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Jung Hwan Baek  (Baek JH) 12 Articles
Thyroid
Thyroid Cancer Screening
Thyroid Cancer Screening: How to Maximize Its Benefits and Minimize Its Harms
Jung Hwan Baek
Endocrinol Metab. 2023;38(1):75-77.   Published online February 27, 2023
DOI: https://doi.org/10.3803/EnM.2023.105
  • 1,009 View
  • 104 Download
  • 1 Web of Science
  • 1 Crossref
PDFPubReader   ePub   

Citations

Citations to this article as recorded by  
  • Multidimensional Prediction Method for Thyroid Cancer Based on Spatiotemporally Imbalanced Distribution Data
    Zhiwei Jia, Yuqi Huang, Yanhui Lin, Min Fu, Chenhao Sun
    IEEE Access.2024; 12: 4674.     CrossRef
Close layer
Clinical Study
Long-Term Results of Thermal Ablation of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis
Se Jin Cho, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
Endocrinol Metab. 2020;35(2):339-350.   Published online June 24, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.2.339
  • 10,201 View
  • 304 Download
  • 37 Web of Science
  • 41 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Ultrasound-guided thermal ablations have become one of the main options for treating benign thyroid nodules. To determine efficacy of thermal ablation of benign thyroid nodules, we performed a meta-analysis of studies with long-term follow-up of more than 3 years.
Methods
Databases were searched for studies published up to August 25, 2019, reporting patients with benign thyroid nodules treated with thermal ablation and with follow-up data of more than 3 years. Data extraction and quality assessment were performed according to PRISMA guidelines. The analysis yielded serial volume reduction rates (VRRs) of ablated nodules for up to 3 years or more, and adverse effect of ablation during follow-up. Radiofrequency ablation (RFA) and laser ablation (LA) were compared in a subgroup analysis.
Results
The pooled VRRs for ablated nodules showed rapid volume reduction before 12 months, a plateau from 12 to 36 months, and more volume reduction appearing after 36 months, demonstrating long-term maintenance of treatment efficacy. Thermal ablation had an acceptable complication rate of 3.8%. Moreover, patients undergoing nodule ablation showed no unexpected delayed complications during the follow-up period. In the subgroup analysis, RFA was shown to be superior to LA in terms of the pooled VRR and the number of patients who underwent delayed surgery.
Conclusion
Thermal ablations are safe and effective methods for treating benign thyroid nodules, as shown by a long follow-up analysis of more than 3 years. In addition, RFA showed superior VRRs compared with LA for the treatment of benign thyroid nodules, with less regrowth and less delayed surgery.

