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Endocrinol Metab : Endocrinology and Metabolism


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Ji Hye Huh  (Huh JH) 2 Articles
Clinical Study
Association between Serum Gamma-Glutamyltransferase and Prevalence of Metabolic Syndrome Using Data from the Korean Genome and Epidemiology Study
Mi Young Lee, Dae Sung Hyon, Ji Hye Huh, Hae Kyung Kim, Sul Ki Han, Jang Young Kim, Sang Baek Koh
Endocrinol Metab. 2019;34(4):390-397.   Published online December 23, 2019
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  • 112 Download
  • 11 Citations
AbstractAbstract PDFPubReader   ePub   CrossRef-TDMCrossref - TDM

The aim of this study was to determine whether there is a positive correlation between gamma-glutamyltransferase (GGT) levels and the prevalence of metabolic syndrome and whether GGT can be used as an easily checkable metabolic index using data from the large-scale Korean Genome and Epidemiology Study (KoGES).


We obtained data of 211,725 participants of the KoGES. The collected data included age, sex, height, weight, waist circumference, and various biochemical characteristics, including serum GGT levels. The data of study participants who ingested more than 40 g/day of alcohol and who were diagnosed with metabolic syndrome at baseline was excluded. We analyzed the prevalence of metabolic syndrome according to GGT quartiles in both genders.


The GGT level was significantly higher in subjects with metabolic syndrome compared to normal subjects (37.92±48.20 mg/dL vs. 25.62±33.56 mg/dL). The prevalence of metabolic syndrome showed a stepwise increase with GGT quartiles in both male and female subjects. Compared to the lowest GGT quartile, the odds ratio was 1.534 (95% confidence interval [CI], 1.432 to 1.643), 1.939 (95% CI, 1.811 to 2.076), and 2.754 (95% CI, 2.572 to 2.948) in men and 1.155 (95% CI, 1.094 to 1.218), 1.528 (95% CI, 1.451 to 1.609), and 2.022 (95% CI, 1.921 to 2.218) in women with increasing GGT quartile. The cutoff value of GGT predicting risk of metabolic syndrome was 27 IU/L in men and 17 IU/L in women.


We suggested that GGT could be an easily checkable marker for the prediction of metabolic syndrome.


Citations to this article as recorded by  
  • Liver fat content assessed by conventional B-mode ultrasound and metabolic profile in non-diabetic patients: Implications for clinical practice
    Rosanna Villani, Grazia Pia Magnati, Giulia Tuccari, Moris Sangineto, Antonino Davide Romano, Tommaso Cassano, Gaetano Serviddio
    Ultrasound.2023; 31(3): 177.     CrossRef
  • Serum γ-glutamyltransferase level and incidence risk of metabolic syndrome in community dwelling adults: longitudinal findings over 12 years
    Jiwon Kwak, In-Ho Seo, Yong-Jae Lee
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Gamma-Glutamyl Transferase as a Diagnostic Marker of Metabolic Syndrome
    Bobbili Tarun Kesava Naidu, Kakarlapudi Santosh Raju, Janapareddi V BhaskaraRao, Nallapati Sunil Kumar
    Cureus.2023;[Epub]     CrossRef
  • “Big Data” Approaches for Prevention of the Metabolic Syndrome
    Xinping Jiang, Zhang Yang, Shuai Wang, Shuanglin Deng
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Can Gamma-glutamyl Transferase Predict Unhealthy Metabolic Phenotypes Among Healthcare Workers in Azar Cohort Study?
    Mohammadhossein Somi, Seyed Sina Zakavi, Alireza Ostadrahimi, Negin Frounchi, Neda Gilani, Sarvin Sanaie, Elnaz Faramarzi
    Hepatitis Monthly.2022;[Epub]     CrossRef
  • Association between liver enzymes and metabolic syndrome in Canadian adults: results from the Canadian health measures survey - cycles 3 &4
    Luan Manh Chu, Chandima Karunanayake, Palok Aich, Markus Hecker, Punam Pahwa
    Journal of Diabetes & Metabolic Disorders.2022; 21(2): 1699.     CrossRef
  • Repeatedly elevated γ-glutamyltransferase levels are associated with an increased incidence of digestive cancers: A population-based cohort study
    Chang-Hoon Lee, Kyungdo Han, Da Hye Kim, Min-Sun Kwak
    World Journal of Gastroenterology.2021; 27(2): 176.     CrossRef
  • Index of Cardiac Age Index and Cardiometabolic Biomarkers in Adults with Metabolic Syndrome
    Eun Jung Choi, Sang Yeoup Lee
    Metabolic Syndrome and Related Disorders.2021; 19(5): 288.     CrossRef
  • Simple metabolic markers associated with tophaceous gout
    Wei Liu, Hui Song, Siliang Man, Hongchao Li, Siming Gao
    Clinical Rheumatology.2021; 40(12): 5047.     CrossRef
  • Expression Status and Prognostic Significance of Gamma-Glutamyl Transpeptidase Family Genes in Hepatocellular Carcinoma
    Shan Tian, Jiao Li, Yingyun Guo, Weiguo Dong, Xin Zheng
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes
    Sang Youn You, Kyungdo Han, Seung-Hawn Lee, Mee Kyoung Kim
    Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
A Case of Latent Autoimmune Diabetes in Adults Developed after Surgical Cure of Growth Hormone Secreting Pituitary Tumor.
Wonjin Kim, Jung Ho Kim, Youngsook Kim, Ji Hye Huh, Su Jin Lee, Mi Sung Park, Eun Yeong Choe, Jeong Kyung Park, Myung Won Lee, Jae Won Hong, Byung Wan Lee, Eun Seok Kang, Bong Soo Cha, Eun Jig Lee, Hyun Chul Lee
Endocrinol Metab. 2012;27(4):318-322.   Published online December 20, 2012
  • 1,832 View
  • 29 Download
AbstractAbstract PDF
Acromegaly is generally caused by a benign growth hormone (GH)-secreting pituitary adenoma. It is characterized by a wide range of complications; cardiovascular, respiratory, bone and joint, and metabolic complications. Among them, impaired glucose tolerance and diabetes mellitus, due to GH-induced insulin resistance, has been reported in approximately 16-46% and 19-56%. They are usually improved following the treatment of acromegaly, surgical or medical therapy. We report a first case of 36-year-old man who was paradoxically diagnosed with GAD antibody positive latent autoimmune diabetes in adults (LADA) after the surgical cure of acromegaly.

Endocrinol Metab : Endocrinology and Metabolism