- Obesity and Metabolism
- Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
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Sang Soo Kim, Jong Ho Kim, In Joo Kim
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Endocrinol Metab. 2016;31(2):245-253. Published online May 27, 2016
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DOI: https://doi.org/10.3803/EnM.2016.31.2.245
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Diabetes is often associated with chronic kidney disease (CKD) and is the primary cause of kidney failure in half of patients who receive dialysis therapy. Given the increasing prevalence of diabetes and its high morbidity and mortality, diabetic nephropathy is a serious drawback in individual patients and a tremendous socioeconomic burden on society. Despite growing concern for the management of diabetic nephropathy, the prevalence of CKD with diabetes is the same today as it was 20 years ago. The current strategy to manage diabetic nephropathy, including the control of hyperglycemia, dyslipidemia, and blood pressure and the wide-spread use of renin-angiotensin-aldosterone system inhibitors, is well established to be beneficial in the early stages of diabetic nephropathy. However, the effects are uncertain in patients with relatively progressed CKD. Therefore, early diagnosis or risk verification is extremely important in order to reduce the individual and socioeconomic burdens associated with diabetic nephropathy by providing appropriate management to prevent the development and progression of this condition. This review focuses on recent research and guidelines regarding risk assessment, advances in medical treatment, and challenges of and future treatments for diabetic nephropathy. -
Citations
Citations to this article as recorded by  - The Role of Angiotensin-Converting Enzyme (ACE) Polymorphisms in the Risk of Development and Treatment of Diabetic Nephropathy
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Journal of Clinical Medicine.2024; 13(4): 995. CrossRef - Diagnostic utility of renal shear wave elastography and renal Doppler findings in diabetic nephropathy: a case–control study
Ahmed Abdelrahman Baz, Eman Muhammad Abdeen, Mona Yousry Helmy, Abo El-Magd Al-Bohy
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Pengyu Wang, Qing Lan, Qi Huang, Ruyi Zhang, Shuo Zhang, Leiming Yang, Yan Song, Tong Wang, Guandi Ma, Xiufen Liu, Xiying Guo, Youzhi Zhang, Chao Liu
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M. Raucoules-Aimé, T. Thierry Nessan Ouattara
EMC - Anestesia-Rianimazione.2023; 28(1): 1. CrossRef - Pyruvate Kinase M2: A New Biomarker for the Early Detection of Diabetes-Induced Nephropathy
Yeon Su Park, Joo Hee Han, Jae Hyeon Park, Ji Soo Choi, Seung Hyeon Kim, Hyung Sik Kim
International Journal of Molecular Sciences.2023; 24(3): 2683. CrossRef - Tratamiento perioperatorio del paciente diabético adulto
M. Raucoules-Aimé, T. Thierry Nessan Ouattara
EMC - Anestesia-Reanimación.2023; 49(1): 1. CrossRef - Renal Protection of Mineralocorticoid Receptor Antagonist, Finerenone, in Diabetic Kidney Disease
Dong-Lim Kim, Seung-Eun Lee, Nan Hee Kim
Endocrinology and Metabolism.2023; 38(1): 43. CrossRef - The role of tubulointerstitial markers in differential diagnosis and prognosis in patients with type 2 diabetes and biopsy proven diabetic kidney disease
Xijian Wang, Liang Ren, Ying Huang, Zhengang Feng, Guangdi Zhang, Houyong Dai
Clinica Chimica Acta.2023; 547: 117448. CrossRef - Network pharmacology and molecular docking technology-based predictive study of the active ingredients and potential targets of rhubarb for the treatment of diabetic nephropathy