Citations

Citations to this article as recorded by  
  • Five-year follow-up results of thermal ablation for benign thyroid nodules: Systematic review and meta-analysis
    Xidong Xu, Ying Peng, Guoxin Han
    American Journal of Otolaryngology.2024; 45(1): 104025.     CrossRef
  • Radiofrequency Ablation for Benign Nodules and for Cancer, Too?
    Jonathon O. Russell, Kaitlyn M. Frazier
    Otolaryngologic Clinics of North America.2024; 57(1): 83.     CrossRef
  • An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules
    Tim Boers, Wyger Brink, Leonardo Bianchi, Paola Saccomandi, Johan van Hespen, Germen Wennemars, Sicco Braak, Michel Versluis, Srirang Manohar
    Medical Physics.2024; 51(2): 826.     CrossRef
  • The safety and efficacy of radiofrequency ablation in benign pediatric thyroid disease in the US: An initial case series
    Grace S. Kim, Hilary Seeley, Julia Noel, Iram Ahmad, Kara Meister
    Laryngoscope Investigative Otolaryngology.2024;[Epub]     CrossRef
  • Radioiodine versus radiofrequency ablation to treat autonomously functioning thyroid nodules: a systematic review and comparative meta-analysis
    Luca Giovanella, Maria Luisa Garo, Alfredo Campenní, Petra Petranović Ovčariček
    European Journal of Nuclear Medicine and Molecular Imaging.2024;[Epub]     CrossRef
  • Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends
    Tim Boers, Sicco J. Braak, Nicole E. T. Rikken, Michel Versluis, Srirang Manohar
    Journal of Clinical Ultrasound.2023; 51(6): 1087.     CrossRef
  • Ultrasound (US)-Guided Ablation of Thyroid Nodules
    Byung Seup Kim
    Journal of Surgical Ultrasound.2023; 10(1): 14.     CrossRef
  • Ultrasound-Guided Radiofrequency Ablation versus Thyroidectomy for the Treatment of Benign Thyroid Nodules in Elderly Patients: A Propensity-Matched Cohort Study
    L. Yan, X.Y. Li, Y. Li, Y. Luo
    American Journal of Neuroradiology.2023; 44(6): 693.     CrossRef
  • Minimally Invasive Ablative Treatments for Benign Thyroid Nodules: Current Evidence and Future Directions
    Enrico Papini, Laszlo Hegedüs
    Thyroid®.2023; 33(8): 890.     CrossRef
  • Influence factors and nomogram for volume reduction rate in benign thyroid nodule after thermal ablation
    Shiliang Cao, Lijia Wang, Ying Wei, Zhenlong Zhao, Jie Wu, Mingan Yu
    International Journal of Hyperthermia.2023;[Epub]     CrossRef
  • Choice in Ablative Therapies for Thyroid Nodules
    Q Lina Hu, Jennifer H Kuo
    Journal of the Endocrine Society.2023;[Epub]     CrossRef
  • 2022 Taiwan clinical multicenter expert consensus and recommendations for thyroid radiofrequency ablation
    Wei-Che Lin, Wen-Chieh Chen, Pei-Wen Wang, Yi-Chia Chan, Yen-Hsiang Chang, Harn-Shen Chen, Szu-Tah Chen, Wei-Chih Chen, Kai-Lun Cheng, Shun-Yu Chi, Pi-Ling Chiang, Chen-Kai Chou, Feng-Fu Chou, Shun-Chen Huang, Feng-Hsuan Liu, Sheng-Dean Luo, Fen-Yu Tseng,
    Ultrasonography.2023; 42(3): 357.     CrossRef
  • Comparison of the Efficiency of Radiofrequency and Microwave Ablation Methods in the Treatment of Benign Thyroid Nodules
    Mahi N. Cerit, Cem Yücel, Ethem T. Cerit, Mehmet M. Yalçın, Halit N. Şendur, Suna Ö. Oktar
    Academic Radiology.2023; 30(10): 2172.     CrossRef
  • Radiofrequency ablation for autonomously functioning nodules as treatment for hyperthyroidism: subgroup analysis of toxic adenoma and multinodular goitre and predictors for treatment success
    M. M. D. van der Meeren, F. B. M. Joosten, S. H. P. P. Roerink, L. N. Deden, W. J. G. Oyen
    European Journal of Nuclear Medicine and Molecular Imaging.2023; 50(12): 3675.     CrossRef
  • Massive Hemorrhage and Mortality Following Thyroid Radiofrequency Ablation
    Seulki Song, Jin Pyeong Kim
    Ear, Nose & Throat Journal.2023;[Epub]     CrossRef
  • Clinical Approach for Thyroid Radiofrequency Ablation
    Jung Suk Sim
    Journal of the Korean Society of Radiology.2023; 84(5): 1017.     CrossRef
  • General Principles for the Safe Performance, Training, and Adoption of Ablation Techniques for Benign Thyroid Nodules: An American Thyroid Association Statement
    Catherine F. Sinclair, Jung Hwan Baek, Kathleen E. Hands, Steven P. Hodak, Timothy C. Huber, Iram Hussain, Brian Hung-Hin Lang, Julia E. Noel, Maria Papaleontiou, Kepal N. Patel, Gilles Russ, Jonathon Russell, Stefano Spiezia, Jennifer H. Kuo
