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Joon Young Chang  (Chang JY) 2 Articles
Obesity and Metabolism
Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress
Min Jeong Choi, Saet-Byel Jung, Joon Young Chang, Minho Shong
Endocrinol Metab. 2021;36(1):1-11.   Published online February 24, 2021
DOI: https://doi.org/10.3803/EnM.2021.956
  • 6,043 View
  • 230 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDFPubReader   ePub   
Paracrine interactions are imperative for the maintenance of adipose tissue intercellular homeostasis, and intracellular organelle dysfunction results in local and systemic alterations in metabolic homeostasis. It is currently accepted that mitochondrial proteotoxic stress activates the mitochondrial unfolded protein response (UPRmt) in vitro and in vivo. The induction of mitochondrial chaperones and proteases during the UPRmt is a key cell-autonomous mechanism of mitochondrial quality control. The UPRmt also affects systemic metabolism through the secretion of cell non-autonomous peptides and cytokines (hereafter, metabokines). Mitochondrial function in adipose tissue plays a pivotal role in whole-body metabolism and human diseases. Despite continuing interest in the role of the UPRmt and quality control pathways of mitochondria in energy metabolism, studies on the roles of the UPRmt and metabokines in white adipose tissue are relatively sparse. Here, we describe the role of the UPRmt in adipose tissue, including adipocytes and resident macrophages, and the interactive roles of cell non-autonomous metabokines, particularly growth differentiation factor 15, in local adipose cellular homeostasis and systemic energy metabolism.

Citations

Citations to this article as recorded by  
  • Imeglimin modulates mitochondria biology and facilitates mitokine secretion in 3T3-L1 adipocytes
    Nobuhiko Takahashi, Atsushi P. Kimura, Takayuki Yoshizaki, Kazumasa Ohmura
    Life Sciences.2024; 349: 122735.     CrossRef
  • Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior
    Carla Igual Gil, Bethany M Coull, Wenke Jonas, Rachel N Lippert, Susanne Klaus, Mario Ost
    Life Science Alliance.2022; 5(11): e202201495.     CrossRef
  • Stress-induced FGF21 and GDF15 in obesity and obesity resistance
    Susanne Keipert, Mario Ost
    Trends in Endocrinology & Metabolism.2021; 32(11): 904.     CrossRef
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Thyroid
Mitochondrial Energy Metabolism and Thyroid Cancers
Junguee Lee, Joon Young Chang, Yea Eun Kang, Shinae Yi, Min Hee Lee, Kyong Hye Joung, Kun Soon Kim, Minho Shong
Endocrinol Metab. 2015;30(2):117-123.   Published online June 30, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.2.117
  • 4,612 View
  • 54 Download
  • 16 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   

Primary thyroid cancers including papillary, follicular, poorly differentiated, and anaplastic carcinomas show substantial differences in biological and clinical behaviors. Even in the same pathological type, there is wide variability in the clinical course of disease progression. The molecular carcinogenesis of thyroid cancer has advanced tremendously in the last decade. However, specific inhibition of oncogenic pathways did not provide a significant survival benefit in advanced progressive thyroid cancer that is resistant to radioactive iodine therapy. Accumulating evidence clearly shows that cellular energy metabolism, which is controlled by oncogenes and other tumor-related factors, is a critical factor determining the clinical phenotypes of cancer. However, the role and nature of energy metabolism in thyroid cancer remain unclear. In this article, we discuss the role of cellular energy metabolism, particularly mitochondrial energy metabolism, in thyroid cancer. Determining the molecular nature of metabolic remodeling in thyroid cancer may provide new biomarkers and therapeutic targets that may be useful in the management of refractory thyroid cancers.