Shaojie Fu, Yena Zhou, Cong Hu, Zhonggao Xu, Jie Hou
BMC Complementary Medicine and Therapies.2022;[Epub] CrossRef - Acrolein plays a culprit role in the pathogenesis of diabetic nephropathy in vitro and in vivo
Zhen-Jie Tong, Chin-Wei Kuo, Po-Cheng Yen, Chih-Ching Lin, Ming-Tsun Tsai, Shing-Hwa Lu, Yi-Ping Chang, Wen-Sheng Liu, Han-Hsing Tsou, Hsiao-Wei Cheng, Hsiang-Tsui Wang
European Journal of Endocrinology.2022; 187(4): 579. CrossRef - Probiotics ameliorates glycemic control of patients with diabetic nephropathy: A randomized clinical study
Hongyang Jiang, Yan Zhang, Dongyan Xu, Qing Wang
Journal of Clinical Laboratory Analysis.2021;[Epub] CrossRef - Blood Oxygen Level-Dependent (BOLD) MRI in Glomerular Disease
Daniel R. Nemirovsky, Puneet Gupta, Sophia Hu, Raymond Wong, Avnesh S. Thakor
Transplantology.2021; 2(2): 109. CrossRef - Amelioration of STZ-induced nephropathy in diabetic rats by saffron hydro alcoholic extract
Jamal Amri, Mona Alaee, Seyed Amirhossein Latifi, Abbas Alimoradian, Mehdi Salehi
Hormone Molecular Biology and Clinical Investigation.2021; 42(4): 411. CrossRef - Exosomes: Biomarkers and Therapeutic Targets of Diabetic Vascular Complications
Anqi Chen, Hailing Wang, Ying Su, Chunlin Zhang, Yanmei Qiu, Yifan Zhou, Yan Wan, Bo Hu, Yanan Li
Frontiers in Endocrinology.2021;[Epub] CrossRef - Sodium-glucose cotransporter 2 inhibitors benefit to kidney and cardiovascular outcomes for patients with type 2 diabetes mellitus and chronic kidney disease 3b-4: A systematic review and meta-analysis of randomized clinical trials
Haiyan Cao, Youxia Liu, Zhixia Tian, Yuhang Lian, Junya Jia, Ming Liu, Dong Li
Diabetes Research and Clinical Practice.2021; 180: 109033. CrossRef - Proteinuria as a significant predictive factor for the progression of carotid artery atherosclerosis in non-albuminuric type 2 diabetes
Young-eun Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-Wan Lee
Diabetes Research and Clinical Practice.2021; 181: 109082. CrossRef - The Role of Mesenchymal Stromal Cells-Derived Small Extracellular Vesicles in Diabetes and Its Chronic Complications
Fu-Xing-Zi Li, Xiao Lin, Feng Xu, Su-Kang Shan, Bei Guo, Li-Min Lei, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Ling-Qing Yuan
Frontiers in Endocrinology.2021;[Epub] CrossRef - Preparation of Ergosterol-Loaded Nanostructured Lipid Carriers for Enhancing Oral Bioavailability and Antidiabetic Nephropathy Effects
Zhonghua Dong, Sajid Iqbal, Zhongxi Zhao
AAPS PharmSciTech.2020;[Epub] CrossRef - Carbon dots as fluorescent nanoprobe for the determination of N-acetyl-β-d-glucosaminidase activity
Jimei Ma, Heng Zhang, Fangfang Peng, Xiaoqing Yang, Zi-Long Li, Linhao Sun, Hong Jiang
Analytica Chimica Acta.2020; 1101: 129. CrossRef - Coffee Consumption is Associated with a Decreased Risk of Incident Chronic Kidney Disease: A Systematic Review and Meta-analysis of Cohort Studies
Thatsaphan Srithongkul, Patompong Ungprasert
European Journal of Internal Medicine.2020; 77: 111. CrossRef - Understanding molecular upsets in diabetic nephropathy to identify novel targets and treatment opportunities
Nidhi Raval, Akshant Kumawat, Dnyaneshwar Kalyane, Kiran Kalia, Rakesh K. Tekade
Drug Discovery Today.2020; 25(5): 862. CrossRef - A meta-analysis of serum Hcy in diagnosis of diabetic nephropathy
Xiaoling Zhou, Aijie Shi, Xiao Zhou
Pteridines.2020; 31(1): 1. CrossRef - Link between ACE I/D gene polymorphism and dyslipidemia in diabetic nephropathy: A case-control study from Hyderabad, India