    Thyroid®.2023; 33(10): 1150.     CrossRef
  • A comprehensive review of interventional ablation techniques for the management of thyroid nodules and metastatic lymph nodes
    Jennifer H. Kuo, Catherine F. Sinclair, Brian Lang, Stefano Spiezia, Mingan Yu, Eun Ju Ha, Dong Gyu Na, Chiara Offi, Kepal N. Patel, Jung Hwan Baek
    Surgery.2022; 171(4): 920.     CrossRef
  • Radiofrequency ablation and related ultrasound‐guided ablation technologies for treatment of benign and malignant thyroid disease: An international multidisciplinary consensus statement of the American Head and Neck Society Endocrine Surgery Section with
    Lisa A. Orloff, Julia E. Noel, Brendan C. Stack, Marika D. Russell, Peter Angelos, Jung Hwan Baek, Kevin T. Brumund, Feng‐Yu Chiang, Mary Beth Cunnane, Louise Davies, Andrea Frasoldati, Anne Y. Feng, Laszlo Hegedüs, Ayaka J. Iwata, Emad Kandil, Jennifer K
    Head & Neck.2022; 44(3): 633.     CrossRef
  • Assessment of thyroid-specific quality of life in patients with benign symptomatic thyroid nodules treated with radiofrequency or ethanol ablation: a prospective multicenter study
    So Yeong Jeong, Eun Ju Ha, Jung Hwan Baek, Tae Yong Kim, Yu-Mi Lee, Jeong Hyun Lee, Jeonghun Lee
    Ultrasonography.2022; 41(1): 204.     CrossRef
  • Thyroid Nodule Radiofrequency Ablation: Complications and Clinical Follow Up
    James Y. Lim, Jennifer H. Kuo
    Techniques in Vascular and Interventional Radiology.2022; 25(2): 100824.     CrossRef
  • Radiofrequency Ablation of Solid, Non-Functional Thyroid Nodules
    Michael Douek
    Techniques in Vascular and Interventional Radiology.2022; 25(2): 100821.     CrossRef
  • Efficacy and Safety of Thermal Ablation for Treating Lymph Node Metastasis From Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
    Zheng Ding, Juan Chen, Zhiguang Chen, Xiaoke Zeng, Pengchao Zheng, Xuemei Wang, Xinwu Cui, Liang Sang
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Intraoperative Neuromonitoring: Evaluating the Role of Continuous IONM and IONM Techniques for Emerging Surgical and Percutaneous Procedures
    Catherine McManus, Jennifer Hong Kuo
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Thermal Ablation for the Management of Papillary Thyroid Microcarcinoma in the Era of Active Surveillance and Hemithyroidectomy
    Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Jeong Hyun Lee
    Current Oncology Reports.2022; 24(8): 1045.     CrossRef
  • enhanced anarchic society optimization technique for the classification of ultrasound thyroid images using ILBP
    D. Anitha, S. Sathya Priya
    International journal of health sciences.2022; : 4713.     CrossRef
  • Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors
    Arian Mansur, Tushar Garg, Apurva Shrigiriwar, Vahid Etezadi, Christos Georgiades, Peiman Habibollahi, Timothy C. Huber, Juan C. Camacho, Sherif G. Nour, Alan Alper Sag, John David Prologo, Nariman Nezami
    Diagnostics.2022; 12(6): 1300.     CrossRef
  • Efficacy and safety of ultrasound-guided microwave ablation versus surgical resection for Bethesda category IV thyroid nodules: A retrospective comparative study
    Jingjing Yang, Ya Zhang, Xingjia Li, Yueting Zhao, Xue Han, Guofang Chen, Xiaoqiu Chu, Ruiping Li, Jianhua Wang, Fei Huang, Chao Liu, Shuhang Xu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Long-term follow-up of the radiofrequency ablation of benign thyroid nodules: the value of additional treatment
    Hyun Jin Kim, Jung Hwan Baek, Woojin Cho, Jung Suk Sim
    Ultrasonography.2022; 41(4): 661.     CrossRef
  • Das „heiße“ Schilddrüsenkarzinom mit einem kritischen Blick auf die Thermoablation
    Joachim Jähne, Andreas Niesen, Joachim Bernhardts, Marija Hillemans
    Der Chirurg.2021; 92(1): 34.     CrossRef
  • Current Practice of Percutaneous Ablation Technologies for Thyroid Nodules 2020
    Haris Muhammad, Jonathon O. Russell, Prasanna Santhanam, Aniqa Tehreem, Ralph P. Tufano
    Current Otorhinolaryngology Reports.2021; 9(1): 52.     CrossRef
  • RFA and benign thyroid nodules: Review of the current literature
    Haris Muhammad, Prasanna Santhanam, Jonathon O. Russell, Jennifer H. Kuo
