Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
Jang Young Kim  (Kim JY) 4 Articles
Miscellaneous
Corrigendum: IRB Approval Number Correction. Cardiac Dysfunction in Association with Increased Inflammatory Markers in Primary Aldosteronism
Jung Soo Lim, Sungha Park, Sung Il Park, Young Taik Oh, Eun Hee Choi, Jang Young Kim, Yumie Rhee
Endocrinol Metab. 2020;35(3):671.   Published online July 30, 2020
DOI: https://doi.org/10.3803/EnM.2020.305
Corrects: Endocrinol Metab 2016;31(4):567
  • 3,580 View
  • 83 Download
PDFPubReader   ePub   
Close layer
Clinical Study
Association between Serum Gamma-Glutamyltransferase and Prevalence of Metabolic Syndrome Using Data from the Korean Genome and Epidemiology Study
Mi Young Lee, Dae Sung Hyon, Ji Hye Huh, Hae Kyung Kim, Sul Ki Han, Jang Young Kim, Sang Baek Koh
Endocrinol Metab. 2019;34(4):390-397.   Published online December 23, 2019
DOI: https://doi.org/10.3803/EnM.2019.34.4.390
  • 5,500 View
  • 119 Download
  • 14 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

The aim of this study was to determine whether there is a positive correlation between gamma-glutamyltransferase (GGT) levels and the prevalence of metabolic syndrome and whether GGT can be used as an easily checkable metabolic index using data from the large-scale Korean Genome and Epidemiology Study (KoGES).

Methods

We obtained data of 211,725 participants of the KoGES. The collected data included age, sex, height, weight, waist circumference, and various biochemical characteristics, including serum GGT levels. The data of study participants who ingested more than 40 g/day of alcohol and who were diagnosed with metabolic syndrome at baseline was excluded. We analyzed the prevalence of metabolic syndrome according to GGT quartiles in both genders.

Results

The GGT level was significantly higher in subjects with metabolic syndrome compared to normal subjects (37.92±48.20 mg/dL vs. 25.62±33.56 mg/dL). The prevalence of metabolic syndrome showed a stepwise increase with GGT quartiles in both male and female subjects. Compared to the lowest GGT quartile, the odds ratio was 1.534 (95% confidence interval [CI], 1.432 to 1.643), 1.939 (95% CI, 1.811 to 2.076), and 2.754 (95% CI, 2.572 to 2.948) in men and 1.155 (95% CI, 1.094 to 1.218), 1.528 (95% CI, 1.451 to 1.609), and 2.022 (95% CI, 1.921 to 2.218) in women with increasing GGT quartile. The cutoff value of GGT predicting risk of metabolic syndrome was 27 IU/L in men and 17 IU/L in women.

Conclusion

We suggested that GGT could be an easily checkable marker for the prediction of metabolic syndrome.