UmmeNajiya Mahwish, KamakshiChaithri Ponnaluri, Babi Heera, SatishReddy Alavala, KRudrama Devi, SreeBhushan Raju, GSuman Latha, Parveen Jahan
Indian Journal of Nephrology.2020; 30(2): 77. CrossRef - Assessment of urinary NGAL for differential diagnosis and progression of diabetic kidney disease
Suyan Duan, Jiajia Chen, Lin Wu, Guangyan Nie, Lianqin Sun, Chengning Zhang, Zhimin Huang, Changying Xing, Bo Zhang, Yanggang Yuan
Journal of Diabetes and its Complications.2020; 34(10): 107665. CrossRef - Urinary Proteins Detected Using Modern Proteomics Intervene in Early Type 2 Diabetic Kidney Disease – A Pilot Study
Alina Golea-Secara, Cristian Munteanu, Mirela Sarbu, Octavian M Cretu, Silvia Velciov, Adrian Vlad, Flaviu Bob, Florica Gadalean, Cristina Gluhovschi, Oana Milas, Anca Simulescu, Maria Mogos-Stefan, Mihaela Patruica, Ligia Petrica, Alina D Zamfir
Biomarkers in Medicine.2020; 14(16): 1521. CrossRef - Efficacy and safety of Shenkang injection as adjuvant therapy in patients with diabetic nephropathy
Yanping Wang, Mingzhu Li, Chenyun Li, Sheng Xu, Jiangfeng Wu, Gaochuan Zhang, Yuanyuan Cai
Medicine.2020; 99(52): e23821. CrossRef - A Nucleoside/Nucleobase-Rich Extract from Cordyceps Sinensis Inhibits the Epithelial–Mesenchymal Transition and Protects against Renal Fibrosis in Diabetic Nephropathy
Zhonghua Dong, Yueyue Sun, Guangwei Wei, Siying Li, Zhongxi Zhao
Molecules.2019; 24(22): 4119. CrossRef - Lack of Association between Past Helicobacter pylori Infection and Diabetes: A Two-Cohort Study
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Nutrients.2019; 11(8): 1874. CrossRef - Serum Homocysteine, cystatin C as Biomarkers for Progression of Diabetic Nephropathy
Weihai Xu, Suhua Tang, Meijuan Xiang, Jianyun Peng
Pteridines.2019; 30(1): 183. CrossRef - Serum leptin in diabetic nephropathy male patients from Gaza Strip
Maged M. Yassin, Ayman M. AbuMustafa, Mohamed M. Yassin
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(2): 1245. CrossRef - Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Renal Outcomes in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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Scientific Reports.2019;[Epub] CrossRef - Association between nonalbumin proteinuria and renal tubular damage of N-acetyl-β-d-glucosaminidase and its clinical relevance in patients with type 2 diabetes without albuminuria
Eugene Han, Mi-Kyung Kim, Yong-ho Lee, Hye Soon Kim, Byung-Wan Lee
Journal of Diabetes and its Complications.2019; 33(3): 255. CrossRef - Supplementation of Abelmoschus manihot Ameliorates Diabetic Nephropathy and Hepatic Steatosis by Activating Autophagy in Mice
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Nutrients.2018; 10(11): 1703. CrossRef - Perioperative management of adult diabetic patients. Preoperative period
Gaëlle Cheisson, Sophie Jacqueminet, Emmanuel Cosson, Carole Ichai, Anne-Marie Leguerrier, Bogdan Nicolescu-Catargi, Alexandre Ouattara, Igor Tauveron, Paul Valensi, Dan Benhamou
Anaesthesia Critical Care & Pain Medicine.2018; 37: S9. CrossRef - Practical management of diabetes patients before, during and after surgery: A joint French diabetology and anaesthesiology position statement
E. Cosson, B. Catargi, G. Cheisson, S. Jacqueminet, C. Ichai, A.-M. Leguerrier, A. Ouattara, I. Tauveron, E. Bismuth, D. Benhamou, P. Valensi
Diabetes & Metabolism.2018; 44(3): 200. CrossRef - MicroRNA‐326‐3p ameliorates high glucose and ox‐LDL‐IC‐ induced fibrotic injury in renal mesangial cells by targeting FcγRIII
Yiting Wang, Rui Zhang, Junlin Zhang, Fang Liu
Nephrology.2018; 23(11): 1031. CrossRef - Urinary Extracellular Vesicle
Wei-Cheng Xu, Ge Qian, Ai-Qun Liu, Yong-Qiang Li, He-Qun Zou