    Laryngoscope Investigative Otolaryngology.2021; 6(1): 155.     CrossRef
  • Thermal Treatment Options for Benign Thyroid Nodules—The Role of Radio-Frequency Ablation and Laser Therapy
    Erivelto Volpi
    Clinical Thyroidology.2021; 33(1): 17.     CrossRef
  • Comparative efficacy of different ultrasound-guided ablation for the treatment of benign thyroid nodules: Systematic review and network meta-analysis of randomized controlled trials
    Linye He, Wanjun Zhao, Zijing Xia, Anping Su, Zhihui Li, Jingqiang Zhu, Ivan D. Florez
    PLOS ONE.2021; 16(1): e0243864.     CrossRef
  • Unresolved Clinical Issues in Thermal Ablation of Benign Thyroid Nodules: Regrowth at Long-Term Follow-Up
    Jung Suk Sim, Jung Hwan Baek
    Korean Journal of Radiology.2021; 22(8): 1436.     CrossRef
  • Current Status and Challenges of US-Guided Radiofrequency Ablation of Thyroid Nodules in the Long Term: A Systematic Review
    Stella Bernardi, Andrea Palermo, Rosario Francesco Grasso, Bruno Fabris, Fulvio Stacul, Roberto Cesareo
    Cancers.2021; 13(11): 2746.     CrossRef
  • Update of Radiofrequency Ablation for Treating Benign and Malignant Thyroid Nodules. The Future Is Now
    Ralph P. Tufano, Pia Pace-Asciak, Jonathon O. Russell, Carlos Suárez, Gregory W. Randolph, Fernando López, Ashok R. Shaha, Antti Mäkitie, Juan P. Rodrigo, Luiz Paulo Kowalski, Mark Zafereo, Peter Angelos, Alfio Ferlito
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Factors Associated with the Efficacy of Radiofrequency Ablation in the Treatment of Benign Thyroid Nodules
    Huynh Q Khanh, Nguyen L Vuong, Tran Q Tien
    World Journal of Endocrine Surgery.2021; 12(3): 117.     CrossRef
  • Long-Term Outcomes of Thermal Ablation for Benign Thyroid Nodules: The Issue of Regrowth
    Jung Suk Sim, Jung Hwan Baek, Rosaria Meccariello
    International Journal of Endocrinology.2021; 2021: 1.     CrossRef
  • Matrix 3D ultrasound-assisted thyroid nodule volume estimation and radiofrequency ablation: a phantom study
    T. Boers, S. J. Braak, M. Versluis, S. Manohar
    European Radiology Experimental.2021;[Epub]     CrossRef
  • Learning curve analysis of radiofrequency ablation for benign thyroid nodules
    Chi-Yu Kuo, Chien-Liang Liu, Chung-Hsin Tsai, Shih-Ping Cheng
    International Journal of Hyperthermia.2021; 38(1): 1536.     CrossRef
Close layer
Clinical Study
Effectiveness of Injecting Cold 5% Dextrose into Patients with Nerve Damage Symptoms during Thyroid Radiofrequency Ablation
Min Kyoung Lee, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Yu-Mi Lee, Tae Yong Kim, Jeong Hyun Lee
Endocrinol Metab. 2020;35(2):407-415.   Published online June 24, 2020
DOI: https://doi.org/10.3803/EnM.2020.35.2.407
  • 5,843 View
  • 138 Download
  • 12 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   ePub   
Background
Although radiofrequency ablation (RFA) is a safe treatment for thyroid tumors, nerve damage is a frequent complication. A previous retrospective study suggested that an injection of cold 5% dextrose in water (5% DW) can reduce nerve damage during RFA. This study validated the efficacy of injecting cold 5% DW for management of nerve damage during RFA.
Methods
Between November 2017 and December 2018, 242 patients underwent 291 RFA sessions for treatment of benign thyroid nodules or recurrent thyroid cancers. Using a standardized technique, cold (0°C to 4°C) 5% DW was immediately injected around the damaged nerve into patients with any symptoms suggesting nerve damage. The incidence of nerve damage, the volume of 5% DW injected, symptom recovery time and the incidence of permanent nerve damage were evaluated.
Results
Nineteen patients experienced nerve damage symptoms related to 21 RFA sessions, including 17 patients during 19 sessions and two patients on the day after two sessions. Patients with nerve damage symptoms detected during RFA were treated by injection of a mean 41 mL (range, 3 to 260) cold 5% DW, but the two patients who experienced symptoms the next day did not receive cold 5% DW injections. Immediate recovery was observed after 15 RFA sessions in 14 patients. No patient experienced permanent nerve damage.
Conclusion
Injection of cold 5% DW is effective in managing nerve damage during RFA of thyroid lesions.

