Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism


Author index

Page Path
June-Key Chung  (Chung JK) 2 Articles
Clinical Study
Effects of Maternal Iodine Status during Pregnancy and Lactation on Maternal Thyroid Function and Offspring Growth and Development: A Prospective Study Protocol for the Ideal Breast Milk Cohort
Young Ah Lee, Sun Wook Cho, Ho Kyung Sung, Kyungsik Kim, Young Shin Song, Sin Je Moon, Jung Won Oh, Dal Lae Ju, Sooyeon Choi, Sang Hoon Song, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Sue K. Park, Jong Kwan Jun, June-Key Chung
Endocrinol Metab. 2018;33(3):395-402.   Published online September 18, 2018
  • 4,504 View
  • 82 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   ePub   

Iodine is an intrinsic element of thyroid hormone, which is essential for childhood growth and development. The Ideal Breast Milk (IBM) cohort study aims to evaluate the effects of maternal iodine status during pregnancy and lactation on maternal thyroid function, offspring growth and development, and offspring thyroid function.


The IBM cohort study recruited pregnant women from Seoul National University Hospital between June 2016 and August 2017, followed by enrollment of their offspring after delivery. For the maternal participants, iodine status is evaluated by urinary iodine concentration (UIC) and dietary records in the third trimester and at 3 to 4 weeks and 12 to 15 months postpartum. For the child participants, cord blood sampling and UIC measurements are performed at birth. At 3 to 4 weeks of age, UIC and breastmilk iodine concentrations are measured. At 12 to 15 months of age, growth and development are assessed and measurements of UIC, a thyroid function test, and ultrasonography are performed.


A total of 198 pregnant women in their third trimester were recruited. Their mean age was 35.1±3.5 years, and 78 (39.4%) of them were pregnant with twins. Thirty-three (16.7%) of them had a previous history of thyroid disease.


Korea is an iodine-replete area. In particular, lactating women in Korea are commonly exposed to excess iodine due to the traditional practice of consuming brown seaweed soup postpartum. The study of the IBM cohort is expected to contribute to developing guidelines for optimal iodine nutrition in pregnant or lactating women.


Citations to this article as recorded by  
  • High intakes of iodine among women during pregnancy and the postpartum period has no adverse effect on thyroid function
    Dal Lae Ju, Sun Wook Cho, Chae Won Chung, Young Ah Lee, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Jong Kwan Jun, June-Key Chung, Sue K. Park, YoonJu Song
    European Journal of Nutrition.2023; 62(1): 239.     CrossRef
  • Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2)
    Anna M. Monaghan, Maria S. Mulhern, Emeir M. Mc Sorley, J.J. Strain, Theresa Winter, Edwin van Wijngaarden, Gary J. Myers, Philip W. Davidson, Conrad Shamlaye, Jude Gedeon, Alison J. Yeates
    Journal of Nutritional Science.2021;[Epub]     CrossRef
Close layer
Radioiodine Therapy in Differentiated Thyroid Cancer: The First Targeted Therapy in Oncology
June-Key Chung, Gi Jeong Cheon
Endocrinol Metab. 2014;29(3):233-239.   Published online September 25, 2014
  • 4,586 View
  • 69 Download
  • 34 Web of Science
  • 34 Crossref
AbstractAbstract PDFPubReader   

Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS). The rat and human NIS-coding genes were cloned and identified in 1996. Evaluation of NIS gene and protein expression is critical for the management of thyroid cancer, and several approaches to increase NIS levels have been tried. Identification of the NIS gene has provided a means of expanding its role in radionuclide therapy and molecular target-specific theragnosis (therapy and diagnosis using the same molecular target). In this article, we describe the relationship between NIS expression and the thyroid carcinoma treatment using I-131 and alternative therapeutic approaches.


