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Juan Cai 1 Article
Diabetes, obesity and metabolism
The Emerging Importance of Mitochondria in White Adipocytes: Neither Last nor Least
Juan Cai, Fenfen Wang, Mengle Shao
Endocrinol Metab. 2023;38(5):493-503.   Published online October 10, 2023
DOI: https://doi.org/10.3803/EnM.2023.1813
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AbstractAbstract PDFPubReader   ePub   
The growing recognition of mitochondria’s crucial role in the regulation of white adipose tissue remodeling and energy balance underscores its significance. The marked metabolic diversity of mitochondria provides the molecular and cellular foundation for enabling adipose tissue plasticity in response to various metabolic cues. Effective control of mitochondrial function at the cellular level, not only in thermogenic brown and beige adipocytes but also in energy-storing white adipocytes, exerts a profound influence on adipose homeostasis. Furthermore, mitochondria play a pivotal role in intercellular communication within adipose tissue via production of metabolites with signaling properties. A more comprehensive understanding of mitochondrial regulation within white adipocytes will empower the development of targeted and efficacious strategies to enhance adipose function, leading to advancements in overall metabolic health.

Citations

Citations to this article as recorded by  
  • Protocol for Seahorse analysis of ex vivo mouse brown and white adipose tissues
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    International Journal of Obesity.2024;[Epub]     CrossRef
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    Stem Cell Research & Therapy.2024;[Epub]     CrossRef
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    Physiological Reports.2024;[Epub]     CrossRef
  • Brown Fat and Metabolic Health: The Diverse Functions of Dietary Components
    Zachary Brown, Takeshi Yoneshiro
    Endocrinology and Metabolism.2024; 39(6): 839.     CrossRef
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