Citations

Citations to this article as recorded by  
  • Clinical and Economic Evaluation of Ultrasound-Guided Radiofrequency Ablation vs. Parathyroidectomy for Patients with Primary Hyperparathyroidism: A Cohort Study
    Hui-hui Chai, Zhan-jing Dai, Bai Xu, Qiao-hong Hu, Hong-feng He, Ying Xin, Wen-wen Yue, Cheng-zhong Peng
    Academic Radiology.2023; 30(11): 2647.     CrossRef
  • Efficacy of single-session radiofrequency ablation (RFA) in rendering euthyroidism for persistent/relapsed Graves’ disease, a pilot study
    Man Him Matrix Fung, Brian Hung Hin Lang
    European Radiology.2023; 33(9): 6534.     CrossRef
  • Radiofrequency Ablation of Cervical Thyroid Cancer Metastases—Experience of Endocrinology Practices in the United States
    Shahzad Ahmad, Jules Aljammal, Ian Orozco, Sheharyar Raashid, Fizza Zulfiqar, Sean P Nikravan, Iram Hussain
    Journal of the Endocrine Society.2023;[Epub]     CrossRef
  • Radiofrequency ablation of benign thyroid nodules: the value of anterolateral hydrodissection
    So Yeong Jeong, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Ki-Wook Chung, Tae Yong Kim, Jeong Hyun Lee
    Ultrasonography.2023; 42(3): 432.     CrossRef
  • Effective and Safe Application of Radiofrequency Ablation for Benign Thyroid Nodules
    Jin Yong Sung
    Journal of the Korean Society of Radiology.2023; 84(5): 985.     CrossRef
  • Assessment of thyroid-specific quality of life in patients with benign symptomatic thyroid nodules treated with radiofrequency or ethanol ablation: a prospective multicenter study
    So Yeong Jeong, Eun Ju Ha, Jung Hwan Baek, Tae Yong Kim, Yu-Mi Lee, Jeong Hyun Lee, Jeonghun Lee
    Ultrasonography.2022; 41(1): 204.     CrossRef
  • Management of Recurrent Laryngeal Nerve Injury During Radiofrequency Ablation of Thyroid Nodules
    Jules Aljammal, Iram Hussain, Shahzad Ahmad
    AACE Clinical Case Reports.2022; 8(2): 102.     CrossRef
  • Thermal Ablation for the Management of Papillary Thyroid Microcarcinoma in the Era of Active Surveillance and Hemithyroidectomy
    Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Jeong Hyun Lee
    Current Oncology Reports.2022; 24(8): 1045.     CrossRef
  • Improving Voice Outcomes after Thyroid Surgery and Ultrasound-Guided Ablation Procedures
    Pia Pace-Asciak, Jon O. Russell, Ralph P. Tufano
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Using Intra‐Operative Laryngeal Ultrasonography as a Real‐Time Tool in Assessing Vocal Cord Function During Radiofrequency Ablation of the Thyroid Gland
    Matrix Man Him Fung, Brian Hung Hin Lang
    World Journal of Surgery.2022; 46(9): 2206.     CrossRef
  • Long-term outcome of microwave ablation for benign thyroid nodules: Over 48-month follow-up study
    Jia-Rui Du, Wen-Hui Li, Cheng-Hai Quan, Hui Wang, Deng-Ke Teng
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Continuous neuromonitoring during radiofrequency ablation of benign thyroid nodules provides objective evidence of laryngeal nerve safety
    Catherine F. Sinclair, Maria J. Téllez, Roberto Peláez-Cruz, Alba Díaz-Baamonde, Sedat Ulkatan
    The American Journal of Surgery.2021; 222(2): 354.     CrossRef
  • Future Considerations and Directions for Thermal Ablative Technologies
    Jonathon Russell, Catherine F. Sinclair
    Current Otorhinolaryngology Reports.2021; 9(2): 210.     CrossRef
Close layer
Clinical Study
Revisiting Rupture of Benign Thyroid Nodules after Radiofrequency Ablation: Various Types and Imaging Features
Sae Rom Chung, Jung Hwan Baek, Jin Yong Sung, Ji Hwa Ryu, So Lyung Jung
Endocrinol Metab. 2019;34(4):415-421.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.415
  • 5,308 View
  • 93 Download
  • 20 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

To evaluate the imaging features, clinical manifestations, and prognosis of patients with thyroid nodule rupture after radiofrequency ablation (RFA).

