As the prevalence and life expectancy of type 2 diabetes mellitus (T2DM) continue to increase, the importance of effective detection and intervention for the complications of T2DM, especially neurocognitive complications including cognitive dysfunction and dementia, is receiving greater attention. T2DM is thought to influence cognitive function through an as yet unclear mechanism that involves multiple factors such as hyperglycemia, hypoglycemia, and vascular disease. Recent developments in neuroimaging methods have led to the identification of potential neural correlates of T2DM-related neurocognitive changes, which extend from structural to functional and metabolite alterations in the brain. The evidence indicates various changes in the T2DM brain, including global and regional atrophy, white matter hyperintensity, altered functional connectivity, and changes in neurometabolite levels. Continued neuroimaging research is expected to further elucidate the underpinnings of cognitive decline in T2DM and allow better diagnosis and treatment of the condition.

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• The level of serum retinol-binding protein is associated with diabetic mild cognitive impairment
  Wenjie Zhang, Yuqi Yuan, Xiaoxia Cui, Shihong Chen, Xianghua Zhuang
  Brain Research.2024; 1822: 148670.     CrossRef
• Research Progress on Lipocalin-2 in Diabetic Encephalopathy
  Wenjie Zhang, Shihong Chen, Xianghua Zhuang
  Neuroscience.2023; 515: 74.     CrossRef
• Voluntary Attention and Quality of Life in Patients With Type 1 and Type 2 Diabetes Mellitus: Differences in Changes Depending on Disease Type and Duration
  N. E. Tadevosyan, A. S. Khachunts, M. Gohargani, A. A. Sahakyan, A. A. Tumanyan
  Journal of Evolutionary Biochemistry and Physiology.2022; 58(2): 569.     CrossRef
• Modifiable risk factors for neurocognitive and psychosocial problems after Hodgkin lymphoma
  AnnaLynn M. Williams, Sedigheh Mirzaei Salehabadi, Mengqi Xing, Nicholas S. Phillips, Matthew J. Ehrhardt, Rebecca Howell, Yutaka Yasui, Kevin C. Oeffinger, Todd Gibson, Eric J. Chow, Wendy Leisenring, Deokumar Srivastava, Melissa M. Hudson, Leslie L. Rob
  Blood.2022; 139(20): 3073.     CrossRef
• Type 2 Diabetes Independent of Glycemic Control is Associated With Cognitive Impairments: Findings From NHANES
  Rozmin Jiwani, Brittany Dennis, Alfonso L. Neri, Chandler Bess, Sara Espinoza, Jing Wang, Monica C. Serra
  Clinical Nursing Research.2022; 31(7): 1225.     CrossRef
• Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis
  Nathalie Marissal-Arvy, Marie-Pierre Moisan
  Metabolism Open.2022; 15: 100202.     CrossRef
• Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
  Bhaskar Jyoti Dutta, Shamsher Singh, Sanket Seksaria, Ghanshyam Das Gupta, Amrita Singh
  Pharmacological Research.2022; 182: 106358.     CrossRef
• The role of LRP1 in Aβ efflux transport across the blood-brain barrier and cognitive dysfunction in diabetes mellitus
  Xue P, Long Zz, Jiang Gg, Wang Lp, Bian Cm, Wang Yl, M.F. Chen, Li W
  Neurochemistry International.2022; 160: 105417.     CrossRef
• Childhood Neurotoxicity and Brain Resilience to Adverse Events during Adulthood
  AnnaLynn M. Williams, Yin Ting Cheung, Geehong Hyun, Wei Liu, Kirsten K. Ness, Matthew J. Ehrhardt, Daniel A. Mulrooney, Nickhill Bhakta, Pia Banerjee, Tara M. Brinkman, Daniel M. Green, Wassim Chemaitilly, I‐Chan Huang, Deokumar Srivastava, Melissa M. Hu
  Annals of Neurology.2021; 89(3): 534.     CrossRef
• Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model
  Xiaoyi Ma, Wenchang Xiao, Hao Li, Pei Pang, Feixiao Xue, Lu Wan, Lei Pei, Huanhuan Yan
  Brain, Behavior, and Immunity.2021; 95: 68.     CrossRef
• Promoting Successful Cognitive Aging: A Ten-Year Update
  Taylor J. Krivanek, Seth A. Gale, Brittany M. McFeeley, Casey M. Nicastri, Kirk R. Daffner
  Journal of Alzheimer's Disease.2021; 81(3): 871.     CrossRef
• Association of Vitamin D Level and Nerve Conduction Study Parameters with Cognitive Function in Diabetic Neuropathy Patients
  Aida Fithrie, Fasihah Irfani Fitri, Muhammad Reza Putra
  Open Access Macedonian Journal of Medical Sciences.2021; 9(B): 72.     CrossRef
• Insulin resistance takes center stage: a new paradigm in the progression of bipolar disorder