Citations

Citations to this article as recorded by  
  • Liver fat content assessed by conventional B-mode ultrasound and metabolic profile in non-diabetic patients: Implications for clinical practice
    Rosanna Villani, Grazia Pia Magnati, Giulia Tuccari, Moris Sangineto, Antonino Davide Romano, Tommaso Cassano, Gaetano Serviddio
    Ultrasound.2023; 31(3): 177.     CrossRef
  • Serum γ-glutamyltransferase level and incidence risk of metabolic syndrome in community dwelling adults: longitudinal findings over 12 years
    Jiwon Kwak, In-Ho Seo, Yong-Jae Lee
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Gamma-Glutamyl Transferase as a Diagnostic Marker of Metabolic Syndrome
    Bobbili Tarun Kesava Naidu, Kakarlapudi Santosh Raju, Janapareddi V BhaskaraRao, Nallapati Sunil Kumar
    Cureus.2023;[Epub]     CrossRef
  • Metabolic syndrome and transaminases: systematic review and meta-analysis
    Elena Raya-Cano, Rafael Molina-Luque, Manuel Vaquero-Abellán, Guillermo Molina-Recio, Rocío Jiménez-Mérida, Manuel Romero-Saldaña
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Associating Liver Enzymes and Their Interactions with Metabolic Syndrome Prevalence in a Japanese Working Population
    Aziz Jamal, Akira Babazono, Ning Liu, Rieko Yamao, Takako Fujita, Sung-a Kim, Yunfei Li
    Metabolic Syndrome and Related Disorders.2023;[Epub]     CrossRef
  • Association between Serum Gamma-glutamyl Transferase and Metabolic Syndrome: A Case–control Study
    Akshay Shelar, Nalini Humaney, Akshay Chhajed, Krunal Domki, Ajay Narwade
    Journal of Datta Meghe Institute of Medical Sciences University.2023; 18(4): 651.     CrossRef
  • “Big Data” Approaches for Prevention of the Metabolic Syndrome
    Xinping Jiang, Zhang Yang, Shuai Wang, Shuanglin Deng
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Can Gamma-glutamyl Transferase Predict Unhealthy Metabolic Phenotypes Among Healthcare Workers in Azar Cohort Study?
    Mohammadhossein Somi, Seyed Sina Zakavi, Alireza Ostadrahimi, Negin Frounchi, Neda Gilani, Sarvin Sanaie, Elnaz Faramarzi
    Hepatitis Monthly.2022;[Epub]     CrossRef
  • Association between liver enzymes and metabolic syndrome in Canadian adults: results from the Canadian health measures survey - cycles 3 &4
    Luan Manh Chu, Chandima Karunanayake, Palok Aich, Markus Hecker, Punam Pahwa
    Journal of Diabetes & Metabolic Disorders.2022; 21(2): 1699.     CrossRef
  • Repeatedly elevated γ-glutamyltransferase levels are associated with an increased incidence of digestive cancers: A population-based cohort study
    Chang-Hoon Lee, Kyungdo Han, Da Hye Kim, Min-Sun Kwak
    World Journal of Gastroenterology.2021; 27(2): 176.     CrossRef
  • Index of Cardiac Age Index and Cardiometabolic Biomarkers in Adults with Metabolic Syndrome
    Eun Jung Choi, Sang Yeoup Lee
    Metabolic Syndrome and Related Disorders.2021; 19(5): 288.     CrossRef
  • Simple metabolic markers associated with tophaceous gout
    Wei Liu, Hui Song, Siliang Man, Hongchao Li, Siming Gao
    Clinical Rheumatology.2021; 40(12): 5047.     CrossRef
  • Expression Status and Prognostic Significance of Gamma-Glutamyl Transpeptidase Family Genes in Hepatocellular Carcinoma
    Shan Tian, Jiao Li, Yingyun Guo, Weiguo Dong, Xin Zheng
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes
    Sang Youn You, Kyungdo Han, Seung-Hawn Lee, Mee Kyoung Kim
    Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
Close layer
Clinical Study
Cardiac Dysfunction in Association with Increased Inflammatory Markers in Primary Aldosteronism
Jung Soo Lim, Sungha Park, Sung Il Park, Young Taik Oh, Eunhee Choi, Jang Young Kim, Yumie Rhee
Endocrinol Metab. 2016;31(4):567-576.   Published online November 3, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.4.567
Correction in: Endocrinol Metab 2020;35(3):671
  • 5,050 View
  • 42 Download
  • 14 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   
Background

Oxidative stress in primary aldosteronism (PA) is thought to worsen aldosterone-induced damage by activating proinflammatory processes. Therefore, we investigated whether inflammatory markers associated with oxidative stress is increased with negative impacts on heart function as evaluated by echocardiography in patients with PA.

Methods

Thirty-two subjects (mean age, 50.3±11.0 years; 14 males, 18 females) whose aldosterone-renin ratio was more than 30 among patients who visited Severance Hospital since 2010 were enrolled. Interleukin-1β (IL-1β), IL-6, IL-8, monocyte chemoattractant protein 1, tumor necrosis factor α (TNF-α), and matrix metalloproteinase 2 (MMP-2), and MMP-9 were measured. All patients underwent adrenal venous sampling with complete access to both adrenal veins.

Results

Only MMP-2 level was significantly higher in the aldosterone-producing adenoma (APA) group than in the bilateral adrenal hyperplasia (BAH). Patients with APA had significantly higher left ventricular (LV) mass and A velocity, compared to those with BAH. IL-1β was positively correlated with left atrial volume index. Both TNF-α and MMP-2 also had positive linear correlation with A velocity. Furthermore, MMP-9 showed a positive correlation with LV mass, whereas it was negatively correlated with LV end-systolic diameter.

Conclusion

These results suggest the possibility that some of inflammatory markers related to oxidative stress may be involved in developing diastolic dysfunction accompanied by LV hypertrophy in PA. Further investigations are needed to clarify the role of oxidative stress in the course of cardiac remodeling.