Citations

Citations to this article as recorded by  
  • Exploring the clinical utility of DPP-IV and SGLT2 inhibitors in papillary thyroid cancer: a literature review
    Angelika Buczyńska, Maria Kościuszko, Adam Jacek Krętowski, Anna Popławska-Kita
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Liquid Biopsy as a Method for Minimally Invasive Diagnosis of Thyroid Cancer
    Tagir I. Rakhmatullin, Mark Jain, Larisa M. Samokhodskaya, Vladimir A. Zhivotov
    Journal of Clinical Practice.2023; 14(3): 69.     CrossRef
  • Development of Metabolic Synthetic Lethality and Its Implications for Thyroid Cancer
    Sang-Hyeon Ju, Seong Eun Lee, Yea Eun Kang, Minho Shong
    Endocrinology and Metabolism.2022; 37(1): 53.     CrossRef
  • Monensin Inhibits Anaplastic Thyroid Cancer via Disrupting Mitochondrial Respiration and AMPK/mTOR Signaling
    Yanli Li, Qianshu Sun, Sisi Chen, Xiongjie Yu, Hongxia Jing
    Anti-Cancer Agents in Medicinal Chemistry.2022; 22(14): 2539.     CrossRef
  • Growth Differentiation Factor 15 is a Cancer Cell-Induced Mitokine That Primes Thyroid Cancer Cells for Invasiveness
    Yea Eun Kang, Jin Man Kim, Mi Ae Lim, Seong Eun Lee, Shinae Yi, Jung Tae Kim, Chan Oh, Lihua Liu, Yanli Jin, Seung-Nam Jung, Ho-Ryun Won, Jae Won Chang, Jeong Ho Lee, Hyun Jung Kim, Hyun Yong Koh, Sangmi Jun, Sun Wook Cho, Minho Shong, Bon Seok Koo
    Thyroid.2021; 31(5): 772.     CrossRef
  • Clinical Significance of the D-Loop Gene Mutation in Mitochondrial DNA in Laryngeal Cancer
    Lei Wang, He-Xiang Cheng, Yan-Hui Zhou, Min Ma
    OncoTargets and Therapy.2021; Volume 14: 3461.     CrossRef
  • Transcriptomic and Genetic Associations between Alzheimer’s Disease, Parkinson’s Disease, and Cancer
    Jaume Forés-Martos, Cesar Boullosa, David Rodrigo-Domínguez, Jon Sánchez-Valle, Beatriz Suay-García, Joan Climent, Antonio Falcó, Alfonso Valencia, Joan Anton Puig-Butillé, Susana Puig, Rafael Tabarés-Seisdedos
    Cancers.2021; 13(12): 2990.     CrossRef
  • KLF5 influences cell biological function and chemotherapy sensitivity through the JNK signaling pathway in anaplastic thyroid carcinoma
    Zheng Wang, Xinguang Qiu, Hao Zhang, Weihan Li
    Journal of Biochemical and Molecular Toxicology.2020;[Epub]     CrossRef
  • Metabolic reprogramming related to whole-chromosome instability in models for Hürthle cell carcinoma
    Ruben D. Addie, Sarantos Kostidis, Willem E. Corver, Jan Oosting, Sepideh Aminzadeh-Gohari, René G. Feichtinger, Barbara Kofler, Mehtap Derya Aydemirli, Martin Giera, Hans Morreau
    Scientific Reports.2020;[Epub]     CrossRef
  • Inhibition of mitochondrial respiration by tigecycline selectively targets thyroid carcinoma and increases chemosensitivity
    Yuehua Wang, Fei Xie, Dejie Chen, Ling Wang
    Clinical and Experimental Pharmacology and Physiology.2019; 46(10): 890.     CrossRef
  • Investigating Therapeutic Effects of Retinoic Acid on Thyroid Cancer via Protein-Protein Interaction Network Analysis
    Majid Rezaei-Tavirani, Mostafa Rezaei-Tavirani, Mona Zamanian Azodi
    International Journal of Cancer Management.2019;[Epub]     CrossRef
  • CASE REPORT: An Extensively Necrotic Hürthle-Cell Carcinoma Mimicked a Thyroid Abscess
    Sanders H. Lin, Shih-Ming Huang, Su-Lin Peng
    Clinical Thyroidology.2018; 30(11): 529.     CrossRef
  • Atovaquone enhances doxorubicin’s efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer
    Zhuo Lv, Xintong Yan, Liying Lu, Chun Su, Yin He
    Journal of Bioenergetics and Biomembranes.2018; 50(4): 263.     CrossRef
  • Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma
    Xianyin Lai, Christopher B. Umbricht, Kurt Fisher, Justin Bishop, Qiuying Shi, Shaoxiong Chen
    Journal of Proteomics.2017; 166: 59.     CrossRef
  • Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer
    Marika H Tesselaar, Johannes W Smit, James Nagarajah, Romana T Netea-Maier, Theo S Plantinga
    Journal of Molecular Endocrinology.2017; 59(4): R141.     CrossRef
  • Integrated microRNA, gene expression and transcription factors signature in papillary thyroid cancer with lymph node metastasis
    Nurul-Syakima Ab Mutalib, Sri Noraima Othman, Azliana Mohamad Yusof, Shahrun Niza Abdullah Suhaimi, Rohaizak Muhammad, Rahman Jamal
    PeerJ.2016; 4: e2119.     CrossRef
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Endocrinol Metab : Endocrinology and Metabolism