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John Paul M. Quisumbing  (Quisumbing JPM) 1 Article
Clinical Study
Factors Associated with Postoperative Diabetes Insipidus after Pituitary Surgery
Antonio L. Faltado, Anna Angelica Macalalad-Josue, Ralph Jason S. Li, John Paul M. Quisumbing, Marc Gregory Y. Yu, Cecilia A. Jimeno
Endocrinol Metab. 2017;32(4):426-433.   Published online November 21, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.4.426
  • 5,734 View
  • 92 Download
  • 13 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   
Background

Determining risk factors for diabetes insipidus (DI) after pituitary surgery is important in improving patient care. Our objective is to determine the factors associated with DI after pituitary surgery.

Methods

We reviewed records of patients who underwent pituitary surgery from 2011 to 2015 at Philippine General Hospital. Patients with preoperative DI were excluded. Multiple logistic regression analysis was performed and a predictive model was generated. The discrimination abilities of the predictive model and individual variables were assessed using the receiving operator characteristic curve.

Results

A total of 230 patients were included. The rate of postoperative DI was 27.8%. Percent change in serum Na (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.15 to 1.69); preoperative serum Na (OR, 1.19; 95% CI, 1.02 to 1.40); and performance of craniotomy (OR, 5.48; 95% CI, 1.60 to 18.80) remained significantly associated with an increased incidence of postoperative DI, while percent change in urine specific gravity (USG) (OR, 0.53; 95% CI, 0.33 to 0.87) and meningioma on histopathology (OR, 0.05; 95% CI, 0.04 to 0.70) were significantly associated with a decreased incidence. The predictive model generated has good diagnostic accuracy in predicting postoperative DI with an area under curve of 0.83.

Conclusion

Greater percent change in serum Na, preoperative serum Na, and performance of craniotomy significantly increased the likelihood of postoperative DI while percent change in USG and meningioma on histopathology were significantly associated with a decreased incidence. The predictive model can be used to generate a scoring system in estimating the risk of postoperative DI.

Citations

Citations to this article as recorded by  
  • Incidence of post-operative diabetes insipidus and associated factors after pituitary surgery in two teaching hospitals, in Addis Ababa, Ethiopia: A prospective observational study
    Abera Chanie, Abat Sahlu
    Interdisciplinary Neurosurgery.2024; 37: 101978.     CrossRef
  • Pituitary Adenoma in the Philippines: A Scoping Review on the Treatment Gaps, Challenges, and Current State of Care
    Mykha Marie B. Tabuzo, Mary Angeline Luz U. Hernandez, Annabell E. Chua, Patricia D. Maningat, Harold Henrison C. Chiu, Roland Dominic G. Jamora
    Medical Sciences.2024; 12(1): 16.     CrossRef
  • In Reply to the Letter to the Editor Regarding “Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study”
    Marcos Ezequiel Yasuda, Daniela Renedo, Rodolfo Recalde, Roberto Zaninovich, Santiago Gonzalez Abbati, Andrés Cervio, Sebastian Giovannini, Juan Villalonga, Liezel Ulloque-Caamaño, Kesava Reddy, Mariano Socolovsky, Alvaro Campero
    World Neurosurgery.2024; 185: 484.     CrossRef
  • Letter to the Editor Regarding “Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study”
    Karlos Acurio, Fritz Fidel Váscones-Román, Fernando Canazas-Paredes, Aryan Wadhwa, Niels Pacheco-Barrios
    World Neurosurgery.2024; 185: 483.     CrossRef
  • Correlation of Pituitary Descent and Diabetes Insipidus After Transsphenoidal Pituitary Macroadenoma Resection
    Josh Ma, Peter Gooderham, Ryojo Akagami, Serge Makarenko
    Neurosurgery.2023; 92(6): 1269.     CrossRef
  • Risk Factors Related to Transient Diabetes Insipidus Development Following Transsphenoidal Pituitary Adenoma Resection: A Multicentric Study
    Marcos Ezequiel Yasuda, Daniela Renedo, Soledad Sosa, Karina Danilowicz, Rodolfo Recalde, Roberto Zaninovich, Santiago Gonzalez Abbati, Andrés Cervio, Sebastian Giovannini, Juan Villalonga, Liezel Ulloque-Caamaño, Kesava Reddy, Mariano Socolovsky, Alvaro
    World Neurosurgery.2023; 175: e636.     CrossRef
  • Importance of Intraoperative Factors in Postoperative Arginine Vasopressin Deficiency After Pituitary Adenoma Surgery
    Nasim Alidaei, Guive Sharifi, Zahra Davoudi
    Endocrine Practice.2023;[Epub]     CrossRef
  • Change in cephalocaudal tumor cavity diameter after transsphenoidal surgery is a predictor of diabetes insipidus in pituitary adenoma
    Kunzhe Lin, Kaichun Fan, Shuwen Mu, Shousen Wang
    European Journal of Medical Research.2022;[Epub]     CrossRef
  • Change in the pituitary stalk deviation angle after transsphenoidal surgery can predict the development of diabetes insipidus for pituitary adenomas
    Liang Xue, Jianwu Wu, Jie Chen, Yongkai Yang
    Endocrine Connections.2022;[Epub]     CrossRef
  • Disorders of Salt and Water Balance After Pituitary Surgery
    Emily K Brooks, Warrick J Inder
    The Journal of Clinical Endocrinology & Metabolism.2022; 108(1): 198.     CrossRef
  • Postoperative diabetes insipidus: how to define and grade this complication?
    Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Wouter R. van Furth, Alberto M. Pereira, Nienke R. Biermasz
    Pituitary.2021; 24(2): 284.     CrossRef
  • Diaphragma sellae sinking can predict the onset of hyponatremia after transsphenoidal surgery for pituitary adenomas
    Kunzhe Lin, Jun Li, Lingling Lu, Shangming Zhang, Shuwen Mu, Zhijie Pei, Cheng Wang, Jingying Lin, Liang Xue, Liangfeng Wei, Lin Zhao, Shousen Wang
    Journal of Endocrinological Investigation.2021; 44(11): 2511.     CrossRef
  • Adrenocorticotropic hormone-secreting pituitary macroadenoma: A pictorial case report and review
    Ujjwala Murkute
    Indian Journal of Continuing Nursing Education.2021; 22(2): 137.     CrossRef
  • Sodium Perturbations After Pituitary Surgery
    Kevin C.J. Yuen, Adnan Ajmal, Ricardo Correa, Andrew S. Little
    Neurosurgery Clinics of North America.2019; 30(4): 515.     CrossRef
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