and s4-1BBL levels in the sera of GD patients may affect modulation of the clinical course in GD patients.


Citations to this article as recorded by  
  • Suppression of Pathogenic Autoreactive CD4+ T Cells by CD137-mediated Expansion of CD4+CD25+ Regulatory T Cells in Graves' Disease
    Eun Sook Kim, Hyo Won Jung, Jung Il Choi, Il Seung Nam-Goong, Soon Hyung Hong, Young IL Kim
    Journal of Korean Endocrine Society.2007; 22(5): 332.     CrossRef
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