Citations to this article as recorded by  
  • A Pilot Nonrandomized Controlled Trial Examining the Use of Artificial Tears on the Radioactivity of Tears After Radioactive Iodine Treatment for Thyroid Cancer
    Irene T. Lee, Jared V. Grice, Xiangyu Ji, Qingxia Chen, Lindsay A. Bischoff, Aaron C. Jessop, Behin Barahimi, Francois Codere, Louise A. Mawn, Rachel K. Sobel
    Thyroid®.2024; 34(1): 82.     CrossRef
  • Research progress of bone metastases: From disease recognition to clinical practice
    Wenbo Yang, Qing Pan, Fuhua Huang, Hongzhi Hu, Zengwu Shao
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Letter to the editor regarding “Bone metastases from differentiated thyroid carcinoma: heterogenous tumor response to radioactive Iodine therapy and overall survival”
    Maria José Veloza Vega, Manuela Gallo, Gonzalo Ucros, Patricia Bernal
    European Journal of Nuclear Medicine and Molecular Imaging.2022; 49(11): 3622.     CrossRef
  • Factors Associated With Radioactive Iodine Therapy–Acquired Nasolacrimal Duct Obstruction
    Irene T. Lee, Wencong Chen, Qingxia Chen, Heather A. Cole, Lindsay A. Bischoff, Aaron C. Jessop, Rachel K. Sobel
    Endocrine Practice.2022; 28(12): 1210.     CrossRef
  • RNA-Seq transcriptome analysis reveals Maackia amurensis leukoagglutinin has antitumor activity in human anaplastic thyroid cancer cells
    Suna Bektas, Engin Kaptan
    Molecular Biology Reports.2022; 49(10): 9257.     CrossRef
  • Radio-Iodide Treatment: From Molecular Aspects to the Clinical View
    Antonio De la Vieja, Garcilaso Riesco-Eizaguirre
    Cancers.2021; 13(5): 995.     CrossRef
  • Current Status and Future Perspective of the Treatment for Radioiodine Refractory Differentiated Thyroid Cancer
    Young Kee Shong
    International Journal of Thyroidology.2021; 14(2): 98.     CrossRef
  • 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography for the prediction of radioiodine therapy response in patients with metastatic differentiated thyroid cancer
    T. M. Geliashvili, A. V. Vazhenin, T. P. Berezovskaya, N. G. Afanasyeva, E. V. Vasilyeva, P. I. Garbuzov, V. V. Krylov
    Head and Neck Tumors (HNT).2020; 9(4): 10.     CrossRef
  • Salivary side effects after radioiodine treatment for differentiated papillary thyroid carcinoma: Long‐term study
    Marc‐Kevin Le Roux, Nicolas Graillon, Laurent Guyot, David Taieb, Philippe Galli, Yves Godio‐Raboutet, Cyrille Chossegros, Jean‐Marc Foletti
    Head & Neck.2020; 42(11): 3133.     CrossRef
  • β-radiating radionuclides in cancer treatment, novel insight into promising approach
    Samieh Asadian, Hamed Mirzaei, Bagher Aziz Kalantari, Mohamad Reza Davarpanah, Morteza Mohamadi, Anastasia Shpichka, Leila Nasehi, Hamidreza Aboulkheyr Es, Peter Timashev, Mustapha Najimi, Nematollah Gheibi, Moustapha Hassan, Massoud Vosough
    Pharmacological Research.2020; 160: 105070.     CrossRef
  • Peptide Receptor Radionuclide Therapy in Patients With Differentiated Thyroid Cancer
    Dong Yun Lee, Yong-il Kim
    Clinical Nuclear Medicine.2020; 45(8): 604.     CrossRef
  • FDG PET/CT for the early prediction of RAI therapy response in patients with metastatic differentiated thyroid carcinoma
    Seo Young Kang, Ji-In Bang, Keon Wook Kang, Ho-young Lee, June-Key Chung, Juri G. Gelovani
    PLOS ONE.2019; 14(6): e0218416.     CrossRef
  • Role of iodide metabolism in physiology and cancer
    Antonio De la Vieja, Pilar Santisteban
    Endocrine-Related Cancer.2018; 25(4): R225.     CrossRef
  • Star-Shaped Intense Uptake of 131I on Whole Body Scans Can Reflect Good Therapeutic Effects of Low-Dose Radioactive Iodine Treatment of 1.1 GBq
    Sung Hye Kong, Jung Ah Lim, Young Shin Song, Shinje Moon, Ye An Kim, Min Joo Kim, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
    Endocrinology and Metabolism.2018; 33(2): 228.     CrossRef
  • Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma
    June-Key Chung, Hyun Woo Kim, Haewon Youn, Gi Jeong Cheon
    Nuclear Medicine and Molecular Imaging.2018; 52(5): 325.     CrossRef
  • LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway
    Xiaomei Sui, Yana Sui, Yonghui Wang
    Molecular Medicine Reports.2018;[Epub]     CrossRef
  • Human sodium iodide transporter gene-mediated imaging and therapy of mouse glioma, comparison between 188Re and 131I
    Rui Guo, Yun Xi, Min Zhang, Ying Miao, Miao Zhang, Biao Li
    Oncology Letters.2018;[Epub]     CrossRef
  • Iodine-131 Therapy and Lacrimal Drainage System Toxicity: Nasal Localization Studies Using Whole Body Nuclear Scintigraphy and SPECT-CT