Methods

The records of 12 patients who experienced thyroid nodule rupture after RFA at four Korean thyroid centers between March 2010 and July 2017 were retrospectively reviewed. Clinical data evaluated included baseline patient characteristics, treatment methods, initial presenting symptoms, imaging features, treatment, and prognosis.

Results

The most common symptoms of post-RFA nodule rupture were sudden neck bulging and pain. Based on imaging features, the localization of nodule rupture was classified into three types: anterior, posterolateral, and medial types. The anterior type is the most often, followed by posterolateral and medial type. Eight patients recovered completely after conservative treatment. Four patients who did not improve with conservative management required invasive procedures, including incision and drainage or aspiration.

Conclusion

Thyroid nodule rupture after RFA can be classified into three types based on its localization: anterior, posterolateral, and medial types. Because majority of thyroid nodule ruptures after RFA can be managed conservatively, familiarity with these imaging features is essential in avoiding unnecessary imaging workup or invasive procedures.

Citations

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Close layer
Thyroid
Response: Long-Term Outcomes Following Thermal Ablation of Benign Thyroid Nodules as an Alternative to Surgery: The Importance of Controlling Regrowth (Endocrinol Metab 2019;34:117–23, Jung Suk Sim et al.)
Jung Suk Sim, Jung Hwan Baek
Endocrinol Metab. 2019;34(3):325-326.   Published online September 26, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.3.325
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Citations

Citations to this article as recorded by  
  • Five-year follow-up results of thermal ablation for benign thyroid nodules: Systematic review and meta-analysis
    Xidong Xu, Ying Peng, Guoxin Han
    American Journal of Otolaryngology.2024; 45(1): 104025.     CrossRef
  • How to Monitor and Manage Nodule Regrowth after Thermal Ablation of Benign Thyroid Nodules
    Sang Ik Park, Jung Hwan Baek
    Korean Journal of Radiology.2021; 22(2): 293.     CrossRef
Close layer
Thyroid
Long-Term Outcomes Following Thermal Ablation of Benign Thyroid Nodules as an Alternative to Surgery: The Importance of Controlling Regrowth
Jung Suk Sim, Jung Hwan Baek
Endocrinol Metab. 2019;34(2):117-123.   Published online June 24, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.2.117
  • 9,520 View
  • 146 Download
  • 56 Web of Science
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AbstractAbstract PDFPubReader   ePub   

Thermal ablation (TA) procedures, such as radiofrequency ablation and laser ablation, are used for the treatment of benign thyroid nodules. Short-term studies (<2 years) have demonstrated that TA is an effective and safe procedure to improve cosmetic or symptomatic problems. However, studies including a longer follow-up period show that treated thyroid nodules can increase in size after 2 to 3 years. Several studies suggest that this results from regrowth at the undertreated nodule margins. Here, we review current data on regrowth after TA and describe factors related to it and possible approaches to prevent it.

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    Jung Suk Sim, Jung Hwan Baek
    Endocrinology and Metabolism.2019; 34(3): 325.     CrossRef
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Close layer
Clinical Study
Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study
Su Min Ha, Jun Young Shin, Jung Hwan Baek, Dong Eun Song, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
Endocrinol Metab. 2019;34(2):169-178.   Published online May 15, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.2.169
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

To evaluate the clinical feasibility of radiofrequency ablation (RFA) of benign thyroid nodules along with cytomorphological alteration, and any malignant transformation through biopsy.

Methods

The data were retrospectively collected between April 2008 and June 2013 and core needle biopsy (CNB) was performed on 16 benign thyroid nodules previously treated using RFA. The parameters of the patients were compared, between the time of enrollment and the last follow-up examination, using linear mixed model statistical analysis.