  Cynthia V. Calkin
  Annals of Medicine.2019; 51(5-6): 281.     CrossRef
• Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial
  Mary A. Byrn, William Adams, Sue Penckofer, Mary Ann Emanuele
  Journal of Diabetes Research.2019; 2019: 1.     CrossRef
• Neurocognitive impairment in type 2 diabetes mellitus
  Marianna Karvani, P. Simos, S. Stavrakaki, D. Kapoukranidou
  Hormones.2019; 18(4): 523.     CrossRef
• Benefits of combination low-dose pioglitazone plus fish oil on aged type 2 diabetes mice
  Yuzuru Iizuka, Hyounju Kim, Satoshi Hirako, Kanako Chiba, Masahiro Wada, Akiyo Matsumoto
  Journal of Food and Drug Analysis.2018; 26(4): 1265.     CrossRef
• Association of ApoE Genetic Polymorphism and Type 2 Diabetes with Cognition in Non-Demented Aging Chinese Adults: A Community Based Cross-Sectional Study
  Jie Zhen, Tong Lin, Xiaochen Huang, Huiqiang Zhang, Shengqi Dong, Yifan Wu, Linlin Song, Rong Xiao, Linhong Yuan
  Aging and disease.2018; 9(3): 346.     CrossRef
• Chronic Health Conditions and Neurocognitive Function in Aging Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
  Yin Ting Cheung, Tara M Brinkman, Chenghong Li, Yasmin Mzayek, Deokumar Srivastava, Kirsten K Ness, Sunita K Patel, Rebecca M Howell, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Kevin R Krull
  JNCI: Journal of the National Cancer Institute.2018; 110(4): 411.     CrossRef
• Diabetes, Depression, and Cognition: a Recursive Cycle of Cognitive Dysfunction and Glycemic Dysregulation
  Sheila Black, Kyle Kraemer, Avani Shah, Gaynell Simpson, Forrest Scogin, Annie Smith
  Current Diabetes Reports.2018;[Epub]     CrossRef
• Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: An analysis based on the Korea National Diabetes Program Cohort
  Sang Ouk Chin, Sang Youl Rhee, Suk Chon, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Ki Hong Chun, Jeong-taek Woo, Young Seol Kim
  Diabetes Research and Clinical Practice.2016; 122: 54.     CrossRef
• Bipolar disorders, type 2 diabetes mellitus, and the brain
  Tomas Hajek, Roger McIntyre, Martin Alda
  Current Opinion in Psychiatry.2016; 29(1): 1.     CrossRef
• 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy
  Min Kyeong Kim, Hye Seung Jung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Seong Yeon Kim
  Endocrinology and Metabolism.2016; 31(2): 284.     CrossRef
• Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
  Seung-Hwan Lee, Janice M. Zabolotny, Hu Huang, Hyon Lee, Young-Bum Kim
  Molecular Metabolism.2016; 5(8): 589.     CrossRef
• Toll-like receptor 2 and type 2 diabetes
  Zahra Sepehri, Zohre Kiani, Ali Akbar Nasiri, Farhad Kohan
  Cellular & Molecular Biology Letters.2016;[Epub]     CrossRef
• Long-term Variability in Glycemic Control Is Associated With White Matter Hyperintensities in APOE4 Genotype Carriers With Type 2 Diabetes
  Abigail Livny, Ramit Ravona-Springer, Anthony Heymann, Rachel Priess, Tammar Kushnir, Galia Tsarfaty, Leeron Rabinov, Reut Moran, Hadass Hoffman, Itzik Cooper, Lior Greenbaum, Jeremy Silverman, Mary Sano, Sterling C. Johnson, Barbara B. Bendlin, Michal Sc
  Diabetes Care.2016; 39(6): 1056.     CrossRef
• DIABETES MELLITUS Y SU ASOCIACIÓN CON DETERIORO COGNITIVO Y DEMENCIA
  Gonzalo Muñoz A., Christina Degen, Johannes Schröder, Pablo Toro E.
  Revista Médica Clínica Las Condes.2016; 27(2): 266.     CrossRef
• Blood electrolyte disturbances during severe hypoglycemia in Korean patients with type 2 diabetes
  Mi Yeon Kang
  The Korean Journal of Internal Medicine.2015; 30(5): 648.     CrossRef
• Whenever You Lose Connection, Take Intranasal Insulin?
  Antje Gottschalk, Björn Ellger
  Diabetes.2015; 64(3): 687.     CrossRef
• Spatial Patterns of Structural Brain Changes in Type 2 Diabetic Patients and Their Longitudinal Progression With Intensive Control of Blood Glucose
  Guray Erus, Harsha Battapady, Tianhao Zhang, James Lovato, Michael E. Miller, Jeff D. Williamson, Lenore J. Launer, R. Nick Bryan, Christos Davatzikos
  Diabetes Care.2015; 38(1): 97.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
• Cerebrolysin reverses hippocampal neural atrophy in a mice model of diabetes mellitus type 1
  Lizzette Sanchez‐Vega, Ismael Juárez, Maria De Jesus Gomez‐Villalobos, Gonzalo Flores
  Synapse.2015; 69(6): 326.     CrossRef