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Jaesang Kim  (Kim J) 1 Article
Gene Expression Regulation by Agonist-Independent Constitutive Signaling of Melanocortin-1 Receptor
Ikjoo Seong, Jaesang Kim
Endocrinol Metab. 2014;29(2):179-184.   Published online June 26, 2014
DOI: https://doi.org/10.3803/EnM.2014.29.2.179
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  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDFPubReader   
Background

Melanocortin-1 receptor (Mc1r), a key signaling receptor for melanogenesis, has been reported to mediate migration of B16F10 melanoma cells. Interestingly, this activity appears to be a part of the constitutive signaling of Mc1r.

Methods

We carried out small interfering RNA-mediated knock-down of Mc1r on murine melanoma B16F10 cells and performed microarray analysis to characterize changes in the gene expression profile.

Results

We isolated 22 and four genes whose expression decreased and increased, respectively, by 2.5-fold or higher as the result of Mc1r knock-down. Several down-regulated genes have been proposed to be involved in cell migration. Among these genes are several members of the chemokine gene family.

Conclusion

We provide a gene set for further functional analyses of Mc1r. The Mc1r target genes we present may be particularly relevant for understanding the ligand-independent activity of Mc1r. Further examination of the mode of action may lead to novel strategies in regulating the migration and metastasis of melanoma cells.

Citations

Citations to this article as recorded by  
  • NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation
    Evan L. Carpenter, Alyssa L. Becker, Arup K. Indra
    Cancers.2022; 14(6): 1531.     CrossRef
  • Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis
    Stuart G. Jarrett, John A. D'Orazio
    Photochemistry and Photobiology.2017; 93(1): 245.     CrossRef
  • Articles in 'Endocrinology and Metabolism' in 2014
    Won-Young Lee
    Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
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