Chinese Medical Journal.2018; 131(11): 1357. CrossRef - Articles inEndocrinology and Metabolismin 2016
Won-Young Lee
Endocrinology and Metabolism.2017; 32(1): 62. CrossRef - Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes
Eugene Han, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Beom Seok Kim, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
Endocrinology and Metabolism.2017; 32(2): 274. CrossRef - WITHDRAWN: Salvianolate attenuates renal fibrosis in rat models of diabetic nephropathy by inhibiting inflammation and oxidative stress mechanisms
Chongxiang Xiong, Jianrao Lu, Xinhua Wang, Monica V. Masucci
Biochemical and Biophysical Research Communications.2017;[Epub] CrossRef - Diffusion tensor imaging of the renal cortex in diabetic patients: correlation with urinary and serum biomarkers
Ahmed Abdel Khalek Abdel Razek, Mohammad Alsayed Abd Alhamid Al-Adlany, Alhadidy Mohammed Alhadidy, Mohammed Ali Atwa, Naglaa Elsayed Abass Abdou
Abdominal Radiology.2017; 42(5): 1493. CrossRef - Texte 2 : période préopératoire
Gaëlle Cheisson, Sophie Jacqueminet, Emmanuel Cosson, Carole Ichai, Anne-Marie Leguerrier, Bogdan Nicolescu-Catargi, Alexandre Ouattara, Igor Tauveron, Paul Valensi, Dan Benhamou
Anesthésie & Réanimation.2017; 3(3): 218. CrossRef - Global Cardiovascular and Renal Outcomes of Reduced GFR
Bernadette Thomas, Kunihiro Matsushita, Kalkidan Hassen Abate, Ziyad Al-Aly, Johan Ärnlöv, Kei Asayama, Robert Atkins, Alaa Badawi, Shoshana H. Ballew, Amitava Banerjee, Lars Barregård, Elizabeth Barrett-Connor, Sanjay Basu, Aminu K. Bello, Isabela Bensen
Journal of the American Society of Nephrology.2017; 28(7): 2167. CrossRef - Salvia miltiorrhizaLipophilic Fraction Attenuates Oxidative Stress in Diabetic Nephropathy through Activation of Nuclear Factor Erythroid 2-Related Factor 2
Lin An, Mei Zhou, Faiz M. M. T. Marikar, Xue-Wen Hu, Qiu-Yun Miao, Ping Li, Jun Chen
The American Journal of Chinese Medicine.2017; 45(07): 1441. CrossRef - Addition of nonalbumin proteinuria to albuminuria improves prediction of type 2 diabetic nephropathy progression
Jong Ho Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Jin Mi Kim, Yong Ki Kim, Sang Soo Kim, In Joo Kim
Diabetology & Metabolic Syndrome.2017;[Epub] CrossRef - Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model
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Journal of Diabetes Research.2016; 2016: 1. CrossRef
- Clinical Study
- Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer
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Sang Mi Kim, Eun Heui Kim, Bo Hyun Kim, Jong Ho Kim, Su Bin Park, Yoon Jeong Nam, Kang Hee Ahn, Min Young Oh, Won Jin Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim, In Ju Kim
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Endocrinol Metab. 2015;30(4):494-501. Published online December 31, 2015
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DOI: https://doi.org/10.3803/EnM.2015.30.4.494
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- Background
Several inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte count ratio (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance of the NLR and PLR in papillary thyroid cancer (PTC). We evaluated the association of the preoperative NLR and PLR with clinicopathological characteristics in patients with PTC. MethodsThis study included 1,066 female patients who underwent total thyroidectomy for PTC. Patients were stratified into 4 quartiles by preoperative NLR and PLR. And the combination of preoperative NLR and PLR was calculated on the basis of data obtained value of tertile as follows: