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Julie O. Denenberg  (Denenberg JO) 1 Article
Clinical Study
Associations of Perirenal Fat Thickness with Renal and Systemic Calcified Atherosclerosis
Bo Kyung Koo, Julie O. Denenberg, C. Michael Wright, Michael H. Criqui, Matthew A. Allison
Endocrinol Metab. 2020;35(1):122-131.   Published online March 19, 2020
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  • 8 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   

We investigated associations between perirenal fat thickness and atherosclerotic calcification in six different vascular beds.


Using a community-based cohort (n=3,919), perirenal fat thickness was estimated from computed tomography scans. It was classified as Q1 (the lowest quartile) to Q4 (the highest quartile) in each sex. Calcification in the carotid arteries, coronary arteries, thoracic aorta, abdominal aorta, iliac arteries, and renal arteries was evaluated.


Perirenal fat thickness was associated with older age (P<0.01) and a higher prevalence of obesity, hypertension, and dyslipidemia (P<0.01 for all). Perirenal fat thickness was independently associated with renal arterial calcification even after adjustment for age, sex, body mass index, hypertension, dyslipidemia, smoking history, and family history of heart diseases in first-degree relatives (odds ratio [OR] per quartile of perirenal fat thickness, 1.25; 95% confidence interval [CI], 1.09 to 1.44). Compared to Q1, the odds of renal arterial calcification in Q4 was about two times higher (OR, 2.05; 95% CI, 1.29 to 3.25). After adjustment for renal arterial calcification and atherosclerotic risk factors, the only other vascular bed where perirenal fat thickness showed a significant association with calcification was the abdominal aorta (OR, 1.11; 95% CI, 1.00 to 1.23; P=0.045).


Perirenal fat thickness was independently associated with vascular calcification in the renal artery and abdominal aorta.


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