- Diabetes, obesity and metabolism
- Association between Serum Amyloid A Levels and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
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Ting Liu, Meng Li, Chunying Cui, Jielin Zhou
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Endocrinol Metab. 2023;38(3):315-327. Published online June 7, 2023
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DOI: https://doi.org/10.3803/EnM.2023.1621
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 Abstract
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- Background
To date, consistent data have not been reported on the association between serum amyloid A (SAA) levels and type 2 diabetes mellitus (T2DM). The purpose of this study was to systematically summarize their relationship.
Methods
Databases including PubMed, Cochrane Library, Embase, Web of Science, and MEDLINE were searched until August 2021. Cross-sectional and case-control studies were included.
Results
Twenty-one studies with 1,780 cases and 2,070 controls were identified. SAA levels were significantly higher in T2DM patients than in healthy groups (standardized mean difference [SMD], 0.68; 95% confidence interval [CI], 0.39 to 0.98). A subgroup analysis showed that the mean age of participants and the continent that participants were from were related to differences in SAA levels between cases and controls. Furthermore, in T2DM patients, SAA levels were positively associated with body mass index (r=0.34; 95% CI, 0.03 to 0.66), triglycerides (r=0.12; 95% CI, 0.01 to 0.24), fasting plasma glucose (r=0.26; 95% CI, 0.07 to 0.45), hemoglobin A1c (r=0.24; 95% CI, 0.16 to 0.33), homeostasis model assessment for insulin resistance (r=0.22; 95% CI, 0.10 to 0.34), C-reactive protein (r=0.77; 95% CI, 0.62 to 0.91), and interleukin-6 (r=0.42; 95% CI, 0.31 to 0.54), but negatively linked with highdensity lipoprotein cholesterol (r=–0.23; 95% CI, –0.44 to –0.03).
Conclusion
The meta-analysis suggests that high SAA levels may be associated with the presence of T2DM, as well as lipid metabolism homeostasis and the inflammatory response.
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Citations
Citations to this article as recorded by  - Recent Advances in Studies of Serum Amyloid A: Implications in Inflammation, Immunity and Tumor Metastasis
Yixin Chang, Yezhou Liu, Yuanrui Zou, Richard D. Ye
International Journal of Molecular Sciences.2025; 26(3): 987. CrossRef - From immune activation to disease progression: Unraveling the complex role of Serum Amyloid A proteins
Praveen Papareddy, Heiko Herwald
Cytokine & Growth Factor Reviews.2025;[Epub] CrossRef - Correlation between insulin resistance and the rate of neutrophils-lymphocytes, monocytes-lymphocytes, platelets-lymphocytes in type 2 diabetic patients
Yuanyuan Zhang, Huaizhen Liu
BMC Endocrine Disorders.2024;[Epub] CrossRef - Integrated Network-Based Analysis of Diseases Associated with Amyloid Deposition Through a Disease–Protein–Drug Network
Aikaterini E. I. Rizou, Georgia I. Nasi, Avgi E. Apostolakou, Meletios A. Dimopoulos, Efstathios Kastritis, Vassiliki A. Iconomidou
Pharmaceuticals.2024; 17(12): 1736. CrossRef - Antioxidant and Anti-Inflammatory Functions of High-Density Lipoprotein in Type 1 and Type 2 Diabetes
Damien Denimal
Antioxidants.2023; 13(1): 57. CrossRef
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