Citations

Citations to this article as recorded by  
  • 2023 Korean Endocrine Society Consensus Guidelines for the Diagnosis and Management of Primary Aldosteronism
    Jeonghoon Ha, Jung Hwan Park, Kyoung Jin Kim, Jung Hee Kim, Kyong Yeun Jung, Jeongmin Lee, Jong Han Choi, Seung Hun Lee, Namki Hong, Jung Soo Lim, Byung Kwan Park, Jung-Han Kim, Kyeong Cheon Jung, Jooyoung Cho, Mi-kyung Kim, Choon Hee Chung
    Endocrinology and Metabolism.2023; 38(6): 597.     CrossRef
  • The role of the mineralocorticoid receptor in immune cells in cardiovascular disease
    Charlotte D. C. C. van der Heijden, Marlies Bode, Niels P. Riksen, Ulrich O. Wenzel
    British Journal of Pharmacology.2022; 179(13): 3135.     CrossRef
  • Prevalence and clinical characteristics of primary aldosteronism in a tertiary-care center in Korea
    Minjae Yoon, Namki Hong, Jaehyung Ha, Chan Joo Lee, Cheol Ryong Ku, Yumie Rhee, Sungha Park
    Hypertension Research.2022; 45(9): 1418.     CrossRef
  • Functional Characteristic and Significance of Aldosterone-Producing Cell Clusters in Primary Aldosteronism and Age-Related Hypertension
    Fatin Athirah Pauzi, Elena Aisha Azizan
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Aldosterone-Regulating Receptors and Aldosterone-Driver Somatic Mutations
    Jung Soo Lim, Samuel W. Plaska, Juilee Rege, William E. Rainey, Adina F. Turcu
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Time-Dependent Risk of Atrial Fibrillation in Patients With Primary Aldosteronism After Medical or Surgical Treatment Initiation
    Kyoung Jin Kim, Namki Hong, Min Heui Yu, Hokyou Lee, Seunghyun Lee, Jung Soo Lim, Yumie Rhee
    Hypertension.2021; 77(6): 1964.     CrossRef
  • Serum Matrix Metalloproteinases and Left Atrial Remodeling—The Hoorn Study
    Pauline B. C. Linssen, Hans-Peter Brunner-La Rocca, Casper G. Schalkwijk, Joline W. J. Beulens, Petra J. M. Elders, Amber A. van der Heijden, Roderick C. Slieker, Coen D. A. Stehouwer, Ronald M. A. Henry
    International Journal of Molecular Sciences.2020; 21(14): 4944.     CrossRef
  • Endothelial Dysfunction in Primary Aldosteronism
    Zheng-Wei Chen, Cheng-Hsuan Tsai, Chien-Ting Pan, Chia-Hung Chou, Che-Wei Liao, Chi-Sheng Hung, Vin-Cent Wu, Yen-Hung Lin
    International Journal of Molecular Sciences.2019; 20(20): 5214.     CrossRef
  • IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis
    Chia-Hung Chou, Chi-Sheng Hung, Che-Wei Liao, Lin-Hung Wei, Ching-Way Chen, Chia-Tung Shun, Wen-Fen Wen, Cho-Hua Wan, Xue-Ming Wu, Yi-Yao Chang, Vin-Cent Wu, Kwan-Dun Wu, Yen-Hung Lin
    Cardiovascular Research.2018; 114(5): 690.     CrossRef
  • European Heart Rhythm Association (EHRA) position paper on arrhythmia management and device therapies in endocrine disorders, endorsed by Asia Pacific Heart Rhythm Society (APHRS) and Latin American Heart Rhythm Society (LAHRS)
    Bulent Gorenek, Giuseppe Boriani, Gheorge-Andrei Dan, Laurent Fauchier, Guilherme Fenelon, He Huang, Gulmira Kudaiberdieva, Gregory Y H Lip, Rajiv Mahajan, Tatjana Potpara, Juan David Ramirez, Marc A Vos, Francisco Marin, Carina Blomstrom-Lundqvist, Aldo
    EP Europace.2018; 20(6): 895.     CrossRef
  • Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism
    Jung Soo Lim, Namki Hong, Sungha Park, Sung Il Park, Young Taik Oh, Min Heui Yu, Pil Yong Lim, Yumie Rhee
    Endocrinology and Metabolism.2018; 33(4): 485.     CrossRef
  • The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis
    Charlotte D C C van der Heijden, Jaap Deinum, Leo A B Joosten, Mihai G Netea, Niels P Riksen
    Cardiovascular Research.2018; 114(7): 944.     CrossRef
Close layer
Two Cases of Cushing's Disease Due to Large Pituitary ACTH Secreting Tumor.
Hong Seung Kim, Choon Hee Chung, Mee Yeon Cho, Young Goo Shin, Il Hoe Kim, Seok Woo Yang, Jang Young Kim
J Korean Endocr Soc. 1998;13(1):83-93.   Published online January 1, 2001
  • 972 View
  • 18 Download
AbstractAbstract PDF
Cushing's syndrome that is caused by an adenoma of the corticotrape cells of the anterior pituitay or, rarely, by couticotrope hyperplasia is refered to as Cushing's disease. Cushings disease is usually characterized by chronic, moderate hypersecretion of ACTH and other POMC derived peptide. Most patients have ACTH-secreting anterior pituitary corticotrope microadenomas, but a small minority have a pituitary macroadenoma. We recently experenced two cases of Cushings disease due to pituitary macroadenoma. and report this cases with review of literatures.
Close layer

Endocrinol Metab : Endocrinology and Metabolism