    Mohammad Javed Ali, Achyut Ram Vyakaranam, Jyotsna Eleshwarapu Rao, Giri Prasad, Palkonda Vijay Anand Reddy
    Ophthalmic Plastic & Reconstructive Surgery.2017; 33(1): 13.     CrossRef
  • Targeted Radionuclide Therapy: An Evolution Toward Precision Cancer Treatment
    Hossein Jadvar
    American Journal of Roentgenology.2017; 209(2): 277.     CrossRef
  • Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differentiated thyroid cancer
    Arun Upadhyaya, Pingping Zhou, Zhaowei Meng, Peng Wang, Guizhi Zhang, Qiang Jia, Jian Tan, Xue Li, Tianpeng Hu, Na Liu, Sen Wang, Xiaoxia Liu, Huiying Wang, Chunmei Zhang, Fengxiao Zhao, Ziyu Yan, Xiaoran Wang, Xuemeng Zhang, Wan Zhang
    Nuclear Medicine Communications.2017; 38(11): 891.     CrossRef
  • Effects of first radioiodine ablation on functions of salivary glands in patients with differentiated thyroid cancer
    Arun Upadhyaya, Zhaowei Meng, Peng Wang, Guizhi Zhang, Qiang Jia, Jian Tan, Xue Li, Tianpeng Hu, Na Liu, Pingping Zhou, Sen Wang, Xiaoxia Liu, Huiying Wang, Chunmei Zhang, Fengxiao Zhao, Ziyu Yan
    Medicine.2017; 96(25): e7164.     CrossRef
  • Growth Kinetics of Macronodular Lung Metastases and Survival in Differentiated Thyroid Carcinoma
    Mijin Kim, Won Gu Kim, Suyeon Park, Hyemi Kwon, Min Ji Jeon, Sang Min Lee, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Thyroid.2017; 27(7): 915.     CrossRef
  • Initial Size of Metastatic Lesions Is Best Prognostic Factor in Patients with Metastatic Differentiated Thyroid Carcinoma Confined to the Lung
    Mijin Kim, Won Gu Kim, Suyeon Park, Hyemi Kwon, Min Ji Jeon, Jong Jin Lee, Jin-Sook Ryu, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Thyroid.2017; 27(1): 49.     CrossRef
  • Lack of Efficacy of Radioiodine Remnant Ablation for Papillary Thyroid Microcarcinoma: Verification Using Inverse Probability of Treatment Weighting
    Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Suyeon Park, Mijin Kim, Tae Yong Kim, Minkyu Han, Dong Eun Song, Tae-Yon Sung, Jong Ho Yoon, Suck Joon Hong, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
    Annals of Surgical Oncology.2017; 24(9): 2596.     CrossRef
  • Preparation and evaluation of 131I-quercetin as a novel radiotherapy agent against dedifferentiated thyroid cancer
    Qinghua Xie, Xia Li, Guanquan Wang, Xuan Hou, Yujun Wang, Hongbo Yu, Changfa Qu, Shunzhong Luo, Yali Cui, Chuanqin Xia, Ruibing Wang
    Journal of Radioanalytical and Nuclear Chemistry.2017; 311(3): 1697.     CrossRef
  • Molecular radiotheragnostics in thyroid disease
    Nitasha Singh, Val Lewington
    Clinical Medicine.2017; 17(5): 453.     CrossRef
  • Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer
    Xuemei Gao, Xinchao Wu, Xiao Zhang, Wenjuan Hua, Yajing Zhang, Yusufu Maimaiti, Zairong Gao, Yongxue Zhang
    Biochemical and Biophysical Research Communications.2016; 469(3): 679.     CrossRef
  • Hepatoprotective Effect of Dexmedetomidine Against Radioiodine Toxicity in Rats: Evaluation of Oxidative Status and Histopathologic Changes
    Kemal Kismet, Murat Sadic, Yusuf Murat Bag, Hasan Ikbal Atilgan, Gokhan Koca, Ali Kemal Onalan, Mehmet Senes, Seydi Ali Peker, Nihat Yumusak, Meliha Korkmaz
    International Surgery.2016; 101(3-4): 176.     CrossRef
  • FoxP3 in papillary thyroid carcinoma induces NIS repression through activation of the TGF-β1/Smad signaling pathway
    Siyuan Ma, Qingzhu Wang, Xiaojun Ma, Lina Wu, Feng Guo, Hongfei Ji, Fei Liu, Yanyan Zhao, Guijun Qin
    Tumor Biology.2016; 37(1): 989.     CrossRef
  • Iodine-131 Therapy and Nasolacrimal Duct Obstructions: What We Know and What We Need to Know
    Mohammad Javed Ali
    Ophthalmic Plastic & Reconstructive Surgery.2016; 32(4): 243.     CrossRef
  • I-131 remnant ablation after thyroidectomy induced hepatotoxicity in a case of thyroid cancer
    Rong Lin, Omar Banafea, Jin Ye
    BMC Gastroenterology.2015;[Epub]     CrossRef
  • Sub-Classification of Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma by Pathologic Criteria
    Min Ji Jeon, Won Gu Kim, Eun Kyung Jang, Yun Mi Choi, Dong Eun Song, Tae-Yon Sung, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong, Jin-Sook Ryu, Ji Min Han, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Konradin Metze
    PLOS ONE.2015; 10(7): e0133625.     CrossRef
  • Targeted Radionuclide Therapy of Human Tumors
    Sergey Gudkov, Natalya Shilyagina, Vladimir Vodeneev, Andrei Zvyagin
    International Journal of Molecular Sciences.2015; 17(1): 33.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism