Endocrinology and Metabolism

Ji Hoon Jeong (Jeong JH)

2 Articles

Diabetes, Obesity and Metabolism
Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors: Yong-Jik Lee, Yoo-Na Jang, Hyun-Min Kim, Yoon-Mi Han, Hong Seog Seo, Youngsub Eom, Jong-suk Song, Ji Hoon Jeong, Tae Woo Jung; Endocrinol Metab. 2022;37(2):221-232. Published online March 23, 2022; DOI: https://doi.org/10.3803/EnM.2021.1237

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Background
Obesity, the prevalence of which is increasing due to the lack of exercise and increased consumption of Westernized diets, induces various complications, including ophthalmic diseases. For example, obesity is involved in the onset of cataracts.
Methods
To clarify the effects and mechanisms of midodrine, an α1-adrenergic receptor agonist, in cataracts induced by obesity, we conducted various analytic experiments in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a rat model of obesity.
Results
Midodrine prevented cataract occurrence and improved lens clearance in OLETF rats. In the lenses of OLETF rats treated with midodrine, we observed lower levels of aldose reductase, tumor necrosis factor-α, and sorbitol, but higher levels of hexokinase, 5’-adenosine monophosphate-activated protein kinase-alpha, adenosine 5´-triphosphate, peroxisome proliferator-activated receptordelta, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, superoxide dismutase, and catalase.
Conclusion
The ameliorating effects of midodrine on cataracts in the OLETF obesity rat model are exerted via the following three mechanisms: direct inhibition of the biosynthesis of sorbitol, which causes cataracts; reduction of reactive oxygen species and inflammation; and (3) stimulation of normal aerobic glycolysis.

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Citations to this article as recorded by

α1-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for COVID-19, Heart Failure, and Alzheimer’s Disease
Dianne M. Perez
International Journal of Molecular Sciences.2023; 24(4): 4188. CrossRef
A new use for old drugs: identifying compounds with an anti-obesity effect using a high through-put semi-automated Caenorhabditis elegans screening platform
Freek Haerkens, Charlotte Kikken, Laurens Kirkels, Monique van Amstel, Willemijn Wouters, Els van Doornmalen, Christof Francke, Samantha Hughes
Heliyon.2022; 8(8): e10108. CrossRef

Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model: Seok Joo Park, Yoon Hee Chung, Jeong Hyun Lee, Duy-Khanh Dang, Yunsung Nam, Ji Hoon Jeong, Yong Sun Kim, Toshitaka Nabeshima, Eun-Joo Shin, Hyoung-Chun Kim; Endocrinol Metab. 2014;29(3):336-348. Published online September 25, 2014; DOI: https://doi.org/10.3803/EnM.2014.29.3.336

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32 Download
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Abstract PDF PubReader

Background

It has been recognized that a defect in klotho gene expression accelerates the degeneration of multiple age-sensitive traits. Accumulating evidence indicates that aging is associated with declines in cognitive function and the activity of growth hormone (GH)/insulin-like growth factor-1 (IGF-1).

Methods

In this study, we examined whether a GH-releaser diet could be effective in protecting against cognitive impairment in klotho mutant mice.

Results

The GH-releaser diet significantly induced the expression of IGF-1 and IGF-1 receptors in the hippocampus of klotho mutant mice. Klotho mutant mice showed significant memory impairments as compared with wild-type mice. In addition, the klotho mutation significantly decreased the expression of cell survival/antiapoptotic factors, including phospho-Akt (p-Akt)/phospho-glycogen synthase kinase3β (p-GSK3β), phospho-extracellular signal-related kinase (p-ERK), and Bcl-2, but significantly increased those of cell death/proapoptotic factors, such as phospho-c-jun N-terminal kinase (p-JNK), Bax, and cleaved caspase-3 in the hippocampus. Treatment with GH-releaser diet significantly attenuated both decreases in the expression of cell survival/antiapoptotic factors and increases in the expression of cell death/proapoptotic factors in the hippocampus of klotho mutant mice. In addition, klotho mutation-induced oxidative stress was significantly attenuated by the GH-releaser diet. Consequently, a GH-releaser diet significantly improved memory function in the klotho mutant mice. GH-releaser diet-mediated actions were significantly reversed by JB-1, an IGF-1 receptor antagonist.

Conclusion

The results suggest that a GH-releaser diet attenuates oxidative stress, proapoptotic changes and consequent dysfunction in klotho mutant mice by promoting IGF-1 expression and IGF-1 receptor activation.

Citations

Citations to this article as recorded by

New insights into the role of Klotho in inflammation and fibrosis: molecular and cellular mechanisms
Xinyue Zhao, Donghe Han, Chun Zhao, Fengfan Yang, Zhimei Wang, Yujiao Gao, Meihua Jin, Ran Tao
Frontiers in Immunology.2024;[Epub] CrossRef
Virgin coconut oil reverses behavioral phenotypes of letrozole-model of PCOS in Wistar rats via modulation of NRF2 upregulation
Olabode O. Akintoye, Ayodeji J. Ajibare, Idowu O. Omotuyi
Journal of Taibah University Medical Sciences.2023; 18(4): 831. CrossRef
Nonlinear relationship between glycated hemoglobin and cognitive impairment after acute mild ischemic stroke
Lei Xu, Qin Xiong, Yang Du, Lu-wen Huang, Ming Yu
BMC Neurology.2023;[Epub] CrossRef
The location, physiology, pathology of hippocampus Melatonin MT2 receptor and MT2-selective modulators
Yueqin Feng, Xiaowen Jiang, Wenwu Liu, Hongyuan Lu
European Journal of Medicinal Chemistry.2023; 262: 115888. CrossRef
Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction
Thomas M. Barber, Ioannis Kyrou, Harpal S. Randeva, Martin O. Weickert
International Journal of Molecular Sciences.2021; 22(2): 546. CrossRef
A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans
Jie Tang, Jian-Fan Zhang, Rui-Qiu Yang, Yuan-Li Chen, Baosen Ni
Biochemical and Biophysical Research Communications.2021; 562: 36. CrossRef
Melatonin Receptor as a Drug Target for Neuroprotection
Pawaris Wongprayoon, Piyarat Govitrapong
Current Molecular Pharmacology.2020; 14(2): 150. CrossRef
Theanine attenuates memory impairments induced by klotho gene depletion in mice
Bao Trong Nguyen, Naveen Sharma, Eun-Joo Shin, Ji Hoon Jeong, Sung Hoon Lee, Choon-Gon Jang, Seung-Yeol Nah, Toshitaka Nabeshima, Yukio Yoneda, Hyoung-Chun Kim
Food & Function.2019; 10(1): 325. CrossRef
Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease
Rikki Hullinger, Luigi Puglielli
Behavioural Brain Research.2017; 322: 191. CrossRef
Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression
Anna Massó, Angela Sánchez, Lydia Gimenez-Llort, Jose Miguel Lizcano, Manuel Cañete, Belen García, Virginia Torres-Lista, Meritxell Puig, Assumpció Bosch, Miguel Chillon, David Blum
PLOS ONE.2015; 10(11): e0143623. CrossRef
Evaluation of individual aging degree by standard-free, label-free LC-MS/MS quantification of formaldehyde-modified peptides
Mei Zhang, Wei Xu, Ming Ke, Jianguo Xu, Yulin Deng
The Analyst.2015; 140(12): 4137. CrossRef
Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
Insulin resistance and cognitive dysfunction
Lina Ma, Jieyu Wang, Yun Li
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