Results

No atypical cells or neoplastic transformation were detected in the undertreated peripheral portion of treated benign nodules on the CNB specimen. RFA altered neither the thyroid capsule nor the thyroid tissue adjacent to the treated area. On histopathological examinations, we observed 81.2% acellular hyalinization, which was the most common finding. After a mean follow-up period of over 5 years, the mean volume of thyroid nodule had decreased to 6.4±4.2 mL, with a reduction rate of 81.3%±5.8% (P<0.0001).

Conclusion

RFA is a technically feasible treatment method for benign thyroid nodules, with no carcinogenic effect or tissue damage of the normal thyroid tissue adjacent to the RFA-treated zone.

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    Enrico Papini, Hervé Monpeyssen, Andrea Frasoldati, Laszlo Hegedüs
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    Jung Suk Sim, Jung Hwan Baek
    Endocrinology and Metabolism.2019; 34(3): 325.     CrossRef
Close layer
Thyroid
A Comparison of Ultrasound-Guided Fine Needle Aspiration versus Core Needle Biopsy for Thyroid Nodules: Pain, Tolerability, and Complications
Eun Ji Jeong, Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Jae Kyun Kim, Jeong Hyun Lee
Endocrinol Metab. 2018;33(1):114-120.   Published online March 21, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.1.114
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  • 58 Download
  • 23 Web of Science
  • 22 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

To compare pain, tolerability, and complications associated with fine needle aspiration (FNA) versus core needle biopsy (CNB).

Methods

FNAs were performed using 23-gauge needles and CNBs were performed using 18-gauge double-action spring-activated needles in 100 patients for each procedure. Patients were asked to record a pain score using a 10-cm visual analog scale and procedure tolerability. Complications and number of biopsies were recorded.

Results

The median pain scores were similar for the FNA and CNB approaches during and 20 minutes after the biopsy procedures (3.7 vs. 3.6, P=0.454; 0.9 vs. 1.1, P=0.296, respectively). The procedure was tolerable in all 100 FNA patients and in 97 CNB patients (P=0.246). The mean number of biopsies was fewer in the CNB group (1.4 vs. 1.2, P=0.002). By subgroup analysis (staff vs. non-staff), no significant difference was detected in any parameter. There were no major complications in either group, but three patients who underwent CNB had minor complications (P=0.246).

Conclusion

FNA and CNB show no significant differences for diagnosing thyroid nodules in terms of pain, tolerability, or complications.

Citations

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Close layer
Recent Advances in Core Needle Biopsy for Thyroid Nodules
Chan Kwon Jung, Jung Hwan Baek
Endocrinol Metab. 2017;32(4):407-412.   Published online December 14, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.407
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AbstractAbstract PDFPubReader   

Core needle biopsy (CNB) was introduced as an alternative diagnostic tool to fine-needle aspiration (FNA), and is increasingly being used in the preoperative assessment of thyroid nodules. CNB provides a definitive diagnosis in most cases, but it sometimes may be inconclusive. CNB has the advantage of enabling a histologic examination in relation to the surrounding thyroid tissue, immunohistochemistry, and molecular testing that can provide a more accurate assessment than FNA in selected cases. Nevertheless, CNB should be performed only by experienced experts in thyroid interventions to prevent complications because CNB needles are larger in caliber than FNA needles. As recent evidence has accumulated, and with improvements in the technique and devices for thyroid CNB, the Korean Society of Thyroid Radiology released its 2016 thyroid CNB guidelines and the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group published a consensus statement on the pathology reporting system for thyroid CNB in 2015. This review presents the current consensus and recommendations regarding thyroid CNB, focusing on indications, complications, and pathologic classification and reporting.

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Close layer
Thyroid
Lack of Associations between Body Mass Index and Clinical Outcomes in Patients with Papillary Thyroid Carcinoma
Hyemi Kwon, Mijin Kim, Yun Mi Choi, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Young Kee Shong, Dong Eun Song, Jung Hwan Baek, Suck Joon Hong, Won Bae Kim
Endocrinol Metab. 2015;30(3):305-311.   Published online November 26, 2014
DOI: https://doi.org/10.3803/EnM.2015.30.3.305
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AbstractAbstract PDFPubReader   
Background

Obesity is associated with aggressive pathological features and poor clinical outcomes in breast and prostate cancers. In papillary thyroid carcinoma (PTC), these relationships remain still controversial. This study aimed to evaluate the associations between body mass index (BMI) and the clinical outcomes of patients with PTC.

