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Endocrinol Metab : Endocrinology and Metabolism


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Joong Hee Kim  (Kim JH) 1 Article
Clinical Study
A Novel Index Using Soluble CD36 Is Associated with the Prevalence of Type 2 Diabetes Mellitus: Comparison Study with Triglyceride-Glucose Index
Ho Jin Kim, Jun Sung Moon, Il Rae Park, Joong Hee Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Endocrinol Metab. 2017;32(3):375-382.   Published online September 18, 2017
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  • 5 Citations
AbstractAbstract PDFPubReader   CrossRef-TDMCrossref - TDM

Plasma soluble cluster determinant 36 (sCD36) level is closely related with insulin resistance and atherosclerosis, but little is known whether it could be a surrogate for estimating risk of developing diabetes or not. To address this, we evaluated association between sCD36 index, the product of sCD36 and fasting plasma glucose (FPG), and the prevalence of type 2 diabetes mellitus (T2DM), and then compared with triglyceride-glucose (TyG) index which has been suggested simple index for insulin resistance.


This was cross-sectional study, and participants were classified as normal glucose tolerance (NGT), prediabetes, and T2DM according to glucose tolerance. The formula of TyG index was ‘ln [FPG (mg/dL)×triglyceride (mg/dL)/2],’ and the sCD36 index was ‘ln [sCD36 (pg/mL)×FPG (mg/dL)/2].’


One hundred and fifty-five subjects (mean age, 55.2 years) were enrolled, and patients with T2DM were 75. Both indexes were significantly increased in prediabetes and T2DM rather than NGT, and sCD36 index was positively correlated with both glycosylated hemoglobin and homeostasis model assessment of insulin resistance (r=0.767 and r=0.453, respectively; P<0.05) and negatively with homeostasis model assessment estimate of β-cell function (r=−0.317). The odds ratio (OR) of sCD36 index for T2DM was 4.39 (95% confidential interval, 1.51 to 12.77) after adjusting age, gender, blood pressure, smoking, alcohol, non-high density lipoprotein cholesterol and high-sensitivity C-reactive protein. However, OR of TyG index did not remained significance after adjustment.


sCD36 index has an independent association with the risk of T2DM, and showed better correlation than TyG index. These results suggest sCD36 index might be useful surrogate marker for the risk of diabetes.


Citations to this article as recorded by  
  • The triglyceride-glucose index as an indicator of insulin resistance and cardiometabolic risk in Brazilian adolescents
    Miriam Beatrís Reckziegel, Patrik Nepomuceno, Tania Machado, Jane Dagmar Pollo Renner, Hildegard Hedwig Pohl, Carlos Alberto Nogueira-de-Almeida, Elza Daniel de Mello
    Archives of Endocrinology and Metabolism.2023;[Epub]     CrossRef
  • Proteomic analysis of epicardial adipose tissue from heart disease patients with concomitant heart failure with preserved ejection fraction
    Shan He, Huagang Zhu, Jianjun Zhang, Xiaopeng Wu, Lei Zhao, Xinchun Yang
    International Journal of Cardiology.2022; 362: 118.     CrossRef
  • New insights into renal lipid dysmetabolism in diabetic kidney disease
    Alla Mitrofanova, George Burke, Sandra Merscher, Alessia Fornoni
    World Journal of Diabetes.2021; 12(5): 524.     CrossRef
  • The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
    Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
    Diabetes & Metabolism Journal.2020; 44(2): 222.     CrossRef
  • The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
    Kamila Puchałowicz, Monika Ewa Rać
    Cells.2020; 9(8): 1877.     CrossRef

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