patients with both an elevated PLR and an elevated NLR were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively. ResultsThe preoperative NLR and PLR were significantly lower in patients aged ≥45 years and in patients with Hashimoto's thyroiditis. The PLR was significantly higher in patients with tumor size >1 cm (P=0.021).When the patients were categorized into the aforementioned four groups, the group with the higher preoperative PLR was found to have a significantly increased incidence of lateral lymph node metastasis (LNM) (P=0.018). However, there are no significant association between the combination of preoperative NLR and PLR and prognostic factors in PTC patients. ConclusionThese results suggest that a preoperative high PLR were significant associated with lateral LNM in female patients with PTC.
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Citations
Citations to this article as recorded by
- Brain Metastasis from Papillary Thyroid Carcinoma: Report of 2 Cases.
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Jung Gu Lee, Ki Young Lee, Yon Sil Jung, Hong Kyu Kim, Hye Young Park, Jong Ho Kim, Moon Ho Kang
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J Korean Endocr Soc. 1999;14(4):745-751. Published online January 1, 2001
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Abstract
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- Papillary carcinoma, the commonest thyroid malignancy, has an indolent clinical course and carries a good prognosis. Metastasis usually occurs to regional lymph nodes, including cervical and upper mediastinal nodes. Distant metastasis is uncommon, lung and bone being the commonest sites. Brain metastasis from papillary thyroid cancer is rare, with a frequency of less than 1% in several reported series and an extremely poor prognosis. The first case was a 74-year-old female patient with papillary cancer who took total thyroidectomy followed by 131I therapy 1 month later. Two days after 131I therapy, she developed headache, vomiting and left hemiplegia. Brain MRI and 131I whole body scan showed solitary brain metastasis in right parietal lobe. After a few weeks her condition improved enough to maintain her usual daily activity despite mild motor weakness. The second one, a 64-year-old female patient presented with headache and vomiting. Two years previously, she had taken total thyroidectomy and 131I ablation therapy after diagnosis of thyroid papillary cancer. Eight months before, she had undergone radical neck dissection because of relapse in cervical lymph nodes. Brain MRI revealed multple metastatic lesions including cerebellum. This patient did not report for follow-up after 2 months of discharge.
- Pachydermoperiostosis mimicking acromegaly.
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Hong Kyu Lee, Jong Ho Kim, Jong You Kim, Hye Young Park, Eon Soo Shin, Hwan Joon Chang, In Soo Han, Moon Ho Kang
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J Korean Endocr Soc. 1993;8(4):439-444. Published online January 1, 2001
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- No abstract available.
- Percutaneous tetracycline injection(PTI) of benign non-cystic thyroid nodules.
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Jong Ho Kim, Byung Chun Moon, Yoon Ja Kim, Jung Soon Kim, Kwang Hoe Kim, Ok Kim, Byung Doo Lee, Jae Whan Moon
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J Korean Endocr Soc. 1991;6(1):58-67. Published online January 1, 2001
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- No abstract available.
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