Methods

This retrospective study included 1,189 patients who underwent total thyroidectomy for PTCs equal to or larger than 1 cm in size. Clinical outcomes were evaluated and compared based on the BMI quartiles.

Results

There were no significant associations between BMI quartiles and primary tumor size, extrathyroidal invasion, cervical lymph node metastasis, or distant metastasis. However, an increase in mean age was associated with an increased BMI (P for trend <0.001). Multifocality and advanced tumor-node-metastasis (TNM) stage (stage III or IV) were significantly associated with increases of BMI (P for trend 0.02 and <0.001, respectively). However, these associations of multifocality and advanced TNM stage with BMI were not significant in multivariate analyses adjusted for age and gender. Moreover, there were no differences in recurrence-free survivals according to BMI quartiles (P=0.26).

Conclusion

In the present study, BMI was not associated with the aggressive clinicopathological features or recurrence-free survivals in patients with PTC.

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Close layer
Management Guidelines for Patients with Thyroid Nodules and Thyroid Cancer.
Won Bae Kim, Tae Yong Kim, Hyuk Sang Kwon, Won Jin Moon, Jae Bok Lee, Young Sik Choi, Seok Ki Kim, Sun Wook Kim, Ki wook Chung, Jung Hwan Baek, Byung Il Kim, Do Joon Park, Dong Gyu Na, Jun Ho Choe, Jae Hoon Chung, Hye Seung Jung, Jeong Han Kim, Kee Hyun Nam, Hang Seok Chang, Woong Youn Chung, Soon Won Hong, Suck Joon Hong, Jeong Hyun Lee, Ka Hee Yi, Young Suk Jo, Ho Cheol Kang, Minho Shong, Jin Woo Park, Jong Ho Yoon, Seong Joon Kang, Kwang Woo Lee
J Korean Endocr Soc. 2007;22(3):157-187.   Published online June 1, 2007
DOI: https://doi.org/10.3803/jkes.2007.22.3.157
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AbstractAbstract PDF
No abstract available.

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The Diagnostic Role of Repeated Biopsy of Thyroid Nodules with Atypia of Undetermined Significance with Architectural Atypia on Core-Needle Biopsy
Hye Hyeon Moon, Sae Rom Chung, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Jung Hwan Baek
Received September 4, 2023  Accepted November 14, 2023  Published online January 3, 2024  
DOI: https://doi.org/10.3803/EnM.2023.1818    [Epub ahead of print]
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Background
We aimed to evaluate the utility of repeat biopsy of thyroid nodules classified as atypia of undetermined significance with architectural atypia (IIIB) on core-needle biopsy (CNB).
Methods
This retrospective study evaluated patients with thyroid nodules categorized as IIIB on CNB between 2013 and 2015. Demographic characteristics, subsequent biopsy results, and ultrasound (US) images were evaluated. The malignancy rates of nodules according to number of CNBs and the number of IIIB diagnoses was compared. Demographic and US features were evaluated to determine factors predictive of malignancy.
Results
Of 1,003 IIIB nodules on CNB, the final diagnosis was determined for 328 (32.7%) nodules, with 121 of them confirmed as malignant, resulting in a malignancy rate of 36.9% (95% confidence interval, 31.7% to 42.1%). Repeat CNB was performed in 248 nodules (24.7%), with 75 (30.2%), 131 (52.8%), 13 (5.2%), 26 (10.5%), one (0.4%), and two (0.8%) reclassified into categories II, IIIB, IIIA, IV, V, and VI, respectively. Malignancy rates were not significantly affected by the number of CNBs (P=0.291) or the number of IIIB diagnoses (P=0.473). None of the nodules confirmed as category II on repeat CNB was malignant. US features significantly associated with malignancy (P<0.003) included solid composition, irregular margins, microcalcifications, and high suspicion on the US risk stratification system.
Conclusion
Repeat biopsy of nodules diagnosed with IIIB on CNB did not increase the detection of malignancy but can potentially reduce unnecessary surgery. Repeat biopsy should be performed selectively, with US features guiding the choice between repeat biopsy and diagnostic surgery.
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Endocrinol Metab : Endocrinology and Metabolism