Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism


Author index

Page Path
June Hyung Kim  (Kim JH) 1 Article
High Brachial Ankle Pulse Wave Velocity as a Marker for Predicting Coronary Artery Stenosis in Patients with Type 2 Diabetes
Bo Hyun Kim, Jae Sik Jang, Yong Seop Kwon, June Hyung Kim, In Joo Kim, Chang Won Lee
Endocrinol Metab. 2018;33(1):88-96.   Published online March 21, 2018
  • 4,758 View
  • 57 Download
  • 14 Web of Science
  • 15 Crossref
AbstractAbstract PDFPubReader   ePub   

We evaluated the ability of brachial ankle pulse wave velocity (baPWV) to predict coronary artery stenosis (CAS) in patients with type 2 diabetes, and compared the predictive power of baPWV to that of well-known cardiovascular disease (CVD) risk calculators.


The study group included 83 consecutive patients over 30 years old with type 2 diabetes who complained of vague chest discomfort. An automatic pulse waveform analyzer was used to measure baPWV. CAS was measured using multi-slice computed tomographic (MSCT) angiography.


Age, maximal baPWV, duration of diabetes, current smoking, the UK Prospective Diabetes Study (UKPDS) Risk Engine score, American College of Cardiology/American Heart Association (ACC/AHA) risk estimator score, the Framingham risk calculator score, and coronary artery calcium score were greater in patients with CAS than in those without CAS. An area under the curve (AUC) indicative of a predictive value for CAS (≥20%) was found for several parameters. The AUC of maximal baPWV, the UKPDS Risk Engine, the ACC/AHA ASCVD risk estimator, and the Framingham risk calculator were 0.672 (95% confidence interval [CI], 0.554 to 0.785; P=0.010), 0.777 (95% CI, 0.675 to 0.878; P<0.001), 0.763 (95% CI, 0.660 to 0.866; P<0.001), and 0.736 (95% CI, 0.629 to 0.843; P<0.001), respectively. The optimal cutoff value of baPWV for the detection of CAS was 1,650 cm/sec (sensitivity, 68.9%; specificity, 63.2%).


Maximal baPWV was closely related with CAS detected by MSCT coronary angiography in patients with type 2 diabetes. baPWV has the potential to be a useful, noninvasive screening tool for the prediction of occult CAS in patients with type 2 diabetes.


Citations to this article as recorded by  
  • The risk factors of early arterial stiffness in type 2 diabetes without diabetic macroangiopathy
    Jia-Hui Wu, Rui Wang, Xiao-Jiao Jia, Na Lu, Qiang Lu, Fu-Zai Yin, Chun-Ming Ma
    International Journal of Diabetes in Developing Countries.2024; 44(2): 271.     CrossRef
  • Polyvinyl Alcohol Phantoms With Heterogeneous Plaques: Estimation of Pulse Wave Velocity at the Stenotic Region Using Pulse Wave Imaging
    Nima Mobadersany, Pengcheng Liang, Paul Kemper, Elisa E. Konofagou
    Ultrasound in Medicine & Biology.2024; 50(1): 91.     CrossRef
  • Baroreflex Sensitivity as a Surrogate Biomarker for Concurrently Assessing the Severity of Arterial Stiffness and Cardiovascular Autonomic Neuropathy in Individuals with Type 2 Diabetes
    Dong-Yi Hsieh, Yun-Ru Lai, Chih-Cheng Huang, Yung-Nien Chen, Szu-Ying Wu, Wen-Chan Chiu, Ben-Chung Cheng, Ting-Yin Lin, Hui-Ching Chiang, Cheng-Hsien Lu
    Journal of Personalized Medicine.2024; 14(5): 491.     CrossRef
  • Arterial Stiffness as a Predictor of the Index of Atherosclerotic Cardiovascular Disease in Hypertensive Patients
    Guili Chang, Yueliang Hu, Qian Ge, Shaoli Chu, Alberto Avolio, Junli Zuo
    International Journal of Environmental Research and Public Health.2023; 20(4): 2832.     CrossRef
  • Pulse wave imaging of a stenotic artery model with plaque constituents of different stiffnesses: Experimental demonstration in phantoms and fluid-structure interaction simulation
    Nima Mobadersany, Nirvedh H. Meshram, Paul Kemper, C.V. Sise, Grigorios M. Karageorgos, Pengcheng Liang, Gerard A. Ateshian, Elisa E. Konofagou
    Journal of Biomechanics.2023; 149: 111502.     CrossRef
  • Computational clustering reveals differentiated coronary artery calcium progression at prevalent levels of pulse wave velocity by classifying high-risk patients
    Maximo Rousseau-Portalis, Leandro Cymberknop, Ignacio Farro, Ricardo Armentano
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • Pepsinogen ratio and brachial-ankle pulse wave velocity: a cross-sectional study on their interrelationship in atherosclerosis
    Yuexi Li, Xiaoqin Liu, Yuhan Luo, Qiaoli Wang
    BMC Cardiovascular Disorders.2023;[Epub]     CrossRef
  • The Plasma Atherogenic Index is an Independent Predictor of Arterial Stiffness in Healthy Koreans
    Ji Sun Nam, Min Kyung Kim, Kahui Park, Arim Choi, Shinae Kang, Chul Woo Ahn, Jong Suk Park
    Angiology.2022; 73(6): 514.     CrossRef
  • Risk assessment indicators and brachial-ankle pulse wave velocity to predict atherosclerotic cardiovascular disease
    Hung-Ju Ko, Chuan-Chuan Liu, Po-Jui Hsu, Kuang-Chun Hu, Chung-Lieh Hung, Lo-Yip Yu, Yun-Chieh Huang, Shou-Chuan Shih
    Medicine.2022; 101(32): e29609.     CrossRef
  • Brachial-ankle pulse wave velocity as a predictor of long-term cardiovascular events in 2174 subjects with type 2 diabetes mellitus: A retrospective cohort study
    Hack-Lyoung Kim, Won Kyeong Jeon, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
    Medicine.2022; 101(45): e31758.     CrossRef
  • Ultrasound Methods in the Evaluation of Atherosclerosis: From Pathophysiology to Clinic
    Gabriel Cismaru, Teodora Serban, Alexandru Tirpe
    Biomedicines.2021; 9(4): 418.     CrossRef
  • A model to predict risk of stroke in middle-aged adults with type 2 diabetes generated from a nationwide population-based cohort study in Korea
    Mee-Kyoung Kim, Kyungdo Han, Jae-Hyoung Cho, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
    Diabetes Research and Clinical Practice.2020; 163: 108157.     CrossRef
  • Association of impaired arterial wall properties with the presence of coronary artery disease in patients with abdominal aortic aneurysms
    Pinelopi Rafouli‐Stergiou, Ignatios Ikonomidis, Niki Katsiki, Nikolaos P. E. Kadoglou, Stefanos Vlachos, John Thymis, John Parissis, Konstantinos G. Moulakakis, John D. Kakisis
    The Journal of Clinical Hypertension.2020; 22(2): 187.     CrossRef
  • Association of serum FAM19A5 with metabolic and vascular risk factors in human subjects with or without type 2 diabetes
    You-Bin Lee, Hwan-Jin Hwang, Jung A Kim, Soon Young Hwang, Eun Roh, So-hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Diabetes and Vascular Disease Research.2019; 16(6): 530.     CrossRef
  • Pulse Wave Velocity in Atherosclerosis
    Hack-Lyoung Kim, Sang-Hyun Kim
    Frontiers in Cardiovascular Medicine.2019;[Epub]     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism